CN100366270C

CN100366270C - Medicine for curing cardiovascular and cerebrovascular diseases

Info

Publication number: CN100366270C
Application number: CNB031220177A
Authority: CN
Inventors: 杨允钊
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-04-22
Filing date: 2003-04-22
Publication date: 2008-02-06
Anticipated expiration: 2023-04-22
Also published as: CN1457832A

Abstract

The present invention discloses a medicine for treating cardiovascular/cerebrovascular diseases. The present invention is characterized in that the medicine is prepared from the following raw materials of the percentage by weight: 20 to 60% of herba rhodiolae extract, 11.3 to 28.3% of carapax testudinis, 0.7 to 28.3% of ghatzae, 2.3 to 37.3% of radix rubiae, 8 to 20.5% of flos campsis, 0.7 to 28.5% of potassium nitrate, 1.1 to 17% of nidus vespae, 1 to 19% of cassia twigs, 0.7 to 28.5% of blackberrylily rhizomes, 0.7 to 28.5% of eupolyphaga, 1 to 19% of red peony roots and 0.3 to 0.9% of musk. The present invention is prepared on the basis of the theory of the traditional Chinese medicine and pharmacy by being combined with the viewpoint of the western medicine and the new achievement of the modern medicine and developing the secret prescription of the tibetan medicine. The present invention has the functions of activating blood circulation to dissipate blood stasis, removing stasis, expelling damp and resolving turbidity, supporting the healthy energy, etc., and has favorable curative effects and no toxic side effect on multiple visceral organ injuries and coronary heart diseases, which are induced by cardiovascular/cerebrovascular diseases, and erythrocytosis induced by oxygen deficiency.

Description

A kind of medicine for the treatment of cardiovascular and cerebrovascular disease

Affiliated technical field: the invention discloses a kind of medicine for the treatment of cardiovascular and cerebrovascular disease.

Background technology:

Each organ of human body connects each other and relies on, and heart and liver, spleen, lung, kidney are particularly close, and heart disease often causes multiple organs dysfunction, thereby jeopardizes people's health, even life.The people with advancing age, immunologic function is also low day by day, particularly in the abominable Qinghai-Tibet Platean of natural environment, one of disease that threatens human health is: cardiovascular and cerebrovascular disease, the physician is devoted to seek the effective measure of treatment myocardial damage always, the medicine of the treatment cardiovascular and cerebrovascular vessel of existing clinical practice is as trimetazidine, sorbitrate, Isosorbide-5-Mononitrate, DIAOXINXUE KANG, NAOXINTONG etc., though they are at relief of symptoms, improve circulation, aspects such as functional status truly have certain curative effect, but act on single, not lasting to the cardiovascular and cerebrovascular disease effect, to the multiple organ injury that cardiovascular and cerebrovascular disease causes, effect is undesirable.

Summary of the invention:

The objective of the invention is for a kind of medicine for the treatment of cardiovascular and cerebrovascular disease is provided, single to solve existing clinical treatment cardiovascular and cerebrovascular diseases medicament curative effect, effect is not lasting, chemical sproof fast shortcoming, it has excellent curative to the damage of many internal organs such as the liver that caused by heart disease, lung, spleen, kidney, and has no side effect.

For achieving the above object, the technical scheme that the present invention takes is: a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, and it can be made by following raw materials by weight percent:

Radix Rhodiolae extractum 20-60% Carapax et Plastrum Testudinis 11.3-28.3%

Add and examine 0.7-28.3% Radix Rubiae 2.3-37.3%

Flos Campsis 8-20.5% Sal Nitri 0.7-28.5%

Nidus Vespae 1.1-17% Ramulus Cinnamomi 1-19%

Rhizoma Belamcandae 0.7-28.5% eupolyphaga 0.7-28.5%

Radix Paeoniae Rubra 1-19% Moschus 0.3-0.9%

Wherein the percentage by weight of optimum formula is: Radix Rhodiolae extractum 23.94%, Carapax et Plastrum Testudinis 11.0%, add examine 7.5%, Radix Rubiae 11.4%, Flos Campsis 9.51%, Sal Nitri 7.5%, Nidus Vespae 5.76%, Ramulus Cinnamomi 5.76% Rhizoma Belamcandae 5.76%, eupolyphaga 5.76%, Radix Paeoniae Rubra 5.76%, Moschus 0.35%.

Medicine provided by the invention is according to Chinese medical theory, in conjunction with the doctor trained in Western medicine viewpoint, excavate Tibetan medicine's secret recipe, connect each other according to each internal organs of human body, complementary organic conception, newly achieve in conjunction with modern medicine, screen through repeated clinical practice, the pure Chinese medicinal preparation of preparation, it has blood circulation promoting and blood stasis dispelling, the blood stasis dispelling eliminating stagnation, it is turbid to remove humidifying, effects such as strengthening the body resistance, the energy diuretic, regulate the flow of vital energy and nourish blood, nourishing the brain and improving intelligence, nourishing and fit keeping function contains tens of seed amino acids, particularly its contain 7 kinds of human bodies can not synthetic aminoacid and the trace element of multiple needed by human, and high energy protein and abundant plant amedica natural activity.It is many that it contains active ingredient, the therapeutical effect multipath, and the therapeutic mechanism many-side, it has a general protective effect unusually to body tissue cellularity aspect, can expand whole body tremulous pulse, improves PaO ₂, physical strength reinforcing, resisting fatigue, improve hypoxia-bearing capability, reduce platelet adhesion, change hemorheology and learn, improve blood plasma flowability and erythrocyte deformability, help the blood oxygen supply, congestion and edema is organized in elimination, prevents thrombosis and dissolving vascular peg stay plug, can improve the ST that resists myocardial ischemia, dwindle ischemia thromboembolism area, reduce serum creatine kinase (CPK) and lactic acid dehydrogenase (LDH) level.The energy blood fat reducing prevents atherosclerosis.Can anti-obstruction of qi in the chest and cardialgia, as coronary disease pain, angina cordis, correct ischemia, the damage of perfusion and struvite free radical again.Remove the activity that suppresses sodium pump and calcium pump, regulate cell calcium overload load, keep membrane structure and internal and external environment balance.

The present invention shows through the immunologic function test: can strengthen mononuclear cell macrophage phagocytic index, strengthen the mononuclear cell macrophage phagocytic function, regulate immunity of organism, the enhancing body resistance against diseases, can make the thymosin secretion increasing, the lymphocyte number of reaching maturity is increased.

The present invention shows through pharmacodynamic experiment: it can treat, prevent obstruction of qi in the chest and cardialgia, as coronary heart disease, angina pectoris etc.Can dredge circulation, thrombolytic, but reinforced immunological regulate, improve symptom fast, have no side effect.

The present invention shows through animal experiment: early stage application promptly possesses the anoxia enduring indication, prevent pulmonary hypertension and formation thereof, systemic inflammatory response syndrome (SIRS), acute lung injury (ALI), multiple organs dysfunction (MODS) to anoxia, wound, infection mediation, aspects such as inhibition of energy multipath and regulation and control inflammatory mediator play an important role, reduce the dangerous hurried course of disease, reduce mortality rate, the inspirer effect of preventing is arranged.Especially can prevent with AA metabolite TXB _2,6-KeT0PGFIa is that the strong material of releiving that shrinks of representative blood vessel is subjected to remarkable inhibition, and it is flat to maintain bottom water from start to finish, and the liver lienomalacia retraction that recovers liver function, can make enlargement is arranged, mice is being proved in normobaric hypoxia test and swimming test, this medicine can increase the mice hypoxia-bearing capability, prolong mice low temperature swimming time, strengthen mouse anti-reflecting fatigue, anti-anoxia ability.(1) resists Electrocardiographic ST section of ischemic rat and the TII rising that pituitrin causes, improve myocardial ischemia, anaerobic condition, (2) obviously reducing the ST that ligation rat coronary artery trunk causes raises, obviously reduce the myocardial infarct size that the ligation main coronary artery causes, experimental myocardial infarction model there is therapeutical effect, (3) obviously reduce the level of serum creatine kinase (CPK) and newborn dehydrogenase (LDH), obviously resist the biochemical metabolism that heart infarction causes; (4) obviously improve hemorheological parameter, reduce the blood adhesiveness, blood stasis state due to the improvement, promoting blood flow, (5) improve endurance and hypoxia-bearing capability, enhancing body resistance.

The present invention is that a kind of preparation technology of medicine for the treatment of cardiovascular and cerebrovascular disease is technology routinely, can make various dosage forms such as capsule, tablet, powder, oral liquid as required.

The invention will be further described below in conjunction with embodiment.

The specific embodiment:

Embodiment 1: a kind of medicine for the treatment of cardiovascular and cerebrovascular disease; it is made into by following raw materials by weight percent: Radix Rhodiolae extractum 23.94%; Carapax et Plastrum Testudinis 11%; add and examine 7.5%; Radix Rubiae 11.4%; Flos Campsis 9.51%; Sal Nitri 7.5%; Nidus Vespae 5.76%; Ramulus Cinnamomi 5.76%; Rhizoma Belamcandae 5.76%; eupolyphaga 5.76%; Radix Paeoniae Rubra 5.76%; Moschus 0.35%; make capsule; this medicine has good curative effect to patients with coronary heart disease; and it is uncomfortable in chest in alleviation; chest pain; cardiopalmus; common sympton aspect such as breathe hard is particularly outstanding; the angina pectoris attacks number of times is reduced; persistent period shortens; and ischaemic ECG change is improved; the protection myocardial function; anti-hypoxia; resisting fatigue, the may command symptomatic recurrence.

Embodiment 2: a kind of medicine for the treatment of cardiovascular and cerebrovascular disease is made up of following raw materials by weight percent: Radix Rhodiolae extractum 45%, Carapax et Plastrum Testudinis 15%, add and examine 5%, Radix Rubiae 4.5%, Flos Campsis 10%, Sal Nitri 2%, Nidus Vespae 12%, Ramulus Cinnamomi 2%, Rhizoma Belamcandae 1%, eupolyphaga 1%, Radix Paeoniae Rubra 2%, Moschus 0.5%, make oral liquid, this medicine can be corrected under high altitude localities and the low-oxygen environment the body tissue organ, brain, the heart, lung, kidney, gastral influence, can improve blood oxygen pressure, to erythrocytosis, the blood viscosity height, vascular resistance is big, blood is slow, hyperlipidemia, pulmonary hypertension organizes diseases such as congestion and edema that the positive therapeutic effect is arranged.

Embodiment 3: its prescription by weight percentage is: Radix Rhodiolae extractum 25%, Carapax et Plastrum Testudinis 11%, add examine 9%, Radix Rubiae 8%, Flos Campsis 8%, Sal Nitri 10%, Nidus Vespae 5.6%, Ramulus Cinnamomi 10%, Rhizoma Belamcandae 8%, eupolyphaga 3%, Radix Paeoniae Rubra 2%, Moschus 0.4%, make tablet, the multiple organ injury of this medicine to causing because of cardiovascular and cerebrovascular disease, acute lung edema, anoxia, wound, the general toxic reaction syndrome that infects medium has well prevents effect, improve the immunocompetence of body, reduce the dangerous hurried course of disease, reduce mortality rate.

This medicine composition, enhance immunity are better than Radix Ginseng and vitamin medicaments, and various types of altitude sickness are also had certain therapeutical effect.

Claims

1. medicine for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is made by following raw materials by weight percent:

Radix Rhodiolae extractum 20-60%, adds and examines 0.7-28.3%, Radix Rubiae 2.3-37.3%, Flos Campsis 8-20.5%, Sal Nitri 0.7-28.5%, Nidus Vespae 1.1-17%, Ramulus Cinnamomi 1-19%, Rhizoma Belamcandae 0.7-28.5%, eupolyphaga 0.7-28.5%, Radix Paeoniae Rubra 1-19%, Moschus 0.3-0.9% Carapax et Plastrum Testudinis 11.3-28.3%.

2. a kind of medicine for the treatment of cardiovascular and cerebrovascular disease as claimed in claim 1 is characterized in that it can be mixed with by following raw materials by weight percent:

Radix Rhodiolae extractum 23.94%, Carapax et Plastrum Testudinis 11.0%, add examine 7.5%, Radix Rubiae 11.4%, Flos Campsis 9.51%, Sal Nitri 7.5%, Nidus Vespae 5.76%, Ramulus Cinnamomi 5.76%, Rhizoma Belamcandae 5.76%, eupolyphaga 5.76%, Radix Paeoniae Rubra 5.76%, Moschus 0.35%.