CN100364567C - Oral liquid for cold - Google Patents
Oral liquid for cold Download PDFInfo
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- CN100364567C CN100364567C CNB2006100435437A CN200610043543A CN100364567C CN 100364567 C CN100364567 C CN 100364567C CN B2006100435437 A CNB2006100435437 A CN B2006100435437A CN 200610043543 A CN200610043543 A CN 200610043543A CN 100364567 C CN100364567 C CN 100364567C
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Abstract
The present invention relates to a cold treating oral liquid which is used for treating colds. The present invention is prepared from the following effective raw materials of the portion by weight: 80 to 120 portions of notopterygium roots, 80 to 120 portions of ledebouriella roots, 200 to 300 portions of pueraria roots, 40 to 90 portions of atractylodes rhizome, 150 to 250 portions of isatis roots, 100 to 200 portions of scutellaria roots, 30 to 90 portions of basket fern rhizome and 50 to 90 portions of licorice roots. The present invention has novel and simple composition, pure Chinese medicinal constituents and no toxic side effect; the results of animal experiments by the traditional Chinese medicine and pharmacy academy of shandong province indicate that the present invention has the obvious functions of lasting refrigeration, antiinflammation, human immunization enhancement and obvious antiviral effect, particularly respiratory syncytial viruses, and the antiviral capability of the present invention is 3.31 times the compound folium isatidis mixture; the clinical application of the present invention has been carried out in the applicant's company since 2003, thousands of people have been cured by the present invention, the cure rate reach 100%, and the present invention has rapid and good curative effect.
Description
Technical field
The present invention relates to a kind of cold oral liquid, be the oral formulations of treatment flu.
Background technology
Flu is one of clinically common disease of internal medicine, all can fall ill throughout the year, and the height of its sickness rate, involvement aspect is wide, and is known by everybody.Equally, the medicine of treatment flu disease also is to have a variety ofly, and Western medicine is arranged, and Chinese medicine is also arranged, the crude drug difference of medicine, and performance is different.
Summary of the invention
The object of the present invention is to provide a kind of cold oral liquid of brand-new composition, form simply, curative effect is fast, good effect.
Cold oral liquid of the present invention, make by the crude drug that following weight is formed:
80～120 parts of Rhizoma Et Radix Notopterygiis, 80～120 parts of Radix Saposhnikoviaes, 200～300 parts of Radix Puerariaes, 40～90 parts of Rhizoma Atractylodis, 150～250 parts of Radix Isatidis, 100～200 parts of Radix Scutellariaes, 30～90 parts of Rhizoma Dryopteris Crassirhizomatiss, 50～90 parts in Radix Glycyrrhizae.
Best group becomes:
100 parts of Rhizoma Et Radix Notopterygiis, 100 parts of Radix Saposhnikoviaes, 250 parts of Radix Puerariaes, 50 parts of Rhizoma Atractylodis, 200 parts of Radix Isatidis, 130 parts of Radix Scutellariaes, 60 parts of Rhizoma Dryopteris Crassirhizomatiss, 60 parts in Radix Glycyrrhizae.
Preparation method is identical with common oral liquor, the decocting method preparation.Generally after remove impurity, need to add an amount of antiseptic and flavoring agent, as sorbic acid, benzoic acid, sodium benzoate antiseptic, sorbic acid is than sodium benzoate price height, and benzoic acid postpone of a specified duration produces muddy, and sodium benzoate is more suitable for; Sucrose, inulin flavoring agent etc.
Cold oral liquid of the present invention is pale brown color liquid, and sweet in the mouth is arduous, and pure Chinese medicine is formed, and has no side effect.
Oral liquid of the present invention is the wind-cold damp pathogen diseases caused by exogenous pathogenic factor, in intrinsic heat arranged and establish.The affection of exogenous wind-cold damp is restrainted in the flesh table, defends gas-tight plug, so fever with aversion to cold is lossless; The cold-evil fights mutually, evil meridians, and QI-blood circulation is not smooth, thus headache, general pain, stiff nape and back, limb aching pain or bitterly heavy, or joint aches; In intrinsic heat is arranged, so bitter taste and thirsty.Control suitable dispersing wind and cold, damp eliminating heresy, the clear interior-heat of holding concurrently.Wherein, the Rhizoma Et Radix Notopterygii relieving the exterior syndrome by diaphoresis, expelling wind and dampness, numbness relieving and pain relieving is with being monarch drug; The Radix Saposhnikoviae relieving the exterior syndrome by diaphoresis, removing dampness to relieve pain, the effect of the expelling wind and dampness of reinforcement Rhizoma Et Radix Notopterygii is so be ministerial drug; The Radix Puerariae expelling pathogenic factors from muscles for clearing heat is the bright medicine administered to bring out the cold of sun, with the bright heat of clear sun, and promoting the production of body fluid to quench thirst, for removing Tianjin that pyretic toxicity has consumed; Rhizoma Atractylodis both can assist the Rhizoma Et Radix Notopterygii table that looses wet outward, can prevent exogenous damp again and caused the change of endogenous dampness; Radix Scutellariae bitter cold clearing interior heat; Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis heat-clearing and toxic substances removing, reducing swelling and alleviating pain is the key medicine of treatment pestilence seasonal noxious pathogen, and energy removing summer-heat throat women's head-ornaments pyretic toxicity, so be adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, but strengthening vital QI to eliminate pathogenic factors, what use is messenger drug.
The present invention forms the residence heat clearing away among suffering is loose, and temperature must not loose help heat, the unlikely evil pathogenic factor in the exterior of heat clearing away; Play the dehumidifying of inducing sweat altogether, the merit of analgesia has the effect of clearing away heat and promoting production of body fluid concurrently, reaches the purpose of eliminating virus row flu, bacillary flu and epidemic virus.Be the agent of inducing diaphoresis to dispel wind, heat-clearing and toxic substances removing, removing damp and stopping pain, decrease cloudyly so medicine, reaches hot dry unlikely impairment of YANG with three hot temperature, three bitter colds, two gentle that the unlikely yin fluid astringing of bitter cold decreases positive, the gentle conciliation property of medicine makes it to bring into play the cold expelling expelling pathogenic factors from muscles, removing damp and stopping pain, the effect of heat-clearing and toxic substances removing.Prevent the tabulation sweating, damp is stayed in the flesh table, and sick is touching.The slight illness due to the flu is eliminated in combineds effect such as antibiotic, the antiviral that makes full use of that each medicine had in prescription, analgesic, analgesia, antiinflammatory, antiallergic action, enhance immunity drug effect.
Function with cure mainly: expelling pathogenic wind from the body surface, heat-clearing and toxic substances removing, removing damp and stopping pain.Be used for the wind and cold fever with aversion to cold due to the heat syndrome in table is held concurrently that wets, the flesh table is lossless, headache, and general pain, limb aching pain, stiff nape and back, the nasal obstruction watery nasal discharge, laryngopharynx swelling and pain is coughed, xerostomia, white, slippery and moist fur, floating pulses etc. are applicable to four seasons common cold.
Instructions of taking: body temperature is taken 10-20ml person below 39 ℃ at every turn, and person more than 39 ℃ takes 30ml at every turn, takes once in 4-5 hour, can drink a small amount of hot water or hot Jiang Shui again after taking medicine.
Cold oral liquid of the present invention is completely newly formed, and forms simply, and pure Chinese medicine ingredients has no side effect.Result after the Medicine Institute, Shandong Province is with animal experiment, its refrigeration function is remarkable and lasting, the antivirus action highly significant, especially to respiratory syncytial virus, be 3.31 times of compound Folium Isatidis mixture, antiinflammatory action, enhancing human body immunity effect etc., also very remarkable.Obtained clinical practice from 2003 in applicant unit, treatment patient several thousand people, cure rate 100%, curative effect is fast, good effect, part contrast situation is listed below:
One, diagnostic criteria
1, case is selected
2, primary symptom: fever with aversion to cold, axillary fossa body temperature is measured 38 ℃.
3, double disease: headache, nasal obstruction watery nasal discharge, systemic pain, laryngopharynx swelling and pain etc.
4, sign: red tongue with thin fur is white, floating and rapid pulse, the hyperemia of throat flushing, cough, uttering phlegm.
5, nasopharyngeal secretions virus detects: with alkali phosphatase bridging enzyme linked immunosorbent assay, be influenza virus, parainfluenza virus, adenovirus positive person.
6, the age is between 15-55 year, generates heat and goes to a doctor in 24 hours, do not use antiviral Chinese medicine and western medicine.
Two, Therapeutic Method
1, treatment group: use cold oral liquid of the present invention, body temperature is person below 39 ℃, take 10-20ml, person more than 39 ℃ takes 30ml at every turn at every turn, took once in 4-5 hour, can drink a small amount of hot water or hot Jiang Shui again after taking medicine, after body temperature descends, medicine be changed clothes be 10ml, after body temperature is normal, consolidate clothes 1-2 time again.
2, matched group: use compound Folium Isatidis mixture, SHUANGHUANGLIAN KOUFUYE, each 20ml took once in every 4-5 hour.
3, observational technique
(1) body temperature: body temperature begins fall time and temperature recovery normal time after observing medication, in 24 hours, surveys body temperature 1 time, and gives record in per 2 hours after the medication.
(2) viral cloudy revolution: medication is got nasopharyngeal secretions and is done virus detection (double-blind method) after 48 hours, observes the cloudy revolution of two papovas.
(3) symptom, sign: before medication and after the medication, respectively write down 1 symptom, sign in 3 hours.
4, curative effect judging standard:
(1) efficacy determination of bringing down a fever: speed is brought down a fever: the endosome temperature drop was to normally no longer ging up in 24 hours; In bring down a fever: 24-48 hour endosome temperature drop is to normally no longer ging up; Slowly bring down a fever: often answer as yet though body temperature fell in 48 hours.
(2) symptom, sign efficacy determination: each symptom, body temperature are by treating previous crops 3 minutes; Counted 2 fens if alleviate 1/3 the treatment back; If alleviated 2/3 1 fens; More be 0 minute entirely.After the treatment respectively and before the treatment ratio of total points be quick-acting between 0-0.33,0.34-0.66 is middle effect, 0.67-1 is effect slowly.
5, therapeutic outcome
(1) body temperature begins fall time after the medication: cold oral liquid group of the present invention 2 hours the earliest, 6 hours at the latest, average 3,41 hours.Matched group 6 hours the earliest, 18 hours at the latest, average 9,46 hours.Two groups of comparing differences significantly (P＜0.01 〉.
(2) body temperature normally rises required time no longer again after the medication: the shortest 3 hours 7 examples of treatment group, 4-6 hour 12 examples, 7-12 hour 14 examples, 13-24 hour 12 examples, 2 examples more than 24 hours, average 12 hours.Matched group 7-12 hour 4 examples, 13-24 hour 8 examples, 24-36 hour 12 examples, 13 examples more than 36 hours, average 31,6 hours.Two groups of comparing differences significantly (P＜0.01 〉.
(3) curative effect of bringing down a fever: 39 examples are organized in treatment, and speed is moved back 35 examples, and the speed rate of bringing down a fever is 89.7%; Matched group 37 examples, speed 12 examples of bringing down a fever, the speed rate of moving back is 32.4%, two group of significant difference.
(4) symptom, sign curative effect: after the medication the 3rd day, two groups of symptoms, signs disappear and the improvement situations show: treatment was organized in 39 examples, quick-acting 31 examples, and middle effect 5 examples are imitated 3 examples slowly; In matched group 37 examples, quick-acting 15 examples, middle effect 10 examples are imitated 12 examples slowly.Two groups of quick-acting rate comparing differences significantly (P＜0.01 〉.
(5) viral negative conversion rate: after medication, rechecked viral negative conversion rate and virus infected cell number on the 2nd, 3 respectively for two groups.Wherein, the treatment group is rechecked 8 examples, and viral negative conversion rate is 83.9%; Matched group is rechecked 7 examples, and viral negative conversion rate is 59.4%, and after the medication the 3rd day, treatment papova infection cell number (individual infection cell/sheet) dropped to 0.43 by treatment preceding 4.52; Matched group drops to 0.89, two group by treatment preceding 4.01 more also notable difference.
Several routine model cases are listed below:
Case 1: poplar, woman, 22 years old, the applicant employee of Zibo City.The then sweating and heat is not understood of fever with chills 3 days, 39 ℃ of body temperature, transfusion and clothes Western medicine, systemic pain, unable, throat pain, nasopharyngeal secretions virus detects, and influenza virus is (+).Change clothes cold oral liquid 20ml of the present invention, take with hot water, second day morning, heat was moved back, and General Symptoms disappears.
Case 2: the Wang, the woman, 42 years old, Zhao, the man, 16 years old, applicant employee one family, surplus the alternate attack of chill and fever 7 day, general pain, the nasal obstruction watery nasal discharge, cough, hoarseness, the western medical treatment a few days has no resolution, and nasopharyngeal secretions virus detects, and influenza virus is (+).Change clothes cold oral liquid 20ml of the present invention, transference cure after two days.
Case 3: Liu, the family of three people, flu, body temperature all about 37.6 ℃, systemic pain, nasal obstruction, laryngopharynx swelling and pain, one day is surplus, and nasopharyngeal secretions virus detects, influenza virus is (+), enjoins everyone to obey cold oral liquid 20ml of the present invention, takes rehabilitation on the two recovery from illness with hot ginger decoction.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1, cold oral liquid of the present invention are made by the crude drug that following weight is formed: Rhizoma Et Radix Notopterygii 100g, Radix Saposhnikoviae 100g, Radix Puerariae 250g, Rhizoma Atractylodis 50g, Radix Isatidis 200g, Radix Scutellariae 130g, Rhizoma Dryopteris Crassirhizomatis 60g, Radix Glycyrrhizae 60g.Sodium benzoate antiseptic 3g, sucrose is an amount of, is mixed with 1000ml oral liquid of the present invention.
Preparation method: raw material weighing is assorted, decocted respectively three times by decocting method.Extractive distillation liquid is standby when decocting, three decocting liquids are merged, through precipitating, filtering and be condensed into the thick paste shape, taking-up cools, and presses decoction and alcohol sedimentation technique again and adds ethanol precipitation, collect supernatant, reclaim ethanol, adding preservative agent takes out after cold preservation, filtration, add syrup again to 1000ml, after fill, sterilization, labeling and packing subsequent treatment get product.
Embodiment 2, cold oral liquid of the present invention, according to the conventional preparation method of oral liquid, make the 1000ml cold oral liquid: Rhizoma Et Radix Notopterygii 90 grams, Radix Saposhnikoviae 105 grams, Radix Puerariae 240 grams, Rhizoma Atractylodis 70 grams, Radix Isatidis 180 grams, Radix Scutellariae 160 grams, Rhizoma Dryopteris Crassirhizomatis 50 grams, Radix Glycyrrhizae 80 grams by the crude drug that following weight is formed.
Embodiment 3, cold oral liquid of the present invention, according to the conventional preparation method of oral liquid, make the 1000ml cold oral liquid: Rhizoma Et Radix Notopterygii 110 grams, Radix Saposhnikoviae 100 grams, Radix Puerariae 270 grams, Rhizoma Atractylodis 55 grams, Radix Isatidis 220 grams, Radix Scutellariae 130 grams, Rhizoma Dryopteris Crassirhizomatis 70 grams, Radix Glycyrrhizae 60 grams by the crude drug that following weight is formed.
Embodiment 4, cold oral liquid of the present invention, according to the conventional preparation method of oral liquid, make the 1000ml cold oral liquid: Rhizoma Et Radix Notopterygii 112 grams, Radix Saposhnikoviae 90 grams, Radix Puerariae 230 grams, Rhizoma Atractylodis 75 grams, Radix Isatidis 230 grams, Radix Scutellariae 150 grams, Rhizoma Dryopteris Crassirhizomatis 45 grams, Radix Glycyrrhizae 80 grams by the crude drug that following weight is formed.
Embodiment 5, cold oral liquid of the present invention, according to the conventional preparation method of oral liquid, make the 1000ml cold oral liquid: Rhizoma Et Radix Notopterygii 120 grams, Radix Saposhnikoviae 85 grams, Radix Puerariae 290 grams, Rhizoma Atractylodis 45 grams, Radix Isatidis 110 grams, Radix Scutellariae 180 grams, Rhizoma Dryopteris Crassirhizomatis 65 grams, Radix Glycyrrhizae 60 grams by the crude drug that following weight is formed.
Embodiment 6, cold oral liquid of the present invention, according to the conventional preparation method of oral liquid, make the 1000ml cold oral liquid: Rhizoma Et Radix Notopterygii 105 grams, Radix Saposhnikoviae 110 grams, Radix Puerariae 250 grams, Rhizoma Atractylodis 60 grams, Radix Isatidis 210 grams, Radix Scutellariae 155 grams, Rhizoma Dryopteris Crassirhizomatis 50 grams, Radix Glycyrrhizae 60 grams by the crude drug that following weight is formed.
Claims (2)
1. cold oral liquid is characterized in that being made by the crude drug that following weight is formed:
80～120 parts of Rhizoma Et Radix Notopterygiis, 80～120 parts of Radix Saposhnikoviaes, 200～300 parts of Radix Puerariaes, 40～90 parts of Rhizoma Atractylodis, 150～250 parts of Radix Isatidis, 100～200 parts of Radix Scutellariaes, 30～90 parts of Rhizoma Dryopteris Crassirhizomatiss, 50～90 parts in Radix Glycyrrhizae.
2. cold oral liquid according to claim 1 is characterized in that being made by the crude drug that following weight is formed:
100 parts of Rhizoma Et Radix Notopterygiis, 100 parts of Radix Saposhnikoviaes, 250 parts of Radix Puerariaes, 50 parts of Rhizoma Atractylodis, 200 parts of Radix Isatidis, 130 parts of Radix Scutellariaes, 60 parts of Rhizoma Dryopteris Crassirhizomatiss, 60 parts in Radix Glycyrrhizae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100435437A CN100364567C (en) | 2006-04-10 | 2006-04-10 | Oral liquid for cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100435437A CN100364567C (en) | 2006-04-10 | 2006-04-10 | Oral liquid for cold |
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| Publication Number | Publication Date |
|---|---|
| CN1872162A CN1872162A (en) | 2006-12-06 |
| CN100364567C true CN100364567C (en) | 2008-01-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100435437A Expired - Fee Related CN100364567C (en) | 2006-04-10 | 2006-04-10 | Oral liquid for cold |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102872323B (en) * | 2012-10-15 | 2014-04-16 | 济南伟传信息技术有限公司 | Chinese medicine for treating common cold in children |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544031A (en) * | 2003-11-12 | 2004-11-10 | 重庆东方药业股份有限公司 | Oral liquid of Jiuwei Qianghuo and its preparation process |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544031A (en) * | 2003-11-12 | 2004-11-10 | 重庆东方药业股份有限公司 | Oral liquid of Jiuwei Qianghuo and its preparation process |
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| CN1872162A (en) | 2006-12-06 |
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Granted publication date: 20080130 Termination date: 20100410 |