CN100356957C - Chinese medicinal plaster for treating mastoncus and its preparation method - Google Patents
Chinese medicinal plaster for treating mastoncus and its preparation method Download PDFInfo
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- CN100356957C CN100356957C CNB2005100954561A CN200510095456A CN100356957C CN 100356957 C CN100356957 C CN 100356957C CN B2005100954561 A CNB2005100954561 A CN B2005100954561A CN 200510095456 A CN200510095456 A CN 200510095456A CN 100356957 C CN100356957 C CN 100356957C
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Abstract
The present invention relates to a specific traditional Chinese medicine plaster for treating hyperplasia of mammary glands, which is prepared from the following traditional Chinese medicines of blister beetle, common monkshood mother root, borneol, cowherb seed, glabrous greenbrier rhizome, raw pinellia, raw rhubarb, scorpion, raw arisaema, horse chestnut bullatine, pangolin, leech, raw notoginseng and mountain water caltrop, wherein the blister beetle, the glabrous greenbrier rhizome, the raw rhubarb, the raw arisaema and the borneol are used for counteracting toxic substances, purging the pathogenic fire and removing pathogenic heat from blood, the pangolin, the mountain water caltrop, the cowherb seed and the horse chestnut bullatine are hardened and integrated, and the scorpion, the common monkshood mother root, the leech, the raw notoginseng and the raw pinellia are used for expelling stasis and alleviating pain. The plaster has the advantages of convenient application, no toxic and side effect, low price and reliable treatment effect, and can fundamentally treat hyperplasia of mammary glands. The traditional Chinese medicinal plaster can also be used for treating sprain, painful swollen joints and chronic lumbago and scelalgia, and has the effects of alleviating pain, eliminating turgescence and promoting healing on restored and fixed parts which suffer closed fracture.
Description
Technical field
The present invention relates to a kind of external Chinese herbs paste, belong to pharmaceutical sanitary field, be mainly used in cyclomastopathy: the treatment of cyclomastopathy, cystic hyperplasia of breast, mastadenoma sample hypertrophy, mastofibroma, tuberculosis of breast, breast pimeloma, breast intraductal papilloma, gynecomastia, mastalgia etc.The present invention relates to also relate to the preparation method of this medicine.
Background technology
Cyclomastopathy is a kind of gynecological common disease, good sending out in anemia of pregnant woman and women breast-feeding their children.At present its Therapeutic Method is a lot of, comprises the Chinese patent medicine (as XIAOJIN WAN, RUPIXIAO, nuclear spirit and RUKUAIXIAO etc. disappear) of estrogen for oral administration or blood circulation promoting and dispersing pathogen accumulation, external infrared ray, electromagnetic curing etc.Physiotherapy only subtracts the disease effect, and method is more loaded down with trivial details.Estrogen for oral administration has increased the part mitigation to distending pain of the breast, enclosed mass, but curative effect is not lasting, and relapse rate is very high, and can upset the balance of endocrine dysfunction, causes systemic adverse reactions.XIAOJIN WAN is made up of Moschus, Semen Momordicae, Radix Aconiti Kusnezoffii, Resina Liquidambaris, Olibanum, Myrrha, Oletum Trogopterori, Radix Angelicae Sinensis, Pheretima and XIANGMO(sic), based on the fragrance eliminating stagnation of regulating the flow of vital energy, to alleviating cyclomastopathy and prevention of recurrence certain effect is arranged, but lump in breast distending pain and radical curing of disease unsatisfactory curative effect to increasing; RUPIXIAO is made up of Cornu Cervi, Herba Taraxaci, Kun cloth, Spica Prunellae, Caulis Spatholobi, Radix Notoginseng, Radix Paeoniae Rubra, Sargassum, Radix Rhapontici, the Radix Aucklandiae, Radix Scrophulariae, Cortex Moutan, and this medical instrument has the antiinflammatory effect of invigorating blood circulation, but the effect deficiency of its hard masses softening and resolving and reducing swelling and alleviating pain; The nuclear spirit that disappears is made up of Rhizoma Corydalis, Squama Manis, Scorpio, Scolopendra, Spica Prunellae, and this medicine is based on the pain relieving softening the hard mass, but the effect deficiency of its reducing swelling and alleviating pain and the eliminating stagnation of regulating the flow of vital energy; RUKUAIXIAO is made up of Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Semen Vaccariae, Fructus Toosendan, Pheretima, has the removing obstruction for relieving pain effect, but a little less than the effect very of lactogenesis circulation of qi promoting, hard masses softening and resolving and the blood circulation and removing stasis of prescription.Though so these medicines can in some pathogenesis link of intervening cyclomastopathy effectively can not be implemented multiple intervention to each pathogenesis link of disease, its curative effect is limited.Simultaneously, these endo-medicines also have following logical fraud: one, adopt administration for oral administration, must adopt because of part medicine wherein is toxic and the method attenuation such as fry, boil, fry in shallow oil, stew and process and get, thereby having destroyed part active drug composition has reduced therapy, though some drug toxicities are got still residual toxicity through processing simultaneously, prolonged application may have toxic side effect, so anemia of pregnant woman or women breast-feeding their children avoid clothes, yet, cyclomastopathy is just fallen ill in the majority with anemia of pregnant woman or women breast-feeding their children, this has just significantly limited its extensive use.Its two, the medicine valency is more expensive.Its three, the administration inconvenience, long-term prescription is difficult for adhering to.
Summary of the invention
The technical problem to be solved in the present invention is the deficiency at prior art or curative effect of medication, has proposed a kind of convenient drug administration, no toxic side effect, cheap and curative effect reliably maybe can be effected a radical cure the special effect Chinese patch of cyclomastopathy.
Another technical problem that will solve of the present invention has provided a kind of preparation method of this medicine.
The technical problem to be solved in the present invention is achieved through the following technical solutions, a kind of cyclomastopathy patch, it is formed by following Chinese prescription: Mylabris 2-6 weight portion, Radix Aconiti 3-7 weight portion, Borneolum Syntheticum 3-7 weight portion, Semen Vaccariae 3-7 weight portion, Rhizoma Smilacis Glabrae 8-15 weight portion, Rhizoma Pinelliae 5-10 weight portion, Radix Et Rhizoma Rhei 5-10 weight portion, Scorpio 3-7 weight portion, Rhizoma Arisaematis 8-15 weight portion, Rhizoma Paridis 6-12 weight portion, Squama Manis 6-12 weight portion, Hirudo 8-15 weight portion, living Radix Notoginseng 6-12 weight portion, SHANLING 6-12 weight portion.Its best proportioning is: Mylabris 4 weight portions, Radix Aconiti 5 weight portions, Borneolum Syntheticum 5 weight portions, Semen Vaccariae 5 weight portions, Rhizoma Smilacis Glabrae 10 weight portions, Rhizoma Pinelliae 7 weight portions, Radix Et Rhizoma Rhei 7 weight portions, Scorpio 5 weight portions, Rhizoma Arisaematis 10 weight portions, Rhizoma Paridis 8 weight portions, Squama Manis 8 weight portions, Hirudo 10 weight portions, living Radix Notoginseng 8 weight portions, SHANLING 8 weight portions.
The side separates: the traditional Chinese medical science is thought: swelling of the breast is appointed discord for dashing, and Liver and kidney is uncomfortable, qi and blood stagnation, in the breast that can not detoxify clearly, outward can not the transport milk ejection, qi depression to blood stasis, endogenous fire fills Sheng, and of a specified duration condensing forms, and should be principle with counteracting toxic substances pathogenic fire purging, clearing away heat and cooling blood, hard masses softening and resolving, removing blood stasis pain relieving etc.We are according to the Therapeutic Principle, with Mylabris, Rhizoma Smilacis Glabrae, Radix Et Rhizoma Rhei, Rhizoma Arisaematis, the pathogenic fire purging of Borneolum Syntheticum counteracting toxic substances, clearing away heat and cooling blood, with Squama Manis, SHANLING, Semen Vaccariae, Rhizoma Paridis hard masses softening and resolving, with Scorpio, Radix Aconiti, Hirudo, living Radix Notoginseng, the pain relieving of Rhizoma Pinelliae removing blood stasis.
The technical problem to be solved in the present invention can also further realize by the following method.It is last (150-200 order) that above-mentioned 14 flavor Chinese medicines are dried, add vinegar 5-7 doubly, soaks 20-45 days (stirring at least every day 1 time) after, filter extruding with the husky cloth of multilamellar and remove the gred, with 10-50 ℃ of low temperature medicinal liquid being concentrated (in case pharmaceutical compositions destruction) then is mixed-powder, and conventional method is made external use plaster.
This Chinese herbs paste also can be used for spraining, the treatment of arthralgia and chronic lambago and skelalgia, the effect that closed fracture is resetted and alleviating pain and detumescence arranged after fixing and promote healing.
Its usage is: skin region or swollen joint sore spot skin region in breast hypertrophy enclosed mass correspondence stick this patch.Once a day, the 10-45 day course of treatment.
Clinical experiment report
(1) purpose: observation and comparison cyclomastopathy patch and XIAOJIN DAN add curative effect and the side effect of infrared physiotherapy to cyclomastopathy.
(2) patient and method
1, testing program: the 238 routine patients that get rid of relevant disease and be diagnosed as cyclomastopathy by following diagnostic criteria are divided into cyclomastopathy patch treatment group (observation group at random by the odevity of patient medical history mantissa, 126 examples) and XIAOJIN DAN add infrared physiotherapy group (matched group, 112 examples), respectively treated 30 for two groups, observe and treat symptom, enclosed mass size and side effect thereof forward and backward, stopped treatment patient after 60 days.
2, diagnostic criteria: 1. breast limitation swelling has or does not have pain; 2. in the palpation breast clear and definite enclosed mass is arranged, can have or not have tenderness; 3. the test of breast printing opacity is positive.
3, exclusion standard: 1. breast carcinoma.2. the skin of breast person of festering; 3. drug allergy person.
4, curative effect judging standard: 1. cure: symptom and sign complete obiteration, drug withdrawal do not have recurrence after 60 days; 2. produce effects: symptom complete obiteration, breast mass are dwindled more than one times; 3. effective: symptom is obviously improved, and breast mass dwindles less than one times; 4. invalid: sings and symptoms improves not obvious; 5. recurrence: drug withdrawal was observed in 60 days, and (light and heavy degree is disregarded) appears in sings and symptoms once more.
5, statistical analysis: adopt X 2 test, P＜0.05 is thought statistical significance.
(3) result
1, clinical efficacy:
Complete each example of group is all finished treatment and is followed up a case by regular visits to, and total obvious effective rate (cure rate+obvious effective rate) is 71.43%, and total effective rate (cure rate+obvious effective rate+effective percentage) is 94.96%.After the drug withdrawal 60 days, total relapse rate is 22.69%.Wherein obvious effective rate and the effective percentage of observation group during treating is respectively 80.16% and 100%, and the utmost point is significantly higher than (P＜0.001) matched group (being respectively 61.61% and 89.29%).After the drug withdrawal 60 days, the relapse rate of observation group is 12.70%, and highly significant is lower than matched group (33.935%, P＜0.01) (seeing Table 1).Case to two groups of recurrences was treated 30 with corresponding method respectively again, and observation group all cures, and the clinical manifestation of matched group does not have obvious improvement again.Reuse cyclomastopathy patch treatment adds infrared physiotherapy through XIAOJIN DAN and controls 52 invalid examples of back again, through all healings of treatment on the 30th.
2, side effect:
Gastrointestinal upset 14.8% takes place in matched group in taking medicine, drug eruption 5.6% disappears through symptomatic treatment; And observation group has 12.7% patient to occur contacting red swelling of the skin or/and painless tiny vesicle disappears after drug withdrawal 3-5 day automatically, does not influence to continue treatment.
Table 1: two groups curative effect relatively
| Group | The example number | Treat after 30 days | After the drug withdrawal 60 days | |||
| Recovery from illness (n/%) | Produce effects (n/%) | Effectively (n/%) | Invalid (n/%) | Recurrence (n/%) | ||
| Observation group | 126 | 78(61.90) | 23(18.25) | 25(19.84) | 0 | 16(12.70) |
| Matched group | 112 | 25(22.32) | 44(39.29) | 31(27.68) | 12(10.71) | 38(33.93) |
In addition, the patient who resets after fixing with cyclomastopathy patch treatment ligament sprain, arthralgia, chronic lambago and skelalgia and closed fracture amounts to 342 examples, finds pain relieving in 1 hour after medication the 10-20 days course of treatment, and 1-3 subsides a swelling after day, and its obvious effective rate still reaches more than 90%.
Four, conclusion:
The result shows, cyclomastopathy patch treatment cyclomastopathy evident in efficacy is better than that XIAOJIN DAN is for oral administration to add infrared physiotherapy, and curative effect is lasting, is difficult for recurrence, and side effect is very little, economical and convenient.Recurrent cases is extended the period of treatment, all cure the specific medicament of a kind of cyclomastopathy of can yet be regarded as.Simultaneously, the treatment of ligament sprain, arthralgia and chronic lambago and skelalgia also there is very favorable effects, the effect that closed fracture is resetted and alleviating pain and detumescence arranged after fixing and promote healing.
The specific embodiment
Embodiment 1, take by weighing the crude drug that dries for powder by Mylabris 4 weight portions, Radix Aconiti 5 weight portions, Borneolum Syntheticum 5 weight portions, Semen Vaccariae 5 weight portions, Rhizoma Smilacis Glabrae 10 weight portions, Rhizoma Pinelliae 7 weight portions, Radix Et Rhizoma Rhei 7 weight portions, Scorpio 5 weight portions, Rhizoma Arisaematis 10 weight portions, Rhizoma Paridis 8 weight portions, Squama Manis 8 weight portions, Hirudo 10 weight portions, living Radix Notoginseng 8 weight portions, SHANLING 8 weight portions, the crude drug comminuted powder is preferably between the 150-200 order, so that absorb.With above-mentioned 14 flavor Chinese medicines, add vinegar 5-7 doubly, soaks 20-45 days (stirring at least every day 1 time) after, filter the extruding slagging-off with the husky cloth of multilamellar, be mixed-powder with 10-50 ℃ of low temperature with medicinal liquid concentrated (in case pharmaceutical compositions destruction) then, conventional method is made external use plaster.
Embodiment 2, and wherein the weight proportion of each crude drug can also be Mylabris 2 weight portions, Radix Aconiti 5 weight portions, Borneolum Syntheticum 7 weight portions, Semen Vaccariae 5 weight portions, Rhizoma Smilacis Glabrae 15 weight portions, Rhizoma Pinelliae 5 weight portions, Radix Et Rhizoma Rhei 10 weight portions, Scorpio 3 weight portions, Rhizoma Arisaematis 8 weight portions, Rhizoma Paridis 6 weight portions, Squama Manis 8 weight portions, Hirudo 15 weight portions, living Radix Notoginseng 12 weight portions, SHANLING 12 weight portions.
Embodiment 3, and wherein the weight proportion of each crude drug can also be Mylabris 6 weight portions, Radix Aconiti 3 weight portions, Borneolum Syntheticum 5 weight portions, Semen Vaccariae 3 weight portions, Rhizoma Smilacis Glabrae 8 weight portions, Rhizoma Pinelliae 10 weight portions, Radix Et Rhizoma Rhei 5 weight portions, Scorpio 7 weight portions, Rhizoma Arisaematis 15 weight portions, Rhizoma Paridis 12 weight portions, Squama Manis 12 weight portions, Hirudo 8 weight portions, living Radix Notoginseng 8 weight portions, SHANLING 8 weight portions.
Embodiment 4, and wherein the weight proportion of each crude drug can also be Mylabris 4 weight portions, Radix Aconiti 7 weight portions, Borneolum Syntheticum 3 weight portions, Semen Vaccariae 7 weight portions, Rhizoma Smilacis Glabrae 10 weight portions, Rhizoma Pinelliae 8 weight portions, Radix Et Rhizoma Rhei 8 weight portions, Scorpio 5 weight portions, Rhizoma Arisaematis 10 weight portions, Rhizoma Paridis 8 weight portions, Squama Manis 6 weight portions, Hirudo 10 weight portions, living Radix Notoginseng 6 weight portions, SHANLING 6 weight portions.
Claims (3)
1. Chinese herbs paste for the treatment of cyclomastopathy is characterized in that it is to be made by following weight proportion crude drug:
Mylabris 2-6, Radix Aconiti 3-7, Borneolum Syntheticum 3-7,
Semen Vaccariae 3-7, Rhizoma Smilacis Glabrae 8-15, Rhizoma Pinelliae 5-10,
Radix Et Rhizoma Rhei 5-10, Scorpio 3-7, Rhizoma Arisaematis 8-15,
Rhizoma Paridis 6-12, Squama Manis 6-12, Hirudo 8-15,
Living Radix Notoginseng 6-12, SHANLING 6-12.
2. the Chinese herbs paste of treatment cyclomastopathy according to claim 1 is characterized in that wherein the weight proportion of each crude drug is:
Mylabris 4, Radix Aconiti 5, Borneolum Syntheticum 5,
Semen Vaccariae 5, Rhizoma Smilacis Glabrae 10, Rhizoma Pinelliae 7,
Radix Et Rhizoma Rhei 7, Scorpio 5, Rhizoma Arisaematis 10,
Rhizoma Paridis 8, Squama Manis 8, Hirudo 10,
Living Radix Notoginseng 8, SHANLING 8.
3. the preparation method of the Chinese herbs paste of claim 1 or 2 described treatment cyclomastopathy, it is characterized in that: described Chinese medicine is dried the back pulverizing be 150-200 order powder, the mixing of weighing by weight ratio adds 5-7 times of vinegar, soak 20-45 day, stir at least every day 1 time; Filter the extruding slagging-off with the husky cloth of multilamellar then, the low temperature that reuse is 10 ℃-50 ℃ is with medicinal liquid simmer down to mixed-powder, and conventional method is made external use plaster.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100954561A CN100356957C (en) | 2005-11-17 | 2005-11-17 | Chinese medicinal plaster for treating mastoncus and its preparation method |
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| CNB2005100954561A CN100356957C (en) | 2005-11-17 | 2005-11-17 | Chinese medicinal plaster for treating mastoncus and its preparation method |
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| CN1785386A CN1785386A (en) | 2006-06-14 |
| CN100356957C true CN100356957C (en) | 2007-12-26 |
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| CN108114240A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Treat lipomatous Chinese medicine composition and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157213A (en) * | 1995-12-22 | 1997-08-20 | 海德堡印刷机械股份公司 | Counterpoise and lift mechanism |
| CN1582988A (en) * | 2004-06-16 | 2005-02-23 | 杨少林 | Wuzishan Chinese medicines for cancer pains |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157213A (en) * | 1995-12-22 | 1997-08-20 | 海德堡印刷机械股份公司 | Counterpoise and lift mechanism |
| CN1582988A (en) * | 2004-06-16 | 2005-02-23 | 杨少林 | Wuzishan Chinese medicines for cancer pains |
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Granted publication date: 20071226 Termination date: 20111117 |