CN100350955C - 一种治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法 - Google Patents
一种治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法 Download PDFInfo
- Publication number
- CN100350955C CN100350955C CNB2005100365641A CN200510036564A CN100350955C CN 100350955 C CN100350955 C CN 100350955C CN B2005100365641 A CNB2005100365641 A CN B2005100365641A CN 200510036564 A CN200510036564 A CN 200510036564A CN 100350955 C CN100350955 C CN 100350955C
- Authority
- CN
- China
- Prior art keywords
- medicine
- kinds
- herba
- granule
- decocted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 208000006454 hepatitis Diseases 0.000 title claims abstract description 20
- 231100000283 hepatitis Toxicity 0.000 title claims abstract description 16
- 241001183967 Isodon Species 0.000 title claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 title description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000004375 Dextrin Substances 0.000 claims abstract description 9
- 229920001353 Dextrin Polymers 0.000 claims abstract description 9
- 235000019425 dextrin Nutrition 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 5
- 229930006000 Sucrose Natural products 0.000 claims abstract description 5
- 229960004793 sucrose Drugs 0.000 claims abstract description 5
- 238000004821 distillation Methods 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000341 volatile oil Substances 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- -1 drying Substances 0.000 claims description 8
- 239000000796 flavoring agent Substances 0.000 claims description 8
- 235000019634 flavors Nutrition 0.000 claims description 8
- 230000006837 decompression Effects 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000001256 steam distillation Methods 0.000 claims description 5
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 11
- 235000009508 confectionery Nutrition 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 abstract description 9
- 210000004185 liver Anatomy 0.000 abstract description 9
- 241000700605 Viruses Species 0.000 abstract description 5
- 230000006870 function Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 208000019423 liver disease Diseases 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 230000002155 anti-virotic effect Effects 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 231100000614 poison Toxicity 0.000 abstract description 2
- 210000004881 tumor cell Anatomy 0.000 abstract description 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 abstract 2
- 235000003097 Artemisia absinthium Nutrition 0.000 abstract 2
- 240000001851 Artemisia dracunculus Species 0.000 abstract 2
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 abstract 2
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract 2
- 241000132012 Atractylodes Species 0.000 abstract 2
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 abstract 2
- 244000236521 Bupleurum rotundifolium Species 0.000 abstract 2
- 239000001138 artemisia absinthium Substances 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
- 244000119298 Emblica officinalis Species 0.000 abstract 1
- 235000015489 Emblica officinalis Nutrition 0.000 abstract 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000157511 Oldenlandia Species 0.000 abstract 1
- 240000007594 Oryza sativa Species 0.000 abstract 1
- 235000007164 Oryza sativa Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000002574 poison Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 235000009566 rice Nutrition 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 17
- 230000000694 effects Effects 0.000 description 16
- 229940079593 drug Drugs 0.000 description 9
- 230000001737 promoting effect Effects 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 230000036528 appetite Effects 0.000 description 7
- 235000019789 appetite Nutrition 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 206010023126 Jaundice Diseases 0.000 description 6
- 208000019790 abdominal distention Diseases 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 230000029087 digestion Effects 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 239000009609 fructus phyllanthi Substances 0.000 description 4
- 210000000232 gallbladder Anatomy 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 208000000197 Acute Cholecystitis Diseases 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 2
- 206010008614 Cholecystitis acute Diseases 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 206010030302 Oliguria Diseases 0.000 description 2
- 231100000354 acute hepatitis Toxicity 0.000 description 2
- 235000019636 bitter flavor Nutrition 0.000 description 2
- 201000001352 cholecystitis Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 230000002443 hepatoprotective effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101710142246 External core antigen Proteins 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 210000000514 hepatopancreas Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 208000023409 throat pain Diseases 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法，制剂以溪黄草、余甘子、白花蛇舌草、茵陈、白术、茯苓、布渣叶、谷芽、麦芽和柴胡为原料，经取茵陈、白术、柴胡用水蒸汽蒸馏法提取挥发油，药渣和其余七味加水煎煮后合并煎液、过滤，滤液减压浓缩所得的浸膏，加蔗糖粉、糊精及乙醇适量或甜味素适量，混匀，制成颗粒。该药对肝炎有较好的治疗作用，并能有效地提高人体免疫力，增强机体的抗病毒能力，调节肝脏机能、抑制肝炎病毒复制，清除肝炎病毒，抑制肿瘤细胞的生长、繁殖与扩散，抑瘤率达85.1%～93.1%，无毒无副作用，是新一代防治肝病的良药。
Description
所属技术领域
本发明涉及一种治疗肝炎的中药，尤其是涉及一种十味溪黄草颗粒中药制剂，本发明还涉及该制剂的制备方法。
背景技术
肝脏是人体新陈代谢的枢纽，也是人体最大的消化腺，人们常称肝脏为人体的“化工厂”，肝炎病则为常见病、多发病，由于现代社会的生活和工作节奏不断加快，发病率有逐步上升趋势。而溪黄草为历代名医治疗肝病的习用药物，据《全国中药汇编》、《中药大辞典》、《粤北中草药》、《翁源县志》等书籍记载，溪黄草的功用是清热利湿、凉血散瘀，可用于治疗急性肝炎、黄疸性肝炎、急性胆囊炎、痢疾、肠炎、跌打瘀肿等，但由于其性寒凉，多服或久服易引起口淡、肠胃不适等。因此若配用不当，则难以适于患慢性肝病的病人，更不适于体弱的中老年人。
发明内容
本发明的目的，就是提供一种克服了现有配用方法存在的缺点，既能发挥溪黄草软坚散瘀、治肝护肝功效，同时又可抑制其寒凉特性的治疗肝炎的十味溪黄草颗粒中药制剂。
本发明的另一个目的，就是提供一种上述十味溪黄草颗粒中药制剂的制备方法。
本发明的中药是由下列组分制成的：(用量为重量份)
按以下主要成份及重量比选取：
溪黄草220～280 余甘子220～280 白花蛇舌草145～185
茵陈145～185 白术85～120 茯苓145～185 布渣叶220～280
谷芽145～185 麦芽145～185 柴胡85～120。
其最佳组分为：(用量为重量份)
溪黄草250 余甘子250 白花蛇舌草165
茵陈165 白术100 茯苓165 布渣叶250
谷芽165 麦芽165 柴胡100。
本发明的十味溪黄草颗粒中药制剂，是在整理民间验方的基础上组成的，独特的组方蕴育着神奇的效果，使其疗效更显著、更确切。
本方重用溪黄草为君药，它，味苦、寒，具有清热利湿、凉血散瘀之功效。用于治疗急性肝炎、黄疸性肝炎、急性胆囊炎、痢疾、肠炎、跌打瘀肿等。
余甘子，味甘、酸、涩、凉，归肺、胃经，具有清热凉血、消食健胃、生津止咳之功效，用于血热血瘀、消化不良、腹胀、咳嗽、喉痛、口干。白花蛇舌草，味苦甘、寒，清热、利湿、解毒，用于治肺热喘咳、扁桃体炎、咽喉炎、黄疸等。茵陈，味苦、辛、微寒，归脾、胃、肝、胆经，具有清湿热、退黄疸之功效，用于黄疸尿少，传染性黄疸型肝炎。三药共为臣药，以助君药加强清热利湿，利胆退黄之功效。
茯苓，气味甘、淡、平，归心、肺、脾、肾经，具有利水渗湿，健脾宁心之功效，用于水肿尿少、痰饮眩晕、脾虚食少、便溏泄泻、心神不安等。白术，味苦、甘、温，归脾、胃经，具有健脾益气、燥湿利水之功效，用于脾虚食少，腹胀泄泻，水肿等。布渣叶，味酸、平，具有清热解毒，消食积及解渴开胃的功效，用于治疗咽喉痛、感冒、消化不良、腹胀及黄疸等。谷芽，味甘、温。归脾、胃经，具有消食和中、健脾开胃之功效，用于食积不消、腹胀、脾胃虚弱，不饥食少。麦芽，味甘、平，归脾、胃经，具有行气消食，健脾开胃之功效，用于食积不消、脘腹胀痛、脾虚食少等。柴胡，味苦、微寒，归肝、胆经，有和解表里，疏肝升阳之功效。共为佐药，诸药合用，组成了独特的组方，使湿热得清、脾得健运、肝胃得和。既增强了清热湿之功，又增加了益脾胃、助睡眠、提高免疫力、协调机体阴阳平衡之效。
本发明的制剂除可制成颗粒外，还可以是任何药剂学上所说的剂型，如胶囊、片剂、散剂等。
本发明的十味溪黄草颗粒中药制剂攻补兼施，标本兼顾，疗效好，副作用少，经中山医科大学附属第三医院、广东省中医院、广州市传染病医院、广州中医药大学附属第一医院临床验证表明：对肝炎(甲、乙、戊)、肝硬化、肝腹水等肝区疾患及肝胆湿热所引起的身黄、发热、腹胀、脘闷、纳差、乏力、呕吐、恶心、倦怠、腹痛、腹水、肝区疼痛、转氨酶偏高、HBsAg阳性等症状有较好的治疗作用，并能有效地提高人体免疫力，增强机体的抗病毒能力，调节肝脏机能、抑制肝炎病毒复制，清除肝炎病毒。
本药还经中国医学科学院、中国协和医科大学抗乙肝病毒试验，中山医科大学、广州中医药大学毒理药理及药效试验表明，具有：
(1)对HBsAg和HBeAg有非常显著的抑制作用；
(2)对乙肝病毒感染有较好的治疗作用；
(3)显著提高机体的免疫功能；
(4)清热利胆，保肝护肝，抑制血清谷丙转氨酶及血清总胆红素的升高，对肝细胞的浊肿、脂变、坏死及肝脏炎症、汇管区炎症有较好的防治作用；
(5)健脾消食，促进肠胃运动，对脾失健运疗效显著；
(6)抑制肿瘤细胞的生长、繁殖与扩散，抑瘤率达85.1％～93.1％，并能延长荷人肝癌裸小鼠的生存时间；
(7)无毒无副作用。
本发明十味溪黄草颗粒中药制剂的制备方法包括以下步骤：
取茵陈、白术、柴胡一起用水蒸汽蒸馏法提取挥发油约1.5～2ml，蒸馏后水溶液另器收集；药渣和其余溪黄草等七味加水煎煮2～3次，第一次加7～9倍量水煎煮1～2小时，第二次加3～5倍量水煎煮0.5～1.5小时，第三次加3～5倍量水煎煮0.3～0.6小时，合并三次煎液、过滤，滤液减压浓缩至相对密度为1.30～1.35(80℃)的浸膏(即清膏)。
①取清膏1份，加蔗糖粉3.0份，糊精1.25份及乙醇适量，混匀，制成颗粒，干燥，喷加上述茵陈等挥发油，制成含糖型颗粒。所得产品为黄棕色颗粒，味甜，微苦。
②取清膏1份，加糊精1份及甜味素适量，混匀，低温干燥，喷加上述茵陈等挥发油，混匀，制成无糖型颗粒。
所得产品为棕褐色颗粒，味微苦。
本发明的原料来源方便，处方中的药材均有法定的标准，一般药材公司均可采购到，其制备方法工艺先进：本发明的挥发油采用总混前喷入颗粒中，改变传统的分装或压片前喷入颗粒中，有利于贮存过程中减少挥发油的损失。本发明的十味溪黄草颗粒经过三个月的加速稳定性试验与2年的稳定性试验，制剂在性状、水分、鉴别、含量测定及卫生学检验方面均达到药品标准规定要求。制剂工艺稳定，稳定期可达两年以上。
附图说明
图1为浸膏生产工艺流程图。
图2为含糖型颗粒生产工艺流程图。
图3为无糖型颗粒生产工艺流程图。
下面结合具体实施例进一步描述本发明。
实施例1由下列组分制成。(用量为重量份)
溪黄草220g 余甘子220g 白花蛇舌草145g
茵陈145g 白术85g 茯苓145g 布渣叶220g
谷芽145g 麦芽145g 柴胡85g
[制法]取茵陈、白术、柴胡用水蒸汽蒸馏法提取挥发油约1.5ml，蒸馏后水溶液另器收集；药渣和其余溪黄草等七味加水煎煮三次，第一次加7倍量水煎煮1小时，第二次加3倍量水煎煮0.5小时，第三次加3倍量水煎煮0.3小时，合并三次煎液、过滤，滤液减压浓缩至相对密度为1.30(80℃)的浸膏。取清膏1份，加蔗糖粉3.0份，糊精1.25份及乙醇适量，混匀，制成颗粒，干燥，喷加上述茵陈等挥发油，制成颗粒1000g(含糖型)，即得。
所得产品为黄棕色颗粒，味甜，微苦。
实施例2由下列组分制成。(用量为重量份)
溪黄草280g 余甘子280g 白花蛇舌草185g
茵陈185g 白术120g 茯苓185g 布渣叶280g
谷芽185g 麦芽185g 柴胡120g
[制法]取茵陈、白术、柴胡用水蒸汽蒸镏法提取挥发油约2ml，蒸馏后水溶液另器收集；药渣和其余溪黄草等七味加水煎煮三次，第一次加9倍量水煎煮2小时，第二次加5倍量水煎煮1.5小时，第三次加5倍量水煎煮0.6小时，合并三次煎液、过滤，滤液减压浓缩至相对密度为1.35(80℃)的浸膏。取清膏1份，加糊精1份及甜味素适量，混匀，低温干燥，喷加上述茵陈等挥发油，混匀，制成颗粒400g(无糖型)，即得。
所得产品为棕褐色颗粒，味微苦。
实施例3由下列组分制成。(用量为重量份)
溪黄草250g 余甘子250g 白花蛇舌草165g
茵陈165g 白术100g 茯苓165g 布渣叶250g
谷芽165g 麦芽165g 柴胡100g
[制法]取茵陈、白术、柴胡用水蒸汽蒸馏法提取挥发油约1.75ml，蒸馏后水溶液另器收集；药渣和其余溪黄草等七味加水煎煮三次，第一次加8倍量水煎煮1.5小时，第二次加4倍量水煎煮1小时，第三次加4倍量水煎煮0.5小时，合并三次煎液、过滤，滤液减压浓缩至相对密度为1.30～1.35(80℃)的浸膏。
取清膏1份，加蔗糖粉3.0份，糊精1.25份及乙醇适量，混匀，制成颗粒，干燥，喷加上述茵陈等挥发油，制成含糖型颗粒1000g，即得。
取清膏1份，加糊精1份及甜味素适量，混匀，低温干燥，喷加上述茵陈等挥发油，混匀，制成无糖型颗粒400g，即得。
服用方法：开水冲服，一次2袋，一日3次；儿童酌减。
Claims (3)
1、一种治疗肝炎的十味溪黄草颗粒中药制剂，其特征在于它是由下述重量配比的原料及制备方法制成：
溪黄草220～280 余甘子220～280 白花蛇舌草145～185
茵陈145～185 白术85～120 茯苓145～185 布渣叶220～280
谷芽145～185 麦芽145～185 柴胡85～120；
制备方法：取茵陈、白术、柴胡一起用水蒸汽蒸馏法提取挥发油约1.5～2ml，蒸馏后水溶液另器收集；药渣和其余溪黄草等七味加水煎煮二～三次，第一次加7～9倍量水煎煮1～2小时，第二次加3～5倍量水煎煮0.5～1.5小时，第三次加3～5倍量水煎煮0.3～0.6小时，合并煎液、过滤，滤液减压浓缩至在80℃时相对密度为1.30～1.35的浸膏；
取清膏1份，加蔗糖粉3.0份，糊精1.25份及乙醇适量，混匀，制成颗粒，干燥，喷加上述茵陈等挥发油，制成含糖型颗粒；
或：取清膏1份，加糊精1份及甜味素适量，混匀，低温干燥，喷加上述茵陈等挥发油，混匀，制成无糖型颗粒。
2、根据权利要求1所述的治疗肝炎的十味溪黄草颗粒中药制剂，其特征是：所述的各原料重量配比为
溪黄草250 余甘子250 白花蛇舌草165
茵陈165 白术100 茯苓165 布渣叶250
谷芽165 麦芽165 柴胡100。
3、根据权利要求1或2所述的治疗肝炎的十味溪黄草颗粒中药制剂，其特征是：所述的制剂是任何一种药剂学上所说的剂型。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100365641A CN100350955C (zh) | 2005-08-18 | 2005-08-18 | 一种治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100365641A CN100350955C (zh) | 2005-08-18 | 2005-08-18 | 一种治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1733271A CN1733271A (zh) | 2006-02-15 |
| CN100350955C true CN100350955C (zh) | 2007-11-28 |
Family
ID=36076026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100365641A Active CN100350955C (zh) | 2005-08-18 | 2005-08-18 | 一种治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100350955C (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823673B (zh) * | 2012-09-18 | 2013-08-07 | 石兆荣 | 大石寺橄榄茶及其加工工艺 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1389258A (zh) * | 2002-06-18 | 2003-01-08 | 肖楚泰 | 一种速效健体凉茶 |
-
2005
- 2005-08-18 CN CNB2005100365641A patent/CN100350955C/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1389258A (zh) * | 2002-06-18 | 2003-01-08 | 肖楚泰 | 一种速效健体凉茶 |
Non-Patent Citations (1)
| Title |
|---|
| 加味健脾气温汤治疗慢性泄泻54例的效观察 黄业芳，罗致强.新中医，第25卷第2期 1993 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1733271A (zh) | 2006-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101361946B (zh) | 一种治疗乙肝的中药组合物 | |
| CN101979070B (zh) | 一种治疗乙肝的中药 | |
| CN1187071C (zh) | 治疗肝癌的药物及制备方法 | |
| CN1067267C (zh) | 一种治疗乙型病毒性肝炎的药物 | |
| CN104758487A (zh) | 一种治疗剥脱性唇炎的中药组合物 | |
| CN1895619A (zh) | 一种用于预防和治疗肝病的中药组合物及其制备方法 | |
| CN104127823A (zh) | 一种治疗小儿疳积、厌食症的中药组合物及其制剂 | |
| CN1060938C (zh) | 中药乙肝散冲剂 | |
| CN100350955C (zh) | 一种治疗肝炎的十味溪黄草颗粒中药制剂及其制备方法 | |
| CN1199630A (zh) | 一种治疗糖尿病的药用醋豆制作方法 | |
| CN1052889C (zh) | 一种治疗肝炎的中成药 | |
| CN102335336A (zh) | 一种治疗红斑狼疮的中药 | |
| CN102028890B (zh) | 一种治疗尿毒症的中药组合物 | |
| CN109700976B (zh) | 芪莪保肝膏 | |
| CN1319587C (zh) | 肝脾灵粉 | |
| CN1294980C (zh) | 一种治疗肝病的药 | |
| CN103705731B (zh) | 一种治疗慢性酒精中毒性肝病的中药组合物 | |
| CN106511612A (zh) | 具有治疗糖尿病功能的保健茶及其制备方法 | |
| CN111000969A (zh) | 一种治疗单纯性肥胖的药物组合物及制备方法 | |
| CN104758676A (zh) | 一种用于治疗湿热中阻症胃脘痛的药物 | |
| CN114129684B (zh) | 一种中药组合物及其制备方法和应用 | |
| CN1195541C (zh) | 一种治疗慢性乙肝的药物组合物 | |
| CN1130529A (zh) | 一种能治愈艾滋病的中成药“艾滋康复宁”及其配制技术 | |
| CN101745071A (zh) | 治疗胆囊炎的药物 | |
| CN105920557A (zh) | 肠灵胃舒片及其制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: WENGYUAN COUNTY QINGYUNSHAN PHARMACEUTICAL CO., L Free format text: FORMER OWNER: QINGYUNSHAN TRADITIONAL CHINESE MEDICINE FACTORY, WENGYUAN COUNTY, GUANGDONG PROVINCE Effective date: 20080215 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20080215 Address after: Guangdong Xian County of Wengyuan Province Dragon Ring Road No. 369 Patentee after: Wengyuan Qingyunshan Pharmaceutical Co.,Ltd. Address before: Xian Zhen Chaoyang Road Guangdong County in Wengyuan province Shaoguan city dragon No. 127 Patentee before: Qingyunshan Chinese medicine factory, Wengyuan County, Guangdong Province |
|
| C56 | Change in the name or address of the patentee |
Owner name: GUANGDONG QINGYUNSHAN MEDICINE CO.,LTD. Free format text: FORMER NAME OR ADDRESS: WENGYUAN COUNTY QINGYUNSHAN PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: Guangdong Xian County of Wengyuan Province Dragon Ring Road No. 369 Patentee after: GUANGDONG QINGYUNSHAN PHARMACEUTICAL Co.,Ltd. Address before: Guangdong Xian County of Wengyuan Province Dragon Ring Road No. 369 Patentee before: Wengyuan Qingyunshan Pharmaceutical Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to a Shiwei Xihuangcao granule traditional Chinese medicine preparation for treating hepatitis and a preparation method thereof Effective date of registration: 20210220 Granted publication date: 20071128 Pledgee: Wengyuan County sub branch of Agricultural Bank of China Ltd. Pledgor: GUANGDONG QINGYUNSHAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021440000055 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231114 Granted publication date: 20071128 Pledgee: Wengyuan County sub branch of Agricultural Bank of China Ltd. Pledgor: GUANGDONG QINGYUNSHAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021440000055 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231127 Address after: Floor 12, No. 77 Nujiang Street, Huanggu District, Shenyang City, Liaoning Province, 110036 Patentee after: Runyuan Pharmaceutical Co.,Ltd. Address before: 512600, No. 369 Huancheng North Road, Longxian Town, Wengyuan County, Guangdong Province Patentee before: GUANGDONG QINGYUNSHAN PHARMACEUTICAL Co.,Ltd. |