CN100346840C - Compobite nanometer antibiosis medical dressing - Google Patents
Compobite nanometer antibiosis medical dressing Download PDFInfo
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- CN100346840C CN100346840C CNB031097529A CN03109752A CN100346840C CN 100346840 C CN100346840 C CN 100346840C CN B031097529 A CNB031097529 A CN B031097529A CN 03109752 A CN03109752 A CN 03109752A CN 100346840 C CN100346840 C CN 100346840C
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Abstract
The present invention relates to a composite nanometer antibacterial medical dressing which belongs to the technical field of manufacturing a medical material. The composite nanometer antibacterial medical dressing comprises an antibacterial layer and a support layer, wherein the antibacterial layer is prepared by compounding ZnO nanometer grains which contain Ag <+> on spunlace nonwoven fabric or carbon fiber adsorption materials, and the diameter of nanometer grains is from 1 to 15 nanometers; the antibacterial layer is fixed on the support layer by adhesives. The dressing used for medical antibacterial materials has comprehensive advantages superior to traditional medical antibacterial agents: wide use, long-time action, safety, super-strong sterilization, no pollution, convenience, wound healing promoting and no bacterial medicine tolerance. The dressing can effectively absorb excessive moisture at a wound, and prevent the intrusion of external bacteria. The nonwoven fabric or the carbon fiber can enhance the absorption for nanometer grains of the dressing, prevent the nanometer grains from gathering into large grains easily, and ensure that the dressing has favorable antibacterial effects.
Description
Technical field
The invention belongs to medical material manufacturing technology field, particularly relate to a kind of composite nano anti-biotic medical dressing with high antibiotic and high absorption property.
Background technology
Nano material has outstanding functional characteristic because of having quantum size effect, skin effect and dielectric confinement effect etc., in technical field of biomedical materials, how to realize the function optimization of nano material, littleization of realization nano-particle and stable is the target that the medical nano material is pursued always.
At present, at the development field of advanced antibiotic material in medical use, nano material has demonstrated the outstanding integrated quality that is better than traditional material.As develop wide spectrum, efficient, safe nano-antibacterial silver granule is used for anti-bacteria cloth and antibiotic fabric is treated burn and scald, wound, infection suppurates etc.But, the particulate cost of preparation fine silver is very high, and the flexible fabric that cloth and conventional art adopted, make the adsorption rate of nanometer silver low excessively on the one hand, cause bigger waste, the lower anti-microbial property that makes of density owing to the absorption nanometer silver of nano-antibacterial cloth or nano-antibacterial flexible fabric is limited to.In addition, the attachment material of former nanometer silver is because absorption property is outstanding, adheres to slowlyer, causes the assembly again of nanoparticle to form larger particles, influences the effect of nanometer silver.
Summary of the invention
The present invention provides a kind of novel composite nano anti-biotic dressing for solving the problem that prior art exists, and utilizes the characteristic of nano material and the high adsorption of bound water prick nonwoven cloth or carbon fiber, can address the above problem dexterously.
The purpose of this invention is to provide a kind of better antibacterial action that has, granule ultra-fine (particle diameter is the 1-15 nanometer) evenly adheres to, and the higher composite nano anti-biotic dressing of adsorption rate.
Along with the nano material preparation technology and be used for the progressively development of process for modifying surface, the wait in expectation advantageous characteristic that can utilize nano material and solve the problems referred to above by certain host material of nano antibacterial fabric application is to obtain the better antibiotic fabric of integrated quality.
The employing of composite nano anti-biotic dressing of the present invention is by containing Ag
+The ZnO nano-particle evenly be attached to spun laced fabric or carbon fiber surface and fibre gap, by spraying or pad and form.The granule of nanometer silver is ultra-fine, and adheres to wide and even.
The composite nano anti-biotic medical dressing is the medical dressing with high antibiotic and high absorption property, and this dressing is made up of antibiotic layer and supporting layer.Antibiotic layer is a composite nano anti-biotic material on spun-laced nonwoven fabric or carbon fiber, utilizes the nano material of high antibiotic property and the high adsorption combined effect mechanism of spun-laced nonwoven fabric or carbon fiber.This dressing is a kind of medical material long-acting, the broad-spectrum antiseptic antiinflammatory that has.
The preparation method of composite nano anti-biotic medical dressing may further comprise the steps:
1. preparation contains Ag earlier
+The nano-particle of ZnO, its particle diameter is the 1-15 nanometer.Preparation contains Ag
2The nano aqueous solution of O and ZnO, the concentration that is mixed with mol ratio Ag: Zn=1: 1-4 is the nanometer solution of 15-35%.
2. spun-laced nonwoven fabric or carbon fiber are put into solution immersion 10-15 minute.
3. oven dry.Dried 20-40 minute down at 100-150 ℃, can obtain function admirable, the composite nano anti-biotic medical dressing that antibacterial effect is good.
Among the present invention, the mechanism of action is the high adsorption of spun laced fabric or carbon fiber, at first in composite nano anti-biotic dressing preparation process, can adsorb nano-particle rapidly, influence antibacterial effect thereby make nano-particle be difficult for being combined into larger particles again, also can make the composite nano anti-biotic microgranule carry out the even absorption of higher density in carbon fiber surface and gap; Secondly, in clinical practice, this material can fully adsorb antibacterial and nuisance, strengthens bacteriostasis.
The present invention adopts following technical scheme:
The composite nano anti-biotic medical dressing contains nano material on adsorbing material, be characterized in being compounded with on adsorbing material containing Ag
+The ZnO nano-particle.
The present invention can also adopt following technical measures:
Above-mentioned composite nano anti-biotic medical dressing is characterized in that adsorbing material is spun-laced nonwoven fabric or carbon fiber.
Above-mentioned composite nano anti-biotic medical dressing is characterized in the compound equably Ag of containing on the adsorbing material
+The ZnO nano-particle, particle diameter is the 1-15 nanometer.
Above-mentioned composite nano anti-biotic medical dressing is characterized in the compound Ag of containing
+The Ag and the Zn mol ratio of ZnO nano-particle be 1: 1-4.
Above-mentioned composite nano anti-biotic medical dressing is characterized in the compound Ag of containing on adsorbing material
+The ZnO nano-particle constitute antibiotic layer, antibiotic layer connects with glue and is fixed on the supporting layer.
Above-mentioned composite nano anti-biotic medical dressing is characterized in that the fixed support layer is a medical proof fabric.
The present invention has following tangible advantage and good effect:
1, composite nano anti-biotic dressing is used for medical antibacterial material aspect and has the incomparable integrated quality of conventional medical antibacterial: wide spectrum, long-acting, safe, superpower sterilization, pollution-free, convenient, can promote wound healing, can not diseaseful drug resistance;
2. can effectively absorb wound location excessive moisture, the intrusion of outside antibacterial;
3. replace cloth or other fabrics with spun laced fabric or carbon fiber, can improve absorption, make the adsorption density that improves nanoparticle, improve utilization, cut the waste, improve fungistatic effect nanoparticle to nanoparticle.
4. replace cloth or other fabrics with spun laced fabric or carbon fiber, can improve absorption to nanoparticle, can make nanoparticle evenly be attached to carbon fiber surface and gap rapidly, and can make nanoparticle be difficult for being combined into larger particles again and influence the function of nanoparticle.
Composite nano anti-biotic medical dressing of the present invention, can treat with staphylococcus aureus, escherichia coli, bacillus pyocyaneus, micrococcus scarlatinae be cause of disease bacterium traumatic patient skin infection and the treatment superficial skin fungus infects and as the antibiotic property dressing of surgical incision postoperative and treatment infection of incisional wound.
Composite nano anti-biotic medical dressing of the present invention, can also treat with staphylococcus aureus, escherichia coli, Candida albicans is gynaecologic vaginal inflammation and the anus hemorrhoid of cause of disease bacterium.
Description of drawings
Fig. 1 is a sectional structure sketch map of the present invention;
Fig. 2 is the circular dressing sketch map of the present invention;
Fig. 3 is electron-microscope scanning figure of the present invention.
The specific embodiment
For further understanding content of the present invention, characteristics and effect, enumerate following example now.
With reference to accompanying drawing 1 and 3.The funtion part of composite Nano medical dressing is divided into two aspects, i.e. antibiotic layer 1 and supporting layer 2.
Antibiotic layer is a composite nano anti-biotic material on spun-laced nonwoven fabric or carbon fiber, utilize the high adsorption combined effect mechanism of composite nano materials and the spun-laced nonwoven fabric or the carbon fiber of high antibiotic property, under the spraying state, high adsorption by spun laced fabric or carbon fiber, make composite nanometer particle be attached to spun laced fabric or carbon fiber surface and gap rapidly, the difficult larger particles that is combined into again that keeps high density, uniform distribution and composite nanometer particle, thereby improve the activity (seeing accompanying drawing 2, electron-microscope scanning figure) of composite Nano.Thereby bring into play wide spectrum, efficient, safe sterilization, bacteria resistance function more fully, and can promote wound healing, and can not produce resistance.
The preparation process of antibiotic layer:
1. preparation contains Ag earlier
+The nano-particle of ZnO, its particle diameter is the 1-15 nanometer.Preparation contains Ag
2The nano aqueous solution of O and ZnO is mixed with mol ratio Ag: Zn=1: 3 concentration is 25% nano aqueous solution.
2. spun-laced nonwoven fabric being put into solution soaked 13 minutes.
3. oven dry.Dried 30 minutes down at 120 ℃, can obtain function admirable, the dressing antibiotic layer that antibacterial effect is good.
The glue of supporting layer connects:
Antibiotic layer even is fixed on (wherein glue logotype nonpoisonous adhesive) on the supporting layer with glue.So just obtain the medical antibacterial dressing that rectangle has complex function.
With reference to accompanying drawing 2.The funtion part of composite Nano medical dressing is divided into two aspects, i.e. antibiotic layer 3 and supporting layer 4.
Method with embodiment 1 prepares the carbon fiber antibiotic layer, antibiotic layer is connected with glue to be fixed on (wherein glue logotype nonpoisonous adhesive) on the supporting layer then.Prepare circular medical antibacterial dressing with complex function.
The composite Nano medical dressing that embodiment 1 makes can be adsorbed to its surface and inner inhibition zone with nuisances such as antibacterials, thereby realize bacteriostasis property more fully by the high absorption property of spun laced fabric or carbon fiber, and its fungistatic effect sees the following form:
Antibacterial ring test
| Test organisms | The inhibition zone diameter that test organisms is various (mm) | Negative control is | |||||
| Sequence number | |||||||
| 1 | 2 | 3 | 4 | Meansigma methods | Ring diameter (mm) | ||
| Staphylococcus aureus | 1 2 3 | 11.02 11.06 10.72 | 12.18 11.68 10.80 | 11.92 12.04 11.16 | 12.68 11.02 10.96 | 11.95 11.45 10.91 | 0 0 0 |
| Escherichia coli | 1 2 3 | 9.28 8.02 7.84 | 9.36 8.08 7.96 | 9.02 8.16 8.04 | 9.75 7.94 8.12 | 9.35 8.05 7.99 | 0 0 0 |
| Bacillus pyocyaneus | 1 2 3 | 13.00 12.88 11.68 | 12.16 13.40 10.00 | 13.02 11.70 11.68 | 13.64 10.80 9.88 | 12.96 12.20 10.81 | 0 0 0 |
| Hemolytic streptococcus | 1 2 3 | 7.46 9.02 8.44 | 10.10 8.74 9.62 | 9.36 9.26 10.06 | 10.12 10.08 10.42 | 9.26 9.28 9.55 | 0 0 0 |
| Candida albicans | 1 2 3 | 13.34 10.02 11.08 | 11.16 10.80 10.12 | 10.02 11.26 11.68 | 12.64 10.56 10.88 | 11.79 10.66 10.94 | 0 0 0 |
Annotate: test is 5 * 10 with suspension concentration
5-5 * 10
6Cm/ml.
This sample inhibition zone diameter shows that all greater than 7 millimeters this product has extremely strong bacteriostasis to above-mentioned antibacterial as a result.
Claims (3)
1. a composite nano anti-biotic medical dressing contains nano material on adsorbing material, it is characterized in that: be compounded with on spun-laced nonwoven fabric or absorbing carbon fiber enclosure material and contain Ag
+The ZnO nano-particle, contain Ag
+The Ag and the Zn mol ratio of ZnO nano-particle be 1: 1-4, particle diameter are the 1-15 nanometer.
2. composite nano anti-biotic medical dressing according to claim 1 is characterized in that: the compound Ag of containing on adsorbing material
+The ZnO nano-particle constitute antibiotic layer, antibiotic layer is fixed on the supporting layer with nonpoisonous adhesive.
3. composite nano anti-biotic medical dressing according to claim 2 is characterized in that: supporting layer is a medical proof fabric.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031097529A CN100346840C (en) | 2003-04-16 | 2003-04-16 | Compobite nanometer antibiosis medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031097529A CN100346840C (en) | 2003-04-16 | 2003-04-16 | Compobite nanometer antibiosis medical dressing |
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| Publication Number | Publication Date |
|---|---|
| CN1537640A CN1537640A (en) | 2004-10-20 |
| CN100346840C true CN100346840C (en) | 2007-11-07 |
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|---|---|---|---|
| CNB031097529A Expired - Fee Related CN100346840C (en) | 2003-04-16 | 2003-04-16 | Compobite nanometer antibiosis medical dressing |
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| CN (1) | CN100346840C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058962A1 (en) | 2010-11-03 | 2012-05-10 | 广东百合医疗科技有限公司 | Antimicrobial fiber, fabric and wound dressing containing nano metal and preparation method thereof |
| CN109267023A (en) * | 2018-08-29 | 2019-01-25 | 江苏理工学院 | A kind of antibacterial active carbon fiber material and preparation method thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100394986C (en) * | 2004-11-09 | 2008-06-18 | 深圳市源兴生物医药科技有限公司 | Wound dressing containing Ag-Zn composition |
| CN1771807B (en) * | 2005-07-29 | 2011-04-13 | 西南交通大学 | Inorganic antiseptic of zinc oxide lattice carried silver and its preparation |
| MX2008012555A (en) | 2006-04-11 | 2008-10-14 | Tyco Healthcare | Wound dressings with anti-microbial and zinc-containing agents. |
| EP3496768B1 (en) * | 2016-08-11 | 2022-06-08 | Imerys Filtration Minerals, Inc. | Antimicrobial compositions and related methods of use |
| CN112315657A (en) * | 2020-11-03 | 2021-02-05 | 江苏汇诚医疗科技有限公司 | Multiple antibacterial metal-doped nano zinc oxide dressing and production device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341358A (en) * | 2000-09-07 | 2002-03-27 | 刘建忠 | Silver zinc combined antimicrobial agent |
-
2003
- 2003-04-16 CN CNB031097529A patent/CN100346840C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341358A (en) * | 2000-09-07 | 2002-03-27 | 刘建忠 | Silver zinc combined antimicrobial agent |
Non-Patent Citations (1)
| Title |
|---|
| 纳米无机抗菌材料抗菌性能研究 李彦峰等.化工新型材料，第30卷第6期 2002 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058962A1 (en) | 2010-11-03 | 2012-05-10 | 广东百合医疗科技有限公司 | Antimicrobial fiber, fabric and wound dressing containing nano metal and preparation method thereof |
| CN109267023A (en) * | 2018-08-29 | 2019-01-25 | 江苏理工学院 | A kind of antibacterial active carbon fiber material and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1537640A (en) | 2004-10-20 |
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Granted publication date: 20071107 |