CN1291666A - Antibacterial fabric containing nm-class silver powder and its making method - Google Patents

Antibacterial fabric containing nm-class silver powder and its making method Download PDF

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CN1291666A
CN1291666A CN 00124854 CN00124854A CN1291666A CN 1291666 A CN1291666 A CN 1291666A CN 00124854 CN00124854 CN 00124854 CN 00124854 A CN00124854 A CN 00124854A CN 1291666 A CN1291666 A CN 1291666A
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fabric
silver
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liters
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CN1147640C (en )
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陈文�
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南京希科集团有限公司
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An nm silver type antibacterial fabric features that the superfine silver particles (1-900 nm in granularity) with the surface of silver oxide are attached between fibres or to fibres. It can be usedto treat skin infection and surficial fungus infection and prevent and cure the incision infection after operation.

Description

纳米银抗菌织物及其制造方法 Nano silver antibacterial fabric manufacturing method thereof

本发明是关于一种抗菌功能性织物及其制造方法,更特别的,是关于一种纳米银抗菌织物及其制造方法,是申请号为99111155.9的延续专利。 The present invention relates to a functional fabric and a manufacturing method of an antimicrobial, more particularly, it relates to a nano silver antibacterial fabric and its manufacturing method, is Application No. continuation patent 99111155.9 of.

功能性纺织品为本世纪八十年代由德国科学家首先提出,并迅速在发达国家得到响应,世界各国均投入了大量资金进行研究开发,至今在可移植于人体的医用功能性织物上已有产品问世并应用于临床;但在非移植于人体的医用功能性织物未见突破,主要原因在于界定该织物的定义必须是以织物为载体的,稳定性好的,对人体疾病超高效、长效、低毒的治疗和辅助治疗功能等等,决不是那种简单用药品浸涂撒上的那种概念,实质上是一种全新的新型“药布”。 Functional textiles based eighties was first proposed by German scientists, and quickly get a response in developed countries in the world have invested heavily in research and development, so far in portable on medical functional fabric of the human body has come on the market and clinical application; but no breakthrough in the medical functional textiles non transplanted human body, mainly due to define the definition of the fabric must be based on the fabric as the carrier, good stability of human disease super-efficient, long-lasting, low toxicity of the therapy and adjuvant therapy functions, etc., is by no means the kind of simple use drugs dip sprinkled with the kind of concept, essentially a brand-new new "drug distribution."

在日本专利昭54-151669中,公开了一种杀菌性布,其将含有铜、银(平均粒径6微米)的化合物单独或混合物的树脂溶液处理纱线,使该溶液均匀涂附在纱线的表面后再织成杀菌性布,该产品可作胶靴的衬里,帆布鞋和袜子。 In Japanese Patent SHO 54-151669 discloses a bactericidal cloth, which contain copper, silver (average particle size of 6 microns) compounds, alone or in a mixture of resin solution treatment of yarn, so that the solution is uniformly coated to yarn surface after wire woven bactericidal fabric, the product can be used for rubber boots liner, canvas shoes and socks.

在日本“加工技术”vol. In Japan, "processing technology" vol. 17 NO7报导中,用铜和硫化物处理腈纶纤维,得腈纶-硫化铜复合物,其对金葡球菌、大肠杆菌、枯草杆菌、皮肤丝状白癣菌有抑菌能力。 17 NO7 reported treated with copper sulfide acrylic fibers, available acrylic - copper sulfide complex, which has antimicrobial activity on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, skin filamentous Trichophyton.

在中国发明专利CN8710023lA,题目为“抗菌防臭纤维织物及制造方法”,公开日:1987年11月18日中公开了一种抗菌织物,其将腈纶织物先后与Cu+、碱性绿4复合交联,产品对金葡球菌、MRSA、白葡球菌、白色念珠菌等10个菌种有抑菌功能,其可用作抗菌防臭的内衣裤、袜、鞋垫和医药工业、食品工业的工作服。 In the Chinese patent CN8710023lA, entitled "antibacterial deodorant fabric and method of manufacturing", Publication Date: 1987 November 18, Japan discloses an antibacterial fabric, which acrylic fabric successively with Cu +, Basic Green 4 Compound crosslinked products are antibacterial function of Staphylococcus aureus, MRSA, white staphylococcus aureus, Candida albicans and other 10 species, clothes that can be used as anti-bacterial deodorant underwear, socks, insoles and pharmaceutical industry, food industry.

在日本专利平3-136649、申请日:1989年10月24日中公开了一种预防奶牛乳房炎的抗菌布。 In Japanese Patent HEI 3-136649, filing date: 1989 October 24 Japan discloses a method of preventing mastitis in dairy cows antibacterial cloth. 其将银离子与聚丙烯腈以配位键形式复合,产品对链球菌、葡萄菌等6种菌种有抑制作用,可用作擦拭奶牛乳房乳头以预防奶牛的乳房炎的抗菌布。 Which silver ion polyacrylonitrile complex to ligand bond forms, products of Streptococcus, grape bacteria six kinds of strains inhibited, can be used as wiping the udder teat to prevent the cow mastitis antibacterial cloth.

以上这些产品均有抗菌作用,但是抗菌谱不广、作用不明显,并且与本发明完全不同。 These products have antibacterial activity, but the antibacterial spectrum is not broad, not obvious, and is completely different from the present invention.

本发明的目的之一是提供一种抗菌织物及其制造方法。 One object of the present invention is to provide an antimicrobial fabric manufacturing method thereof.

本发明的目的之二是提供一种纳米银抗菌织物。 Another object of the present invention II is to provide a nano-silver antimicrobial fabric.

本发明的目的之三是提供一种纳米银抗菌织物的制造方法。 Another object of the present invention, three is provided a nano-silver antibacterial fabric manufacturing method.

本发明的这些以及其它目的将通过下列详细说明和描述来进一步阐述。 These and other objects of the present invention will be further illustrated by the following detailed description and description.

在本发明的纳米银抗菌织物中,在织物的纤维之间或纤维之上附着有超微粒银,超微粒银的表面层是氧化银,核心为金属银,超微粒银粒径为1~900纳米;在织物的纤维之间或纤维之上附着的超微粒银的量为2~200微克/厘米2。 In the nano silver antibacterial fabric of the present invention, attached to or on the fiber between the fibers of the fabric are ultrafine particles of silver, the surface layer of ultra-fine silver particles are silver oxide, core metallic silver, ultra-fine silver particle diameter of 1 to 900 nanometers ; the amount of ultra fine silver particles in or on the fibers between the fiber fabric adhered is 2 to 200 g / cm 2.

本发明的纳米银长效广谱抗菌功能性织物的制备方法,包括按配方配制整理剂,然后将织物浸轧整理液,然后在保持充足氧气条件下用热风烘燥,洗涤、最后烘干。 Preparation nanosilver long acting broad spectrum antibacterial function of the fabric of the present invention, including by formulation with finishing agents, fabric is then padded finishing solution, then drying with hot air while maintaining sufficient oxygen conditions, washing and finally drying.

在本发明中,整理液含有:(以200公斤织物计)硝酸银 5~30公斤, 氨水 15~40升,加水至1000升。 In the present invention, the finishing liquor containing :( to 200 kg fabric basis) of silver nitrate 5 to 30 kg of aqueous ammonia of 15 to 40 liters of water was added to 1,000 liters.

进一步的,整理液还含有1~20公斤葡萄糖。 Further, finishing solution also contains 1 to 20 kg glucose.

进一步的,本发明的整理剂包括:(以200公斤织物计)硝酸银 5~30 公斤, 氨 水 15~40 升,氢氧化钠 0.8~3公斤, 葡萄糖 0.2~10公斤,硝 酸 0.2~0.5升, 余量为水 总计1000升。 Further, the finishing agent of the present invention comprises :( to 200 kg fabric basis) of silver nitrate 5 to 30 kg of aqueous ammonia of 15 to 40 liters of sodium hydroxide 0.8 to 3 kg of glucose 0.2 to 10 kg, nitrate 0 .2 to 0.5 liters, the balance being water Total 1000 liters.

在本发明中,将织物浸轧整理液,轧液率为60~90%,然后在鼓风和抽风条件下用热风烘燥,时间为1~10分钟,温度为90~200℃,多次洗涤、浸轧,轧液率为100~150%,最后烘干;所述的烘燥可以为热风烘燥,也可以是加热辊、辐射或远红外加热等。 In the present invention, the fabric padding finishing solution pickup of 60 to 90%, and then hot air drying under the blowing and ventilation conditions, for 1 to 10 minutes at a temperature of 90 ~ 200 ℃, multiple washed, padding, pickup of 100% to 150%, and finally drying; the drying may be hot-air drying, may be a heating roller, radiation, or far infrared heating.

本发明的产品可以作为治疗烧烫伤的医用(外)材料,和治疗外伤患者的皮肤感染和皮肤浅部真菌感染以及外科手术切口术后预防和治疗切口感染的材料,也可以作为日常生活用品。 Product of the invention can be used as treatment of burns medical (outer) material, and the treatment of trauma patients skin infections and materials surgical incision after the prevention and treatment of wound infection of the skin superficial fungal infections as well, can be used as daily necessities.

本发明产品的抑菌机理为: Antibacterial mechanism of the present invention is the product of: Ag+易与带阴电的细菌蛋白中的巯基-SH结合,使一些细菌赖以生存的活性酶丧失活性,从而达到抑菌效果。 Ag + easy to combine with the negative charge of the bacterial proteins mercapto group -SH, that the activity of the enzyme on which some bacteria survive the loss of activity, so as to achieve the inhibitory effect.

在本发明中,根据经典理论,银具有较好的杀菌作用,杀菌机理为: In the present invention, according to the classical theory, silver has good bactericidal action, bactericidal mechanism is: 银是比较稳定的物质,基本不溶于水,且本身的杀菌力及抗菌谱既没有那么强也没有那么广,这在宏观世界中是不好解决的,故必须向纳米科学的微观世界中寻求答案,应用到临床对疾病的治疗和预防上。 Silver is relatively stable material, substantially insoluble in water, and is itself bactericidal and antimicrobial spectrum neither so strong nor so extensive, that in the macro world is not resolved, we must seek answers to the microscopic world of nanoscience in , applied to the clinical disease treatment and prevention. 纳米银技术是建立在量子化学、材料化学、生物化学三大基础学科上的产物,通过将银的材料尺度上的细微化,使其达到10-9m的纳米量级,充分利用它的表面效应、小尺寸效应和利用它反映出的不同于宏观世界银的各种新的特异性质和效应,实现其长效性、广谱性、抗菌强、稳定性好、遇水功效不但不减弱,反而增强的特性和在杀灭致病菌的过程中,不受人体酸碱度的影响等等特性。 Nano silver technology is based products on a quantum chemistry, materials chemistry, biochemistry three basic subjects, the fine structure the material dimensions to silver to reach 10-9m order of nanometers, full advantage of its surface effects small size effect and the use of new specific nature and effect of it reflects different from the macroscopic world of silver to achieve its long-acting, broad-spectrum, antibacterial, good stability, water effect not only not diminished, but enhanced features and in the process kill pathogens, the not affected by body pH, etc. characteristics. 同时银的渗透力加强,促进生肌收敛,发挥其治疗功能。 While the penetration of silver to strengthen and promote myogenic convergence, exert its therapeutic function. 由于其表面积大大增加,表面结构也发生较大变化,表面活性大大增强,并表现出极高的特异性功能,经检测,对致病菌的MIC为0.16~8.97毫克/毫升,MBC为3.05~81.97毫克/毫升,其杀菌能力提高了200多倍。 Due to significantly increase its surface area, the surface structure is also greatly changed, surfactants greatly enhanced, and exhibit a very high specific function, tested, the MIC of the bacteria is 0.16 to 8.97 mg / ml, MBC of 3.05 - 81.97 mg / ml, the bactericidal capacity increased by 200 times.

应用纳米银技术制作出的纳米银织物在非移植于人体的医用功能性织物上具有广泛的应用前景,除可制作成各种抗菌敷料应用于人体体表、粘膜疾病外,同时还可预防疾病;另外,在人类生活、工作的各种抗菌性产品开发应用上更具广泛性,如制作成各种抗菌服、卧具、袜鞋等等纺织品、轻工产品和医院设备等。 Application of nano-silver technology to produce nanosilver fabric having broad application prospect in medical functional textiles non-engrafting human body, in addition can be made into various antibacterial dressing applied to the human body surface, mucosal disease outside, while also preventing the disease ; in addition, more extensive on various antibacterial product development and application of human life, work, such as the production into a variety of anti-bacterial clothing, bedding, socks, shoes and so on textiles, light industrial products and hospital equipment. 可以说,纳米银的应用,将使人类生活有一个质的提高,纳米银医用功能性织物必将掀起一轮新的产业革命,必将促进医用功能性织物产业的迅速成长和发展。 It can be said nanosilver applications, will make human life there is a qualitative improvement, nano silver medical functional fabric will set off a new round of Chanyegeming, will promote the medical functional textiles industry rapid growth and development.

本发明的纳米银抗菌织物(以下简称LBDF)经试验,各项指标如下:1、长效性:经过以下3种方式处理后再与不经任何处理的LBDF原品一起作体外抑菌试验,结果证实经处理的LBDF与LBDF原品其抑菌效果基本不变。 Nano silver antimicrobial fabric of the present invention (hereinafter referred to LBDF) After testing, the indicators are as follows: 1, long-term resistance: After three ways process followed and without LBDF original product of any process for the in vitro antibacterial test together, the results confirmed LBDF and LBDF processed raw materials the antibacterial effect is basically the same.

(1)洗涤50次,每次用肥皂手工搓洗,清水漂洗,共50次;(2)洗涤100次,每次仅用清洗搓洗共100次;(3)LBDF经45天的水浸泡(每天换水)。 (1) was washed 50 times with soap hand scrub, rinse, total 50 times; (2) washed 100 times, each time with only clean scrub total of 100 times; (3) LBDF over 45 days water immersion (per day changing the water).

2、广谱性:(1)LBDF的体外抑菌试验:对LBDF进行MH平板(或哥伦比亚琼脂平板或血平板)体外抑菌试验,菌株鉴定及药敏试验用法国生物梅里埃公司Vitek-32微生物全自动分析仪。 2, broad-spectrum: (1) LBDF Antibacterial Test: The LBDF for MH plate (or Columbia agar or blood agar) Antibacterial test strain identification and susceptibility test Vitek-32 with French bioMerieux microbial automatic analyzer. 试验样品包括未作任何处理的LBDF原品及经前述(1)、(2)处理的LBDF。 Test samples include without any treatment LBDF raw materials and by the (1), LBDF (2) process. 体外抑菌试验的菌种包括革兰氏阳性菌、革兰氏阴性菌、真菌和芽胞等共计40多个致病菌种。 Antibacterial test species include gram-positive bacteria, Gram-negative bacteria, fungi and spores and a total of more than 40 pathogenic species. 结果证明LBDF对这40多个菌种都显示有明显抑菌功能,并且这40多个菌种除有少数几个是国际标准菌株,大多数是从患者分泌物中分离出来的菌株,其抑菌难度更大。 The results demonstrate LBDF these 40 strains showed significant antibacterial function, and this is more than 40 species in addition to a few international standard strains, mostly isolated from a patient secretions strain which inhibition more bacteria difficult.

以上体外抑菌试验系由中国人民解放军全军医药试验中心微生物实验室、上海医科大学华山医院细菌室等国内著名单位检测。 Above Antibacterial test system by the People's Liberation Army medicine testing center Microbiology Laboratory, Shanghai Medical University Huashan Hospital Bacteria room and other famous units detected.

LBDF抗菌织物与8种抗菌药物的抑菌结果LBDF抗菌织物与对照组抑菌直径 抗菌药物MIC法药敏结果菌名来源 洗涤 洗涤 阴性 苯唑 氨苄 头孢 头孢 头孢 庆大 环丙未洗涤 红霉素50次 100次 对照 西林 西林 唑啉 呋肟 他啶 霉素 沙星金黄色葡萄球菌 ATCC25923 20 18 18 7 24 S S S S S S S大肠埃希菌 ATCC25922 15 14 14 7 10 S S S S S S铜绿假单胞菌 ATCC27853 13 12 12 7 6 S S S产气荚膜梭菌 CMCC(B)64606 10金黄色葡萄球菌(MRSE)分泌物 19 17 17 7 6 R R R R R R R表皮葡萄球菌(MRSE) 分泌物 20 17 17 7 6 R R R R R R R化脓性链球菌 分泌物 11 8 8 7 6 S S S S S Antibacterial Results LBDF antibacterial fabric with the eight kinds of antibiotics LBDF antibacterial fabric with the control group antibacterial diameter antimicrobial susceptibility results MIC method Bacteria name Origin washed with a negative oxacillin, ampicillin-cephem cephalosporin cephalosporin gentamicin cyclopropylmethyl unwashed Erythromycin 50 Ci 100 controls methicillin resistant oxazoline cefuroxime Betahistine neomycin gatifloxacin Staphylococcus aureus ATCC25923 20 18 18 7 24 SSSSSSS coli ATCC25922 15 14 14 7 10 SSSSSS Pseudomonas aeruginosa ATCC27853 13 12 12 7 6 SSS Clostridium perfringens CMCC (B) 64606 10 Staphylococcus aureus (MRSE) secretion 19 17 17 7 6 RRRRRRR Staphylococcus epidermidis (MRSE) secretion 20 17 17 7 6 RRRRRRR pyogenes secretions 1188 7 6 SSSSS S S淋病奈瑟菌 分泌物 11 10 10 7 31 S S S S S S大肠埃希菌 分泌物 17 15 15 7 6 R R R R R R阴沟肠杆菌 分泌物 10 8 8 7 11 R R R R R R产气肠杆菌 分泌物 15 13 13 7 6 R R R R R R铜绿假单胞菌 分泌物 17 15 15 7 6 R R R R R R嗜麦芽窄食单胞菌 分泌物 16 13 14 7 6 R R R S R S鲍曼不动杆菌 分泌物 15 12 12 7 19 R R R S S S肺炎克雷伯菌 分泌物 17 14 14 7 6 R R R S R S粘质沙雷菌 分泌物 18 13 14 7 6 R R R R R S费劳地枸橼酸杆菌 分泌物 13 10 10 7 6 SS Neisseria gonorrhoeae secretion 11 10 10 7 31 SSSSSS coli secretion 17 15 15 7 6 RRRRRR Enterobacter secretions 10 8 8 7 11 RRRRRR aerogenes secretions 15 13 13 7 6 RRRRRR Pseudomonas Aeromonas secretion 17 15 15 7 6 RRRRRR maltophilia Aeromonas secretion 16 13 14 7 6 RRRSRS Acinetobacter baumannii secretions 15 12 12 7 19 RRRSSS secretions Klebsiella pneumoniae 1714147 6 RRRSRS Serratia marcescens secretion 18 13 14 7 6 RRRRRS costs of labor to Citrobacter secretions 13101076 R R R R R R雷积普罗维登菌 分泌物 15 13 13 7 6 R R R S R S亲水气单胞菌 分泌物 13 11 13 7 16 R R R S R S温和气单胞菌 分泌物 14 12 12 7 17 R I I S R S创伤弧菌 分泌物 19 17 17 7 6 R R R S I S奇异变形杆菌 分泌物 13 11 11 7 9 R R R S R R普通变形杆菌 分泌物 12 10 11 7 6 R R R S R R潘氏变形杆菌 分泌物 11 10 10 7 6 R R I S R S白色念珠菌 分泌物 23 21 21 7 6热带念珠菌 分泌物 20 17 17 7 6近平滑念珠菌 分泌物 21 20 20 7 6光滑球拟酵母菌 分泌物 28 27 27 7 RRRRRR Ray product Providencia bacterial secretion 15 13 13 7 6 RRRSRS hydrophilic Aeromonas secretion 13 11 13 7 16 RRRSRS Aeromonas bacteria secretions 14 12 12 7 17 RIISRS vulnificus exudates 191717 7 6 RRRSIS mirabilis secretions 13 11 11 7 9 RRRSRR Proteus secretions 12 10 11 7 6 RRRSRR Pan Proteus secretions 11 10 10 7 6 RRISRS albicans discharge 23212176 Candida tropicalis secretions 20171776 parapsilosis secretions 21202076 smooth Torulopsis yeast secretion 2,827,277 6注:S: 敏感 I:中介 R:耐药菌株 空白 AB织物 MS织物织物 未洗 洗20次 高压 未洗 高压 洗20次 洗50次绿脓杆菌 - - - - 17 14 17 18金黄色葡萄球菌 - - - - 17 17 17 17大肠杆菌 - - - - 15 14 20 17MRSA - - - - 16 14 18 17蜡样杆菌 - - 11 - 15 15 15 17创伤弧菌 - - - - 18 16 18 19白色念珠菌 - 21 - - 13 11 11 13B群溶血性链球菌 - - - - 13 11 14 13嗜麦芽假单胞菌 - - - - 14 12 17 6 Note: S: Sensitive I: Mediation R: Blank AB fabric MS textile fabric resistant strains No wash 20 high-pressure unwashed high pressure wash 20 wash 50 Pseudomonas aeruginosa - - - -. 17 14. 17 18 is Staphylococcus aureus - - - -. 17. 17. 17. 17 Escherichia coli - - - - 15 14 20 17MRSA - - - - 16 14 18 17 cereus - -. 11 - 15 15 15. 17 Vibrio vulnificus - - - - 18 is 16 18 is. 19 Candida albicans bacteria - 21 - - 13 11 11 13B group hemolytic streptococcus - - - - 13 is. 11 14 13 is Pseudomonas maltophilia - - - - 14 12 is. 17 16硝酸盐阴性杆菌 - - - - 16 15 15 17丙型副伤寒沙门氏菌 - 12 - - 14 16 21 16亚利桑那菌 - - - - 16 16 17 16枸橼酸杆菌 - - - - 16 16 17 15肺炎杆菌 - - - - 15 15 19 15枯草杆菌 - - - - 14 14 14 14摩根氏菌 - - 10 - 14 14 14 14粪产硷杆菌 - - - - 16 14 18 18斯氏普图菲登氏菌 - - - - 14 14 16 15阴沟肠杆菌 - - - - 15 15 15 15淋球菌 - - - - 13 13 13 13 16 nitrate negative bacilli - - - - 16 15 15 17 paratyphi C Salmonella - 12 - - 14 16 21 16 Arizona bacteria - - - - 16 16 17 16 Citrobacter - - - - 16 16 17 15 Klebsiella pneumoniae - - - - 15 15 19 15 Bacillus subtilis - - - - 14 14 14 14 morganii - - 10 - 14 14 14 14 manure produced alkaline bacillus - - - - 16 14 18 18 Steinmann Putufeideng coli - - - - 14 14 16 15 Enterobacter cloacae - - - - 15 15 15 15 Neisseria gonorrhoeae - - - - 13 13 13 13

以上结果表明,MS对20株细菌均有抑制作用,且对易产生抗药性的细菌,如金黄色葡萄球菌耐药株(MRSA),绿脓杆菌,嗜麦芽假单胞菌及硝酸盐阴性杆菌等均有抑制作用,高压及洗涤20次及50次后均与未经洗涤一样,对抑菌作用无明显影响,并且有了新的提高,而AB织物经洗涤20次后,对以上细菌不能抑制,由此可见,MS织物抑菌范围双AB织物广泛且不会因为洗涤而影响抑菌效果。 These results show that, the MS 20 are inhibited bacteria and resistant bacteria, drug-resistant strains such as Staphylococcus aureus (MRSA), Pseudomonas aeruginosa commutation, Pseudomonas maltophilia and nitrate negative bacillus was inhibited, high pressure and washed after 20 and 50 in both times without washing the same, no significant effect on the inhibition of, and has been enhanced, while AB fabrics after washing 20 times, of the above bacteria can not inhibition, we can see, the MS fabric antibacterial wide range of bis AB fabric and will not be washed affect the inhibitory effect.

3、LBDF对耐药性致病菌具有优异的抑菌性能将LBDF和8个抗菌药物同时对28个致病菌作体外抑菌试验,结果显示LBDF对28个菌种全部显示有明显的抑菌功能,红霉素仅对8个菌种有抑菌功能,苯唑西林(2个)、氨苄西林(4个)、头孢唑啉(4个)、头孢呋肟(4个)、头孢他啶(15个)、庆大霉素(6个)、环丙沙星(14个)。 3, LBDF having excellent antibacterial activity to pathogenic bacteria for resistance to antibiotics LBDF 8 and 28 at the same time as the pathogen in vitro antibacterial test showed LBDF all 28 strains displayed a significant inhibition bacteria function, erythromycin only 8 strains have antibacterial function, oxacillin (2), ampicillin (4), cefazolin (4), cefuroxime (4), ceftazidime ( 15), gentamycin (6), ciprofloxacin (14).

实验证明LBDF与这8个抗菌药物的体外抑菌试验比较,说明LBDF对耐药性的菌种有明显优势的抑菌功能。 Experiments show LBDF trials comparing Bacteriostasis eight antimicrobial agents described antibacterial function LBDF species of resistance has obvious advantages.

4、药代动力学研究以豚鼠和家兔为试验对象,LBDF对皮肤急性毒性试验、刺激试验、过敏试验。 4, pharmacokinetic studies in guinea pigs and rabbits as test objects, LBDF acute toxicity test skin irritation test, allergy test. 试验单位:南京军区总医院药理科。 Test: Nanjing Military Region General Hospital Pharmacology Department. 试验结果证明LBDF无毒性、无刺激性、无过敏性。 The test results prove LBDF non-toxic, non-irritating, non-allergenic.

5、临床验证经过上述试验后已开展了临床验证,现已有:(1)中国人民解放军南京总医院烧伤整形科作的50个烧伤病例的临床报告。 5, clinical validation After these tests have been carried out clinically proven, is now available: plastic surgery made 50 clinical reports of burn cases (1) the PLA Nanjing General Hospital burn unit.

(2)江苏省人民医院普外科作的Ⅱ类切口术后观察的临床报告。 (2) clinical report class Ⅱ postoperative incision Jiangsu Provincial People's Hospital General Surgery made.

(3)中国医学科学院皮肤病研究所作的皮肤浅部真菌的临床报告。 (3) skin shallow Institute of Dermatology, Chinese Academy of Medical Sciences for clinical reports fungi.

此外还有几家医院对植皮区、肿瘤切口术后观察、烧烫伤、皮肤溃疡观察等临床试验正在进行。 There are also several hospitals Clinical trials are ongoing graft area, postoperative tumor incisions, burns, skin ulcers observation.

以下通过具体实施例来进一步说明本发明,但实施例仅用于说明,并不能限制本发明范围。 The following further illustrate the invention by way of specific embodiments, but the embodiments are illustrative only, and not intended to limit the scope of the invention.

在本发明中,若非特指,所有的份、量均为以总重量为基础的重量单位。 In the present invention, if not especially, all parts, amounts are based on the total weight of the basis weight of the unit.

例1称取硝酸银8公斤,溶于350升水中,加入浓氨水25升,加水使其体积为1000升,并混合均匀。 Example 1 weighed silver nitrate 8 kg, was dissolved in 350 liters of water, was added concentrated aqueous ammonia 25 l water was added so that a volume of 1,000 liters, and mixed well. 将织物浸轧整理液,一浸一轧,轧液率为60%,然后在鼓风和抽风条件下用热风烘燥,时间为3分钟,温度为150℃,然后四浸四轧,轧液率为100%,最后烘干,即得本发明的产品。 The fabric padding finishing liquid, a dip roll, rolling was 60%, and then drying with hot air in the blowing and ventilation conditions, the time is 3 minutes, a temperature of 150 deg.] C, four dip four and rolling, mangle 100%, and finally dried, to obtain the present invention product.

例2称取硝酸银20公斤,溶于650升水中,加入浓氨水35升,加水使其体积为1000升,并混合均匀。 Example 2 weighed silver nitrate 20 kg, was dissolved in 650 liters of water, was added concentrated aqueous ammonia 35 l water was added so that a volume of 1,000 liters, and mixed well. 将织物浸轧整理液,一浸一轧,轧液率为90%,然后在鼓风和抽风条件下用远红外加热烘燥,时间为10分钟,温度为180℃,然后四浸四轧,轧液率为120%,最后烘干,即得本发明的产品。 The fabric padding finishing liquid, a dip roll, rolling was 90%, and with a far infrared heating drying under blowing and ventilation conditions, for 10 minutes at 180 ℃, and four dip four rolls, pickup of 120%, and finally dried, to obtain the present invention product.

例3称取硝酸银15公斤,溶于550升水中,加入浓氨水25升,取葡萄糖3公斤、溶于100升水中,加水使其体积为1000升,并混合均匀。 Example 3 weighed silver nitrate, 15 kg, was dissolved in 550 liters of water, concentrated ammonia 25 liters, to take glucose 3 kg dissolved in 100 liters of water, add water so that a volume of 1000 liters, and mix well. 将织物浸轧整理液,一浸一轧,轧液率为60%,然后在鼓风和抽风条件下用加热辊加热烘燥,时间为8分钟,温度为110℃,然后四浸四轧,轧液率为100%,最后烘干,即得本发明的产品。 The fabric padding finishing liquid, a dip roll, pickup of 60%, then the blower and exhaust conditions with a heating roll drying time of 8 minutes, the temperature is 110 deg.] C, and four dip four rolls, mangle 100%, and finally dried, to obtain the present invention product.

例4称取硝酸银28公斤,溶于750升水中,加入浓氨水35升,取葡萄糖5公斤、溶于100升水中,再加浓硝酸0.3升,氢氧化钠1公斤,加水使其体积为1000升,并混合均匀。 Example 4 was weighed silver nitrate 28 kg, was dissolved in 750 liters of water, was added concentrated aqueous ammonia 35 liters, taking glucose 5 kg, was dissolved in 100 liters of water, together with concentrated nitric acid 0.3 l, sodium 1 kg, addition of water volume of 1,000 liters, and mixed well. 将织物浸轧整理液,一浸一轧,轧液率为60%,然后在鼓风和抽风条件下用辐射加热烘燥,时间为10分钟,温度为100℃,然后四浸四轧,轧液率为100%,最后烘干,即得本发明的产品。 The fabric padding finishing liquid, a dip roll, pickup of 60%, then the blower and exhaust conditions with a radiant heating drying, for 10 minutes at 100 deg.] C, and four dip four rolling, rolling It was 100%, and finally dried, to obtain the present invention product.

例5称取硝酸银10公斤,溶于350升水中,加入浓氨水15升,取葡萄糖0.8公斤、溶于60升水中,再加浓硝酸0.4升,氢氧化钠2公斤,加水使其体积为1000升,并混合均匀。 Example 5 weighed silver nitrate 10 kg, was dissolved in 350 liters of water, was added concentrated aqueous ammonia 15 liters, taking glucose 0.8 kg, was dissolved in 60 liters of water, together with concentrated nitric acid in 0.4 liter of sodium 2 kg, add water so that a volume of 1,000 liters, and mixed well. 将织物浸轧整理液,一浸一轧,轧液率为90%,然后在鼓风和抽风条件下用辐射加热烘燥,时间为5分钟,温度为150℃,然后四浸四轧,轧液率为100%,最后烘干,即得本发明的产品。 The fabric padding finishing liquid, a dip roll, pickup of 90%, then the blower and exhaust conditions with a radiant heating drying time was 5 minutes at a temperature of 150 deg.] C, and four dip four rolling, rolling It was 100%, and finally dried, to obtain the present invention product.

Claims (10)

  1. 1.一种钠米银抗菌织物,其特征在于在织物的纤维之间或纤维之上附着有超微粒银,超微粒银的表面层是氧化银,核心为金属银,其粒径为1~900纳米。 A Nano silver antibacterial fabric, characterized in that attached to or on the fiber between the fibers of the fabric are ultrafine particles of silver, the surface layer of ultra-fine silver particles are silver oxide, core metallic silver having a particle size of 1 to 900 nm.
  2. 2.如权利要求1所述的纳米银抗菌织物,其特征在于在织物的纤维之间或纤维之上附着的超微粒银的量为2~200微克/厘米2。 2. Nano silver antimicrobial fabric according to claim 1, wherein the amount of ultra-fine silver particles between the fibers of the fabric or fiber on attachment 2 to 200 g / cm 2.
  3. 3.如权利要求1、2所述的纳米银抗菌织物的制备方法,其特征在于将织物浸轧整理液,然后在保持充足氧气条件下用热风烘燥,洗涤、最后烘干。 3. The production method of claim 1, nano silver antibacterial fabric as claimed in claim, wherein the fabric is padded finishing agent, followed by hot air drying at maintaining sufficient oxygen conditions, washing and finally drying.
  4. 4.如权利要求3所述的纳米银抗菌织物的制备方法,其特征在于整理液含有:(以200公斤织物计)硝酸银 5~30公斤, 氨水 15~40升,加水至1000升。 4. The preparation method of claim 3 nano silver antibacterial fabric as claimed in claim, characterized in that the finishing liquor containing :( to 200 kg fabric basis) of silver nitrate 5 to 30 kg of aqueous ammonia of 15 to 40 liters of water was added to 1,000 liters.
  5. 5.如权利要求4所述的纳米银抗菌织物的制备方法,其特征在于整理液还含有1~20公斤葡萄糖。 5. The preparation method according to nano silver antibacterial fabric as claimed in claim, characterized in that the finishing agent further comprises 1 to 20 kg glucose.
  6. 6.如权利要求3所述的纳米银抗菌织物的制备方法,其特征在于整理液含有:(以200公斤织物计)硝酸银 5~30 公斤, 氨 水 15~40 升,氢氧化钠 0.8~3公斤, 葡萄糖 0.2~10公斤,硝 酸 0.2~0.5升, 余量为水 总计1000升。 According to claim 3, wherein the nano-silver antibacterial fabric preparation, characterized in that the finishing liquor containing :( to 200 kg fabric meter) silver nitrate 5 to 30 kilograms of ammonia from 15 to 40 liters of sodium hydroxide 0.8 to 3 kg of glucose 0.2 to 10 kg of nitric acid of 0.2 to 0.5 liters, the balance being water Total 1000 liters.
  7. 7.如权利要求3所述的纳米银抗菌织物的制备方法,其特征在于将织物浸轧整理液,轧液率为60~90%,然后在鼓风和抽风条件下用热风烘燥,时间为1~10分钟,温度为90~200℃,多次洗涤、浸轧,轧液率为100~150%,最后烘干。 7. The method of claim 3 for preparing nano silver antibacterial fabric as claimed in claim, characterized in that the padded fabric finishing liquor, pickup of 60 to 90%, and then drying under a hot air blowing and ventilation conditions, time 1 to 10 minutes at a temperature of 90 ~ 200 ℃, washed several times, padding, pickup of 100% to 150%, and finally drying.
  8. 8.如权利要求3所述的纳米银抗菌织物的制备方法,其特征在于所述的烘燥可以为热风烘燥,也可以是加热辊、辐射或远红外加热等。 8. The preparation method of claim 3 nano silver antibacterial fabric as claimed in claim, wherein said drying may be hot-air drying, may be a heating roller, radiation, or far infrared heating.
  9. 9.如权利要求1、2所述的纳米银抗菌织物,其特征在于该织物可以作为治疗烧烫伤的医用(外)材料,和治疗外伤患者的皮肤感染和皮肤浅部真菌感染以及外科手术切口术后预防和治疗切口感染的材料。 9. A nano-silver antimicrobial fabric according to claims 1, 2, characterized in that the fabric can be used as treatment of burns medical (outer) material, and the treatment of trauma patients skin infections and skin superficial fungal infections as well as surgical incisions postoperative prevention and treatment of material wound infection.
  10. 10.如权利要求1、2所述的纳米银抗菌织物,其特征在于可以作为日常生活用品。 10. A nano-silver antimicrobial fabric according to claims 1, 2, characterized in that as daily necessities.
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