CN100344295C - Ganoderma lucidum capsule of lycopene - Google Patents
Ganoderma lucidum capsule of lycopene Download PDFInfo
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- CN100344295C CN100344295C CNB2004100815954A CN200410081595A CN100344295C CN 100344295 C CN100344295 C CN 100344295C CN B2004100815954 A CNB2004100815954 A CN B2004100815954A CN 200410081595 A CN200410081595 A CN 200410081595A CN 100344295 C CN100344295 C CN 100344295C
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Abstract
The present invention discloses a ganoderma lucidum capsule of lycopene, which relates to dual-purpose dietetic therapy health products. The ganoderma lucidum capsule of lycopene is mainly composed of 1 portion of lycopene, 50 to 500 portions of ganoderma lucidum spore powder or fine ganoderma lucidum powder and a proper amount of auxiliary materials of capsules, and 1 to 10 portions of vitamin E are also added. The ganoderma lucidum capsule of lycopene has the health-care functions of regulating human bodies' immune functions, inhibiting tumors and delaying aging.
Description
One, technical field
The present invention relates to health product, especially for immunomodulating, suppress tumor, slow down aging, contain the health product of Ganoderma.
Two, background technology
Traditional medicine and modern medicine confirm that Ganoderma is the different grass of rarity that function at most, range of application is the widest, the crowd that suits does not have limitation in the world.China's traditional medicine thinks, Ganoderma property is flat, goes into the heart, kidney, lung, liver, the spleen Five Classics, " all medicines be the medicine of each disease, and Ganoderma is the medicine of all kinds of diseases and ailments ", and Ganoderma is unique medicine of going into the five internal organs in all tonify deficiency medicines, eats dual-purpose thing.Modern medicine study confirms, contains kind surplus the precious compositions 150 such as polysaccharide, triterpenes, steroid class in the Ganoderma sporophore altogether.Ganoderma has immunomodulating, improves sleep, improves anemia, improves memory, improves renal function, looks improving and the skin nourishing, slow down aging, inhibition tumor, antiallergic, radioprotective, mutation, anti-immunodeficiency, blood lipid regulation, blood sugar regulation, blood pressure regulation, anoxia enduring, sedation and analgesia, relieving cough and asthma, protection heart, suppresses atherosclerosis, eliminates thrombosis, improves blood circulation, liver detoxification, promotion hemopoietic, promote health care such as children ' s healthy growth.Generally speaking, Ganoderma can be regulated the function balance of each big system such as human immune system, respiratory system, digestive system, urinary system, hormonal system, cardiovascular system, nervous system comprehensively, is turned out to be " best human body integral equilibrium modifier " by medical circle.But the mode of taking of existing Ganoderma can not make human body that the nutritional labeling of Ganoderma is absorbed fully comprehensively and utilize, and has caused waste and loss to the ganoderma lucidum composition.As, the existing blister Ganoderma (as: manufacture technology of glossy ganoderma health-care tea, application number 92102494), can only be with the water soluble ingredient in the Ganoderma, (ganoderan comprises neutral heteropolysaccharide., peptide polysaccharide and Ganoderma extracellular polysaccharide three major types to the water soluble polysaccharide lower as molecule, relative molecular mass is 6000-50000, and with 10
4-10
6High-molecular weight physiologically active is the strongest) soak, the high-molecular weight ganoderan that its physiologically active is stronger and other many precious composition to the human body beneficial (indissoluble and pure melt into branch) have been slatterned in vain, and for example, with packed soaked the drinking of Ganoderma powder, the one, partly (only water soluble ingredient) takes in the nutritional labeling of Ganoderma; The 2nd, the Ganoderma bitter in the mouth is difficult to allow the people accept.For another example, wine bubble Ganoderma, it can only soak the alcohol of the part in Ganoderma soluble components out, and other precious composition has also been slatterned in vain.And drunk people drinks a cuvette every day, and Ganoderma content is few.Therefore, blister, bag bubble, wine bubble Ganoderma, the Ganoderma composition that people's physical ability touches is very limited, and that does not bring into play Ganoderma should have health-care effect.
Chinese patent literature discloses a kind of " multi-vitamin nutrient " (application number 03117004.8), and it is by vitamin, Radix Panacis Quinquefolii, Radix Ginseng, Herba Dendrobii, Lac regis apis, propolis, pollen, barley green, tea polyphenols, Ganoderma, Semen Ginkgo, Fructus Lycii, spirulina, Radix et Caulis Opuntiae Dillenii, the mixture that 15 kinds of raw materials such as lycopene are formed, its prescription is more numerous and diverse, neither mainly act as purpose with outstanding glossy ganoderma health-care.
Three, summary of the invention
The purpose of this invention is to provide a kind of ganoderma lucidum capsule of lycopene, make Ganoderma components utilising degree higher, health-care effect is more remarkable.The technical scheme that realizes the object of the invention is: a kind of ganoderma lucidum capsule of lycopene, mainly form 1 part of lycopene, the smart powder 50-500 of Ganoderma spore powder and/or Ganoderma part, and appropriate amount of auxiliary materials by the raw material of following weight portion.
Also be added with 1-10 part vitamin E.
Above-mentioned adjuvant is a gelatin, glycerol, water.Concerning soft capsule, the adjuvant gelatin, water, glycerol three ratio is 100: 110: 20, and can add proper amount of edible oil.
In the above prescription, lycopene is a kind of of carotenoid, and the major physiological effect is as antioxidant.Vitamin E also is a kind of antioxidant.As everyone knows, Ganoderma has the effect that suppresses oxygen-derived free radicals, and it is to O
2 -, HO clearance rate about 50%, be 45-86% to the suppression ratio of erythrocyte lipid peroxidation.Lycopene and vitamin E and Ganoderma three are shared, and the three is the different antioxidant of molecular structure, and three's antioxidation principle is inequality.After the three uses with, prove that whole antioxygenic property (quencher singlet oxygen and removing peroxylradicals) is greatly enhanced, to O through rat experiment
2 -, HO clearance rate reach 60-65%, the suppression ratio of erythrocyte lipid peroxidation is reached 90%.From the drug effect principle, the complete antioxidant system of a cover is arranged in the body, under normal physiological conditions, free radical constantly generates, and constantly is eliminated again, thereby keeps relative dynamic equilibrium.Singlet oxygen and organic free radical are mainly hydroxyl peroxide and superoxides, they are the metabolic by-products of many Esters often, important macromolecular reactions such as DNA, protein, carbohydrate and esters in energy and the body, damage their function, cause a series of disease, as cancer, cardiovascular disease and aging etc.And compare with the blank group through the rat of the mixture feeding of Ganoderma, lycopene, vitamin E, obviously reduced the peroxidating of serum lipids and the oxidation of low-density lipoprotein cholesterol, and reflected by a series of oxidoreduction enzyme activities in the rat body.This mixture makes dihydrocoenzyme II cytochrome P in the rat liver microsomes
450Reductase, DPNH cytochrome b
5Reductase, G-6-P reductase activity reduce, and liver superoxide dismutase, catalase, glutathion reduced oxide enzyme, glutathion reductase vigor are increased, thereby improve the antioxidant system ability, reduce sensitivity poisonous substance.
Capsule of the present invention has following distinguishing feature;
1, capsule preparations can be avoided the bitterness of Ganoderma on the one hand, be easy to accept for the user, can effectively improve lycopene stability on the other hand, help the absorption (pure product lycopene can destroy because of light, oxygen, high temperature, acid, alkali, especially easily oxidation, can absorb oxygen and reach 30%) of its nutritive and health protection components.
2, take in effective component of glossy ganoderma with existing single water-soluble or pure molten mode and compare, among the present invention, the Ganoderma composition utilize degree higher, health-care effect is more remarkable.To Ganodenic acid esters of the main functional component of Ganoderma (belong to triterpene substance, known contain 106 kinds of triterpenoids) and molecular weight is big, physiologically active is stronger ganoderan, there is not single water-soluble or pure molten absorption mode and the waste problem that produces.
3, diabetes are commonly encountered diseases of middle-aged and elderly people, are nicknamed " affluenza ".World Health Organization (WHO) classifies it and tumor, cardiovascular and cerebrovascular disease as the world three disaster diseases together.The present invention more helps the absorption of ganoderan, ganoderan can alleviate the occurring degree of non-insulin-dependent diabetes mellitus, recover the blood glucose normal level, the balance between the coherent system organ pipe, the appearance of minimizing and inhibition complication such as hypertension, apoplexy wind, coronary heart disease, uremia etc.Can alleviate simultaneously the toxic and side effects of medicine.Thereby capsule of the present invention has fabulous stable regulation effect to diabetes.
Four, the specific embodiment
Among the present invention, lycopene is body of powder or oily liquids.Pure product are the needle-like red crystals.174 ℃ of fusing points, flammable, meltable in Carbon bisulfide (1g/50ml), boiling ethanol (1g/3l), normal hexane (1g/14l, 0 ℃); Be dissolved in chloroform and benzene; Be slightly soluble in ethanol and methanol.Quality index removing heavy metals, the content of arsenic and remaining solvent should satisfy outside the hygienic requirements, and the color valency is: dichloromethane solution, 1cm, 472nm.Production unit has: Taihe county, Shanxi commerce and trade company limited, israeli tomato red pigment natural prodcuts industrial group etc.; The quality index of Ganoderma spore powder is removed and is satisfied outside the hygienic requirements (heavy metal, bacterial population etc.), its total sugar 〉=14%, total positive reaction of triterpene, unsaturated fatty acid 〉=14.3%, iodine number 〉=64.2, moisture≤8%; The smart powder of Ganoderma (Ganoderma water extract) except that satisfying sanitary index, moisture≤8%, fineness 〉=120 orders, water soluble polysaccharide 〉=10%, triterpenes 〉=4%, total nitrogen≤4%, crude fat 〉=5%, crude protein 〉=18%, the vitamin E quality should satisfy national standard.
Embodiment 1
Get lycopene 1kg, Ganoderma spore powder 50kg, vitamin E 2kg, adding the 50kg edible oil earlier mixes with Ganoderma spore powder, add appropriate amount of auxiliary materials (as gelatin 50kg, glycerol 10kg, water 55kg) and three raw material stirring mix homogeneously again, make soft capsule by soft capsule technology; Perhaps add and make hard capsule after adjuvant mixes; After also can mixing, tabletting is made coated tablet.
Embodiment 2
Get lycopene 1kg, Ganoderma spore powder 100kg, vitamin E 3kg makes soft capsule by embodiment 1 mode, or hard capsule, or coated tablet.
Embodiment 3
Get lycopene 1kg, Ganoderma spore powder 200kg, vitamin E 5kg makes soft capsule by embodiment 1 mode, or hard capsule, or coated tablet.
Embodiment 4
Get lycopene 1kg, Ganoderma spore powder 300kg, vitamin E 6kg makes soft capsule by embodiment 1 mode, or hard capsule, or coated tablet.
Embodiment 5
1 part of kg of lycopene, the smart powder 350kg of Ganoderma, vitamin E 7kg adds appropriate amount of auxiliary materials and mixes, and makes hard capsule, soft capsule or coated tablet.
Embodiment 6
Lycopene 1kg, the smart powder 400kg of Ganoderma, vitamin E 8kg adds appropriate amount of auxiliary materials and mixes, and makes hard capsule, soft capsule or coated tablet.
Embodiment 7
1 part of kg of lycopene, the smart powder 300kg of Ganoderma, Ganoderma spore powder 200kg, vitamin E 10kg adds appropriate amount of auxiliary materials and mixes, and makes hard capsule, soft capsule or coated tablet.
It is as follows to make the slow down aging controlled trial with capsule of the present invention:
Test material: old Carnis Coturnicis japonicae (400 days) does not have obviously morbid state, and is outer existing healthy, is divided into 5 groups at random, 30/group.
A organizes (matched group): feed normal feedstuff.
The B group adds and feeds the 1mg lycopene except that normal feedstuff every day.
The C group adds and feeds the 50mg Ganoderma spore powder except that normal feedstuff every day.
The D group adds and feeds the 3mg vitamin E except that normal feedstuff every day.
The E group adds and feeds 1mg lycopene, 150mg Ganoderma spore powder, 3mg vitamin E except that normal feedstuff every day.
Each group was pressed the such scheme feed 180 days, transferred normal feedstuff then to, and its mean survival time goes out to see the following form:
| Each organize the Carnis Coturnicis japonicae mean survival time (my god) | ||||
| A | B | C | D | E |
| 203 | 256 | 281 | 220 | 326 |
Result of the test shows that the effect that the E group prolongs the animal life-span is better than B, C, D, A group.
This capsule human body amount every day is 6-30mg (in the weight of lycopene in the capsule).
Concrete trial state is as follows;
Examination trencherman A: women, 48 years old, hysteromyoma (2.5cm), weak, catch cold easily, once took Ganoderma spore powder 6 months, do not have obviously and improve, change clothes capsule of the present invention after 3 months, body constitution is obviously improved, and body weight is increased to 105 jin by 98 jin, continue to take 1 year after, times of common cold is reduced to 0.5-1 time/month by the 2-3 time/moon, and hysteromyoma disappears.
Examination trencherman B: the women, 52 years old, hysteromyoma, tumor body 2.7cm, 18 months posterior tuberosity bodies of this product on probation disappear.
Examination trencherman C: the male, 71 years old, take this product before spirit not good enough, drowsiness, easy catching a cold was taken this product after 3 months, conscious spirit takes a turn for the better, daytime somnolence reduces, times of common cold reduces.
Claims (10)
1, a kind of ganoderma lucidum capsule of lycopene is characterized in that, mainly is made of 1 part of lycopene, the smart powder 50-500 of Ganoderma spore powder and/or Ganoderma part, and appropriate amount of auxiliary materials the raw material of following weight portion.
2, capsule according to claim 1 is characterized in that, also is added with 1-10 part vitamin E.
3, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 50 parts of Ganoderma spore powders, vitamin E2 part.
4, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 100 parts of Ganoderma spore powders, 3 parts of vitamin Es.
5, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 200 parts of Ganoderma spore powders, 5 parts of vitamin Es.
6, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 300 parts of Ganoderma spore powders, 6 parts of vitamin Es.
7, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 350 parts in the smart powder of Ganoderma, 7 parts of vitamin Es.
8, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 400 parts in the smart powder of Ganoderma, 8 parts of vitamin Es.
9, capsule according to claim 2 is characterized in that, described raw material is composed as follows: 1 part of lycopene, 300 parts in the smart powder of Ganoderma, 200 parts of Ganoderma spore powders, 0 part of vitamin e1.
According to the described capsule of the arbitrary claim of claim 1-8, it is characterized in that 10, described adjuvant is a gelatin, G ﹠ W.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100815954A CN100344295C (en) | 2004-12-27 | 2004-12-27 | Ganoderma lucidum capsule of lycopene |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100815954A CN100344295C (en) | 2004-12-27 | 2004-12-27 | Ganoderma lucidum capsule of lycopene |
Publications (2)
| Publication Number | Publication Date |
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| CN1795877A CN1795877A (en) | 2006-07-05 |
| CN100344295C true CN100344295C (en) | 2007-10-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100815954A Active CN100344295C (en) | 2004-12-27 | 2004-12-27 | Ganoderma lucidum capsule of lycopene |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750094B (en) * | 2013-06-29 | 2015-09-30 | 明光市昊昊蜂业有限公司 | Male hachinoko health-care paste and preparation method thereof |
| CN103622015A (en) * | 2013-11-28 | 2014-03-12 | 江西仙客来生物科技有限公司 | Ganoderma lucidum spores oil VE soft capsule |
| CN104857045A (en) * | 2015-05-18 | 2015-08-26 | 于惊涛 | Drug or food composition having protection function on electromagnetic radiation exposed people |
| CN107232594A (en) * | 2017-06-22 | 2017-10-10 | 利康行(北京)生物科技有限公司 | A kind of complex health care product of strengthen immunity |
| CN109432159A (en) * | 2018-11-13 | 2019-03-08 | 广西志诚孝善三商贸有限公司 | The gynecological gel of reproductive system immunity can be enhanced |
| WO2020113495A1 (en) * | 2018-12-06 | 2020-06-11 | 江苏安惠生物科技有限公司 | Soft ganoderma lucidum spore oil capsule |
| CN112569192A (en) * | 2020-11-18 | 2021-03-30 | 中科健康产业集团股份有限公司 | Production method of lycopene-containing particles with efficient antioxidant effect |
| CN113599401A (en) * | 2021-07-22 | 2021-11-05 | 康道生物（南通）有限公司 | Wall-broken ganoderma lucidum spore powder capsule and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548070A (en) * | 2003-05-16 | 2004-11-24 | 沈余勤 | Nutrient with vitamines |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548070A (en) * | 2003-05-16 | 2004-11-24 | 沈余勤 | Nutrient with vitamines |
Non-Patent Citations (1)
| Title |
|---|
| 中老年营养研究新进展 范群等，江苏预防医学，第13卷第3期 2002 * |
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