CN100337633C - Rhodiola root glycosides injection for treating cardiovascular/cerebrovascular diseases and preparation method thereof - Google Patents
Rhodiola root glycosides injection for treating cardiovascular/cerebrovascular diseases and preparation method thereof Download PDFInfo
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- CN100337633C CN100337633C CNB2005100259322A CN200510025932A CN100337633C CN 100337633 C CN100337633 C CN 100337633C CN B2005100259322 A CNB2005100259322 A CN B2005100259322A CN 200510025932 A CN200510025932 A CN 200510025932A CN 100337633 C CN100337633 C CN 100337633C
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Abstract
The present invention relates to a salidroside injection and a preparation method for curing cardiovascular and cerebrovascular diseases, which is used for the technical field of medicine. The salidroside injection comprises by weight: 0.2 to 2 wt % of salidroside, 0.5 to 1.5 wt % of sodium chloride, 0.2 to 0.5% of trichlorbutanolum, and water. The present invention has the preparation method that 80% of the preparation amount of injection water is added in a preparation container, the salidroside, the sodium chloride and the trichlorbutanolum are orderly added and are stirred for complete dissolution; the injection water is added to 1000 ml, a G3 sintered glass funnel is used for filtering, and the injection is filled in ampoules with the volume of 2 ml and is sterilized at the temperature of 100 DEG C. for half an hour. The present invention has the advantages of high speed of effect, quick control of state of cardiovascular and cerebrovascular diseases, suitable used for emergency treatment, high biologic utilization and good curative effect.
Description
Technical field
The present invention relates to injection of a kind of medical technical field and preparation method thereof, specifically is rhodiola root glycosides injection of a kind of treatment cardiovascular and cerebrovascular disease that is used to inject and preparation method thereof.
Background technology
Cardiovascular and cerebrovascular disease is commonly encountered diseases, frequently-occurring disease clinically, in recent years, raising along with people's living standard, add the aging of population structure, its sickness rate is ascendant trend year by year, and the medicine of exploitation treatment cardiovascular and cerebrovascular disease has become the focus of current drug research, increasing clinical report shows, Chinese medicine is having a good application prospect aspect the treatment cardiovascular and cerebrovascular disease, and particularly the toxic and side effects of Chinese medicine is little, and it is more and more to accept the crowd.
Radix Rhodiolae is the root and rhizome of Crassulaceae rhodiola (Rhodiola L.) plant, Rhodida plant has 100 kinds approximately in the whole world, can in extremely abominable and changeable natural environment, grow,, mainly be distributed in Himalayas, the northwestward, Asia and North America for a kind of adaptation former state plant.China has 80 kinds approximately, is distributed in southwest, northwest, North, Northeast China area more, has reported that kind medicinal or that health product are used has: Radix Rhodiolae Rhodiola crenulata (Hook.f.et Thoms.) H.Ohba at present; Storehouse page or leaf Radix Rhodiolae R.sachalinensis A.Bor; Radix Rhodiolae R.rosea L; Rhodiola kirilowii (Regel) Maxim. R.kirilowii (Regel) Maxim; Dark red Radix Rhodiolae R.coccinea (Royle) A.Bor..
Radix Rhodiolae has pharmacological action widely to the cardiovascular system aspect, and blood circulation promoting and blood stasis dispelling, microcirculation improvement effect are arranged; Can stop atherosclerotic generation; Has the effect of tangible antagonism arrhythmia; Can directly improve cardiac contractility ability, increase Peripheral resistance, the rising blood pressure improves cardiac function; Have anti-hypoxia, resisting fatigue, the effect of protection myocardial ischemia etc.Rhodioside is the maximum effective ingredient of research in the Radix Rhodiolae, is one of main effective ingredient of treatment cardiovascular and cerebrovascular disease, capable of inhibiting cell in calcium ion concentration raise, intervene neuronal apoptosis, neuroprotective cell and treat ischemic brain injury; Radical damage to the rat layer neurocyte has protective effect, can be used for ischemic cerebrovascular; Can obviously increase anoxia animal cardiac muscle content of glycogen, reduce the load effect of heart front and back, help improving and recovering cardiac function; Can improve the myocardial ischemia tolerance, myocardial cell injury is had protective effect etc.And toxicity research shows, rhodioside toxicity is very little: the mouse subcutaneous injection rhodioside gives 1g/kg and does not cause toxic reaction; Mouse mainline rhodioside 3g/Kg did not see any toxic reaction in continuous 5 days.
By prior art documents, do not see the report of the Application and Development aspect of independent application rhodioside aspect cardiovascular and cerebrovascular disease.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of rhodiola root glycosides injection that is used for cardiovascular and cerebrovascular disease and preparation method thereof is provided, make its treatment cardiovascular and cerebrovascular disease good effect, instant effect, injection that bioavailability is high.
The present invention is achieved by the following technical solutions.Component of the present invention and percentage by weight thereof are: rhodiola root glycosides injection, and its each composition and weight percentage ranges thereof that comprises is: rhodioside 0.2%～2%, sodium chloride 0.5%-1.5%, chlorobutanol 0.2%～0.5%, surplus is a water for injection.
Preferably rhodioside 0.5%～1.5%, sodium chloride 0.7%～1.2%, and chlorobutanol 0.2%～0.4%, surplus is a water for injection.
More preferably rhodioside 0.8%～1.0%, sodium chloride 0.8%～1.0%, and chlorobutanol 0.3%, surplus is a water for injection.
Preparation method of the present invention is: in the preparation container, add the water for injection of amount of preparation 80%, add rhodioside, sodium chloride, chlorobutanol successively, stir and make dissolving fully, add the injection water to 1000ml, use G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
The present invention has following advantage: the injection back is rapid-action, can control the cardiovascular and cerebrovascular disease state of an illness rapidly, is beneficial to rescue; The bioavailability height, the curative effect height.Rhodioside is made injection, can avoid the first-pass effect of liver, a kind of rhodiola root glycosides injection direct, rapid-action, that bioavailability is high that acts on is provided, can effectively control the cardiovascular and cerebrovascular disease anxious, serious symptom of falling ill at short notice.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.
Embodiment one:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 0.2%, and sodium chloride 0.5%, chlorobutanol 0.2%, surplus is a water for injection.
Preparation method is: in the preparation container, add the water for injection of amount of preparation 80%, add rhodioside, sodium chloride, the chlorobutanol of above-mentioned percentage by weight successively, stir and make dissolving fully, add the injection water to 1000ml, use G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.5～6.5, and containing rhodioside is 99.26% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment two:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 2%, and sodium chloride 1.5%, chlorobutanol 0.5%, surplus is a water for injection.
Preparation method is: in the preparation container, adds the water for injection of amount of preparation 80%, adds the rhodioside of above-mentioned percentage by weight successively, and sodium chloride, chlorobutanol stirs and makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.4～6.5, and containing rhodioside is 99.69% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment three:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 1%, and sodium chloride 1%, chlorobutanol 0.3%, surplus is a water for injection.
Preparation method is: in the preparation container, adds the water for injection of amount of preparation 80%, adds the rhodioside of above-mentioned percentage by weight successively, and sodium chloride, chlorobutanol stirs and makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.3～6.4, and containing rhodioside is 99.43% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment four:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 0.5%, and sodium chloride 0.7%, chlorobutanol 0.2%, surplus is a water for injection.
Preparation method is: in the preparation container, add the water for injection of amount of preparation 80%, add rhodioside, sodium chloride, the chlorobutanol of above-mentioned percentage by weight successively, stir and make dissolving fully, add the injection water to 1000ml, use G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.4～6.5, and containing rhodioside is 99.15% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment five:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 1.5%, and sodium chloride 1.2%, chlorobutanol 0.4%, surplus is a water for injection.
Preparation method is: in the preparation container, adds the water for injection of amount of preparation 80%, adds the rhodioside of above-mentioned percentage by weight successively, and sodium chloride, chlorobutanol stirs and makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.4～6.4, and containing rhodioside is 99.48% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment six:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 0.8%, and sodium chloride 1%, chlorobutanol 0.3%, surplus is a water for injection.
Preparation method is: in the preparation container, adds the water for injection of amount of preparation 80%, adds the rhodioside of above-mentioned percentage by weight successively, and sodium chloride, chlorobutanol stirs and makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.6～6.5, and containing rhodioside is 99.23% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment seven:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 0.8%, and sodium chloride 0.8%, chlorobutanol 0.3%, surplus is a water for injection.
Preparation method is: in the preparation container, add the water for injection of amount of preparation 80%, add rhodioside, sodium chloride, the chlorobutanol of above-mentioned percentage by weight successively, stir and make dissolving fully, add the injection water to 1000ml, use G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.3～6.5, and containing rhodioside is 99.32% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment eight:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 1%, and sodium chloride 1%, chlorobutanol 0.3%, surplus is a water for injection.
Preparation method is: in the preparation container, adds the water for injection of amount of preparation 80%, adds the rhodioside of above-mentioned percentage by weight successively, and sodium chloride, chlorobutanol stirs and makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.3～6.6, and containing rhodioside is 99.65% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Embodiment nine:
Rhodiola root glycosides injection is formed and percentage by weight: rhodioside 0.9%, and sodium chloride 0.9%, chlorobutanol 0.3%, surplus is a water for injection.
Preparation method is: in the preparation container, adds the water for injection of amount of preparation 80%, adds the rhodioside of above-mentioned percentage by weight successively, and sodium chloride, chlorobutanol stirs and makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Implementation result: character is a colourless clear liquid, and pH value is 5.3～6.4, and containing rhodioside is 99.13% of labelled amount, no local excitation reaction, and all other all meet the prescription of the general injection of Chinese Pharmacopoeia regulation.
Claims (4)
1. a rhodiola root glycosides injection that is used for cardiovascular and cerebrovascular disease is characterized in that, component and percentage by weight thereof are: rhodioside 0.2%～2%, and sodium chloride 0.5%-1.5%, chlorobutanol 0.2%～0.5%, surplus is a water for injection.
2. according to the described rhodiola root glycosides injection that is used for cardiovascular and cerebrovascular disease of claim 1, it is characterized in that component and percentage by weight thereof are: rhodioside 0.5%～1.5%, sodium chloride 0.7%～1.2%, chlorobutanol 0.2%～0.4%, surplus are water for injection.
3. according to the described rhodiola root glycosides injection that is used for cardiovascular and cerebrovascular disease of claim 1, it is characterized in that component and percentage by weight thereof are: rhodioside 0.8%～1.0%, sodium chloride 0.8%～1.0%, chlorobutanol 0.3%, surplus is a water for injection.
4. according to the described preparation method that is used for the rhodiola root glycosides injection of cardiovascular and cerebrovascular disease of claim 1, it is characterized in that, be specially: in the preparation container, the water for injection that adds amount of preparation 80%, add rhodioside, sodium chloride, chlorobutanol successively, stirring makes dissolving fully, adds the injection water to 1000ml, uses G
3Sintered glass funnel filters, and embedding is in the ampoule of 2ml, and 100 ℃ of sterilization 30min promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100259322A CN100337633C (en) | 2005-05-19 | 2005-05-19 | Rhodiola root glycosides injection for treating cardiovascular/cerebrovascular diseases and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100259322A CN100337633C (en) | 2005-05-19 | 2005-05-19 | Rhodiola root glycosides injection for treating cardiovascular/cerebrovascular diseases and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1698627A CN1698627A (en) | 2005-11-23 |
| CN100337633C true CN100337633C (en) | 2007-09-19 |
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| CNB2005100259322A Expired - Fee Related CN100337633C (en) | 2005-05-19 | 2005-05-19 | Rhodiola root glycosides injection for treating cardiovascular/cerebrovascular diseases and preparation method thereof |
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| CN (1) | CN100337633C (en) |
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2005
- 2005-05-19 CN CNB2005100259322A patent/CN100337633C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 高山红景天苷对大鼠心钠素基因表达的影响 黄颖等，中国药学杂志，第35卷第9期 2000 * |
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Granted publication date: 20070919 Termination date: 20100519 |