CN100336535C - Children health pectoral mixture for treating child wind and heat caused by exopathogen and its preparing method - Google Patents
Children health pectoral mixture for treating child wind and heat caused by exopathogen and its preparing method Download PDFInfo
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Abstract
The present invention provides a children health cough relieving mixture for treating children wind and heat outer contraction and a preparing method thereof, and the children health cough relieving mixture carries out treatment by safely, reliably and effectively combining the two effects of relieving cough and removing heat. The children health cough relieving mixture comprises the following medical raw materials: honeysuckle flower, pyrrosia leaf, great burdock achene, dyers woad leaf, wolfberry bark, cortex mori radices, tatarian aster root, pummelo peel, platycodon root and raw licorice. The preparing method of the children health cough relieving mixture comprises the following steps: the honeysuckle flower and the pummelo peel are added with water and are soaked, steaming distillation is carried out by water steam, and distillation liquid is collected; medical dregs and the rest 8 kinds of medical materials are boiled by adding water, filtration is carried out, filtering liquid is concentrated, alcohol content can be 70% by adding ethanol, a standing process is carried out, supernatant liquid is taken, the ethanol is recovered, concentration is carried out, water is added again, a uniformly stirring process is carried out, the standing process is carried out again, supernatant liquid is taken, the filtration is carried out again, and filtering liquid is concentrated again; sucrose is taken and made into syrup, the syrup is mixed with the medical liquid and the steaming distillation liquid, a mixture is added with benzoic acid, weight is regulated, the uniformly stirring process is carried out, the filtration is carried out, a filling process and a sterilizing process are carried out, and then a finished product is obtained.
Description
Technical field:
The present invention relates to field of medicaments, particularly a kind of valiant fighter's cough mixture that is used for the treatment for the treatment of cold due to wind-heat and preparation method thereof.
Background technology:
Show that according to State Food and Drug Administration south medication economics institute research data China 0-14 in 2002 year child population accounts for 22.4% of domestic total population, is about 2.8 hundred million.0-14 year child prevalence accounts for 19.35% of total ill population, wherein has 85% disease that the child takes a disease to be diseases of respiratory system and digestive system disease approximately.
Doctor trained in Western medicine mainly is to treat to the ill, general Physical temperature-lowering and the ntipyretic analgesic medicines such as oral paracetamol, ibuprofen and aspirin of adopting of cooling are lowered the temperature, cough expelling phlegm for arresting cough medicine commonly used such as bromhexine hydrochloride, child cough mixture, mixture of ammonium chloride etc., spasmolytic is used aminophylline, salbutamol, prednisone etc. always.As be viral infection then with virazole or interferon, bacterial infection is then controlled with antibiotic.But the side effect of Western medicine has obtained understanding widely.
The bigger cough-relieving series products in the related symptoms market share that the treatment by Chinese herbs respiratory tract infection causes has CHUANBEI PIPA GAO, JIZHI TANGJIANG.The product of treatment heating class has children clearing heat granule, children's antipyretic oral liquid etc., and the Chinese traditional treatment heating generally is to treat at its pathogenic factor, as treatment flu class preparation.But above-mentioned Chinese patent medicine or contain slightly poisonous Chinese medicine ingredients such as Herba Ephedrae, or curative effect is limited.
Summary of the invention:
The objective of the invention is to provide at the weak point that exists in the above-mentioned technology a kind of safe and reliable, effectively the cough-relieving and the two kinds of effects of bringing down a fever are combined treat be used for the treatment of valiant fighter's cough mixture for the treatment of cold due to wind-heat and preparation method thereof.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Flos Lonicerae 80-150, Folium Pyrrosiae 80-150, Fructus Arctii 80-150, Folium Isatidis 80-150, Cortex Lycii 80-150, Cortex Mori 80-150, Radix Asteris 80-150, Exocarpium Citri Grandis 40-100, Radix Platycodonis 40-100, Radix Glycyrrhizae 10-50
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Flos Lonicerae 90-110, Folium Pyrrosiae 90-110, Fructus Arctii 90-110, Folium Isatidis 90-110, Cortex Lycii 90-110, Cortex Mori 90-110, Radix Asteris 90-110, Exocarpium Citri Grandis 50-70, Radix Platycodonis 50-70, Radix Glycyrrhizae 20-40
Above-mentioned each component is made medicine production method of the present invention is:
Flos Lonicerae, Exocarpium Citri Grandis add the water of 4 times of amounts, soak 1 hour, use steam distillation, collect distillate 5 hours.Medicinal residues and all the other eight flavor medical materials decoct with water twice, add to for the first time 10 times of water gagings of medical material total amount, add for the second time 8 times of water gagings of medical material total amount, each 1 hour, collecting decoction filtered, filtrate concentrates, making its weight is 0.8～2.2 times of weight of medical material total amount, adds ethanol and makes that to contain alcohol amount be 70%, leaves standstill more than 24 hours.Get supernatant and reclaim ethanol, be concentrated into 0.2-0.5 times of weight of medical material total amount, amount of water to medicinal liquid is 0.8～2.2 times of weight of medical material total amount, stirs evenly, and leaves standstill, and gets supernatant, filters, and filtrate is concentrated into 0.2-0.5 times of weight of about medical material total amount.Other makes syrup at the get it filled sucrose of 0.15-0.3 times of weight of material total amount, merges with above-mentioned medicinal liquid and distillate, adds benzoic acid again, adjusts total amount to 0.8～2.2 times of weight of medical material total amount, stirs evenly, filter, and fill, sterilization gets product.
Valiant fighter's cough mixture proof in the process of long-term clinical application contrast is more effective, and cough-relieving combined with the two kinds of effects of bringing down a fever treats; The 2nd, valiant fighter's cough mixture reasonable recipe does not contain Chinese medicine cough-relieving medicines commonly used such as Herba Ephedrae (on December 31st, 2003, and U.S. FDA announces to ban the ephedrine quasi drugs with side effect), will be safer.
Specify the curative effect advantage of product of the present invention below with regard to clinical setting:
The clinical case of including in is for meeting affection due to external wind and heat disease, and double disease having held expectorant, being accompanied by dyspepsia under the arm, held frightened disease person under the arm.
2 Therapeutic Method
Treatment group 1: writing out a prescription is Flos Lonicerae, Folium Pyrrosiae, Fructus Arctii, Folium Isatidis, Cortex Lycii, Cortex Mori, Radix Asteris, Exocarpium Citri Grandis, Radix Platycodonis, Radix Glycyrrhizae.Treatment group 2: writing out a prescription is Herba Ephedrae, Semen Armeniacae Amarum, Folium Pyrrosiae, Fructus Schisandrae Chinensis, Cortex Mori, Radix Asteris, Exocarpium Citri Grandis, Radix Platycodonis, Radix Glycyrrhizae.Treatment group 3: writing out a prescription is Herba Ephedrae, Semen Armeniacae Amarum, Folium Pyrrosiae, sea clam powder, Cortex Mori, Radix Asteris, Exocarpium Citri Grandis, Radix Platycodonis, Radix Glycyrrhizae.Below 3 years old, 3 times on the one, a 10ml; More than 3 years old, 3 times on the one, a 15ml.Matched group is taken the infantile heat-clearing and antitussive oral liquid.
Two groups equal 7 days be 1 course of treatment, finish back evaluation curative effect the course of treatment.
3 observation of curative effect
3.1 criterion of therapeutical effect: items such as symptom, sign, routine examination and etiological examination are marked.Treatment back according to the form below is judged curative effect: recovery from illness---took medicine 24-48 hour in, temperature recovery is normal, and sign disappears, and unusual physical and chemical index recovers normal; Produce effects---took medicine 24-48 hour in, temperature recovery is normal, and main sign is most of to disappear, and unusual physical and chemical index is near normal; Effectively---took medicine 48-72 hour in, temperature recovery is normal, and main sign is most of to disappear, and unusual physical and chemical index makes moderate progress; Invalid---do not meet above standard person.
3.2 therapeutic outcome
3.2.1 comparability inspection before the treatment
3.2.1.1 sex ratio sees Table 1 before two groups of treatments.Treat preceding sex ratios for two groups, difference does not have significance.
Sex ratio before the table 1 liang group treatment
| Group | The man | The woman |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 19 20 22 9 | 21 21 22 11 |
More than each the group through X
2Check, difference that there are no significant.
3.2.1.2 age distribution sees Table 2 before two groups of treatments.Age distribution is compared before two groups of treatments, and difference does not have significance.
Age distribution before the table 2 liang group treatment
| Group | 1-6 year | 7-12 year |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 25 24 21 10 | 15 17 23 11 |
More than each the group through X
2Check, difference that there are no significant.
3.2.1.3 sick the kind relatively sees Table 3 before two groups of treatments.The sick kind compared there was no significant difference before two groups of treatments.
The sick kind relatively before the table 3 liang group treatment
| Group | Wind heat is held phlegm syndrome under the arm | Wind heat being accompanied by dyspepsia disease | Wind heat is held frightened disease under the arm |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 16 14 16 6 | 15 12 15 8 | 9 15 13 7 |
More than each the group through X
2Check, difference that there are no significant.
3.2.2 efficacy analysis
3.2.2.1 total effects relatively sees Table 4 between group.The Ridit assay shows that other each group and 1 total effects of treatment group have significant difference, and it is 95.0% that 1 total effective rate is organized in treatment, obviously is better than treatment group 263.4%, treatment group 368.1%, matched group 81.0%; It is better that 1 curative effect is organized in the prompting treatment.
Total effects relatively between table 4 group
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate % |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 40 41 44 21 | 11 6 8 4 | 20 10 25 9 | 7 10 7 4 | 2 15 4 4 | 95.0 63.4 68.1 81.0 |
3.2.2.2 holding the phlegm syndrome efficacy analysis under the arm, wind heat sees
See Table 5.The treatment wind heat is held the phlegm syndrome treatment under the arm, and to organize 1 total effective rate be 100%, treatment group 285.7%, and treatment organizes 3 87.5%, matched group 83.3%; It is better that prompting treatment of control group wind heat is held the phlegm syndrome curative effect under the arm.
Table 5 wind heat is held the phlegm syndrome curative effect under the arm relatively
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate % |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 16 14 16 6 | 4 3 3 1 | 8 7 8 3 | 4 2 3 1 | 0 2 2 1 | 100 85.7 87.5 83.3 |
3.2.2.2 wind heat being accompanied by dyspepsia disease efficacy analysis
See Table 6.It is 93.3% that 1 total effective rate is organized in the treatment of treatment wind heat being accompanied by dyspepsia disease, treatment group 258.3%, and treatment organizes 3 66.7%, matched group 87.5%; Prompting treatment group 1 treatment wind heat being accompanied by dyspepsia disease curative effect is better.
Table 6 wind heat being accompanied by dyspepsia disease curative effect relatively
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate % |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 15 12 15 8 | 6 3 3 2 | 8 2 4 4 | 0 2 3 1 | 1 5 5 1 | 93.3 58.3 66.7 87.5 |
3.2.2.2 wind heat is held frightened disease efficacy analysis under the arm
See Table 7.The treatment wind heat is held frightened disease treatment under the arm, and to organize 1 total effective rate be 88.9%, treatment group 246.7%, and treatment organizes 3 46.2%, matched group 71.4%; It is relatively poor that prompting treatment group 1 treatment wind heat is held frightened disease curative effect under the arm.
Table 7 wind heat is held frightened disease curative effect under the arm relatively
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate % |
| Treatment is organized 1 treatment and is organized 2 treatments and organize 3 matched groups | 9 15 13 7 | 1 0 2 1 | 4 1 3 2 | 3 6 1 2 | 1 8 7 2 | 88.9 46.7 46.2 71.4 |
The analysis of comparable result shows between this group data set, physical data between each group, and no significant differences such as sex, age, the course of disease and the distribution of sick kind, comparability is better between the prompting group, and two groups have harmony.
It is 95.0% that 1 total effective rate is organized in treatment, obviously is better than treatment and organizes 2 63.4%, treatment group 368.1%, matched group 81.0%; It is better that 1 curative effect is organized in the prompting treatment.The sick efficacy analysis of planting shows that it is better that treatment group 1 treatment wind heat is held phlegm syndrome, wind heat being accompanied by dyspepsia disease under the arm, wind heat is held frightened disease curative effect under the arm.
In addition, do not see that obvious adverse reaction takes place, feeling sick appears in small number of patients, symptoms of emesis but treatment group 2 and treatment group 3 have, and degree is lighter, need not the drug withdrawal spontaneous remission.Illustrate that this product has no side effect substantially, safe and reliable.
The specific embodiment:
By weight extracting honeysuckle 100 grams, Folium Pyrrosiae 100 grams, Fructus Arctii 100 grams, Folium Isatidis 100 grams, Cortex Lycii 100 grams, Cortex Mori 100 grams, Radix Asteris 100 grams, Exocarpium Citri Grandis 60 grams, Radix Platycodonis 60 grams, Radix Glycyrrhizae 30 grams, the water that Flos Lonicerae, Exocarpium Citri Grandis is added 4 times of amounts, soaked 1 hour, and used steam distillation, collected distillate 5 hours.Medicinal residues and all the other eight flavor medical materials decoct with water twice, add 10 times of water gagings for the first time, add 8 times of water gagings for the second time, and each 1 hour, collecting decoction filtered, and filtrate is concentrated into 1000ml, add ethanol and make that to contain the alcohol amount be 70%, leave standstill more than 24 hours.Get supernatant and reclaim ethanol, be concentrated into about 200ml, add 5 times of water gagings and stir evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 200ml.Other gets sucrose 200g and makes syrup, merges with above-mentioned medicinal liquid and distillate, adds benzoic acid 2g again, adjusts total amount to 1000ml, stirs evenly, filter, and fill, sterilization gets product.
Claims (3)
1, the valiant fighter's cough mixture that is used for the treatment for the treatment of cold due to wind-heat, the crude drug that wherein makes active ingredient consists of: Flos Lonicerae 80-150, Folium Pyrrosiae 80-150, Fructus Arctii 80-150, Folium Isatidis 80-150, Cortex Lycii 80-150, Cortex Mori 80-150, Radix Asteris 80-150, Exocarpium Citri Grandis 40-100, Radix Platycodonis 40-100, Radix Glycyrrhizae 10-50.
2, according to the described valiant fighter's cough mixture of claim 1, it is characterized in that the weight proportion of each raw material is: Flos Lonicerae 90-110, Folium Pyrrosiae 90-110, Fructus Arctii 90-110, Folium Isatidis 90-110, Cortex Lycii 90-110, Cortex Mori 90-110, Radix Asteris 90-110, Exocarpium Citri Grandis 50-70, Radix Platycodonis 50-70, Radix Glycyrrhizae 20-40.
3, a kind of method for preparing claim 1,2 described valiant fighter's cough mixture, it is characterized in that: Flos Lonicerae, Exocarpium Citri Grandis add the water of 4 times of amounts, soak 1 hour, use steam distillation, collect distillate 5 hours.Medicinal residues and all the other eight flavor medical materials decoct with water twice, add to for the first time 10 times of water gagings of medical material total amount, add for the second time 8 times of water gagings of medical material total amount, each 1 hour, collecting decoction filtered, filtrate concentrates, making its weight is 0.8～2.2 times of weight of medical material total amount, adds ethanol and makes that to contain alcohol amount be 70%, leaves standstill more than 24 hours; Get supernatant and reclaim ethanol, be concentrated into 0.2-0.5 times of weight of medical material total amount, amount of water to medicinal liquid is 0.8～2.2 times of weight of medical material total amount, stirs evenly, and leaves standstill, and gets supernatant, filters, and filtrate is concentrated into 0.2-0.5 times of weight of about medical material total amount.Other makes syrup at the get it filled sucrose of 0.15-0.3 times of weight of material total amount, merges with above-mentioned medicinal liquid and distillate, adds benzoic acid again, adjusts total amount to 0.8～2.2 times of weight of medical material total amount, stirs evenly, filter, and fill, sterilization gets product.
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| CNB2004100688889A CN100336535C (en) | 2004-07-14 | 2004-07-14 | Children health pectoral mixture for treating child wind and heat caused by exopathogen and its preparing method |
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| CNB2004100688889A CN100336535C (en) | 2004-07-14 | 2004-07-14 | Children health pectoral mixture for treating child wind and heat caused by exopathogen and its preparing method |
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| CN100336535C true CN100336535C (en) | 2007-09-12 |
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| CN102688343B (en) * | 2012-06-14 | 2013-09-04 | 李良 | Dayflower Chinese medicine decoction for treating cough and preparation method thereof |
| CN108210637A (en) * | 2018-03-28 | 2018-06-29 | 蒋田英 | A kind of Chinese medicine composition for treating flu |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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