CL2023000675A1 - [6-[(dietilamino)metil]naftalen-2-il]metil[4-(hidroxicarbamoil)fenil]carbamato de alta pureza - Google Patents

[6-[(dietilamino)metil]naftalen-2-il]metil[4-(hidroxicarbamoil)fenil]carbamato de alta pureza

Info

Publication number
CL2023000675A1
CL2023000675A1 CL2023000675A CL2023000675A CL2023000675A1 CL 2023000675 A1 CL2023000675 A1 CL 2023000675A1 CL 2023000675 A CL2023000675 A CL 2023000675A CL 2023000675 A CL2023000675 A CL 2023000675A CL 2023000675 A1 CL2023000675 A1 CL 2023000675A1
Authority
CL
Chile
Prior art keywords
methyl
hydroxycarbamoyl
naphthalen
diethylamino
carbamate
Prior art date
Application number
CL2023000675A
Other languages
English (en)
Inventor
Turchetta Stefano
Maurizio Zenoni Zenoni
Ullucci Elio
COCCIOLO Stefania
Berardi Giorgio
MAULUCCI Nakia
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of CL2023000675A1 publication Critical patent/CL2023000675A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

Abstract

(6-((dietilamino)metil)naftalen-2-il)metil(4-(hidroxicarbamoil)fenil)carbamato y/o las sales farmacéuticamente aceptables del mismo, preferiblemente clorhidrato, más preferiblemente hidrocloruro monohidrato de alta pureza, con una cantidad de cualquier impureza única desconocida igual o inferior al 0,10 % y con una pureza igual o superior al 99,6 %.
CL2023000675A 2019-03-06 2023-03-09 [6-[(dietilamino)metil]naftalen-2-il]metil[4-(hidroxicarbamoil)fenil]carbamato de alta pureza CL2023000675A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000003281A IT201900003281A1 (it) 2019-03-06 2019-03-06 Processo per preparare {6-[(dietilammino)metil]naftalen-2-il}metil [4-(idrossicarbamoil)fenil]carbammato ad elevata purezza

Publications (1)

Publication Number Publication Date
CL2023000675A1 true CL2023000675A1 (es) 2023-12-11

Family

ID=66690827

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2021002302A CL2021002302A1 (es) 2019-03-06 2021-09-02 Proceso para preparar {6-[(dietilamino)metil]naftalen-2-il}metil [4-(hidroxicarbamoil) fenil]carbamato de alta pureza
CL2023000675A CL2023000675A1 (es) 2019-03-06 2023-03-09 [6-[(dietilamino)metil]naftalen-2-il]metil[4-(hidroxicarbamoil)fenil]carbamato de alta pureza

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2021002302A CL2021002302A1 (es) 2019-03-06 2021-09-02 Proceso para preparar {6-[(dietilamino)metil]naftalen-2-il}metil [4-(hidroxicarbamoil) fenil]carbamato de alta pureza

Country Status (14)

Country Link
US (2) US20220177421A1 (es)
EP (1) EP3891124A1 (es)
JP (1) JP2022527146A (es)
KR (1) KR20210137098A (es)
CN (4) CN116947703A (es)
AU (1) AU2020231702A1 (es)
CA (2) CA3129436A1 (es)
CL (2) CL2021002302A1 (es)
CO (1) CO2021011714A2 (es)
IL (1) IL284811A (es)
IT (1) IT201900003281A1 (es)
MX (1) MX2021010549A (es)
PE (1) PE20212321A1 (es)
WO (1) WO2020178776A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3120626B1 (fr) 2021-03-09 2023-11-24 Saint Gobain Dispositif de positionnement de feuilles de verre, installation de fabrication de vitrages comportant un tel dispositif et procédé pour piloter automatiquement le positionnement des feuilles de verre dans une telle installation
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283637B1 (it) * 1996-05-14 1998-04-23 Italfarmaco Spa Composti ad attivita' antinfiammatoria ed immunosoppressiva
ITMI20030063A1 (it) 2003-01-17 2004-07-18 Italfarmaco Spa Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico.
IT1397912B1 (it) * 2010-01-28 2013-02-04 Chemi Spa Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato.

Also Published As

Publication number Publication date
IT201900003281A1 (it) 2020-09-06
AU2020231702A1 (en) 2021-08-05
EP3891124A1 (en) 2021-10-13
CN113614066A (zh) 2021-11-05
CA3129436A1 (en) 2020-09-10
US20220177421A1 (en) 2022-06-09
CN113614066B (zh) 2023-08-29
US20230348368A1 (en) 2023-11-02
MX2021010549A (es) 2021-11-12
CA3230330A1 (en) 2020-09-10
CL2021002302A1 (es) 2022-05-06
WO2020178776A1 (en) 2020-09-10
CO2021011714A2 (es) 2021-10-29
WO2020178776A9 (en) 2021-06-24
PE20212321A1 (es) 2021-12-14
CN116947702A (zh) 2023-10-27
CN116947703A (zh) 2023-10-27
CN116947701A (zh) 2023-10-27
JP2022527146A (ja) 2022-05-31
KR20210137098A (ko) 2021-11-17
IL284811A (en) 2021-08-31

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