CL2022000257A1 - Regímenes de dosificación para inhibidores orales del factor d del complemento - Google Patents

Regímenes de dosificación para inhibidores orales del factor d del complemento

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Publication number
CL2022000257A1
CL2022000257A1 CL2022000257A CL2022000257A CL2022000257A1 CL 2022000257 A1 CL2022000257 A1 CL 2022000257A1 CL 2022000257 A CL2022000257 A CL 2022000257A CL 2022000257 A CL2022000257 A CL 2022000257A CL 2022000257 A1 CL2022000257 A1 CL 2022000257A1
Authority
CL
Chile
Prior art keywords
inhibitors
oral
dosing regimens
complement factor
prodrugs
Prior art date
Application number
CL2022000257A
Other languages
English (en)
Inventor
Yarlagadda S Babu
William P Sheridan
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of CL2022000257A1 publication Critical patent/CL2022000257A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se divulgan compuestos y sales y profármacos farmacéuticamente aceptables de los mismos, que son inhibidores del sistema del complemento. También se proveen formas de dosificación orales que comprenden dicho compuesto, sal o profármaco. También se divulgan métodos para usar los compuestos, sales, y profármacos, y formas de dosificación orales de los mismos, para el tratamiento o prevención de una enfermedad o una condición que se caracteriza por una actividad aberrante del sistema de complemento (por ejemplo, hemoglobinuria paroxística nocturna).
CL2022000257A 2019-07-31 2022-01-31 Regímenes de dosificación para inhibidores orales del factor d del complemento CL2022000257A1 (es)

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JP2022543760A (ja) 2022-10-14
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TW202120484A (zh) 2021-06-01
PE20221033A1 (es) 2022-06-17
KR20220041846A (ko) 2022-04-01
CN114302719A (zh) 2022-04-08
ECSP22014980A (es) 2022-06-30
CR20220074A (es) 2022-06-03
IL289949A (en) 2022-03-01
WO2021021909A1 (en) 2021-02-04
UY38817A (es) 2021-02-26
CO2022001862A2 (es) 2022-04-08
AU2020323532A1 (en) 2022-03-03
CA3148119A1 (en) 2021-02-04
JOP20220011A1 (ar) 2023-01-30
US20220257556A1 (en) 2022-08-18
BR112022001600A2 (pt) 2022-06-07

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