CL2021002167A1 - Síntesis de omecamtiv mecarbil (divisional de la solicitud no. 201903898) - Google Patents

Síntesis de omecamtiv mecarbil (divisional de la solicitud no. 201903898)

Info

Publication number
CL2021002167A1
CL2021002167A1 CL2021002167A CL2021002167A CL2021002167A1 CL 2021002167 A1 CL2021002167 A1 CL 2021002167A1 CL 2021002167 A CL2021002167 A CL 2021002167A CL 2021002167 A CL2021002167 A CL 2021002167A CL 2021002167 A1 CL2021002167 A1 CL 2021002167A1
Authority
CL
Chile
Prior art keywords
synthesis
divisional
application
omecamtiv mecarbil
omecamtiv
Prior art date
Application number
CL2021002167A
Other languages
English (en)
Inventor
Sebastien Caille
Xianqing Shi
Kyle Quasdorf
Philipp Roosen
Andrew Cosbie
Fang Wang
Zufan Wu
Archana Neergunda
Bin Peter Quan
Lianxiu Guan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2021002167A1 publication Critical patent/CL2021002167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Abstract

En la presente se proporciona una síntesis de hidrato de diclorhidrato de omecamtiv mecarbil y diversos intermedios.
CL2021002167A 2017-06-30 2021-08-16 Síntesis de omecamtiv mecarbil (divisional de la solicitud no. 201903898) CL2021002167A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762527174P 2017-06-30 2017-06-30
US201862664363P 2018-04-30 2018-04-30

Publications (1)

Publication Number Publication Date
CL2021002167A1 true CL2021002167A1 (es) 2022-03-18

Family

ID=62976317

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019003898A CL2019003898A1 (es) 2017-06-30 2019-12-30 Síntesis de omecamtiv mecarbil.
CL2021002167A CL2021002167A1 (es) 2017-06-30 2021-08-16 Síntesis de omecamtiv mecarbil (divisional de la solicitud no. 201903898)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2019003898A CL2019003898A1 (es) 2017-06-30 2019-12-30 Síntesis de omecamtiv mecarbil.

Country Status (27)

Country Link
US (3) US11040956B2 (es)
EP (3) EP4265597A3 (es)
JP (2) JP7181896B2 (es)
KR (1) KR102625774B1 (es)
CN (1) CN110799503B (es)
AU (2) AU2018294254C1 (es)
BR (1) BR112019028205A2 (es)
CA (1) CA3063102A1 (es)
CL (2) CL2019003898A1 (es)
CY (1) CY1124427T1 (es)
DK (1) DK3645518T3 (es)
ES (1) ES2882905T3 (es)
GE (1) GEP20227340B (es)
HR (1) HRP20211290T1 (es)
HU (1) HUE055242T2 (es)
IL (2) IL294834A (es)
LT (1) LT3645518T (es)
MD (1) MD3645518T2 (es)
MX (2) MX2021013326A (es)
PL (1) PL3645518T3 (es)
PT (1) PT3645518T (es)
RS (1) RS62328B1 (es)
SG (1) SG10202111790YA (es)
SI (1) SI3645518T1 (es)
TW (2) TW202235415A (es)
UA (1) UA127517C2 (es)
WO (1) WO2019006231A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2837038T3 (es) 2013-03-14 2021-06-29 Amgen Inc Compuestos heterocíclicos y sus usos
WO2019006235A1 (en) 2017-06-30 2019-01-03 Amgen Inc. METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS
PL3645518T3 (pl) 2017-06-30 2021-12-06 Amgen Inc. Synteza omekamtywu mekarbilu
MX2020002696A (es) 2017-09-13 2020-09-25 Amgen Inc Compuestos de bisamida que activan el sarcomero y sus usos.
EP3837009A1 (en) 2018-08-17 2021-06-23 Amgen, Inc Salts and crystal forms of omecamtiv mecarbil
WO2021070123A1 (en) * 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
US20220411374A1 (en) * 2019-10-09 2022-12-29 Dr. Reddy's Laboratories Limited Alternate processes for the preparation of omecamtiv mecarbil
CA3212491A1 (en) 2021-03-10 2022-09-15 Sebastien Caille Synthesis of omecamtiv mecarbil
WO2023205291A2 (en) * 2022-04-21 2023-10-26 The Board Of Regents Of The University Of Oklahoma Targeting myocardial tissue for delivery of therapeutic and imaging agents

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US6492529B1 (en) * 2000-01-18 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Bis pyrazole-1H-pyrazole intermediates and their synthesis
PL1765327T3 (pl) 2004-06-17 2015-01-30 Cytokinetics Inc Związki, kompozycje i sposoby
WO2007070683A2 (en) 2005-12-15 2007-06-21 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US20070208000A1 (en) 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
US7989455B2 (en) 2005-12-19 2011-08-02 Cytokinetics, Inc. Compounds, compositions and methods
MX2009004233A (es) 2006-10-18 2009-08-12 Pfizer Prod Inc Compuestos de biaril eter urea.
US20090192168A1 (en) 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
WO2010141817A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
MX2015012416A (es) 2013-03-14 2016-04-07 Amgen Inc Compuestos heterociclicos y sus usos.
ES2837038T3 (es) 2013-03-14 2021-06-29 Amgen Inc Compuestos heterocíclicos y sus usos
EP3127564B1 (en) 2014-03-31 2018-12-26 Med-tech Inc. Blood purification device and priming method for blood purification device
KR101909092B1 (ko) 2014-11-24 2018-10-17 (주) 메디프론디비티 바닐로이드 수용체 리간드 ii로서의 치환된 옥사졸계 및 싸이아졸계 카복스아미드 및 우레아 유도체
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CA2988796A1 (en) 2015-06-26 2016-12-29 Amgen Inc. Combination therapy of cardiac myosin activator and sinus node if current inhibitor
WO2019006235A1 (en) 2017-06-30 2019-01-03 Amgen Inc. METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS
PL3645518T3 (pl) 2017-06-30 2021-12-06 Amgen Inc. Synteza omekamtywu mekarbilu
EP3594199B1 (en) 2018-07-09 2020-07-01 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Crystalline 2-fluoro-3-nitrotoluene and process for the preparation thereof
EP3837009A1 (en) 2018-08-17 2021-06-23 Amgen, Inc Salts and crystal forms of omecamtiv mecarbil
WO2020131574A1 (en) 2018-12-18 2020-06-25 Amgen Inc. Method of reducing aromatic nitro compounds
US20220411374A1 (en) 2019-10-09 2022-12-29 Dr. Reddy's Laboratories Limited Alternate processes for the preparation of omecamtiv mecarbil
EP4103159A1 (en) 2020-02-10 2022-12-21 Amgen Inc. Omecamtiv mecarbil tablet
CA3200673A1 (en) 2020-11-12 2022-05-19 Amgen Inc. Methods of treating heart failure by administering omecamtiv mecarbil
CA3212491A1 (en) 2021-03-10 2022-09-15 Sebastien Caille Synthesis of omecamtiv mecarbil

Also Published As

Publication number Publication date
JP7181896B2 (ja) 2022-12-01
UA127517C2 (uk) 2023-09-20
US20200308143A1 (en) 2020-10-01
HRP20211290T1 (hr) 2021-11-12
KR20200018664A (ko) 2020-02-19
AU2022204648A1 (en) 2022-07-28
PL3645518T3 (pl) 2021-12-06
CL2019003898A1 (es) 2020-07-31
TW202235415A (zh) 2022-09-16
AU2018294254C1 (en) 2022-10-13
RS62328B1 (sr) 2021-10-29
CN110799503A (zh) 2020-02-14
CA3063102A1 (en) 2019-01-03
GEP20227340B (en) 2022-01-25
ES2882905T3 (es) 2021-12-03
BR112019028205A2 (pt) 2020-10-06
EP3925950A1 (en) 2021-12-22
EP3645518B1 (en) 2021-05-19
EP4265597A2 (en) 2023-10-25
KR102625774B1 (ko) 2024-01-16
US11753394B2 (en) 2023-09-12
EP4265597A3 (en) 2023-11-22
MX2021013326A (es) 2022-08-11
LT3645518T (lt) 2021-10-11
US20210371397A1 (en) 2021-12-02
AU2018294254B2 (en) 2022-04-07
MD3645518T2 (ro) 2021-11-30
TW201906826A (zh) 2019-02-16
IL294834A (en) 2022-09-01
SG10202111790YA (en) 2021-12-30
TWI769272B (zh) 2022-07-01
US20230373955A1 (en) 2023-11-23
PT3645518T (pt) 2021-08-23
US11040956B2 (en) 2021-06-22
CN110799503B (zh) 2023-06-27
IL270663B (en) 2022-08-01
EP3925950B1 (en) 2023-09-06
DK3645518T3 (en) 2021-08-02
IL270663A (es) 2020-01-30
EP3925950C0 (en) 2023-09-06
CY1124427T1 (el) 2022-07-22
AU2018294254A1 (en) 2019-11-21
MX2021009594A (es) 2022-10-24
WO2019006231A1 (en) 2019-01-03
HUE055242T2 (hu) 2021-11-29
EP3645518A1 (en) 2020-05-06
JP2020526476A (ja) 2020-08-31
SI3645518T1 (sl) 2021-11-30
JP2022166243A (ja) 2022-11-01

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