CL2018003688A1 - Método y equipo de preparación de una composición de micropartículas - Google Patents

Método y equipo de preparación de una composición de micropartículas

Info

Publication number
CL2018003688A1
CL2018003688A1 CL2018003688A CL2018003688A CL2018003688A1 CL 2018003688 A1 CL2018003688 A1 CL 2018003688A1 CL 2018003688 A CL2018003688 A CL 2018003688A CL 2018003688 A CL2018003688 A CL 2018003688A CL 2018003688 A1 CL2018003688 A1 CL 2018003688A1
Authority
CL
Chile
Prior art keywords
preparing
liquid mixture
equipment
microparticle composition
nebulizing
Prior art date
Application number
CL2018003688A
Other languages
English (en)
Inventor
Nathalie Delhom
Nicolas Pierre Yves Carboulec
Original Assignee
Virbac
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virbac filed Critical Virbac
Publication of CL2018003688A1 publication Critical patent/CL2018003688A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0233—Rickettsiales, e.g. Anaplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se relaciona con un método mejorado de preparación de una composición de partículas, por ejemplo, de administración oral a un animal para entrega intestinal de un agente farmacéuticamente activo, método que comprende los pasos de nebulización (es decir, rociado) bajo presión de una primera mezcla líquida directamente en una segunda mezcla líquida con el fin de obtener partículas homogéneas gracias a la dispersión obtenida al nebulizar la primera mezcla líquida
CL2018003688A 2016-06-20 2018-12-19 Método y equipo de preparación de una composición de micropartículas CL2018003688A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16175308 2016-06-20

Publications (1)

Publication Number Publication Date
CL2018003688A1 true CL2018003688A1 (es) 2019-04-26

Family

ID=56148230

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2018003682A CL2018003682A1 (es) 2016-06-20 2018-12-19 Composición farmacéutica oral, que comprende un agente farmacéuticamente activo, al menos un polímero catiónico bioadhesivo y al menos dos polímeros aniónicos.
CL2018003688A CL2018003688A1 (es) 2016-06-20 2018-12-19 Método y equipo de preparación de una composición de micropartículas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2018003682A CL2018003682A1 (es) 2016-06-20 2018-12-19 Composición farmacéutica oral, que comprende un agente farmacéuticamente activo, al menos un polímero catiónico bioadhesivo y al menos dos polímeros aniónicos.

Country Status (3)

Country Link
EP (2) EP3471705A1 (es)
CL (2) CL2018003682A1 (es)
WO (2) WO2017220615A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2841098A4 (en) 2012-04-23 2016-03-02 Allertein Therapeutics Llc NANOPARTICLES FOR THE TREATMENT OF ALLERGIES
WO2019140318A1 (en) * 2018-01-11 2019-07-18 N-Fold Llc Nanoparticle systems
EP3768323A1 (en) * 2018-03-19 2021-01-27 Algipharma As Use of alginate oligomers to enhance the translocation of micro/nanoparticles across mucus layers
CN111568881A (zh) * 2020-06-08 2020-08-25 广东悦生生物科技有限公司 一种核壳体缓释氨基酸补剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018934A1 (en) * 1997-10-09 1999-04-22 Vanderbilt University Micro-particulate and nano-particulate polymeric delivery system
DE19923628C2 (de) * 1999-05-22 2002-03-07 Herbert Huettlin Verfahren und Vorrichtung zum Herstellen von partikelförmigen Teilchen
ITMI20031617A1 (it) 2003-08-06 2005-02-07 Fond Carlo E Dirce Callerio Onlus Microcapsule a doppio strato di polisaccaridi utilizzabili
JP5068646B2 (ja) 2004-06-29 2012-11-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ ミクロスフェア
WO2007067145A1 (en) * 2005-12-07 2007-06-14 Mip Technologies Ab Monodisperse molecularly imprinted polymer beads
EP2227085A4 (en) 2007-12-06 2013-10-09 Berg Pharma Llc INGREDIBLE COMPOSITIONS WITH INCREASED BIOLOGICAL AVAILABILITY
EP2105129B1 (en) * 2008-03-24 2018-01-17 Intervet International B.V. Encapsulated Vaccines for the Oral Vaccination and Boostering of Fish and Other Animals
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
IT1395524B1 (it) * 2009-09-02 2012-09-28 Fond Carlo E Dirce Callerio Onlus Metodo e apparato per la preparazione di micro-particelle di polisaccaridi
RU2688136C1 (ru) * 2013-12-06 2019-05-20 Интервет Интернэшнл Б.В. Композиция для пероральной доставки биоактивных агентов

Also Published As

Publication number Publication date
EP3471705A1 (en) 2019-04-24
WO2017220611A1 (en) 2017-12-28
EP3471706A1 (en) 2019-04-24
EP3471706B1 (en) 2023-12-20
WO2017220615A1 (en) 2017-12-28
CL2018003682A1 (es) 2019-04-26

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