CL2018003573A1 - Anti-c5 antibodies and methods of use. - Google Patents
Anti-c5 antibodies and methods of use.Info
- Publication number
- CL2018003573A1 CL2018003573A1 CL2018003573A CL2018003573A CL2018003573A1 CL 2018003573 A1 CL2018003573 A1 CL 2018003573A1 CL 2018003573 A CL2018003573 A CL 2018003573A CL 2018003573 A CL2018003573 A CL 2018003573A CL 2018003573 A1 CL2018003573 A1 CL 2018003573A1
- Authority
- CL
- Chile
- Prior art keywords
- antibody
- present
- provides
- antibodies
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
LA INVENCIÓN SE REFIERE A ANTICUERPOS ANTI-C5 Y MÉTODOS PARA USARSE. EN ALGUNAS MODALIDADES, UN ANTICUERPO ANTI-C5 AISLADO DE LA PRESENTE INVENCIÓN SE UNE A UN EPÍTOPO DENTRO DE LA CADENA BETA DE C5 CON MAYOR AFINIDAD A UN PH NEUTRO QUE A UN PH ÁCIDO. LA INVENCIÓN TAMBIÉN PROPORCIONA ÁCIDOS NUCLÉICOS AISLADOS QUE CODIFICAN UN ANTICUERPO ANTI-C5 DE LA PRESENTE INVENCIÓN. LA INVENCIÓN TAMBIÉN PROPORCIONA CÉLULAS HOSPEDERAS QUE COMPRENDEN UN ÁCIDO NUCLÉICO DE LA PRESENTE INVENCIÓN. LA INVENCIÓN TAMBIÉN PROPORCIONA UN MÉTODO PARA PRODUCIR UN ANTICUERPO QUE COMPRENDE CULTIVAR UNA CÉLULA HOSPEDERA DE LA PRESENTE INVENCIÓN A FIN DE PRODUCIR EL ANTICUERPO. LA INVENCIÓN PROPORCIONA ADEMÁS UN MÉTODO PARA PRODUCIR UN ANTICUERPO ANTI-C5 QUE COMPRENDE INMUNIZAR UN ANIMAL CONTRA UN POLIPÉPTIDO QUE COMPRENDE EL DOMINIO MG1-MG2 DE LA CADENA BETA DE C5. LOS ANTICUERPOS ANTI-C5 DE LA PRESENTE INVENCIÓN SE PUEDEN USAR COMO MEDICAMENTO.THE INVENTION REFERS TO ANTI-C5 ANTIBODIES AND METHODS FOR USE. IN SOME MODES, AN ANTI-C5 ANTIBODY ISOLATED FROM THE PRESENT INVENTION JOINS AN EPITHOPE WITHIN THE BETA CHAIN OF C5 WITH GREATER AFFINITY TO A NEUTRAL PH THAN AN ACID PH. THE INVENTION ALSO PROVIDES ISOLATED NUCLETIC ACIDS THAT CODIFY AN ANTI-C5 ANTIBODY OF THE PRESENT INVENTION. THE INVENTION ALSO PROVIDES HOSPED CELLS THAT INCLUDE A NUCLETIC ACID OF THE PRESENT INVENTION. THE INVENTION ALSO PROVIDES A METHOD FOR PRODUCING AN ANTIBODY THAT INCLUDES CULTIVATING A HOSPED CELL OF THIS INVENTION TO PRODUCE THE ANTIBODY. THE INVENTION ALSO PROVIDES A METHOD FOR PRODUCING AN ANTI-C5 ANTIBODY THAT INCLUDES IMMUNIZING AN ANIMAL AGAINST A POLYPEPTIDE THAT INCLUDES DOMAIN MG1-MG2 OF THE BETA CHAIN OF C5. THE ANTI-C5 ANTIBODIES OF THE PRESENT INVENTION CAN BE USED AS A MEDICINAL PRODUCT.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016120325 | 2016-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018003573A1 true CL2018003573A1 (en) | 2019-02-01 |
Family
ID=59969459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018003573A CL2018003573A1 (en) | 2016-06-17 | 2018-12-12 | Anti-c5 antibodies and methods of use. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP3472316A4 (en) |
| JP (3) | JP6202774B1 (en) |
| KR (2) | KR102226975B1 (en) |
| CN (3) | CN115925922A (en) |
| AU (1) | AU2017285763B2 (en) |
| BR (1) | BR112018075688A2 (en) |
| CA (1) | CA3021956A1 (en) |
| CL (1) | CL2018003573A1 (en) |
| CR (1) | CR20190013A (en) |
| EA (1) | EA201990018A1 (en) |
| IL (2) | IL300611A (en) |
| MX (2) | MX2018015030A (en) |
| MY (1) | MY187848A (en) |
| PE (1) | PE20190394A1 (en) |
| PH (1) | PH12018502354A1 (en) |
| SG (2) | SG10201800265UA (en) |
| TW (4) | TWI610941B (en) |
| UA (1) | UA126561C2 (en) |
| WO (1) | WO2017217524A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3056568T3 (en) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | PROCEDURES FOR CONTROL OF THE BLOOD PHARMACOKINETICS OF ANTIBODIES |
| CN106519025B (en) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | Method for changing isoelectric point of antibody by using amino acid substitution of CDR |
| KR102469853B1 (en) | 2008-04-11 | 2022-11-22 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| RU2746356C2 (en) | 2014-12-19 | 2021-04-12 | Чугаи Сейяку Кабусики Кайся | C5 antibodies and their application methods |
| US10633434B2 (en) | 2016-06-14 | 2020-04-28 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibodies |
| MY187848A (en) * | 2016-06-17 | 2021-10-26 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| CN116251182A (en) | 2016-08-05 | 2023-06-13 | 中外制药株式会社 | Compositions for preventing or treating IL-8 related diseases |
| MX2020003619A (en) * | 2017-10-04 | 2020-10-28 | Alexion Pharma Inc | Dosage and administration of anti-c5 antibodies for treatment of patients with membranoproliferative glomerulonephritis. |
| AU2018383751A1 (en) | 2017-12-13 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibody combinations and uses thereof |
| US20220177556A1 (en) * | 2018-09-06 | 2022-06-09 | The Trustees Of The University Of Pennsylvania | Humanized anti-c5 antibodies and uses thereof |
| MX2021012997A (en) * | 2019-04-24 | 2022-03-04 | Univ Pennsylvania | Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof. |
| CN113563467A (en) * | 2020-04-28 | 2021-10-29 | 上海普铭生物科技有限公司 | Antibodies against human complement protein C5 and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0230985Y2 (en) | 1985-07-08 | 1990-08-21 | ||
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| WO2002102110A1 (en) | 2001-06-12 | 2002-12-19 | Telefonaktiebolaget Lm Ericsson (Publ) | Synchronisation in a umts terrestrial radio access network (utran) |
| CN100391537C (en) | 2001-08-17 | 2008-06-04 | 建南德克公司 | Complement pathway inhibitors binding to C5 and C5A without preventing formation of C5B |
| JP4333939B2 (en) | 2001-08-27 | 2009-09-16 | ロード・コーポレーション | Trolley wire suspension system |
| DE10253331A1 (en) | 2002-11-14 | 2004-06-03 | Symrise Gmbh & Co. Kg | Use of trans-pellitori as a flavoring |
| US7267849B2 (en) | 2004-03-02 | 2007-09-11 | Nitto Denko Corporation | Compensator for liquid crystal display |
| KR20080069889A (en) | 2007-03-20 | 2008-07-29 | (주)화도 | Pe pipe |
| JP2010521194A (en) * | 2007-03-22 | 2010-06-24 | ノバルティス アーゲー | C5 antigen and uses thereof |
| WO2008126921A1 (en) | 2007-04-11 | 2008-10-23 | Sekisui Chemical Co., Ltd. | Method for production of crosslinked polyvinyl acetal resin, and crosslinked polyvinyl acetal resin |
| KR102469853B1 (en) * | 2008-04-11 | 2022-11-22 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| EA027575B1 (en) * | 2008-08-05 | 2017-08-31 | Новартис Аг | Antibody or antigen binding fragment thereof, binding human c5 protein, composition comprising same, nucleic acid encoding antibody or antigen binding fragment thereof, vector and host cell comprising said acid, and use of antibody or antigen binding fragment thereof |
| KR20100054403A (en) | 2008-11-14 | 2010-05-25 | 삼성전자주식회사 | Online composition apparatus and method for writing by multiple participants |
| WO2011111007A2 (en) * | 2010-03-11 | 2011-09-15 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| TW201206466A (en) * | 2010-03-11 | 2012-02-16 | Rinat Neuroscience Corp | Antibodies with pH dependent antigen binding |
| KR20110111007A (en) | 2010-04-02 | 2011-10-10 | 이화여자대학교 산학협력단 | Octahydro-binaphthol derivatives for l/d optical conversion and optical resolution |
| KR20110122011A (en) | 2010-05-03 | 2011-11-09 | 황보철종 | System for administrating combine store point and method therefor |
| WO2014028354A1 (en) * | 2012-08-13 | 2014-02-20 | Regeneron Pharmaceuticals, Inc. | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
| CA2899589C (en) * | 2013-01-31 | 2022-02-22 | Seoul National University R & Db Foundation | C5 antibody and method for preventing and treating complement-related diseases |
| ES2768648T3 (en) * | 2013-03-29 | 2020-06-23 | Alexion Pharma Inc | Compositions and methods for increasing serum half-life of a complement C5-targeted therapeutic agent |
| NZ711451A (en) * | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| RU2746356C2 (en) * | 2014-12-19 | 2021-04-12 | Чугаи Сейяку Кабусики Кайся | C5 antibodies and their application methods |
| PL3390442T3 (en) * | 2015-12-18 | 2024-03-18 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use |
| MY187848A (en) * | 2016-06-17 | 2021-10-26 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
-
2017
- 2017-06-16 MY MYPI2018002581A patent/MY187848A/en unknown
- 2017-06-16 EA EA201990018A patent/EA201990018A1/en unknown
- 2017-06-16 KR KR1020187010179A patent/KR102226975B1/en active IP Right Grant
- 2017-06-16 CN CN202211023851.9A patent/CN115925922A/en active Pending
- 2017-06-16 UA UAA201810992A patent/UA126561C2/en unknown
- 2017-06-16 TW TW106120143A patent/TWI610941B/en active
- 2017-06-16 TW TW111107923A patent/TWI807666B/en active
- 2017-06-16 WO PCT/JP2017/022253 patent/WO2017217524A1/en active Application Filing
- 2017-06-16 CN CN201780036916.4A patent/CN109312326B/en active Active
- 2017-06-16 CA CA3021956A patent/CA3021956A1/en active Pending
- 2017-06-16 CN CN202211018018.5A patent/CN115960223A/en active Pending
- 2017-06-16 TW TW106141573A patent/TWI789369B/en active
- 2017-06-16 TW TW112120479A patent/TW202337903A/en unknown
- 2017-06-16 AU AU2017285763A patent/AU2017285763B2/en active Active
- 2017-06-16 IL IL300611A patent/IL300611A/en unknown
- 2017-06-16 SG SG10201800265UA patent/SG10201800265UA/en unknown
- 2017-06-16 JP JP2017118226A patent/JP6202774B1/en active Active
- 2017-06-16 CR CR20190013A patent/CR20190013A/en unknown
- 2017-06-16 KR KR1020177020545A patent/KR101852739B1/en active IP Right Grant
- 2017-06-16 PE PE2018003148A patent/PE20190394A1/en unknown
- 2017-06-16 SG SG11201705584VA patent/SG11201705584VA/en unknown
- 2017-06-16 MX MX2018015030A patent/MX2018015030A/en unknown
- 2017-06-16 EP EP17813418.5A patent/EP3472316A4/en active Pending
- 2017-06-16 BR BR112018075688-1A patent/BR112018075688A2/en unknown
- 2017-08-28 JP JP2017162934A patent/JP7032077B2/en active Active
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2018
- 2018-11-08 PH PH12018502354A patent/PH12018502354A1/en unknown
- 2018-12-04 MX MX2023001360A patent/MX2023001360A/en unknown
- 2018-12-12 IL IL263657A patent/IL263657A/en unknown
- 2018-12-12 CL CL2018003573A patent/CL2018003573A1/en unknown
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2022
- 2022-02-24 JP JP2022026406A patent/JP2022091748A/en active Pending
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