CL2017001514A1 - Inhibidores de erk - Google Patents
Inhibidores de erkInfo
- Publication number
- CL2017001514A1 CL2017001514A1 CL2017001514A CL2017001514A CL2017001514A1 CL 2017001514 A1 CL2017001514 A1 CL 2017001514A1 CL 2017001514 A CL2017001514 A CL 2017001514A CL 2017001514 A CL2017001514 A CL 2017001514A CL 2017001514 A1 CL2017001514 A1 CL 2017001514A1
- Authority
- CL
- Chile
- Prior art keywords
- erk inhibitors
- erk
- kinner
- pirrol
- ona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE TIENO[2,3-C]PIRROL-4-ONA QUE INHIBEN LA ACTIVIDAD DE LA CINASA DE SEÑAL EXTRACELULAR REGULADA (ERK) Y PUEDEN SER ÚTILES EN EL TRATAMIENTOS DEL CÁNCER.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462095185P | 2014-12-22 | 2014-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001514A1 true CL2017001514A1 (es) | 2018-02-09 |
Family
ID=55135525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001514A CL2017001514A1 (es) | 2014-12-22 | 2017-06-13 | Inhibidores de erk |
Country Status (44)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS57058B1 (sr) | 2013-10-03 | 2018-05-31 | Kura Oncology Inc | Ekr inhibitori i postupci primene |
| TWI704151B (zh) * | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
| ES2700200T3 (es) | 2014-12-22 | 2019-02-14 | Lilly Co Eli | Inhibidores de ERK |
| IL291017B2 (en) | 2015-10-21 | 2023-11-01 | Otsuka Pharma Co Ltd | Benzolactam compounds as protein kinase inhibitors |
| JP2019523778A (ja) * | 2016-06-29 | 2019-08-29 | イーライ リリー アンド カンパニー | 膵癌の治療に使用するための、ｅｒｋ１／２阻害剤化合物と、ゲムシタビン、またはゲムシタビンおよびｎａｂ−パクリタキセルとの併用 |
| WO2018081204A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | DEUTERATED N-(5-((4-ETHYLPIPERAZIN-1-YL)METHYL) PYRIDIN-2-YL)-5-FLUORO-4-(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[d]IMIDAZOL-6-YL)PYRIMIDIN-2-AMINE |
| GB201706327D0 (en) | 2017-04-20 | 2017-06-07 | Otsuka Pharma Co Ltd | A pharmaceutical compound |
| MX2020005344A (es) | 2017-11-24 | 2020-08-13 | Janssen Pharmaceutica Nv | Compuestos de pirazolopiridinona. |
| KR20210006365A (ko) * | 2018-04-09 | 2021-01-18 | 쥐원 쎄라퓨틱스, 인크. | 구동 종양원성 돌연변이를 갖는 암의 치료 |
| MY206521A (en) | 2018-05-22 | 2024-12-19 | Js Innomed Holdings Ltd | Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof |
| AU2019407426A1 (en) | 2018-12-21 | 2021-07-22 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
| ES2944857T3 (es) * | 2019-03-27 | 2023-06-26 | Lilly Co Eli | Sales del compuesto 5,6-dihidro-4H-tieno[2,3-c]pirrol-4-ona como inhibidores de ERK |
| EP3950693A4 (en) * | 2019-03-28 | 2022-09-07 | Jiangsu Hengrui Medicine Co., Ltd. | THIENOHETEROCYCLIC DERIVATIVE, METHOD FOR PREPARING IT AND ITS MEDICAL USE |
| WO2020200069A1 (zh) * | 2019-03-29 | 2020-10-08 | 江苏恒瑞医药股份有限公司 | 吡咯并杂环类衍生物、其制备方法及其在医药上的应用 |
| CN113811303A (zh) * | 2019-05-16 | 2021-12-17 | 伊莱利利公司 | 用于治疗brafv600e结直肠癌的erk1/2抑制剂与braf抑制剂和egfr抑制剂的三药组合 |
| CN112457326B (zh) * | 2019-09-06 | 2022-02-15 | 上海凌达生物医药有限公司 | 一类芳香杂环并内酰胺类化合物、制备方法和用途 |
| ES3017422T3 (en) * | 2019-12-06 | 2025-05-12 | D3 Bio Wuxi Co Ltd | Spiro compound serving as erk inhibitor, and application thereof |
| CN110950876B (zh) * | 2019-12-10 | 2021-08-17 | 上海凌达生物医药有限公司 | 一类呋喃并内酰胺类化合物、制备方法和用途 |
| WO2021216777A1 (en) * | 2020-04-21 | 2021-10-28 | The Trustees Of The Stevens Institute Of Technology | Erk inhibitors for cancer therapy |
| CN116437915B (zh) * | 2020-09-29 | 2025-03-18 | 江苏恒瑞医药股份有限公司 | 一种吡咯并杂环类衍生物的晶型及其制备方法 |
| CN114315837B (zh) * | 2020-09-29 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 一种erk抑制剂的结晶形式及其制备方法 |
| US20240309018A1 (en) * | 2021-06-28 | 2024-09-19 | D3 Bio (Wuxi) Co., Ltd | Thiazole-lactam-spiroheterocyclic compounds and applications thereof |
| MX2024000084A (es) * | 2021-06-28 | 2024-01-18 | D3 Bio Wuxi Co Ltd | Compuesto de tiazololactama dimetil sustituido y uso de este. |
| CA3238655A1 (en) * | 2021-11-15 | 2023-05-19 | Erasca, Inc. | Thiophene ulk1/2 inhibitors and their use thereof |
| WO2023137297A2 (en) * | 2022-01-11 | 2023-07-20 | Suvalent Therapeutics, Inc. | 5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo inhibitors and uses thereof |
| US20240352029A1 (en) * | 2023-04-14 | 2024-10-24 | Prelude Therapeutics Incorporated | CDK Inhibitors And Their Use As Pharmaceuticals |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4023048A1 (de) * | 1990-07-20 | 1992-01-23 | Basf Ag | Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2001290914A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2003075840A2 (en) | 2002-03-04 | 2003-09-18 | Imclone Systems Incorporated | Human antibodies specific to kdr and uses thereof |
| ES2289349T3 (es) * | 2002-11-04 | 2008-02-01 | Vertex Pharmaceuticals Incorporated | Derivados de heteroaril-pirimidina como inhibidores de jak. |
| UA80571C2 (en) | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
| EP1948647A1 (en) * | 2005-11-03 | 2008-07-30 | SGX Pharmaceuticals, Inc. | Pyrimidinyl-thiophene kinase modulators |
| TWI409265B (zh) | 2008-08-20 | 2013-09-21 | Merck Sharp & Dohme | 經取代之吡啶及嘧啶衍生物及彼等於治療病毒感染之用途 |
| US8344160B2 (en) * | 2008-10-08 | 2013-01-01 | Bristol-Myers Squibb Company | Pyrrolone melanin concentrating hormone receptor-1 antagonists |
| PA8852901A1 (es) * | 2008-12-22 | 2010-07-27 | Lilly Co Eli | Inhibidores de proteina cinasa |
| BR112013007499A2 (pt) * | 2010-09-01 | 2016-07-12 | Genentech Inc | piridazinonas - métodos de criação e usos |
| JO3148B1 (ar) | 2011-07-27 | 2017-09-20 | Lilly Co Eli | مركب مثبط لإشارات مسار notch |
| MY191936A (en) | 2012-03-01 | 2022-07-19 | Genentech Inc | Serine/threonine kinase inhibitors |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| US20140093498A1 (en) * | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents |
| ES2700200T3 (es) * | 2014-12-22 | 2019-02-14 | Lilly Co Eli | Inhibidores de ERK |
| TWI704151B (zh) * | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
-
2015
- 2015-12-09 TW TW104141368A patent/TWI704151B/zh not_active IP Right Cessation
- 2015-12-10 JO JOP/2015/0310A patent/JO3596B1/ar active
- 2015-12-11 AR ARP150104045A patent/AR102977A1/es unknown
- 2015-12-16 LT LTEP15823869.1T patent/LT3237423T/lt unknown
- 2015-12-16 NZ NZ731531A patent/NZ731531A/en not_active IP Right Cessation
- 2015-12-16 JP JP2017533381A patent/JP6445701B2/ja not_active Expired - Fee Related
- 2015-12-16 WO PCT/US2015/065940 patent/WO2016106029A1/en active Application Filing
- 2015-12-16 MX MX2017008242A patent/MX371206B/es active IP Right Grant
- 2015-12-16 KR KR1020177016748A patent/KR101917972B1/ko not_active Expired - Fee Related
- 2015-12-16 SG SG11201704521SA patent/SG11201704521SA/en unknown
- 2015-12-16 AU AU2015369983A patent/AU2015369983C1/en not_active Ceased
- 2015-12-16 MY MYPI2017702263A patent/MY178426A/en unknown
- 2015-12-16 BR BR112017011130A patent/BR112017011130A2/pt active Search and Examination
- 2015-12-16 UA UAA201706046A patent/UA119686C2/uk unknown
- 2015-12-16 EA EA201791133A patent/EA031659B1/ru not_active IP Right Cessation
- 2015-12-16 RS RS20190906A patent/RS59015B1/sr unknown
- 2015-12-16 US US14/970,588 patent/US9469652B2/en not_active Ceased
- 2015-12-16 SI SI201530773T patent/SI3237423T1/sl unknown
- 2015-12-16 DK DK15823869.1T patent/DK3237423T3/da active
- 2015-12-16 PE PE2017001109A patent/PE20171043A1/es unknown
- 2015-12-16 HR HRP20191268 patent/HRP20191268T1/hr unknown
- 2015-12-16 HU HUE15823869A patent/HUE045933T2/hu unknown
- 2015-12-16 CR CR20170182A patent/CR20170182A/es unknown
- 2015-12-16 PL PL15823869T patent/PL3237423T3/pl unknown
- 2015-12-16 MA MA41251A patent/MA41251B1/fr unknown
- 2015-12-16 CA CA2966559A patent/CA2966559C/en active Active
- 2015-12-16 MD MDE20170231 patent/MD3237423T2/ro not_active IP Right Cessation
- 2015-12-16 TR TR2019/09887T patent/TR201909887T4/tr unknown
- 2015-12-16 CN CN201580070315.6A patent/CN107108648B/zh active Active
- 2015-12-16 ES ES15823869T patent/ES2738406T3/es active Active
- 2015-12-16 ME MEP-2019-201A patent/ME03490B/me unknown
- 2015-12-16 PT PT15823869T patent/PT3237423T/pt unknown
- 2015-12-16 EP EP15823869.1A patent/EP3237423B1/en active Active
- 2015-12-16 TN TN2017000233A patent/TN2017000233A1/en unknown
-
2016
- 2016-09-08 US US15/259,381 patent/US9526733B1/en active Active
-
2017
- 2017-04-20 ZA ZA2017/02786A patent/ZA201702786B/en unknown
- 2017-05-01 IL IL252065A patent/IL252065B/en active IP Right Grant
- 2017-05-15 SV SV2017005443A patent/SV2017005443A/es unknown
- 2017-05-16 DO DO2017000122A patent/DOP2017000122A/es unknown
- 2017-05-25 CO CONC2017/0005217A patent/CO2017005217A2/es unknown
- 2017-06-13 CL CL2017001514A patent/CL2017001514A1/es unknown
- 2017-06-19 GT GT201700134A patent/GT201700134A/es unknown
- 2017-06-20 PH PH12017501155A patent/PH12017501155B1/en unknown
- 2017-06-22 EC ECIEPI201738500A patent/ECSP17038500A/es unknown
-
2019
- 2019-05-22 US US16/419,141 patent/USRE48635E1/en active Active
- 2019-07-23 CY CY20191100777T patent/CY1121831T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2017001514A1 (es) | Inhibidores de erk | |
| TWD187904S (zh) | 追蹤裝置 | |
| CY1119419T1 (el) | C1-inh συνθεσεις για χρηση στην προληψη και αγωγη κληρονομικου αγγειοοιδηματος (ηαε) | |
| CR20150462A (es) | Inhibidores de erk y sus usos | |
| AU362319S (en) | Pet treat | |
| TWD173411S (zh) | 項鍊 | |
| FR3024945B1 (fr) | Article absorbant avec graphismes | |
| PH12017500836A1 (en) | Transdermal formulations | |
| AU363883S (en) | Tracking device | |
| MX386861B (es) | Composiciones inhibidoras de nitrificación microencapsuladas. | |
| MY165760A (en) | Absorbent article | |
| UY36107A (es) | Composición microencapsulada inhibidora de la nitrificación | |
| BR112018005863A2 (pt) | endófitos de brachiaria e métodos relacionados | |
| MX2016011413A (es) | Formulaciones que comprenden xiloglucano polimérico como portador para agentes agronómicamente beneficiosos. | |
| AU361576S (en) | Extension member | |
| RS54907B1 (sr) | Upotreba odiparsila u lečenju mukopolisaharidoze | |
| TH1601001598A (th) | การใช้ทางการเกษตรของแบคทีเรียชนิดใหม่ของจีนัส Streptomyces | |
| BR112017008659A2 (pt) | ?métodos e compostos de agonista de gip? | |
| AU362428S (en) | Absorbent article | |
| UA100258U (en) | PROTECTIVE GLOVE HOUSEHOLD | |
| UA97245U (en) | Succinic acid application to strengthen the antihypoxic effect of thiotriazoline and quercetin | |
| TWD169258S (zh) | 蹦床 | |
| UA88010U (ru) | Устройство для ушивания кожи при формировании эстетического рубца | |
| NI201500033S (es) | Chainsaw ms382-1119 | |
| AU361230S (en) | Inline fluid distribution emitter |