CL2015001660A1 - Composicion farmaceutica oral de accion prolongada (pap) que comprende un compuesto derivado de betulina en forma de microparticulas y encapsulado en un polimero, y un sistema tensoactivo que comprende un tensoactivo, un estabilizador y una sal amortiguadora; metodo para la prevencion y el tratamiento de una infeccion por vih. - Google Patents
Composicion farmaceutica oral de accion prolongada (pap) que comprende un compuesto derivado de betulina en forma de microparticulas y encapsulado en un polimero, y un sistema tensoactivo que comprende un tensoactivo, un estabilizador y una sal amortiguadora; metodo para la prevencion y el tratamiento de una infeccion por vih.Info
- Publication number
- CL2015001660A1 CL2015001660A1 CL2015001660A CL2015001660A CL2015001660A1 CL 2015001660 A1 CL2015001660 A1 CL 2015001660A1 CL 2015001660 A CL2015001660 A CL 2015001660A CL 2015001660 A CL2015001660 A CL 2015001660A CL 2015001660 A1 CL2015001660 A1 CL 2015001660A1
- Authority
- CL
- Chile
- Prior art keywords
- surfactant
- betulin
- pap
- microparticles
- encapsulated
- Prior art date
Links
- 239000004094 surface-active agent Substances 0.000 title 2
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 title 1
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 title 1
- MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 title 1
- 239000000337 buffer salt Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 239000011859 microparticle Substances 0.000 title 1
- 239000008203 oral pharmaceutical composition Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000003381 stabilizer Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737177P | 2012-12-14 | 2012-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015001660A1 true CL2015001660A1 (es) | 2015-10-02 |
Family
ID=50935020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015001660A CL2015001660A1 (es) | 2012-12-14 | 2015-06-12 | Composicion farmaceutica oral de accion prolongada (pap) que comprende un compuesto derivado de betulina en forma de microparticulas y encapsulado en un polimero, y un sistema tensoactivo que comprende un tensoactivo, un estabilizador y una sal amortiguadora; metodo para la prevencion y el tratamiento de una infeccion por vih. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9795619B2 (enExample) |
| EP (1) | EP2931285A4 (enExample) |
| JP (1) | JP2016503030A (enExample) |
| KR (1) | KR20150093819A (enExample) |
| CN (1) | CN104902905A (enExample) |
| AU (1) | AU2013358897B2 (enExample) |
| BR (1) | BR112015013695A2 (enExample) |
| CA (1) | CA2893959A1 (enExample) |
| CL (1) | CL2015001660A1 (enExample) |
| CR (1) | CR20150313A (enExample) |
| EA (1) | EA201590862A1 (enExample) |
| HK (1) | HK1209638A1 (enExample) |
| IL (1) | IL238807A0 (enExample) |
| MA (1) | MA38182A1 (enExample) |
| MX (1) | MX2015007563A (enExample) |
| PE (1) | PE20151326A1 (enExample) |
| PH (1) | PH12015501156A1 (enExample) |
| SG (2) | SG11201503807TA (enExample) |
| WO (1) | WO2014093941A1 (enExample) |
| ZA (1) | ZA201503594B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
| MA38182A1 (fr) * | 2012-12-14 | 2018-04-30 | Glaxosmithkline Llc | Compositions pharmaceutiques a action prolongée pur une utilisation dans le traitement ou la prévention d'infections par le virus de l’immunodéficience humaine (vih) |
| DK3067358T3 (da) | 2012-12-21 | 2019-11-04 | Gilead Sciences Inc | Polycykliske carbamoylpyridon-forbindelser og deres farmaceutiske anvendelse |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| PL3019503T3 (pl) | 2013-07-12 | 2018-01-31 | Gilead Sciences Inc | Policykliczne związki karbamoilopirydonowe i ich zastosowanie do leczenia infekcji hiv |
| NO2865735T3 (enExample) | 2013-07-12 | 2018-07-21 | ||
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (enExample) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
| SG11201702379TA (en) * | 2014-09-26 | 2017-04-27 | Glaxosmithkline Ip No 2 Ltd | Long acting pharmaceutical compositions |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
| US10370405B2 (en) | 2015-03-16 | 2019-08-06 | Hetero Labs Limited | C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors |
| EP3277691B1 (en) | 2015-04-02 | 2019-01-30 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| WO2018042331A1 (en) * | 2016-08-31 | 2018-03-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations and uses and treatments thereof |
| WO2018042332A1 (en) * | 2016-08-31 | 2018-03-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations and uses and treatments thereof |
| AU2018304591A1 (en) | 2017-07-21 | 2020-03-05 | Janssen Sciences Ireland Unlimited Company | Regimens for treating hiv infections and aids |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| US5358721A (en) * | 1992-12-04 | 1994-10-25 | Alza Corporation | Antiviral therapy |
| EP1292562A1 (en) | 2000-05-23 | 2003-03-19 | Univerzita palackeho V Olomouci | Triterpenoid derivatives |
| US7163700B2 (en) * | 2001-07-31 | 2007-01-16 | Capricorn Pharma, Inc. | Amorphous drug beads |
| US20080206161A1 (en) * | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
| WO2005112929A2 (en) | 2004-05-20 | 2005-12-01 | Cornell Research Foundation, Inc. | Anti-hiv-1 activity of betulinol derivatives |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| CN1682740A (zh) * | 2005-03-11 | 2005-10-19 | 中国药科大学 | 五环三萜类化合物在制备糖原磷酸化酶抑制剂中的应用 |
| WO2006105356A2 (en) | 2005-03-29 | 2006-10-05 | Regents Of The University Of Minnesota | Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid |
| TWI457136B (zh) | 2005-04-04 | 2014-10-21 | Tibotec Pharm Ltd | Hiv-感染之預防 |
| WO2006117666A2 (en) * | 2005-04-29 | 2006-11-09 | Pfizer Inc. | Dosage forms, pharmaceutical compositions and methods for sub-tenon delivery |
| US20070197646A1 (en) | 2006-02-21 | 2007-08-23 | Achillion Pharmaceuticals, Inc. | Substituted taraxastanes useful for treating viral infections |
| FI121468B (fi) | 2006-06-07 | 2010-11-30 | Valtion Teknillinen | Betuliiniperäiset yhdisteet antimikrobisina aineina |
| HUE068406T2 (hu) | 2006-06-23 | 2024-12-28 | Janssen Sciences Ireland Unlimited Co | A TMC278 vizes szuszpenziója |
| WO2008127364A2 (en) | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
| AR063546A1 (es) | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
| AU2008274185B2 (en) * | 2007-07-12 | 2014-07-03 | Janssen Sciences Ireland Uc | Crystalline form of (E) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2 pyrimidinyl]amino]benzonitrile |
| CN101977924A (zh) | 2008-01-03 | 2011-02-16 | Viro化学制药公司 | 新的c-21-酮基羽扇烷衍生物、其制备方法和应用 |
| WO2009082819A1 (en) | 2008-01-03 | 2009-07-09 | Virochem Pharma Inc. | Novel lupane derivatives |
| DE102008037025C5 (de) * | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
| US8778990B2 (en) | 2008-11-04 | 2014-07-15 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| CZ301318B6 (cs) | 2008-11-13 | 2010-01-13 | Univerzita Palackého v Olomouci | 2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo |
| EP3210603A1 (en) * | 2008-12-11 | 2017-08-30 | Shionogi & Co., Ltd | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| US8802727B2 (en) | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| EA201290632A1 (ru) * | 2010-02-11 | 2013-03-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Производные бетулина |
| TWI577377B (zh) * | 2010-09-16 | 2017-04-11 | Viiv醫療保健公司 | 醫藥組合物 |
| WO2013020245A1 (en) | 2011-08-08 | 2013-02-14 | Glaxosmithkline Llc | Carbonyl derivatives of betulin |
| WO2013020246A1 (en) | 2011-08-08 | 2013-02-14 | Glaxosmithkline Llc | Methylene derivatives of betulin |
| ES2584684T3 (es) | 2011-12-14 | 2016-09-28 | Glaxosmithkline Llc | Derivados de propenoato de betulina |
| JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
| WO2014035945A1 (en) | 2012-08-28 | 2014-03-06 | Glaxosmithkline Llc | Pharmaceutical compositions |
| MA38182A1 (fr) * | 2012-12-14 | 2018-04-30 | Glaxosmithkline Llc | Compositions pharmaceutiques a action prolongée pur une utilisation dans le traitement ou la prévention d'infections par le virus de l’immunodéficience humaine (vih) |
| SG11201702379TA (en) | 2014-09-26 | 2017-04-27 | Glaxosmithkline Ip No 2 Ltd | Long acting pharmaceutical compositions |
-
2013
- 2013-12-14 MA MA38182A patent/MA38182A1/fr unknown
- 2013-12-14 PE PE2015000924A patent/PE20151326A1/es not_active Application Discontinuation
- 2013-12-14 HK HK15110448.0A patent/HK1209638A1/xx unknown
- 2013-12-14 US US14/651,673 patent/US9795619B2/en not_active Expired - Fee Related
- 2013-12-14 MX MX2015007563A patent/MX2015007563A/es unknown
- 2013-12-14 SG SG11201503807TA patent/SG11201503807TA/en unknown
- 2013-12-14 AU AU2013358897A patent/AU2013358897B2/en not_active Ceased
- 2013-12-14 KR KR1020157018488A patent/KR20150093819A/ko not_active Withdrawn
- 2013-12-14 WO PCT/US2013/075196 patent/WO2014093941A1/en not_active Ceased
- 2013-12-14 CA CA2893959A patent/CA2893959A1/en not_active Abandoned
- 2013-12-14 BR BR112015013695A patent/BR112015013695A2/pt not_active IP Right Cessation
- 2013-12-14 CN CN201380065306.9A patent/CN104902905A/zh active Pending
- 2013-12-14 SG SG10201704467SA patent/SG10201704467SA/en unknown
- 2013-12-14 EA EA201590862A patent/EA201590862A1/ru unknown
- 2013-12-14 EP EP13863026.4A patent/EP2931285A4/en not_active Withdrawn
- 2013-12-14 JP JP2015548025A patent/JP2016503030A/ja active Pending
-
2015
- 2015-05-13 IL IL238807A patent/IL238807A0/en unknown
- 2015-05-21 ZA ZA2015/03594A patent/ZA201503594B/en unknown
- 2015-05-25 PH PH12015501156A patent/PH12015501156A1/en unknown
- 2015-06-12 CR CR20150313A patent/CR20150313A/es unknown
- 2015-06-12 CL CL2015001660A patent/CL2015001660A1/es unknown
-
2017
- 2017-10-19 US US15/787,987 patent/US20180042944A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA201590862A1 (ru) | 2016-05-31 |
| KR20150093819A (ko) | 2015-08-18 |
| PE20151326A1 (es) | 2015-10-12 |
| MA38182A1 (fr) | 2018-04-30 |
| AU2013358897A1 (en) | 2015-07-02 |
| SG11201503807TA (en) | 2015-06-29 |
| ZA201503594B (en) | 2018-11-28 |
| US9795619B2 (en) | 2017-10-24 |
| US20180042944A1 (en) | 2018-02-15 |
| SG10201704467SA (en) | 2017-06-29 |
| EP2931285A4 (en) | 2016-06-01 |
| US20150313917A1 (en) | 2015-11-05 |
| CN104902905A (zh) | 2015-09-09 |
| MX2015007563A (es) | 2015-10-14 |
| CR20150313A (es) | 2015-10-19 |
| PH12015501156A1 (en) | 2015-08-10 |
| CA2893959A1 (en) | 2014-06-19 |
| EP2931285A1 (en) | 2015-10-21 |
| HK1209638A1 (en) | 2016-04-08 |
| IL238807A0 (en) | 2015-06-30 |
| WO2014093941A1 (en) | 2014-06-19 |
| JP2016503030A (ja) | 2016-02-01 |
| AU2013358897B2 (en) | 2017-01-05 |
| BR112015013695A2 (pt) | 2017-07-11 |
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