CL2008002291A1 - Compuestos derivados del acido 4-fluor-benzoico, inhibidores de la polimerasa hcv, composicion farmaceutica, kit farmaceutico y su uso para el tratamiento de una infeccion viral por hepatitis c. - Google Patents
Compuestos derivados del acido 4-fluor-benzoico, inhibidores de la polimerasa hcv, composicion farmaceutica, kit farmaceutico y su uso para el tratamiento de una infeccion viral por hepatitis c.Info
- Publication number
- CL2008002291A1 CL2008002291A1 CL2008002291A CL2008002291A CL2008002291A1 CL 2008002291 A1 CL2008002291 A1 CL 2008002291A1 CL 2008002291 A CL2008002291 A CL 2008002291A CL 2008002291 A CL2008002291 A CL 2008002291A CL 2008002291 A1 CL2008002291 A1 CL 2008002291A1
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- hepatitis
- treatment
- viral infection
- fluoro
- compounds derived
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- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Compuestos derivados del ácido 4-fluor-benzoico, inhibidores de la polimerasa hcv, composición farmacéutica, kit farmacéutico y su uso para el tratamiento de una infección viral por hepatitis C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95382007P | 2007-08-03 | 2007-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008002291A1 true CL2008002291A1 (es) | 2009-09-11 |
Family
ID=40340908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008002291A CL2008002291A1 (es) | 2007-08-03 | 2008-08-01 | Compuestos derivados del acido 4-fluor-benzoico, inhibidores de la polimerasa hcv, composicion farmaceutica, kit farmaceutico y su uso para el tratamiento de una infeccion viral por hepatitis c. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20100286131A1 (es) |
EP (1) | EP2185539A4 (es) |
JP (1) | JP2010535155A (es) |
AR (1) | AR068050A1 (es) |
CA (1) | CA2693495A1 (es) |
CL (1) | CL2008002291A1 (es) |
TW (1) | TW200909393A (es) |
WO (1) | WO2009018656A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
US8410091B1 (en) | 2009-09-11 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Process for preparation of substituted 2-amino-5-(5-(heterocyclemethyl)pyridin-2-yloxy)benzoic acid |
US20110230465A1 (en) * | 2009-09-18 | 2011-09-22 | Boehringer Ingleheim International Gmbh | Viral polymerase inhibitors |
CN103601671B (zh) * | 2013-10-22 | 2016-08-17 | 上海泰坦科技股份有限公司 | 碘代三氟甲基吡啶的制备方法 |
CA2959208C (en) | 2014-08-29 | 2023-09-19 | Tes Pharma S.R.L. | Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase |
WO2016077232A2 (en) * | 2014-11-10 | 2016-05-19 | Forge Life Science, Llc | Anti-hcmv compositions and methods |
KR102401963B1 (ko) * | 2016-06-27 | 2022-05-25 | 케모센트릭스, 인크. | 면역조절제 화합물 |
JP2021534215A (ja) * | 2018-08-24 | 2021-12-09 | ゼニオプロ ゲーエムベーハー | 病的症状の治療における使用のための芳香族分子 |
CN110156620B (zh) * | 2019-07-02 | 2022-04-15 | 中节能万润股份有限公司 | 一种氨甲环酸的制备方法 |
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GB1507457A (en) * | 1974-11-12 | 1978-04-12 | Agfa Gevaert | Fixer compositions used in planographic printing |
LU85544A1 (fr) * | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
US5633388A (en) * | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
CN1208321C (zh) * | 1999-07-20 | 2005-06-29 | 道农业科学公司 | 杀真菌的杂环芳族酰胺和它们的组合物、使用方法和制备 |
CA2363274A1 (en) * | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
DE10012823A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
US6434489B1 (en) * | 2000-04-03 | 2002-08-13 | Schering Corporation | Compositions of hepatitis C virus NS5B polymerase and methods for crystallizing same |
US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
MXPA03007760A (es) * | 2001-03-08 | 2004-03-16 | Boehringer Ingelheim Ca Ltd | Analisis para identificar los inhibidores de la arn-polimerasa (ns5b) del hcv, dependiente del arn. |
AR035543A1 (es) * | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
US6841566B2 (en) * | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
CA2480583C (en) * | 2002-04-01 | 2008-07-15 | Pfizer Inc. | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase |
AP2021A (en) * | 2002-10-23 | 2009-08-03 | Glenmark Pharmaceuticals Ltd | Novel tricyclic compounds useful for the treatmentof inflammatory and allergic disorders: Process f or their preparation and pharmaceutical compositions containing them |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP1625154B1 (en) * | 2003-05-09 | 2014-01-08 | Boehringer Ingelheim International GmbH | Hepatitis c virus ns5b polymerase inhibitor binding pocket |
US7371743B2 (en) * | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
US20060004197A1 (en) * | 2004-07-02 | 2006-01-05 | Thomas Thrash | Sulfonamide-based compounds as protein tyrosine kinase inhibitors |
UY29017A1 (es) * | 2004-07-16 | 2006-02-24 | Boehringer Ingelheim Int | Inhibidores de polimerasa viral |
US20060025480A1 (en) * | 2004-08-02 | 2006-02-02 | Boehringer Ingelheim International Gmbh | Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors |
EP1919898B1 (en) * | 2005-07-29 | 2011-01-26 | Tibotec Pharmaceuticals | Macrocyclic inhibitors of hepatitis c virus |
US7816348B2 (en) * | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
RU2009109355A (ru) * | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
US8242140B2 (en) * | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2009077500A2 (de) * | 2007-12-19 | 2009-06-25 | Basf Se | Azolylmethyloxirane, ihre verwendung sowie sie enthaltende mittel |
EP2234977A4 (en) * | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
US20100311581A1 (en) * | 2007-12-19 | 2010-12-09 | Basf Se | Azolylmethyloxiranes, use Thereof and Agents Containing the Same |
US20100317515A1 (en) * | 2007-12-19 | 2010-12-16 | Basf Se | Azolylmethyloxiranes, use Thereof and Agents Containing the Same |
-
2008
- 2008-07-31 CA CA2693495A patent/CA2693495A1/en not_active Abandoned
- 2008-07-31 JP JP2010518467A patent/JP2010535155A/ja active Pending
- 2008-07-31 US US12/671,765 patent/US20100286131A1/en not_active Abandoned
- 2008-07-31 EP EP08783322A patent/EP2185539A4/en not_active Withdrawn
- 2008-07-31 WO PCT/CA2008/001411 patent/WO2009018656A1/en active Application Filing
- 2008-08-01 CL CL2008002291A patent/CL2008002291A1/es unknown
- 2008-08-01 AR ARP080103382A patent/AR068050A1/es unknown
- 2008-08-01 TW TW097129432A patent/TW200909393A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20100286131A1 (en) | 2010-11-11 |
EP2185539A1 (en) | 2010-05-19 |
AR068050A1 (es) | 2009-11-04 |
WO2009018656A1 (en) | 2009-02-12 |
CA2693495A1 (en) | 2009-02-12 |
JP2010535155A (ja) | 2010-11-18 |
TW200909393A (en) | 2009-03-01 |
EP2185539A4 (en) | 2011-07-20 |
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