CH96608A - Process for the preparation of an acridine derivative. - Google Patents

Process for the preparation of an acridine derivative.

Info

Publication number
CH96608A
CH96608A CH96608DA CH96608A CH 96608 A CH96608 A CH 96608A CH 96608D A CH96608D A CH 96608DA CH 96608 A CH96608 A CH 96608A
Authority
CH
Switzerland
Prior art keywords
acridine
preparation
methoxy
acridine derivative
diamino
Prior art date
Application number
Other languages
German (de)
Inventor
Farbwerke Vorm Meiste Bruening
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CH96608A publication Critical patent/CH96608A/en

Links

Description

  

      Verfahren    zur Darstellung eines     Aeridinderivates.       Es wurde gefunden, dass man in dem Ver  fahren des Zusatzpatentes Nr. 94625 an Stelle  von 3     #    9     #        7-Niti-o-amino-methoxy-aci-idin,    aus  welchem man durch Behandlung mit Reduk  tionsmitteln zu dem 3     #    9     #        7-Diamino-methoxy-          acridin        gelangt,

      auch ein aus dein 3     #    9     #        7-          Nitro-chlor-ixietlioxy-aeridiii    durch     Umsetzung     mit einem     Hydrazin,    z. B.     Phenylhydrazin,     erhältliches 3     #    9     #        7-Niti#o-hydrazino-inethoxy-          acridin    verwenden kann.

   Das 3     #    7     #        9-Nitro-          methoxy-phenylhydrazirio-acridin    ist eine rote  Verbindung, unlöslich in Wasser, löslich in  Alkohol, ihr Schmelzpunkt liegt höher als  300  ; als Chlorhydrat ist sie in Wasser  sehr schwer löslich.  



  <I>Beispiel:</I>  27 Teile     3.7.9-Nitro-methoxy-phenyl-          liydrazirio-acridin-chlorhydrat    werden mit 300  Teilen Wasser, 100 Teilen Alkohol, 5 Teilen    Salmiak und 44 Teilen Zinkstaub einige  Stunden zum Sieden erhitzt, sodann wird der  Alkohol     abdestilliert,    die wässerige Lösung       abfiltriert    und aus ihr durch Salzsäure das       Diamino-methoxy-acridin    als salzsaures Salz  gefällt; es bildet gelbe Nadeln, die aus ihr  abgeschiedene Base schmilzt bei     240-2420.  



      Process for the preparation of an aeridine derivative. It was found that in the process of additional patent no. 94625 instead of 3 # 9 # 7-Niti-o-amino-methoxy-aci-idin, from which one can by treatment with reducing agents to the 3 # 9 # 7-diamino-methoxy-acridine arrives,

      also one from your 3 # 9 # 7-nitro-chloro-ixietlioxy-aeridiii by reaction with a hydrazine, e.g. B. phenylhydrazine, available 3 # 9 # 7-Niti # o-hydrazino-inethoxy-acridine can use.

   The 3 # 7 # 9-nitro-methoxy-phenylhydrazirio-acridine is a red compound, insoluble in water, soluble in alcohol, its melting point is higher than 300; as a chlorine hydrate it is very sparingly soluble in water.



  <I> Example: </I> 27 parts of 3.7.9-nitro-methoxy-phenyl-liydrazirio-acridine chlorohydrate are heated to the boil for a few hours with 300 parts of water, 100 parts of alcohol, 5 parts of ammonia and 44 parts of zinc dust the alcohol is distilled off, the aqueous solution is filtered off and the diamino-methoxy-acridine is precipitated from it as a hydrochloric acid salt using hydrochloric acid; it forms yellow needles, the base deposited from it melts at 240-2420.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines Acridin- der-ivates, dadurch gekennzeichnet, dass man ein 3.9.7 -Nitro-hydrazino-methoxy-acridin durch Behandlung mit Reduktionsmitteln in 3 # 9 # 7-Diamino-inetlioxy-aeridin überführt. Das 3 # 9 # 7-Diamino-methoxy-acridin schmilzt bei 240-2420. PATENT CLAIM: Process for the preparation of an acridine derivates, characterized in that a 3.9.7 -nitro-hydrazino-methoxy-acridine is converted into 3 # 9 # 7-diamino-inetlioxy-aeridine by treatment with reducing agents. The 3 # 9 # 7-diamino-methoxy-acridine melts at 240-2420.
CH96608D 1920-10-28 1921-08-11 Process for the preparation of an acridine derivative. CH96608A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE96608X 1920-10-28
CH93439T 1921-09-12

Publications (1)

Publication Number Publication Date
CH96608A true CH96608A (en) 1922-11-01

Family

ID=25704670

Family Applications (1)

Application Number Title Priority Date Filing Date
CH96608D CH96608A (en) 1920-10-28 1921-08-11 Process for the preparation of an acridine derivative.

Country Status (1)

Country Link
CH (1) CH96608A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544659A (en) * 1982-11-26 1985-10-01 Hoffman-La Roche Inc. Schistosomicidal acridanone hydrazones
US4711889A (en) * 1983-11-15 1987-12-08 Hoffman-La Roche Inc. Schistosomicidal acridanone hydrazones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544659A (en) * 1982-11-26 1985-10-01 Hoffman-La Roche Inc. Schistosomicidal acridanone hydrazones
US4711889A (en) * 1983-11-15 1987-12-08 Hoffman-La Roche Inc. Schistosomicidal acridanone hydrazones

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