CH711344A2 - Injection device. - Google Patents

Abstract

The invention relates to injection devices for administering a fluid medicament substance with an elongated housing (6). The injection device comprises a first clutch (K1), with which a push button and a display element can be coupled in a rotationally fixed manner, a second clutch (K2) with which the push button and the housing (6) can be coupled in a rotationally fixed manner, a transmission device which functions the display element coupled with an output device, so that a rotation of the display element relative to a mechanism holder (7) has an axial displacement of the output element relative to the mechanism holder (7) result and vice versa. The couplings (K1, K2) are actuated by an axial displacement of the push button. When setting and correcting a dose, the first clutch (K1) is closed, the second clutch (K2) is opened, and the dose is adjusted by rotating a Dosierknopfs (13). To administer the set dose, the push button is moved distally, thereby first closing the second clutch (K2) and then opening the first clutch (K1). During administration, an energy store (11) acts operatively on the display element, whereby it rotates and the transmission device causes an axial displacement of the output device (9, 109).

Description

Technical area

The invention relates to injection devices, in particular Injektionspens, with which a product contained in a product fluid product, in particular in several and variable doses, is automatically emptied. The fluid product is in particular a medicament. In particular, the invention relates to an injection device which is cost-adaptive to various drugs and drug concentrations.

background

An injection device, such as a Injektionspen, in which the force required for the administration of drug is applied at least partially by an energy stored in the Injektionspen energy source may be suitable in principle for the administration of a variety of drugs, provided that the drug is a consistency has, which can be distributed with the injection device.

As used herein, the term "medicament" includes any fluid medical formulation suitable for controlled administration by an agent, such as e.g. a cannula or hollow needle, for example, comprising a liquid, a solution, a gel or a fine suspension containing one or more medicinal agents. "Drug" may be a single drug composition or a premixed or co-formulated multi-drug composition from a single container. Drug includes drugs such as peptides (eg, insulins, insulin-containing drugs, GLP-1 containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active agents, hormone or gene based drugs, nutritional formulas, enzymes, and other substances both in the art solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or oligonucleotides, antibodies or parts of antibodies and suitable base, excipients and carriers.

From WO 2009/105 909 an automatic Injektionspen is known, in which a coil spring is arranged, which provides the energy required for drug release. The coil spring is stretched when setting a dose, which means that the user must mechanically clamp the spring at each dose.

From US 8,608,708 an injection device is known, in which a prestressed torsion spring as the drive spring provides the energy for the administration of the doses. Prestressed means in this case that the torsion spring by the bias voltage stores enough energy to distribute the entire contents of the carpule shown. As a result, the user does not have to apply any force when setting the dose in order to tension the drive spring.

From WO 2014/170 267 a medication delivery device is known, in which a plurality of series-connected, biased springs provide the energy for the administration of the doses.

From EP 2 881 131 A1 a drive and metering device for an injection device is known, in which a mainspring, which is biased between a Doseinstellglied and a drive member, provides the energy for the administration of the doses.

For manufacturers of injection devices, drug manufacturers, health insurance and people to be cared for, there is a need to have injection devices on hand, which are as cheap as possible, but safe and effective.

task

It is an object of the invention to provide an alternative injection device which is inexpensive adaptable to various drugs and drug concentrations.

Solution and general description

The object is achieved according to the independent claim 1, advantageous developments emerge from the dependent claims, the description and the figures.

The injection device according to the invention has an elongate housing, in particular in the form of an elongated cylinder, and a product container arranged in the housing. The product container is preferably a pre-filled syringe or a carpule. The product container can be fixedly arranged in the housing, in particular the product container can be held by a carpule holder or syringe holder on the injection device. Furthermore, the injection device comprises a dispensing mechanism which can preferably effect a dispensing of the product by means of an energy store arranged in or on the injection device, such as a spring, a battery, a gas pressure container, a gas generator or an osmotic drive device. The injection device further comprises, in the case that the product container is a carpule, a detachable on the housing attachable injection needle, which produces a fluid path between the cartridge contents and injection tip of the injection needle. If the product container is a pre-filled syringe with a fixed injection needle, no separate injection needle is needed.

In a further aspect, the injection device further comprises a metering device, which allows the setting of a specific subset or dose of the product present in the product container, wherein subsequently the set dose is distributed with the Ausschüttmechanismus. In this case, metering device and dispensing mechanism can be designed so that exactly one dose can be distributed or that several doses of variable size can be distributed in succession from the same product container. In a further aspect, it is possible to dispense several equal-sized cans by means of a discharge mechanism.

In another aspect, the injection device may be intended for single use, so that the device must be disposed of after emptying the product container. In further embodiments, the product container can be exchanged and the injection device can thus be designed to be reusable. Alternatively, parts of the injection device can be interchangeable with the product container, so that a so-called semi-disposable system is created.

In the event that the injection device is intended for single use, the energy store may also be discharged or emptied after the emptying of the product container. With replaceable product containers and reusable injection devices, the energy store may be rechargeable, refillable, or interchangeable. Alternatively, the energy storage can also contain energy for the emptying of several product containers.

In a further aspect, the injection device may comprise a needle protection sleeve which covers the injection needle. In a preferred form, the needle guard is movable in one direction to inject product so as to release the injection needle for injection. In a further preferred form, the needle protection sleeve moves over the injection needle again after the injection and is firmly locked relative to the housing, so that no further, in particular unwanted, lancing operations are possible.

In another aspect, the injection device may include a peel cap covering the end of the injection device that houses the injection needle. The withdrawal cap may protect the injection device from accidental deployment prior to intended use or protect the needle protection sleeve from accidental manipulation, for example, during shipping or unpacking. In a further aspect, the peel cap may be used to remove any needle shield from the injection device prior to use, such as is used in pre-filled syringes, for example, to keep the needle sterile.

The housing of the injection device is preferably elongated and forms the longitudinal axis of the injection device. The housing is preferably sleeve-shaped and / or cylindrical, in particular circular-cylindrical. Coaxially with the housing, at the proximal end of the housing, a metering knob is disposed which is rotatable relative to the housing to adjust or correct a dose, but is axially fixed. The dosing button is preferably approximately annular, wherein the central axis of the ring is arranged coaxially to the longitudinal axis of the injection device. The dosing button is open in the proximal direction. In this opening, a push button is arranged, which is secured against rotation relative to the Dosierknopf, but in the axial direction has a particular limited displaceability.

Arranged in the housing is a housing insert, which is axially and rotationally fixed in the housing. In a preferred embodiment, this insert is approximately disk-shaped and has an opening in the middle, so that a ring results. On its periphery radial stops can be arranged for the pen mechanism. A coaxially aligned with the housing sleeve-shaped mechanism holder is rotatably and axially fixed to the insert. At its distal end, the mechanism holder has an opening into which an elongated output member can be inserted. In this case, the driven member is mounted axially displaceable and secured against rotation in the mechanism holder. The output member may be designed as a classic piston rod, but may also be sleeve-shaped. The rotation and longitudinal guidance between the mechanism holder and driven member can be done via a spring / groove connection or alternatively also via a non-circular in cross-section inner shape of the mechanism holder or outer shape of the output member. Alternatively, the longitudinal guide can also be designed as a very steep threaded connection, so that the longitudinal guide includes a rotational component, wherein an anti-rotation device continues to exist at each individual time point. The distal end of the driven member serves to act on the plug or piston of the carpule or pre-filled syringe with an axial force, in particular low-torque, to expel medicament from the medicament container.

On the outside of the mechanism holder, but within the housing, a display device is axially fixed and rotatable. The nature of the device entails that the display device is designed sleeve or annular. On the lateral surface of the display device, a dose scale is arranged. At least two in particular radial stops are arranged on the periphery of the display device. Alternatively, it can also be a two-sided stop. The angle swept around the longitudinal axis of the injection device between the at least two stops gives the possible span for a dose, as the range between a zero position and the maximum adjustable dose. Due to the construction, the swept angle α is <360 °. In this case, the display device is arranged so that the attacks of the display device with complementary stops on the housing insert or alternatively to other parts of the housing at the zero position resp. the position of the maximum dose interact and thereby a movement of the display device below the zero position resp. is mechanically prevented beyond the maximum dose position. These complementary stops potentially further restrict the possible angle a to be swept (0 °> α> 360 °). The stops are dimensioned so that they can withstand a force (or torque), which is generated by energy from the energy storage, permanently.

In alternative embodiments of the display device, this is designed in several parts, in particular in two parts. In the two-part design, the dose compared to the above example is designed as a separate display drum, which is guided axially displaceably on the display device. On the outside of the display drum threaded elements are arranged, which are in engagement with an internal thread of the housing. Now, if the display device is rotated relative to the housing, for example for setting a dose, the display drum performs a helical movement. Accordingly, the dose scale on the display drum is also arranged in the form of a helix on the drum. Basically, this allows attaching more readable scale information.

In one aspect of the invention, the display device is operatively connected to the output member via a transmission unit. In particular, such that a rotation of the display device relative to the mechanism holder causes a displacement of the output member relative to the mechanism holder. In a simple embodiment according to the invention, the transmission unit is designed as a threaded connection between the output member and the display device. In this case, the thread pitch determines how much the output member shifts axially relative to the mechanism holder when the display device is rotated by a predetermined angle.

In a further possible embodiment, the transmission unit consists of a transmission. In this case, at least one gear is rotatably mounted in the distal region of the mechanism holder, which can rotate about an axis approximately perpendicular to the longitudinal axis of the injection device (with slight deviations from the vertical constructive reasons may make sense). The gear is designed so that it has two partial gears with different diameters and / or different numbers of teeth. Alternatively, two gears may be arranged one behind the other and be firmly connected to each other via a central axis of rotation. A partial gear, the input gear, receives relative rotation of the display device. For this purpose, a ring gear is arranged on the display device, which engages in the toothing of the input gear. If the display device rotates relative to the mechanism holder, then the input gear is set in rotation, whereby the second gear, the output gear is rotated. Due to the arrangement of the gear on the mechanism holder, the second part gear can forward the movement to the output member, wherein the rotation of the output gear is converted into a linear axial movement of the output member. For this purpose, an axially extending toothing is arranged on the output member, similar to a rack, which engages with the toothing of the output gear. By the appropriate choice of the diameter of the input and output gear, the transmitted from the display device on the driven member movement over or under set. The gears have in one embodiment via radially aligned teeth. The orientation can also be different, for example, bevel gears can be used as input and / or output gear.

The described two variants of the transmission units allow easy adaptation to various drugs or drug concentrations by changes to the transmission units, with which the over- or reductions can be changed.

The envisaged energy storage is in preferred forms a mechanical spring. It may be a pressure or a torsion spring, a spiral or clock spring would be possible. If a torsion spring is used, then the spring can be arranged kinematically between the dosing button and the display device and can be preloaded with enough energy before the first use that at least the entire contents of the medicament container can be administered with it. If a compression spring is used, the compression spring can be arranged between the output member and the mechanism holder. After assembly, the compression spring is then charged with enough energy so that the entire drug container can be administered.

In one aspect, dosing or push button against rotation of the mechanism holder, for example, secured against rotation by at least one suitable longitudinal guide.

According to another aspect of the invention, the injection device comprises various releasable couplings. A coupling may be disposed between the push button and the housing of the injection device. If the clutch is closed, the push button and all other elements, which are secured against rotation relative to the push button, can not rotate relative to the housing. Another coupling may be arranged between the display device and the push button. If this clutch is opened, then the push button and all other elements, which are secured against rotation relative to the push button, rotate relative to the display device. In the resting state of the injection device arranged in the injection device clutch spring (or clutch spring elements) act so that the clutch between the push button and the housing is open, and any coupling between the push button and display device is closed.

The housing of the injection device has on its lateral surface an opening or a window. Through this opening, the currently set dose is visible, which is arranged on the lateral surface of the display device.

The function of a general embodiment according to the invention will be briefly explained below. In this example, an injector injection device is described which permits the administration of multiple doses of a variable size drug. In this example, there is a coupling between the push button and the housing as well as a coupling between the push button and the display device. The former is open at rest and when setting and correcting a dose, the latter, however, closed. Furthermore, the injection device of this example comprises a compression spring as energy storage. The compression spring is clamped between the mechanism holder and the output member. For this purpose, the output member is cup-shaped, as a sleeve which is closed distally and is open proximally. The spring is dimensioned so that it can be inserted into the output member. The distal end of the output member correspondingly supports one end of the spring. The other end of the spring is supported at the proximal end of the mechanism holder. Now, if the output member is inserted during assembly of the injection device in the mechanism holder, the spring is tensioned and stores in the sequence sufficient energy to be able to pour out the entire contents of the drug container. The transmission unit is formed in this embodiment as a non-self-locking thread between the display device and output member.

To set a dose to be administered, the dosing button is rotated about the longitudinal axis of the injection device relative to the housing. Due to the different security against rotation, the push button, the mechanism holder, the output element, the display device and the transmission unit rotate with the dosing button. Through the corresponding opening in the housing then the set dose is visible. If too high a dose is set by mistake, it can be corrected by simply turning back the dosing knob. Due to the rotation of the display device, the display device has moved away from its zero position. The dosing button can be rotated until the radial stop for the maximum dose of the indicator engages the complementary stop of the housing insert or housing. Since the coupling between the push button and the display device is closed and the push button in turn is secured against rotation with respect to the dosing button, rotation of the dosing button beyond the maximum dose is prevented. The same applies to the zero position. Since the energy store already contains the energy needed to administer a dose, the metering movement does not involve accumulating energy. For example, in the case of a torsion or compression spring as an energy store, the relative position of the spring ends or of the spring fastening elements remains unchanged relative to each other during the metering movement. When the dose is set, the push button is depressed, closing the clutch between the push button and the housing first and then opening the clutch between the push button and the indicator. As a result, output member, mechanism holder, dosing and push button against rotation of the housing are secured against rotation. By contrast, in this state, the display device relative to the housing and other elements rotatable. The compression spring is stretched as mentioned between the output member and the mechanism holder. As a result, a force acts in the distal direction on the driven member. The output member is mounted axially displaceable in the mechanism holder and connected via a thread to the display device. As long as the clutch between the push button and the display device is closed, an axial movement of the output member is not possible. If the clutch is opened, then the display can rotate relative to the mechanism holder, wherein the range of motion is limited by the particular radial stops. Due to the threaded connection between the display device and the output member, the axial force of the compression spring acts on the display device via the thread. Since the thread is not designed to be self-locking, the display device is rotated by the force in rotation and the output member shifts in the distal direction. In this case, the pitch of the thread determines how much the output member is displaced in the distal direction per displayed dosage unit. Reached the display device again the zero position so come the particular radial stop of the display device for the zero position and the complementarily shaped stop of the housing insert or the housing with each other. As a result, a further rotation of the display device is prevented. As a result, the output member also stops. In a final step, the coupling between the display device and the push button is closed again, so that the display device is secured against rotation relative to the push button, and the coupling between the push button and the housing is opened. The injection device is thus again in a state in which a further dose can be set.

The described embodiment can be relatively easily adapted to different drugs and different drug concentrations. As mentioned, the transmission unit determines how much the output member shifts when the display device is rotated by a certain angle. In order to adapt in the described embodiment, the injection device to another drug or a different concentration, only two parts must be changed with the same design of the drug container. The display device must be adjusted in terms of scale. The transfer unit must be adapted to the new scale, which means that the thread pitch of the thread between output element and display device must be adapted to the new scale.

In a further aspect, the injection device comprises at least one sensor device which can qualitatively and / or quantitatively detect rotation of parts of the injection device relative to the housing. In one embodiment, a plurality of pulse generators can be arranged on the display device and at least one pulse sensor on the housing. In preferred variants, the pulse generators are arranged at regular intervals on the lateral surface of the display device. The pulse sensor is arranged locally on the housing such that the pulse generators are moved past the pulse sensor in a rotation of the display device relative to the housing and thereby trigger a pulse on the pulse sensor. The terms pulse generator and pulse sensor are to be interpreted broadly.

Thus, it may be the pulse sensor to one or more mechanical switches or buttons, which is actuated by trained as surveys on the display pulse generator momentarily. The switches or buttons are connected to an electronic circuit, which count the operation in particular. The elevations may be arranged in one embodiment on the circumference of the display device, in particular at regular intervals and at a same axial position. The distances can then represent individual dosing steps, and it is thus possible to determine the set dose via the number of switching operations. About the geometric shape and arrangement of the surveys can also be closed to the direction of rotation.

In a further variant, a simple cylindrical surface of the display device is the pulse generator. The pulse sensor is then designed as a rotatably mounted on the housing wheel which rotates about an axis which is parallel to the central axis of the injection device. The periphery of the wheel is in contact with the cylindrical surface and is driven by a relative rotation between the housing and the display device. A sensor connected to the wheel with associated electronics determines the rotation angle, the number of revolutions and the direction of rotation. Thus, the set dose can be determined via the rotation, including a possible correction of the dose.

The pulse generator can also be designed as a magnet and the pulse sensor as a magnetic sensor. Likewise, optical systems are conceivable in which a light source as a particular reflectors designed pulse position-dependent lights and designed as a light sensor with control electronics pulse sensor takes depending on the relative position between the light sensor and reflectors, the light pulses and converts them into an electrical signal which of the Control electronics can be evaluated, from which the set dose can be determined.

In a further possible embodiment, the pulse generator is not arranged on the display device, but on the push button, the mechanism holder, the output member, or another part which rotates when setting and correcting a dose relative to the housing, while the pulse sensor at best moved in the axial direction remains on the housing. The possibility of arranging impulse generators also on other parts which are not obvious at first glance lies in the nature of the injection device according to the invention, in which the metering movement is attended by most parts of the injection device. On a suitable part of the pulse generator can be carried out by means of a coding so that the pulse sensor at any time readily a possible current position of the part can read absolutely. Alternatively or additionally, the coding is designed such that the current position of the part relative to a reference position can be determined, for example by counting pulses.

The control electronics may include a display with which the specific dose can be displayed. Further, the control electronics include a memory in which information, in particular the dose history can be stored. The control electronics may also comprise a communication module with which information, in particular the dose history and in particular to computers and smart phones, can be transmitted. For this purpose, wireless connections via Bluetooth, NFC or WLAN can be used, or the information can be wired via USB in particular. The control electronics can be fixedly arranged on the injection device or accommodated in a preferred variant in a detachable from the injection device module.

For the skilled person directly and obviously further embodiments and embodiments can be seen, which result from combinations of the described examples or combinations of the examples described with the general knowledge of the skilled person. The examples listed here and in the following are intended to show basic possibilities of the invention and should in no way be construed restrictively.

characters

[0038] <Tb> FIG. 1: <SEP> Perspective view of a first embodiment <Tb> FIG. 2: <SEP> Exploded view of the first embodiment <Tb> FIG. 3a: <SEP> Top view of the distal end of the first embodiment <Tb> FIG. 3b: <SEP> Longitudinal section A-A through the first embodiment in the initial state <Tb> FIG. 3c: <SEP> Longitudinal section B-B through the first embodiment in the initial state <Tb> FIG. 4a: <SEP> Top view of the distal end of the first embodiment <Tb> FIG. 4b: <SEP> Longitudinal section E-E through the first embodiment at the end of the last of the emptying of the medicament container <Tb> FIG. 4c: <SEP> Longitudinal section F-F through the first embodiment at the end of the last emptying of the medicament container <Tb> FIG. 5: <SEP> Detail section through the proximal part of the first embodiment <Tb> FIG. 6: <SEP> Perspective view of a second embodiment <Tb> FIG. 7: <SEP> Exploded view of the second embodiment <Tb> FIG. 8a: <SEP> Top view of the distal end of the second embodiment <Tb> FIG. 8b: <SEP> Longitudinal section A-A through the second embodiment in the initial state <Tb> FIG. 8c: <SEP> Longitudinal section B-B through the second embodiment in the initial state <Tb> FIG. 9a: <SEP> Top view of the distal end of the second embodiment <Tb> FIG. 9b: <SEP> Longitudinal section E-E through the second embodiment at the end of the last of the emptying of the medicament container <Tb> FIG. 9c: <SEP> Longitudinal section F-F through the second embodiment at the end of the last of the emptying of the medicament container <Tb> FIG. 10a <SEP> Longitudinal section through the second embodiment with drawn cross-section K-K <Tb> FIG. 10b <SEP> Cross section K-K <Tb> FIG. 11 <SEP> Perspective view of a gear

figure description

In the following preferred forms of an injection device are described, for which the invention could find application, in particular Injektionspens, with automatic distribution. This description should by no means be construed restrictively, but merely show a possible embodiment.

In the first embodiment described below is a pen-drive injection pen, with which several doses can be administered at a selectable dose. The injection pen is designed as a one-off pen, which means that the pen is disposed of after complete emptying of the reservoir and can not be reused, for example, in which the medicament container is replaced. The injection pen of the first embodiment is shown in perspective in FIG. Fig. 2 shows the injection pen 1 in an exploded view. The injection pen 1 comprises a proximal housing 6 and a carpule holder 4. The housing 6 and the carpule holder 4 can be connected to one another via a snap connection. For this purpose, 4 snap projections 4a are attached to the proximal end of the carpule holder. At the distal end of the housing 6 corresponding complementary elements (not shown) are arranged on the inside thereof, which can verschnappen with the Schnapperhebungen 4a. The medicament container is in this first embodiment, a classic carpule 5, as used in many injection devices for use. It has a filling volume of 3 ml, although other sizes such as 1.6 ml, 2 ml, or 6 ml are conceivable and possible. The carpule is inserted into the carpule holder 4 during assembly. After snapping the housing 6 and carpule holder 4, the carpule 5 is fixed axially and radially, it is immovably mounted in the injection device 1.

At the distal end of the carpule holder, the commercially available injection needle 3 can be attached. The carpule holder 4 with and without attached injection needle 3 can be protected by the protective cap 2. Protective cap 2 can be attached to the carpule holder and fixed via a detachable snap connection (not shown).

In the housing 6 axially fixed and rotatably arranged is the mechanism holder 7, wherein the flanges 7a in an annular groove (not shown) are guided on the inside of the housing 6. At the flanges 7a, the grid arms 7b are arranged. If the mechanism holder 7 is rotated relative to the housing 6, the grid arms are guided over a toothing (not shown) arranged on the inside of the housing 6, which on the one hand leads to an audible noise as well as to a tactile feedback on the vibration caused. On the other hand, the mechanism holder 7 can thereby occupy in particular discrete preferential positions, the distances of which may preferably correspond to individual dose steps. Axially firmly snapped with the mechanism holder 7 is the display 8. For this purpose, the groove 7c is arranged at the distal end of the mechanism holder 7, in which the snap elements 8c of the display can engage 8 (see Fig. 3c). The display 8 is rotatably mounted on the mechanism holder 7. On the lateral surface of the display, the dose scale 8a is arranged (numbers not shown), which is visible through the window 6a of the housing (in the assembled state). Next, a radial two-sided stop 8e is arranged in the form of an axially oriented rib on the outside of the display 8.

The housing insert 10 is arranged axially fixed and rotationally fixed in the housing. On the housing insert 10 two complementary to the two-sided stop 8e radial stops 10a and 10b are arranged. These limit the rotation of the display 8 relative to the housing. The stop for the zero position 10a limits the rotation of the display 8 by engagement with the stopper 8e in counterclockwise rotation. The maximum dose stop 10b limits the rotation of the display 8 in a clockwise direction by engagement with the stop 8e of the display 8. The possible angle of rotation between the stops 10a and 10b thus determines the possible adjustable dose.

On the inside of the display 8 threaded elements 8b are arranged, which is in threaded engagement with the external thread 9a of the output member 9. The output member 9 is axially slidably mounted on the longitudinal groove 9b and secured against rotation in the mechanism holder 7. For this purpose, a longitudinal rib (not shown) is arranged on the inside of the mechanism holder 7, which engages the longitudinal groove 9b.

As can be seen in Figs. 3b and 3c, the output member 9 is formed sleeve-shaped. While the distal end of the driven member 9 is closed by the distal end surface 9c, the proximal end is open. The compression spring 11 is inserted into the proximal end of the output member 9. The distal end of the compression spring 11 is mounted on the distal end surface 9c. The proximal end of the compression spring 11 is supported by the closed proximal end surface 7d of the mechanism holder 7. When assembling the Injektionspens 1, the compression spring 11 is first inserted into the output member 9. Subsequently, the output element 9 is inserted against the force of the spring in the mechanism holder 7, whereby the compression spring 11 is tensioned and stores enough potential energy to empty the entire carpule 5.

At the proximal end of the housing, the Dosierknopf 13 is arranged, as shown in Fig. 3c. This Dosierknopf 13 is axially and rotationally fixed to the mechanism holder. Also at the proximal end of the housing 6, the push button 12 is arranged, which is guided through the Dosierknopf 13 into the interior of the injection pen 1. The two arms 12d lead up to the window 6a of the housing. The arms 12d thereby partially comprise the mechanism holder 7. The arms 12d are guided axially movably by the guides 7e of the mechanism holder 7 and secured against rotation.

As mentioned, the push button 12 is guided through the Dosierknopf 13 therethrough. The arms 12d are axially guided on the guide ribs 13a, so that a relative axial movement between the push button 12 and the metering button 13 is possible, but relative rotation is prevented. On the outside of the push button 12, the push button spring elements 12a are arranged. These push button spring elements 12a press against the inside of the dosing button 13. Their formal configuration (see FIG. 2) causes the push button to be pressed in the proximal direction. 5 shows a longitudinal section through the proximal region of the injection pen 1 through the push-button spring elements 12a. The push button spring elements 12a are chamfered at their distal end and press on the snap tooth 13b of the Dosierknopfs. If the push button 12 is now displaced in the distal direction, the push-button spring elements 12a are deflected radially inwards, which due to the elastic nature of the deformation results in a restoring force in the proximal direction. The movement of the push button in the proximal direction is limited by snapping between the snap teeth 13b and the snapper 12g. In the distal direction, the push button spring elements 12a limit the movement of the push button 12. This embodiment has two clutches. A first clutch K1 is coupled to the push button 12 releasably connected to the display 8. At the distal end of the arms 12d coupling members 12e are arranged, which are in the idle state of the Injektionspens 1 with complementary trained coupling members 8d of the display 8 in clutch engagement K1, whereby a rotation between the push button 12 and display 8 is formed.

A second clutch K2 releasably couples the push button 12 to the housing 6. On the jacket of the push button 12, the coupling members 12f are arranged. If the push button 12 is pressed in the distal direction against the force of the push button spring elements 12a, the coupling members 12f engage with coupling members 6b of the housing 6. In Fig. 3b the push button is in its rest position, in Fig. 4b the push button is in the distal direction pressed. The comparison of the two figures shows how the push button 12 and thus the coupling members 12f move in the distal direction and thus close the clutch K2. As a result, with the clutch K2 closed, the housing 6 and the push button 12 against rotation against each other.

In the resting state of the Injektionspens 1, the clutch K1 is closed and the clutch K2 is open. The coupling members 12e and 12f are now arranged so that when moving the push button 12 in the distal direction preferably K2 closes first and only upon further movement of the push button 12, the clutch K1 opens.

The push button is via the thread 12b in threaded engagement with the internal thread 14a of the stop ring 14. This stop ring 14 is mounted axially displaceable but secured against rotation in the housing 6. For this purpose, 14 longitudinal ribs 14 b are arranged on the outside of the stop ring, which are guided on the inside of the housing by guides (not shown). On its proximal side 14 radial stops 14 c are arranged on the stop ring, which engage with radial stops 12 c of the push button when the stop ring 14 is screwed to the proximal end of the thread 12 b. The function of the stop ring 14 is to prevent a setting of a dose which is greater than the remaining amount of medicament still present in the carpule 5. The exact functionality will be explained in more detail below.

In the following, the mode of operation of the injection pen 1 will now be explained. The injection pen 1 is delivered to the person using the carpule inserted. Before use, the protective cap 2 is removed, and placed the injection needle 3. Then - if necessary - a venting of the carpule done, so-called priming. To set a dose, proceed as follows (priming is analogous to a small set dose and without piercing the injection needle into tissue). The Dosierknopf 13 is rotated clockwise relative to the housing 6. Due to the existing anti-rotation lock, the push button 12, the mechanism holder 7, the output member 9 rotate with the Dosierknopf 13 with. Since the push button 12 remains in setting its dose in its proximal rest position, K1 is closed, whereby the display 8 against the dose knob 13 is secured against rotation and rotates when dosing with the Dosierknopf 13. As a result, mechanical holder 7, output member 9 and display 8 are secured against rotation to each other in this state, which also causes the compression spring 11 rotates, the relative axial position of the output member 9 and the mechanism holder 7 remains unchanged, and the compression spring is neither tensioned nor relaxed becomes. Since the display 8 rotates with the Dosierknopf 13, the set dose in the window 6a can be read. If too high a dose is set by mistake, the dosing knob can simply be turned back in the opposite direction until the desired dose is reached. The possible rotation of the dose knob 13 in adjusting and correcting the dose is limited by the radial stops 10a and 10b which engage the radial stop 8e of the display 8 at the zero position and the maximum adjustable dose because the indicator 8 faces the dosing button is secured against rotation.

After the desired dose is now set, the injection needle 3 is inserted at the desired location in tissue. Then, the push button 12 is moved in the distal direction, whereby K2 is first closed and K1 is opened upon further movement. The closing of K2 causes the push button 12 and, in consequence, the dosing knob 13, the mechanism holder 7 and the output member 9 to be secured against rotation relative to the housing 6 via the anti-rotation devices. As long as K1 is still closed, the display 8 is secured against rotation with respect to the housing. If the push button 12 is moved further in the distal direction, K1 is opened. Now, the display 8 against the push button 12 is no longer secured against rotation and thus rotatable relative to the mechanism holder 7. Between the display 8 the output member 9 is the mentioned threaded connection. The compression spring 11 exerts a force in the distal direction on the distal end surface 9c of the driven member 9. Since the output member 9 is slidably mounted in the mechanism holder 7, so there is a force which can cause a displacement of the output member 9 in the distal direction. The display 8 is still mounted axially fixed on the mechanism holder after the opening of K1, but is now rotatable relative to the housing 6 and the mechanism holder 7 (in the area between the stops 10a and 10b). Since the threaded connection between output member 9 and display 8 is not designed to be self-locking, induces the force of the compression spring 11 on the output member 9, thus on the threaded connection and in consequence on the axially fixed display, a rotation of the display 8 in the counterclockwise direction back to the zero position , Due to the rotation of the display 8 relative to the output member 9, the output member 9 shifts relative to the display 8 and thus to the mechanism holder 7 and the housing 6 in the distal direction. The distal end surface 9 then presses on the plug 5a of the carpule 5 and causes a displacement of the plug 5a in the distal direction, whereby the volume is reduced in the carpule 5 and finally drug is pressed through the pen needle 3 into the tissue. The display 8 rotates until the radial stop 8e comes into engagement with the stop 10a for the zero position. The engagement stops the rotation, which also stops the movement of the output member 9 in the distal direction. The push button 12 can now be released and moves, driven by the restoring force of the push button spring elements 12, back to the starting position, whereby the first clutch K1 is closed and then the clutch K2 is opened. The next dose can then be adjusted at the injection pen.

When setting a dose, the Dosierknopf 13 is rotated relative to the housing 6. Thus, the push button 12 is rotated relative to the housing 6. As mentioned above, the arms 12d are in threaded engagement with the stop ring 14, which in turn is mounted axially displaceable but secured against rotation in the housing 6. If a dose is set, then the stop ring 14 moves induced by the rotation of the push button 12 in the proximal direction. When administering a set dose, the push button 12 is due to the closed clutch K2 as the stop ring 14 against rotation secured against the housing 6 and there is no relative movement between the stop ring 14 and push button 12 instead. Each time a new dose is adjusted, the stop ring continues to move in the proximal direction (or distally with a decrease in the dose just set) until the radial stops 14c of the stop ring and 12c of the push button engage in increasing the dose just set advised, whereby a further relative rotation between the stop ring 14 and push button 12 is inhibited and consequently prevents further increase of the dose just set by turning the Dosierknopfs 13 relative to the housing. It will be readily appreciated by those skilled in the art that this function may be used to prevent the setting of a dose exceeding the residual amount of drug present in the carpule 5. For this purpose, the distance between the starting position (i.e., at full carpule) of the stop ring 14 relative to the radial stop 12c of the push button 12 is selected such that it exceeds or understates the amount of medication present in the carpule 5 and / or dispensed in total.

The second embodiment of the invention shown is also a spring-driven injection pen. This injection pen 100 is shown in FIG. 6 and does not differ externally from the injection pen 1. FIG. 7 shows an exploded view of the injection pen 100 showing some differences between the pen 1 and the pen 100. FIGS. 8a to 10b show various sections through the injection pen 100. Differences arise in mechanics.

The first difference can be found in the drive spring. Spring 111 is a torsion spring which, when assembling the injection pen 100, is tensioned by as many turns as to store enough energy to deflate the entire contents of the carpule 5. The torsion spring 111 is stretched between the Dosierknopf 113 and the display 108 and connected to the respective ends 111a, 111b with the display 108 and the Dosierknopf 113 firmly, in particular form-fitting, to the spring mounting element 108e and 113a (see Fig. 10a). As explained below, display 108 and push button 112 are in the idle state of the injection pen 100 against rotation secured against each other via the clutch K1, so that the torsion spring 111 at rest can neither tension nor relax.

Another difference arises in the transmission unit which operatively connects the display 108 to the output member 109. Display 108 and output member 109 are connected to each other via at least one, preferably two gears 115. In this case, the toothed wheels 115 each have two partial gears 115a and 115b, respectively, which have different diameters, in particular pitch diameters. This means that movement of the display is not transmitted 1: 1 to the output member 109, but the movement is over- or understated.

Firmly anchored in the injection pen 100 is the housing insert 110 with the stops for the zero position 110a or for the maximum adjustable dose 110b. Snapped with the housing insert 110 is the mechanism holder 107. In this case, the mechanism holder 107 is rotatably mounted on the housing insert 110. Movement in the proximal direction of the mechanism holder 107 relative to the housing insert 110 is prevented by the flange 107f. In the opposite direction, the snap 107g block the relative movement. Inserted into the mechanism holder 107 is the output member 109. In this case, the output member 109 is axially displaceably mounted but secured against rotation in the mechanism holder 107. The driven member is designed as a piston rod and has a non-circular cross-section except for the region of the distal end surface 109c. The output member 109 has two axial guide grooves 109d (see FIG. 10b). Complementarily, the mechanism holder 107 has the guides 107e (shown only from the outside, see FIG. 7), which engage in the grooves 109d and thus guide the output member. In the proximal region of the mechanism holder 107, the groove 107c extends circumferentially. In the distal region of the mechanism holder 107, the gears 115 are arranged. The axis of rotation Q of the gears 115 stands transversely to the longitudinal axis L of the Injektionspens 100, wherein the axes L and Q intersect in particular. The gears 115 are supported by the mechanism holder via the bearing pin 115c, the bearing surface 115d and the support 115e so that they can rotate about the axis Q. A gear of the second embodiment is shown in FIG. 11. The partial gears 115a and 115b are clearly visible. The bearings 115c, 115d, 115e can be seen in this illustration. Fig. 10b shows the arrangement of the output member 109, mechanism holder 107, two gears 115 and the display 108 in the assembled state. The display 108 holds the two gears 115 in their bearing in the mechanism holder 107. Alternatively, it would also be possible that adapted gears would be snapped with the mechanism holder 107 in the region of the bearing 107h and rotatably supported.

The display 108 is formed in the second embodiment as an elongated sleeve, in which the mechanism holder 107 can be inserted. In the proximal area of the display 108, the snap ribs 108c (see FIG. 8c) are formed complementary to the groove 107c, by means of which the display 108 can be axially fixedly connected to the mechanism holder 108 so that relative rotation between the mechanism holder 107 and the display 108 remains possible , In the distal region of the display 108, the scale drum 108a is arranged. Compared to the rest of the display 108, the scale drum 108a has a larger diameter. In preferred embodiments of the display 108, this may be formed integrally with the scale drum 108a. Alternatively, it is also possible that the display is composed of several parts, for example from the scale drum and a second sub-sleeve. On the outside of the scale drum 108a a metering scale is arranged, which is visible through the window 106a of the housing. As can be seen in FIG. 7, the display 108 has a toothing 108b. The toothing 108b extends over the entire circumference, the individual teeth are directed axially in the distal direction. The toothing 108b engages in the assembled state of the injection pin 100 in the toothings of the partial gears 115b and is thus functionally connected to the gears 115. As a consequence, relative rotation about the axis L between the mechanism holder 107 and the display 108 results in the gears 115 being rotated.

The driven member 109 is formed as mentioned as a piston rod. The grooves 109b have a base and two side surfaces. In each case one of the side surfaces has a toothing 109d, which engages in the assembled state in the toothing of a partial gear 115a and is thus functionally connected to one of the gears 115. This has the consequence that when the gears 115 rotate about the axis Q, that then the output member 109 moves in the axial direction.

The teeth 108b together with the gears 115 and the teeth 109d together form the transmission device of the injection pen. That is, when the display 109 is rotated relative to the mechanism holder 107, the gears 115 are rotated, and as a result, the output member 109 moves in the axial direction. About the size ratio of the pitch circle diameter of the gear teeth 115a and 115b and the pitch circle diameter of the teeth 108b results in a translation or reduction of the relative movement between display 108 and output member 109th

The Dosierknopf 113 is rotatably but snapped axially fixed to the housing 106, to the dosing 113, the Schnapper 113b and on the inside of the housing 106 a complementary recess (not shown) are arranged. The push button 112 is rotationally fixed and axially movable connected to the Dosierknopf 113 and is inserted into the Dosierknopf 113. At the same time, the push button 112 is rotatably snapped with the housing 106 as described below. In the axial direction of the push button 112 relative to the housing 106 is movable to a certain extent. The snap arms 112b of the push button limit the movement of the push button 112 in the proximal direction due to the mentioned complementary recess on the housing, which also holds the Dosierknopf 113. In the distal direction, the movement of the push button 112 is limited by the Dosierknopf. Between the Dosierknopf 113 and the push button 112, the push button spring 112a is clamped and pushes the push button 112 in the proximal direction. In the rest position, the push button 112 is in its proximal end position. The push button 112 is connected via the teeth 112c (see Fig. 7) with the teeth 107i of the mechanism holder 107, with the effect of the push button 112 and mechanism holder 107 are secured against rotation to each other, but can move axially to each other.

As in the first embodiment, the second embodiment includes two clutches, see Figs. 7 and 9b. K1 is a coupling with which the push button 112 is coupled to the display 108. At rest, this clutch is closed. It is formed by the clutch teeth 112d on the push button 112 and 108d on the display 108. In Fig. 9b, the push button 112 is displaced in the distal direction and the clutch K1 is opened, which means that a relative rotation between the push button 112 and the Display 108 is possible. In contrast, Fig. 8b shows the push button 112 in its rest position (ie, proximal), in this state, the clutch K1 closed and a relative rotation between the push button 112 and display 108 is not possible. K2 is a coupling with which the push button 112 can be coupled to the housing 106. The clutch K2 is closed, in which the push button 112 is displaced in the distal direction. As a result, the coupling members 106b of the housing engage with the coupling members 112e of the push button 112, whereby the push button 112 is secured against rotation with respect to the housing 106 (see FIGS. 7, 8b and 9b). The clutch teeth 112d and the clutch members 112e are disposed on the push button such that upon movement of the push button 112 in the distal direction, K2 is first closed, and thereafter the clutch K1 is opened.

The torsion spring 111 of the injection pen 100 is tensioned during assembly of the injection pen.

For the person using, the injection pen 100 functions the same as the injection pen 1. For setting or correcting a dose, the user rotates the dosing button 113 about the axis L, thus the corresponding dose is visible through the window 106a, because it coincides with the Dosierknopf 113 due to the different anti-rotation and the push button 112, the mechanism holder 107, the output member 109 and due to the closed state of the push button 112 clutch K1 also turn the display 108. The torsion spring 111, in particular the ends 111a and 111b of the torsion spring, makes the rotational movement with. Since push button 112 and display 108 rotate at identical angles, the torsion spring 111 is neither tensioned nor relaxed. To increase the dose, the dosing knob 113 is rotated clockwise to correct in the opposite direction. Zero position and position of the maximum dose are marked by the radial stops 108e, 110a and 108g, 110b. The display 108 can therefore only be moved over an angle of less than 360 °. As a result, the rotation of the dosing button 113 is also limited by the clutch K1. When the desired dose is set, the push button 112 is moved by pushing in the distal direction, as previously mentioned, the clutch K2 is first closed and then the clutch K1 is opened. By closing K2, the push button 112 and the proximal end 111b of the torsion spring 111, the metering button 113, the mechanism holder 107 and the output member 109 are rotationally fixed with respect to the housing. By subsequently opening K1, the display 108 may rotate relative to the push button 112. Since the torsion spring 111 is biased, a torque acts on the display 108, which after the opening of the clutch K1, the display 108 in rotation (relative to the elements which are secured against rotation with respect to the housing). Thus, the display 108 rotates counterclockwise from the set dose toward the zero position at which the rotation of the display 108 relative to the housing 106 is stopped by the radial stops 108e and 110a. As already mentioned above, a relative rotation between display 108 and mechanism holder 107 causes a rotation of the gears 115 and consequently a displacement of the output member 109 in the axial direction. A relative rotation of the display 107 in the counterclockwise direction causes an axial displacement of the output member 109 in the distal direction. As a result, the distal end surface 109c of the output member 109 can displace the plug 5a of the carpule 5 in the distal direction, whereby medicament is squeezed out of the carpule 5. After the stops 108e and 110a are engaged and the movement is stopped, it is possible to stop pressing the pushbutton 112, whereby the pushbutton 112 again moves into the proximal rest position via the action of the pushbutton spring 112a. During the movement, first the clutch K1 is closed and subsequently the clutch K2 is released. The injection pen 100 is then ready for the next dose selection.

Injection pen 100 has no function in the version shown with which the setting of a dose exceeding the residual amount of medicament present in the carpule 5 is prevented. However, this function could be realized in Injektionspen 100 analogous to Injektionspen 1. For this purpose, the push button 112 would have to be extended in the distal direction and provided on its outside with an external thread. Accordingly, a stop ring would then be arranged on the thread, which would be mounted veschiebbar against the housing but secured against rotation.

In the variants shown, the output members 9, 109 described in the two embodiments have distal end surfaces 9c, 109c, which displace the plug 5a of the carpule 5 in the distal direction. As can be seen from the above description, the output members 9, 109 rotate in adjusting respectively correcting a dose relative to the plug 5a. As a result, in order to adjust or correct a dose, friction must be overcome between the proximal end surface of the plug 5a and the distal end surface 9c, 109c. This can have a negative effect on the dosing experience of the person using it, since on the one hand the person has to apply additional force while dosing, on the other hand sticking out the dosing can become sticky. It is also the case that it should be avoided that the stopper 5a of the carpule 5 or the carpule 5 itself rotate during the metering movement in order to be able to ensure the closure integrity ("container closure integrity") of the carpule 5. Therefore, the output members 9, 109 in advantageous embodiments of the two embodiments, a plurality of parts, in particular in two parts, configured. The distal end surfaces 9 c, 109 c, are designed as separate flanges, which are arranged via a low-friction and momentary connection to the output members 9, 109. For this purpose, flange and driven member can be snapped together. The snap connection can be designed as a low friction sliding bearing. By way of example, at the distal end of the driven member 9, 109 a ball head can be arranged, which is snapped with a complementary cavity on the flange. If the output member 9, 109 is now rotated during the dosing process relative to the plug 5a, the relative rotation between the flange and the output member 9, 109 can take place with little friction. For this purpose, the selection of the materials of flange and driven member 9, 109 is also advantageous in that the friction between the two elements is minimized. As materials, polyoxymethylene, polybutylene terephthalate or fiber-reinforced polymers, such as polyamides can be used by way of example. Alternatively, such a multi-part design can be dispensed with by reducing the friction between plug 5a and the distal end surfaces 9c, 109c by suitable material pairing and / or shaping, in particular by using lubrication.

Further, the following can be noted An injection device for administering a fluid medicament substance, at least comprising an elongate housing (6.106) having a fixed insert (10, 110) and a longitudinal axis L, a medicament substance container holder (5) attached to the distal end of the housing (6, 106) and containing a movable medicament expressing member (5a); an energy store (11, 111) which releases energy for administering drug substance, wherein the energy store can store enough energy to be able to empty at least a whole drug substance container (5), a sleeve-shaped mechanism holder (7, 107) which is axially fixed but rotatably mounted on the insert (10, 110) about the longitudinal axis L, a metering element (13, 113), which is axially fixed but rotatable about the axis L at the proximal end of the housing (6, 106), wherein the metering element (13, 113) for setting a dose about the axis L relative to housing ( 6, 106) can be rotated a push-button (12, 112), which is arranged secured against rotation on the dosing element (13, 113) and extends through the dosing element (13, 113), wherein the push-button is secured against rotation and slidably connected to the mechanism holder by the region extending through the dosing element is a sleeve-shaped display element (8, 108), which is axially fixed and rotatably mounted on the mechanism holder (7, 107), an elongate output device (9, 109), in particular a piston rod, which is rotatably and axially along the axis L slidably mounted in the mechanism holder (7, 107), wherein the output device (9, 109) in displacement in the distal direction of the movable element (5a ) can move to squeeze drug substance, a first clutch (K1, K1), with which the push button (12, 112) and the display element (8, 108) can be coupled in a rotationally fixed manner, a second clutch (K2, K2) with which the push-button (12, 112) and the housing (6, 106) can be non-rotatably coupled, a transmission device which operatively couples the display element (8, 108) to the output device such that rotation of the display element (8, 108) relative to the mechanism holder (7, 107) causes axial displacement of the output element (9, 109) relative to the mechanism holder (10). 7, 107) and vice versa, wherein the clutches (K1, K1, K2, K2) are actuated via an axial displacement of the push button, characterized in that when setting and correcting a dose, the first clutch (K1, K1) is closed, the second clutch (K2, K2) is opened, the dose is adjusted by rotating the dosing knob (13, 113) the push button (12, 112) is moved in the distal direction for administering the set dose, thereby first closing the second clutch (K2, K2) and then opening the first clutch (K1, K1) and during the administration of the energy storage (11, 111) acts on the display element (8, 108), which rotates and the transmission device causes an axial displacement of the output device (9, 109). An injection device, characterized in that on the outside of the display element (8, 108), a dose scale (8a, 108a) is arranged, which is partially visible through the opening or the window (6a, 106a) and in setting and correcting a dose the set dose in the opening or the window of the housing (6a, 106a) is read. An injection device, characterized in that the transmission device is formed by a threaded connection (8b, 9a) between the display element (8) and the output member (9). An injection device, characterized in that the energy store (11, 111) is a compression spring (11) which is biased between a bearing surface (9c) of the output member (9) and a bearing surface (7d) of the mechanism holder (7). An injection device, characterized in that the transmission device comprises at least one toothed wheel (115), wherein the at least one toothed wheel (115) is mounted rotatably about an axis (Q) on the mechanism holder (107) and the axis (Q) is transverse to the longitudinal axis (L), further characterized that the indicator member (108) is in operative engagement with the gear (115) and rotation of the indicator member (108) about the axis L relative to the mechanism holder (107) causes the at least one gear (115) to rotate about the axis (Q); and that the at least one gear (115) is in operative engagement with the output member (109) and rotation of the at least one gear (115) about the axis (Q) results in displacement of the output member (109) relative to the mechanism holder (107). An injection device according to claim 5, characterized in that the display element (108) comprises a toothing (108b) which is arranged on the inside of the sleeve-shaped display element and whose individual teeth are aligned in the axial direction. An injection device, characterized in that the driven member (109) comprises an axially extending toothing (109d) whose individual teeth are approximately perpendicular to the longitudinal axis (L). An injection device according to claims 6 and 7, characterized in that the toothing (108b) of the display element (108) in a first toothing (115b) of the gear (115) engages and the toothing (109d) of the output member (109) in a second Teeth (115a) of the gear (115) engages. An injection device, characterized in that the toothings (115a, 115b) are arranged on partial gears (115a, 115b) which have identical or different pitch circle diameters. An injection device, characterized in that the partial gears have different pitch diameters and either together form a one-piece gear (115) which is made of one part or consists of at least two parts which are assembled into a gear (115) and then immovably connected to each other are. An injection device, characterized in that the energy store (11, 111) is a torsion spring (111) comprising a distal spring end (111a) and a proximal spring end (111b), the distal spring end (111a) being fixedly attached to a spring attachment element (108f ), the indicator member (108) is disposed and the proximal spring end (111b) is fixedly secured to a spring attachment member (113a) of the metering member (113) and the torsion spring 111 is biased by relative rotation of the metering member (113) and indicator member (108) , An injection device, characterized in that the housing insert (10, 110) at least one radial stop (10a, 10b, 110a, 110b) and the display element (8, 108) complementary thereto at least one radial counter-stop (8e, 108e, 108g) wherein the cooperation of the at least one radial stop with the at least one radial counter stop limits the relative rotation between the display element (8, 108) and the housing insert (10, 110) in at least one direction. An injection device, characterized in that the rotation of the Dosierknopfes (13, 113) relative to the housing (6, 106) when setting and correcting a dose by at least one sensor is detected qualitatively and / or quantitatively, wherein the at least one sensor generates a sensor signal wherein the sensor signal is evaluated by an electronic circuit provided on the injection device. An injection device, characterized in that the sensor detects the rotation of the Dosierknopfes at least quantitatively and outputs a quantitative sensor signal and that the electronic circuit can convert the quantitative sensor signal into the effectively set dose. An injection device, characterized in that the electronic circuit has a display which can display the calculated dose.

identifiers

LIST OF REFERENCE NUMBERS

[0068] <Tb> 1 <September> injection pen <Tb> 2 <September> cap <tb> 3 <SEP> Pen needle <Tb> 4 <September> carpule holder <Tb> 4 <September> Snap Survey <Tb> 5 <September> carpule <Tb> 5 <September> Plug <Tb> 6 <September> Housing <Tb> 6 <September> Window <Tb> 6b <September> coupling member <Tb> 7 <September> mechanism holder <Tb> 7 <September> flange <Tb> 7b <September> Rasterarm <Tb> 7c <September> Nut <tb> 7d <SEP> proximal end surface <Tb> 7e <September> Leadership <Tb> 8 <September> Display <Tb> 8 <September> Skala <Tb> 8b <September> threaded element <Tb> 8c <September> snap element <Tb> 8d <September> coupling member <tb> 8e <SEP> Radial stroke <Tb> 9 <September> driven member <Tb> 9 <September> external thread <Tb> 9b <September> longitudinal groove <tb> 9c <SEP> distal end surface <Tb> 10 <September> housing insert <tb> 10a <SEP> Stop zero position <tb> 10b <SEP> stop maximum dose <Tb> 11 <September> spring <Tb> 12 <September> Pushbutton <Tb> 12 <September> button spring arms <Tb> 12b <September> Thread <tb> 12c <SEP> radial stop <Tb> 12d <September> Arm <Tb> 12e <September> coupling member <Tb> 12f <September> coupling member <Tb> 12g <September> snapper <Tb> 13 <September> dose <Tb> 13 <September> guide rib <Tb> 13b <September> Snaptooth <Tb> 14 <September> Stop Ring <Tb> 14 <September> internal thread <Tb> 14b <September> longitudinal rib <Tb> 14c <September> stop <Tb> <September> <Tb> 100 <September> injection pen <Tb> 106 <September> Housing <Tb> 106 <September> Window <Tb> 106b <September> coupling member <Tb> 107 <September> mechanism holder <Tb> 107c <September> Nut <Tb> 107e <September> Leadership <tb> 107f <SEP> distal flange <Tb> 107g <September> snapper <Tb> 107h <September> Bearings <Tb> 107i <September> teeth <Tb> 108 <September> Display <Tb> 108 <September> thimble <Tb> 108b <September> teeth <Tb> 108c <September> Snap ribs <Tb> 108d <September> Kupplungszahnung <tb> 108e <SEP> radial stop zero position <Tb> 108f <September> spring fastener <tb> 108g <SEP> radial stop maximum dose <Tb> 109 <September> driven member <Tb> 109b <September> guide <tb> 109c <SEP> distal end surface <Tb> 109d <September> teeth <Tb> 110 <September> housing insert <tb> 110a <SEP> Stop zero position <tb> 110b <SEP> stop maximum dose <Tb> 111 <September> torsion <tb> 111a <SEP> distal end of spring <tb> 111b <SEP> proximal end of spring <Tb> 112 <September> Pushbutton <Tb> 112 <September> button spring <Tb> 112b <September> latch arm <Tb> 112c <September> teeth <Tb> 112d <September> Kupplungszahnung <Tb> 112e <September> coupling element <Tb> 113 <September> dose <Tb> 113 <September> spring fastener <Tb> 113b <September> snapper <Tb> 115 <September> Gear <Tb> 115 <September> partial gear <Tb> 115b <September> partial gear <Tb> 115c <September> journals <Tb> 115d <September> warehouse space <Tb> 115e <September> support <Tb> <September> <Tb> L <September> longitudinal axis <Tb> Q <September> transverse axis <Tb> K1 <September> Clutch <Tb> K2 <September> Clutch <tb> K1 <SEP> Clutch <tb> K2 <SEP> Clutch

Claims (15)

An injection device for administering a fluid medicament substance comprising at least an elongate housing (6.106) having a fixed insert (10, 110) and a longitudinal axis L, a medicament substance container holder (5) attached to the distal end of the housing (6, 106) and containing a movable medicament expressing member (5a); an energy store (11, 111) which releases energy for administering drug substance, wherein the energy store can store enough energy to be able to empty at least a whole drug substance container (5), a sleeve-shaped mechanism holder (7, 107) which is axially fixed but rotatably mounted on the insert (10, 110) about the longitudinal axis L, a metering element (13, 113), which is axially fixed but rotatable about the axis L at the proximal end of the housing (6, 106), wherein the metering element (13, 113) for setting a dose about the axis L relative to housing ( 6, 106) can be rotated a push-button (12, 112), which is arranged secured against rotation on the dosing element (13, 113) and extends through the dosing element (13, 113), wherein the push-button is secured against rotation and slidably connected to the mechanism holder by the region extending through the dosing element is a sleeve-shaped display element (8, 108), which is axially fixed and rotatably mounted on the mechanism holder (7, 107), an elongate output device (9, 109), in particular a piston rod, which is rotatably and axially along the axis L slidably mounted in the mechanism holder (7, 107), wherein the output device (9, 109) in displacement in the distal direction of the movable element (5a ) can move to squeeze drug substance, a first clutch (K1, K1), with which the push button (12, 112) and the display element (8, 108) can be coupled in a rotationally fixed manner, a second clutch (K2, K2) with which the push-button (12, 112) and the housing (6, 106) can be non-rotatably coupled, a transmission device which operatively couples the display element (8, 108) to the output device such that rotation of the display element (8, 108) relative to the mechanism holder (7, 107) causes axial displacement of the output element (9, 109) relative to the mechanism holder (10). 7, 107) and vice versa, wherein the clutches (K1, K1, K2, K2) are actuated via an axial displacement of the push button, characterized in that when setting and correcting a dose, the first clutch (K1, K1) is closed, the second clutch (K2, K2) is opened, the dose is adjusted by rotating the dosing knob (13, 113) the push button (12, 112) is moved in the distal direction for administering the set dose, thereby first closing the second clutch (K2, K2) and then opening the first clutch (K1, K1) and during the administration of the energy storage (11, 111) acts on the display element (8, 108), which rotates and the transmission device causes an axial displacement of the output device (9, 109). 2. Injection device according to claim 1, characterized in that on the outside of the display element (8, 108), a Dosisskala (8a, 108a) is arranged, which through the opening or the window (6a, 106a) is partially visible and when adjusting and correcting a dose of the set dose in the opening or window of the housing (6a, 106a) is read. 3. Injection device according to claim 1 or 2, characterized in that the transmission device by a threaded connection (8b, 9a) between the display element (8) and the output member (9) is formed. 4. Injection device according to claim 3, characterized in that the energy store (11, 111) is a compression spring (11) which is biased between a bearing surface (9c) of the output member (9) and a bearing surface (7d) of the mechanism holder (7) , 5. Injection device according to claim 1 or 2, characterized in that the transmission device comprises at least one toothed wheel (115), wherein the at least one gear (115) about an axis (Q) is rotatably mounted on the mechanism holder (107) and the axis (Q) transverse to the longitudinal axis (L), further characterized in that the indicator member (108) is in operative engagement with the gear (115) and rotation of the indicator member (108) about the axis L relative to the mechanism holder (107) causes the at least one gear (115) to rotate about the axis (Q); and that the at least one gear (115) is in operative engagement with the output member (109) and rotation of the at least one gear (115) about the axis (Q) results in displacement of the output member (109) relative to the mechanism holder (107). 6. Injection device according to claim 5, characterized in that the display element (108) comprises a toothing (108b) which is arranged on the inside of the sleeve-shaped display element and whose individual teeth are aligned in the axial direction. 7. Injection device according to claim 5, characterized in that the output member (109) comprises an axially extending toothing (109d) whose individual teeth are approximately perpendicular to the longitudinal axis (L). 8. Injection device according to claims 6 and 7, characterized in that the toothing (108b) of the display element (108) in a first toothing (115b) of the gear (115) engages and the toothing (109d) of the output member (109) in a second Teeth (115a) of the gear (115) engages. 9. Injection device according to claim 8, characterized in that the toothings (115a, 115b) are arranged on partial gears (115a, 115b) which have identical or different pitch circle diameters. 10. Injection device according to claim 9, characterized in that the partial gears have different pitch circle diameter and either together form a one-piece gear (115) which is made of one part or consist of at least two parts, which are assembled into a gear (115) and then immovably connected to each other. 11. Injection device according to one of claims 8 to 10, characterized in that the energy store (11, 111) is a torsion spring (111) which comprises a distal end of the spring (111a) and a proximal spring end (111b), wherein the distal end of the spring ( 111a) is fixedly arranged on a spring attachment element (108f) of the display element (108) and the proximal spring end (111b) is fixedly arranged on a spring attachment element (113a) of the metering element (113), and the torsion spring 111 is rotated by a relative rotation of metering element (113 ) and display element (108) is biased. 12. Injection device according to claim 1, characterized in that the housing insert (10, 110) at least one radial stop (10a, 10b, 110a, 110b) and the display element (8, 108) complementary thereto at least one radial counter-stop (8e, 108e , 108g), wherein the cooperation of the at least one radial stop with the at least one radial counter-stop limit the relative rotation between the display element (8, 108) and the housing insert (10, 110) in at least one direction. 13. Injection device according to claim 1, characterized in that the rotation of the Dosierknopfes (13, 113) relative to the housing (6, 106) when setting and correcting a dose by at least one sensor is detected qualitatively and / or quantitatively, wherein the at least one Sensor generates a sensor signal, wherein the sensor signal is evaluated by a provided on the injection device electronic circuit. 14. Injection device according to claim 13, characterized in that the sensor detects the rotation of the Dosierknopfes at least quantitatively and outputs a quantitative sensor signal and that the electronic circuit can convert the quantitative sensor signal into the effectively set dose. 15. Injection device according to claim 14, characterized in that the electronic circuit has a display which can display the calculated dose.