CH710119A2 - An injection device with a sequencer. - Google Patents

Abstract

According to a first aspect of the invention, an injection device is described, inter alia, with a blocking device which can be switched from a blocking state into a release state. In its blocking state, the blocking device prevents a plunger (7) from being moved in the distal direction, and in its release state allows the plunger (7) to be moved in the distal direction by muscle power about a delivery stroke. By moving a needle protection sleeve (2) from its initial position to its puncturing position, the blocking device is switched from the blocking state into the release state. According to a second aspect of the invention, an injection device with a locking device, which is switchable by means of the displacement of a plunger (7) in the distal direction from a deactivated state to an activated state, is described. In the deactivated state of the locking device, the needle protection sleeve (2) between its initial position and its piercing position is repeatedly displaced back and forth. In the activated state of the locking device, the needle protection sleeve (2) from its puncture position once in the needle protection position in which movement of the needle guard is blocked in the puncture position, displaced.

Description

The invention is in the field of injection devices for administering a liquid product, in particular medicament. In particular, the injection device can be manually actuable or be such that the force required for the release of the product is applied manually or by muscle power of the user of the device. In contrast, there are auto-injectors in which the force for the release of the product is applied, for example by means of a spring.

The term "medicament" as used herein encompasses any flowable medical formulation which is suitable for controlled administration by an agent, such as e.g. a cannula or hollow needle, for example, comprising a liquid, a solution, a gel or a fine suspension containing one or more medicinal agents. "Drug" may be a single drug composition or a premixed or co-formulated multi-drug composition from a single container. Drug includes drugs such as peptides (eg, insulins, insulin-containing drugs, GLP-1 containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active agents, hormone or gene based drugs, nutritional formulas, enzymes, and other substances both in the art solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or Oglionukleotide, antibodies or parts of antibodies and suitable base, excipients and carriers.

From WO 2014/056 635 A1 discloses an injection device is known which has a housing, wherein at the distal end of the housing a needle protection sleeve protrudes from the housing, which in an initial state, the needle tip of a needle disposed in the housing product container covering, wherein by moving the needle guard in the proximal direction, the needle emerges from the distal end of the needle guard. At the proximal end of the housing, a dispensing button protrudes from the housing, which is manually pushed into the housing for dispensing or dispensing the product, thereby ejecting product from the product container via the needle. The needle protection sleeve and the operating knob can be operated independently of each other. As a result, the following mistranslations are possible: the needle guard can be locked by moving it from the puncture position to the needle guard position without spilling product and Product can be spilled without the needle being pierced.

It is an object of the invention to provide an injection device, in particular of the type mentioned, which reduces the risk of incorrect manipulation. The object is achieved with the features of the independent claims. Advantageous developments emerge from the dependent claims, the description and the figures.

The injection device preferably allows the selection of one of a plurality of predetermined doses, wherein the selected dose, in particular by moving a plunger to a dose-dependent delivery stroke, in particular by muscle power, is ausschüttbar. In particular, the injection device can be locked after a delivery stroke against re-injection and / or dosage, so that a subset remains in a product container of the injection device or may remain, and disposed of together with the injection device.

The injection device has a particular elongated and / or sleeve-shaped housing, which includes, for example, a proximal end and a distal end. The housing can be one or more parts. A rotationally and axially fixedly connected to the housing part, which may also be referred to as a fixed part housing, in particular kinematically be considered belonging to the housing. In the housing, a product container, in particular a carpule or a syringe (pre-filled syringe) was added. The product container has a sealingly against an inner wall of the product container and slidably received piston. Attached to the product container is a needle, in particular an injection needle, which can be detachably or preferably fixedly connected to the product container. By moving the piston towards the needle, the product between the piston and the needle can be released from the product container via the needle.

The injection device has a particular elongated plunger, which is arranged in the housing and in particular by muscle power of the user of the injection device along a longitudinal axis L in the distal direction is displaceable by a Ausschütthub. The displacement of the plunger in the distal direction causes the piston is taken from the plunger and the product is displaced from the product container via the needle. The plunger is preferably rotationally fixed relative to the housing and axially displaceable. For example, housing or a housing-fixed element and the plunger can engage rotationally. For example, a mechanism holder may be provided, which is rotationally fixed on the one hand to the housing and on the other hand connected to the plunger, so that the plunger is in effect rotationally fixed relative to the housing. In particular, the plunger can be displaceable relative to the mechanism holder along the longitudinal axis. In particular, the plunger may protrude from the proximal end of the housing so that it can be displaced in the distal direction and thus in the housing with the thumb of the hand with which the user engages around the housing of the injection device in order to effect the product dispensing.

In the housing a displaceable relative to the housing and along the longitudinal axis needle protective sleeve is arranged. The needle guard is in particular relative to the housing and rotationally fixed about the longitudinal axis, in particular rotationally connected to the housing or in a rotationally fixed engagement with the housing. The needle guard protruding from the distal end of the housing is from a home position in which a distal end of the needle guard extends distally over the needle tip, thereby preventing access to the needle, to a puncture position in which the needle extends from the distal end of the needle guard protrudes, in particular with approximately a length corresponding to the puncture depth, for example, a subcutaneous injection, displaced. By moving the needle guard from its initial position to its piercing position, the needle tip protrudes from the distal end of the needle guard. In particular, in the puncture position of the needle guard, a piercing stopper formed by the needle guard can rest against a piercing counterpart stop of the housing or a housing-fixed element, wherein the piercing counter-stop blocks further movement of the needle guard in the proximal direction relative to the housing.

The needle guard may be movable or moved relative to the housing from its piercing position in the distal direction to a needle guard position. In the needle guard position, the distal end of the needle guard extends distally over the needle point, preventing access to the needle. In its needle guard position, the needle shield may continue to protrude approximately equidistant or less far from the distal end of the housing than at its initial position, thereby providing e.g. advantageous use of the injection device can be determined.

The injection device may advantageously have a needle protection spring, which acts with its distal end, for example, on the needle protection sleeve and with its proximal end, for example, on the housing. As a result, the needle guard spring is stretched during the movement of the needle guard from its original position to its puncturing position, the needle guard spring can move the needle guard from its puncture position to its original position and / or its needle guard position.

In a further development, the injection device, for example, a sleeve-shaped dose setting, in particular a dosing sleeve, wherein the dose setting for setting a auszuschüttenden from the product container dose of the product relative to a dose selection stop and / or the plunger is rotatable. The dose setting element can assume at least two different rotational positions, in particular predetermined by quasi-stable detent positions, relative to the dose selection stop and / or the plunger. For example, two, three, four, five, six, seven, eight or even more rotational positions for the dose setting member may be provided by detent positions, with the dose setting dose setting member rotated to one of these multiple rotational positions to select the desired dose.

The dose setting element has a plurality of dosing stops, in particular on an inner circumferential surface of the preferably sleeve-shaped dose setting element. The plurality of metering stops may be angularly offset with respect to each other about the longitudinal axis, i. occupy different angular positions. In particular, the plurality of metering stops may be disposed at different positions along the longitudinal axis with respect to each other. In this way, by rotating the dose setting element, one of the metering stops can be brought into alignment with the dose selection stop, in particular rotated, whereby the distance along the longitudinal axis between the dose selection stop and the metering stop aligned with it essentially corresponds to the delivery stroke.

In particular, in a first rotational position of the at least two rotational positions of the dose-selection stop and a first metering stop of the plurality of metering stops can be arranged in alignment along the longitudinal axis. In a second rotational position of the at least two rotational positions, the dose-selection stop is arranged at an angle to the first dosing stop about the longitudinal axis and / or the dose-selection stop and a second dosing stop of the plurality of dosing stops are aligned along the longitudinal axis. The distance along the longitudinal axis between the first metering stop and the dose selection stopper is different, in particular smaller than the distance between the second metering stop and the dose selection stop.

This causes the first metering stopper to be triggered at the dose selection stop when the dose setting element is in its first rotational position and the plunger is displaced in the distal direction. When the dose setting member is in its second rotational position and the plunger is displaced in the distal direction, the metering stop is moved past the dose selection stop along the longitudinal axis. Additionally or alternatively, the second metering stop abuts on the dose selection stop.

In a further development, the device may be designed so that priming, i. a movement or displacement of the plunger and e.g. the dose setting element must take place by a priming stroke in the distal direction of the product container in order to set a dose with the dose setting. The injection device may have a metering lock, which blocks a rotation of the dose setting element relative to the plunger and / or the housing in the delivery state of the injection device and / or before the priming stroke of the plunger. To perform priming, i. the displacement of air from the product container or the filling of the fluid-carrying system to the needle tip with liquid, the injection device is aligned with the needle tip up and the plunger moved together with the dose setting in the distal direction to the priming stroke, whereby the piston in the product container is also moved. By means of the priming stroke, the lock is released, whereby the dose setting element for adjusting the dose to be dispensed is rotatable relative to the housing and / or the plunger.

Further details for setting the dose and the priming including the dosing lock can be found in WO 2014/056 635 A1.

A first aspect of the invention solves the problem of preventing product release when the needle is not pierced.

Accordingly, a blocking device is provided, which is switchable from a blocking state in a release state. In its locked state, the blocking device prevents the plunger from being moved in the distal direction. In its release state, the blocking device allows the plunger to be moved relative to the housing in the distal direction by means of muscular force around a delivery stroke which, as described above, may depend on the set dose. In particular, by means of the displacement of the needle protection sleeve from its starting position into its puncturing position, the blocking device can be switched from the blocking state into the release state or be switchable.

In a first variant of the first aspect, the blocking device may comprise a release sleeve which relative to the housing from a first rotational position in which the release sleeve is axially fixed to the housing, in a second rotational position in which the release sleeve relative to the Housing along the longitudinal axis L, in particular in the distal direction is displaceable, be rotatable. The first and second rotational positions described in this context are not to be confused with the first and second rotational positions of the optional dose setting element. The release sleeve has at least one blocking stop or forms a blocking stop, wherein the plunger or a part axially fixedly connected thereto, in particular one or the dose setting, a blocking counter-attack, in particular advantageous for the second aspect driving counter-stop, wherein the blocking counter-attack with the at least one blocking stop is in alignment with the longitudinal axis when the release sleeve is in its first rotational position, wherein the displacement of the needle guard from its initial position in the puncturing causes the release sleeve is rotated from its first rotational position to the second rotational position, wherein in the second rotational position of the Release sleeve, the at least one blocking stop from the flight with or angular offset from the blocking counter-stop, so that the blocking counter-stop on the blocking stop in the distal direction is moved past. For example, a gap, in particular a guideway, may be formed between two blocking stops, through which or in which the blocking counterpart stop is movable. The guideway may extend along the longitudinal axis, for example. For example, a guide track may be provided on the release sleeve for each dose. By pushing the plunger in the distal direction, the metering stop, which is in alignment with the metering counter-stop, can be moved towards it until it finally strikes there and blocks the product discharge.

In particular, the needle guard and the release sleeve may be coupled via a gear, which causes the displacement of the needle guard from its initial position in the puncture position, the release sleeve from its first rotational position about the longitudinal axis rotates to the second rotational position. For example, one of the needle guard and release sleeve may have a guide cam and the other of the needle guard and release sleeve may have a guideway having a track or surface inclined with respect to the direction of travel in or on which the guide cam slides as the needle guard moves to its puncture position is, whereby the rotational movement of the release sleeve is effected.

In a second variant of the first aspect, the blocking device can have a release sleeve and a retaining clip which engages positively and detachably in the plunger. The holding snapper may be formed, for example, on the housing or a housing-fixed element. Alternatively, the holding snapper may be formed on a mechanism holder which is at least rotationally fixed to the housing. Such a mechanism holder may be supported, for example, at the proximal end of the product container or a product container holder in which the product container is arranged, whereby it is secured against displacement in the distal direction.

The plunger may have a recess, in which engages the retaining Schnapper. As a result, the plunger is blocked against movement in the distal direction. In order to be able to move the plunger for the product distribution in the distal direction, this blockage must be solved. The release sleeve, in particular a holding surface of the release sleeve is positioned next to the holding snapper, in particular along the longitudinal axis arranged approximately at the position of the retaining snap, that the holding snapper is prevented from disengaging from the positive engagement, in particular by means of a movement transverse to the longitudinal axis. The displacement of the needle guard from its initial position to the puncture position causes the release sleeve, in particular the holding surface, from its position in which it prevents the holding snapper to release from the positive engagement, is moved or rotated in a position in which Halteschnapper with a movement transverse to the longitudinal axis out of engagement with the plunger is movable. The release sleeve can be displaced along the longitudinal axis in the proximal direction, in particular by being carried along by the needle protection sleeve during its movement into the puncturing position. When the release sleeve is rotatable with its holding surface with a rotational movement about the longitudinal axis in the position in which it allows the release of the retaining pawl from the engagement with the plunger, a transmission can be arranged between the release sleeve and the needle guard, which causes the Release sleeve is rotated when the needle guard is moved from its initial position to the puncture position. The transmission may be, for example, a transmission or additional transmission as described for the first variant of the first aspect.

If the position of the release sleeve allows the movement of the retaining snapper transversely to the longitudinal axis from engagement with the plunger, by moving the plunger in the distal direction of the holding snapper can be pressed out of engagement with the plunger, ie, that the Ausschütthub be performed can.

A second aspect of the invention solves the problem that a pushing back of the needle protection sleeve is blocked to its puncture position out only when the discharge stroke has been carried out in particular substantially completely.

For this purpose, the injection device has a locking device, which is switchable by means of the displacement of the plunger in the distal direction, in particular by the dose-dependent dispensing stroke, for example, from a deactivated state to an activated state. In the deactivated state of the blocking device, the needle protection sleeve is displaceable from its initial position into its puncturing position, in particular even if the needle protection sleeve has already been in its puncturing position once or several times before. In other words, the needle protection sleeve is repeatedly displaceable back and forth between its initial position and its piercing position. This has the advantage that the user of the device can pull the pierced needle out of the puncture site once again, for example, when he feels a pain during insertion or hits a nerve end. The needle can then be inserted again elsewhere. With each piercing the needle guard is moved from its original position to the puncture position, with each withdrawal, the needle guard is moved from its puncture position to its original position, in particular by means of acting on the needle guard needle protection spring. In the activated state of the blocking device, the needle protection sleeve is displaceable from its puncturing position into the needle protection position, in particular by means of the needle protection spring. In the needle guard position, movement of the needle guard into the puncture position, e.g. blocked by a latching when reaching the needle protection position of the needle guard snap-in connection. This will ensure that the needle is secured against access when product dispensing has occurred and the needle has been withdrawn from the puncture site, i. the needle guard sleeve has been moved from its puncture position into the needle protection position with the locking device activated.

In one embodiment, the locking device comprises a retaining cam and a locking cam. The retaining cam may for example be coupled or connected to the plunger such that it can be displaced by the plunger along the longitudinal axis. The locking cam may, for example, be coupled to the needle protection sleeve such that it can be displaced from the needle protection sleeve along the longitudinal axis. In particular, the locking cam, for example, arranged transversely to the direction of movement of the needle guard elastically deflectable on an arm and so coupled to the needle guard, in particular be formed on or from the needle guard, that the locking cam participates in the movements of the needle guard along the longitudinal axis. The retaining cam has a proximal, in particular tapering, end, and is displaceable from the first position in the distal direction to a second position during at least part of the delivery stroke of the plunger. When the retaining cam is in its first position, the locking cam can be displaced by sliding the needle guard into its staking position only to the extent to the proximal end of the retaining cam or slidable that the locking cam is not or not completely moved past the proximal end of the retaining cam, whereby the locking device remains disabled in particular. For activation, the locking cam would have to be moved past the proximal end and snap past the proximal end of the retaining cam to produce a shift that switches from deactivated to activated. Since the locking device is still disabled, the needle guard can be moved back to its original position and moved from the starting position to the puncture position.

When the needle guard is in its puncture position, the retaining cam can be displaced so far in the distal direction or be displaced, in particular in its second position, that the locking cam snaps transversely to the direction of displacement of the retaining cam at the proximal end of the retaining cam. As a result, the locking device is in particular irreversibly activated, in particular because the locking cam is then located on the other side (for example, the second side) of the retaining cam than in the deactivated state (for example, the first side).

The retaining cam may have on its first side a first edge and on its second side a second edge. The locking cam, in particular the first flank, can be shaped so that the locking cam is deflected elastically during the displacement of the needle protection sleeve from its initial position into the piercing position transversely to the direction of displacement. Upon displacement of the locking cam towards the proximal end of the retaining cam, the locking cam may abut and slide along the first flank.

When the retaining cam is in its first position and the needle guard is displaced from its puncture position in the distal direction, in particular to the starting position, the locking cam slides along the first flank. When the retaining cam is in its second position and the needle guard is moved from its puncture position in the distal direction, in particular in the needle protection position, the locking cam slides along the second flank. For example, the locking cam of the second flank, in particular a corresponding shape of the second flank, are deflected elastically transversely to the direction of movement of the needle protection sleeve when the needle protection sleeve is moved from its puncture position to the needle protection position.

Advantageously, the retaining cam on a product container holder, in which the product container is laterally edged and held, be formed, wherein the product container holder is displaceable at least during a portion of the delivery stroke, in particular towards the end of the delivery stroke of the plunger in the distal direction, or is moved. The dispensing stroke can thus be divided into two parts, namely a first part during which the plunger does not displace the retaining cam, and a second part during which the plunger shifts the retaining cam from the first position to the second position. In this way, it can be advantageously achieved that when the needle is inserted and the dispensing stroke is complete or almost complete, the blocking device is switched from deactivated to activated. The product container holder is preferably displaced relative to the product container, that is, the product container maintains its position along the longitudinal axis with respect to the housing, for example, a flange from the product container in a gap formed by the housing and a housing fixed member, in particular by the mechanism holder , in particular is clamped.

The housing or a housing-fixed element may comprise a holding snapper, which is snapped so in a first position of the retaining cam with the housing that the part, in particular the product container holder which forms the holding cam, movable in the distal direction and in the proximal Direction is immovable. The holding snapper can be released from the snapping with the part by displacing the holding cam from the first position to the second position, in particular being pressed out of the part from the snap, wherein the holding snapper snaps with the part at another location, in particular in a second one Recess snapped or snapped into another positive engagement when the retaining cam is in its second position or reaches its second position. The holding snapper is in particular elastically yielding to the housing.

In a further development is advantageously achieved that the retaining cam is always taken independently of the set dose during the execution of the delivery stroke to a uniform mass or a uniform stroke, namely approximately the distance along the longitudinal axis between the first position and the second Position of the retaining cam. For this purpose, the injection device has at least one driving stop, which is formed on a sleeve, in particular a driving sleeve or a release sleeve, which is supported on the product container holder, in particular at its proximal end, wherein the plunger or an axially fixedly connected to the plunger element, such as the dose setting, has a Mitnahmegegenanschlag, the Mitgegengegenanschlag is moved during the first part of the Ausschütthubs to the driving stop and during the second part of the Ausschultthubs rests against the driving stop and the driving stop and thus the sleeve, in particular the driving sleeve or the release sleeve , and shifts the product container holder and thus the holding cam in the distal direction, in particular from the first position to the second position of the holding cam. For example, a plurality of driving stops can be formed on the sleeve. For example, the sleeve per metering stop on a corresponding driving stop.

In particular, the driving stops can be spaced relative to each other along the longitudinal axis and arranged angularly offset about the longitudinal axis. The offset along the longitudinal axis and the angular offset correspond, for example, to the offset along the longitudinal axis and the angular offset of the metering stops with respect to each other.

For example, a plurality of driving strokes may be formed on the at the product container holder, in particular at its proximal end, supporting sleeve, in particular driving sleeve or release sleeve, wherein the dose setting or at least rotationally fixed with the Doseinstellelement preferably axially connected element, a driving counter-stop , In the first rotational position of the at least two rotational positions of the dose setting element, the driving counterstop and a first driving stop of the plurality of driving stops are aligned along the longitudinal axis. In a second rotational position of the at least two rotational positions of the dose setting element, the driving counterstop and a second driving stop of the plurality of driving stops are arranged in alignment along the longitudinal axis.

When the dose setting member is in its first rotational position and the plunger is displaced in the distal direction, the driving stop initially strikes and engages the first driving stop, thereby displacing the holding cam in the distal direction to its second position. When the dose setting member is in its second rotational position and the plunger is displaced in the distal direction, the driving counter stop on the first driving stop is movable past or past the longitudinal axis. Alternatively or additionally, the driving counter-stop abuts the second driving stop, whereby the holding cam is moved in the distal direction to its second position.

In particular, the first driving stop and the second driving stop are spaced relative to one another along the longitudinal axis and arranged angularly offset about the longitudinal axis, in particular with the masses, such as the first metering stop with respect to the second metering stop. This results in a constant second part of the Ausschütthubs regardless of the length of the Ausschütthubs or the set dose.

For all aspects and variants, it is preferred that the dose setting element is connected to the plunger, in particular snapped, such that the dose setting element is rotatable and axially fixed relative to the plunger. As a result, ram and dose setting element are displaced as a unit in the distal direction for priming and / or product dispensing.

The first aspect and the second aspect may be independently realized in an injection device. However, both the first aspect and the second aspect can be realized in an injection device.

The invention has been described with reference to several aspects and variants. Hereinafter, a first and a second embodiment of an injection device will be described. In the first embodiment, the first variant of the first aspect and the second aspect are realized. In the second embodiment, the second variant of the first aspect and the second aspect are realized. The features disclosed in the figures advantageously form the subject of the invention individually and in any combination of features. Show it: <Tb> FIG. 1 <SEP> an exploded view of the individual parts of a first embodiment of an injection device according to the invention, <Tb> FIG. 2a, 2b <SEP> different sectional views of the first embodiment in an off state, <Tb> FIG. 3a, 3b <SEP> are various sectional views of the first embodiment in a state after priming, <Tb> FIG. 4a, 4b <SEP> show various sectional views of the first embodiment after or during the setting of the product dose to be dispensed, wherein dispensing is blocked; <Tb> FIG. 5a, 5b <SEP> show various sectional views of the first embodiment in an inserted state in which the dispensing is enabled, <Tb> FIG. FIGS. 6a, 6b show various sectional views of the first embodiment after dispensing, with a needle protection sleeve activated for its needle protection position, but not yet shifted into its needle protection position, FIG. <Tb> FIG. 7 <SEP> is an illustration of selected parts of the first embodiment showing a blocking device and a locking device, <Tb> FIG. 8a, 8b <SEP> different states of the blocking device, which prevents a product distribution, <Tb> FIG. 9a - 9d <SEP> different switching states of a locking device, which switches the needle protection sleeve from deactivated to activated, for the first embodiment and a second embodiment, <Tb> FIG. 10 <SEP> an exploded view of the individual parts of a second embodiment of an injection device according to the invention, <Tb> FIG. 11a, 11b <SEP> different sectional views of the second embodiment in its delivery state, <Tb> FIG. 12a, 12b <SEP> different sectional views of the second embodiment in a state after priming, <Tb> FIG. 13a, 13b <SEP> show various sectional views of the second embodiment after or during the setting of the product dose to be dispensed, wherein dispensing is blocked; <Tb> FIG. 14a, 14b <SEP> are various sectional views of the second embodiment in an inserted state in which the pouring is released, and <Tb> FIG. 15a, 15b <SEP> are various sectional views of the second embodiment after dispensing with a needle guard activated for its needle guard position but not yet shifted to its needle guard position.

The first and second embodiments of an injection device according to the invention described in the figures will first be described in terms of their similarities. Functionally similar parts preferably have the same reference numerals.

The injection device has a sleeve-shaped housing 1, whose longitudinal axis corresponds to the longitudinal axis L of the injection device. From the distal end of the housing 1 protrudes a needle protection sleeve 2, which is rotationally guided by the housing 1 about the longitudinal axis L and slidable along the longitudinal axis L. A needle protection spring 11, which acts as a compression spring and is designed as a helical spring, is supported with its distal end against the needle protection sleeve 2 and with its proximal end against the housing 1. In the housing 1, a product container 9, in particular a syringe, accommodated in a product container holder 3, in particular a syringe holder, is accommodated. The product container holder 3 surrounds a cylindrical part of the product container 9, wherein on the cylindrical inner circumference of the product container 9, a relative to the product container 9 displaceable piston 9c sealingly. The product container 9 has at its distal end an injection needle 9b, which in the initial state, i. when the injection device is delivered, it is covered by a needle cap which is detachably fastened to the product container 9. The needle cap may be of the rigid type ("rigid needle shield") or the compliant type ("soft needle shield"). At the proximal end of the housing 1, a peel cap 10 is releasably secured, which has driving hooks which engage between the part of the product container 9 tapering from the cylindrical part to the needle 9b and the proximal end of the Nadelabdeckkappe, so that when removing or removing the Abziehkappe 10 of the distal end of the housing 1, the Nadelabdeckkappe is removed and removed.

As can be seen for example in Figures 2a, 2b and 12a, 12b, the distal end of the needle guard sleeve 2 in its initial position projects distally over the needle tip of the needle 9b, thereby restricting access to the needle 9b. The needle guard 2 is displaceable relative to the housing 1 along the longitudinal axis L in the proximal direction to a puncture position, whereby the needle 9b emerges from the distal end of the needle guard 2. The product container 9 is axially fixedly connected to the housing 1 or in particular also during the insertion of the needle 9b axially fixed with respect to the housing 1. The needle tip of the needle 9b is in the puncture position of the needle guard 2 over the distal end of the needle guard 2. In the piercing position strikes the needle guard 2 with a piercing 2d on a Einstechgegenanschlag 1i of the housing 1, whereby a movement of the needle guard 2 in the proximal direction is prevented when the needle guard 2 is in its puncture position. When the needle guard 2 is displaced relative to the housing 1 in the proximal direction, the needle guard 11 is tensioned. The cocked needle guard spring 11 can push the needle guard 2 relative to the housing 1 in the distal direction.

The product container holder 3 is formed of a transparent plastic. The housing 1 has a viewing window 1, through which the liquid product contained in the product container 9, in particular medicine can be inspected from the outside. The housing 1 has a holding snapper 1c which, in the delivery state, removably engages in a first catch recess 3a on the outer circumference of the product container holder 3. The product container holder 3 is displaceable in the distal direction, whereby the holding snapper 1c is pushed out of the latching recess 3a and again snapped with the product container holder 3 displaced by a stroke HA2 so as to block the movement of the product container holder 3 in the proximal direction.

The proximal end of the housing 1 is formed by an end cap 5, which rotatably and axially fixedly connected to the sleeve-shaped housing base body of the housing 1, in particular snapped. From the proximal end of the housing 1 or the end cap 5 protrudes a plunger 7, which is displaceable relative to the housing 1 and rotatable relative to the housing 1 along the longitudinal axis L. The plunger 7 is guided axially displaceably and non-rotatably by a mechanism holder 4, which in turn is rotatably connected to the housing 1 and snapped axially fixed (Fig. 2a) or axially held in relation to the housing 1, in which he, for example, at the proximal End of the product container 9 is applied.

A Doseinhülse formed as dosing 8 protrudes from the proximal end of the housing 1 and is snapped with the plunger 7 that plunger 7 and dose setting 8 are axially fixed to each other, the dose setting 8 for setting a distributable product dose relative to the plunger 7 is rotatable. The dose setting element 8 has, over its inner circumference, a plurality of latching recesses 8d into which at least one elastic pawl 7e of the plunger 7 releasably engages. When the dose setting member 8 is rotated relative to the plunger 7, an audible and / or tactile signal is generated because the pawl 7e snaps over the recesses 8d. The division of the recesses 8d is preferably such that a quasi-stable latching position for the pawl 7e is specified for each dose. The dosage setting element 8 has on its inner circumference a plurality of metering stops 110, 111, 112 axially offset along the longitudinal axis L and angularly offset about the longitudinal axis L.

The dose setting 8 is in the delivery state with respect to the housing 1 by means of a metering lock secured against rotation and is in a Primingdrehposition. For this purpose, the dose setting element 8 has a projection 8b which engages in a form-locking manner in a groove of the end cap 5, in which engagement a rotation of the dose setting element 8 relative to the end cap 5 and thus to the housing 1 is blocked.

The mechanism holder 4 has a switching snapper 4f, which is elastically deflectable transversely to the longitudinal axis L. On the inner circumference of the dose setting element 8, a projection 8n is formed, whose distal end forms a priming stop 8c. The mechanism holder 4 forms a priming counter-stop 4e, which also serves as a dose-selection stop 100. Alternatively (not shown), priming stop 4e and dose selection stop 100 could be separate from each other. Before a dose adjustment can take place, the injection device must be primed. For this purpose, the plunger 7 by means of muscle power, which can be exerted on the proximal end of the plunger 7 or the dose setting 8, for example, by the thumb of the hand, which surrounds the housing 1 of the injection device, so far moved in the distal direction that the Abragung 8n deflects the switch catcher 4f transversely to the longitudinal axis L and the prime stop 8c abuts the primary counter stop 4e, so that further movement of the plunger 7 in the distal direction is blocked. With the displacement of the dose setting member 8 in the distal direction, the engagement of the projection 8b is released from the groove, so that the dose setting member 8 is rotatable relative to the plunger 7, whereby the product dose to be dispensed can be adjusted. To adjust the dose, one of the metering stops 110, 111, 112, such as a first metering stop 110, is brought by rotation into alignment with the dose selection stop 100 along the longitudinal axis L. By turning the dose setting element 8 from the priming rotational position, the projection 8n is rotated out of engagement with the switching catch 4f, so that the switching snapper 4f again springs back to its starting position transversely to the longitudinal axis L. In an attempt to rotate the dose setting member 8 to its rotational position (priming rotational position) which it had during priming, the projection 8n circumferentially strikes the switch latch 4f, thereby preventing the rotation of the dose setting member to its priming rotational position (Figs. 4b, 13a, 13b).

A release sleeve 6 of the first embodiment or a driving sleeve 12 of the second embodiment has on its inner circumference a plurality of driving stops 210, 211, 212, which are axially offset relative to each other along the longitudinal axis L and angularly offset from each other about the longitudinal axis L. The release sleeve 6 or the entrainment sleeve 12 is supported on the product container holder 3, in particular at its proximal end, whereby a displacement of the sleeve 6, 12 in the distal direction, e.g. about a partial stroke HA2 of a delivery stroke HA, a corresponding displacement of a retaining cam 3d, e.g. is formed by the product container holder 3 or another along the longitudinal axis L displaceable and rotatable about the longitudinal axis L relative to the housing 1 part to the second partial stroke HA2effirkt. For each metering stop 110, 111, 112, a corresponding driving stop 210, 211, 212 is provided. That for the first metering stop 110 is a first driving stop, for the second metering stop 111 is a second driving stop 211, for the third metering stop 112 is a third driving stop 212 or, generally, for the n-th metering stop an n-th driving stop is provided (z B. n = 1 ... m; m = 2 ... 10, where n and m are integers).

The dose setting 8, in this example the Abragung 8b, alternatively another Abragung forms a Mitnahmegegenanschlag 200. In the first rotational position of the dose setting 8, the Mitnahmegegenanschlag 200 and the first entrainment stop 210 along the longitudinal axis L are aligned and the dose selection stop 100 and the first metering stop 110 along the longitudinal axis L arranged aligned with each other. In a second rotational position of the dose setting element 8, the driving counterstop 200 and the second driving stop 211 are aligned with one another along the longitudinal axis L and the dose selection stop 100 and the second dosing stop 111 are aligned with one another along the longitudinal axis L. In a third rotational position of the dose setting element 8, the driving counterstop 200 and the third driving stop 212 are aligned with one another along the longitudinal axis L and the dose selection stop 100 and the third dosing stop 112 are aligned with one another along the longitudinal axis L. General: In an n-th rotational position of the dose setting element 8, the driving counter stop 200 and the nth driving stop along the longitudinal axis L are aligned with each other and the dose selection stop 100 and the n-th metering stop along the longitudinal axis L to each other in alignment.

The plunger 7 is movable in the distal direction as a function of the set dose by a variable delivery stroke HA. The dispensing stroke HA corresponds to the distance of the dose selection stop 100 to the dispensing stop 110; 111; 112 with whom he escapes. The dispensing stroke HA is divided into two partial strokes, namely a first partial stroke HA1, in which the driving counter-abutment 200 is aligned with the driving stop 210 aligned with it; 211; 212 is moved until it finally abuts it, and a second partial stroke HA2, wherein the driving counter-stop 200 the driving stop 210; 211; 212, where it rests, to take the second partial stroke HA2. The second partial stroke HA2is constant, irrespective of the set dose, the length of the first partial stroke HA1d being dose-dependent. Thus, it is ensured that, regardless of the dose set, the sleeve 6 or 12 will travel a constant distance, i. about the second partial stroke HA2mit taken. The distribution of the dose has been completed when the dose stop 110 corresponding to the set dose. 111; 112 to the dose selection stop 100 abuts. Towards the end of the delivery stroke HAor towards the end of the second sub-stroke HA2, the metering stop (e.g., metering stop 112) relevant to the product dose, e.g. is formed by a Abragung, the switching snapper 4f over and deflects this until the switch latch 4f snaps behind the dosing stop 112 again, whereby the dosing stop 112 between the Dosiergegenanschlag 100 and the Schaltschnapper 4f is bordered (Fig. 6a, 15a). As a result, the retraction of the dose setting element 8 and the plunger 7 in the proximal direction can advantageously be prevented.

For example, if the dosage setting element 8 is: is in its first rotational position and the plunger 7 is displaced in the distal direction, the driving counter-abutment 200 strikes on the first driving stop 210 after execution of the first partial stroke HA1 and takes it during the second partial stroke HA2, is in its second rotational position and the plunger 7 is moved in the distal direction, proposes the driving counter-abutment 200 after execution of the first partial stroke HA1 to the second driving stop 211 and takes this during the second partial stroke HA2mit, etc. is general, its nth rotational position and the plunger 7 is displaced in the distal direction, the driving counter-stop 200 proposes after execution of the first partial stroke HA1 on the n-th driving stop and takes this during the second partial stroke HA2.

According to the second aspect of the invention, the needle guard 2 is only blocked or locked against displacement in the proximal direction from a position in which the distal end of the needle guard 2 distally over the needle tip, when the product is discharged substantially ie the plunger 7 has been displaced essentially around its delivery stroke HA, but at least by the first partial stroke HA1 in the distal direction. This allows a multiple insertion of the needle 9b, as long as the set dose has not yet been distributed.

For this purpose, the injection device has a blocking device 2e, 3d, which can be switched from a deactivated state into an activated state by means of the displacement of the plunger 7 by the second partial stroke HA2. In the deactivated state of the locking device 2e, 3d, the needle protection sleeve 2 is repeatedly displaced back and forth between its initial position and its puncture position, provided that the set dose has not been or not completely distributed. In the activated state of the locking device 2e, 3d, the needle guard 2 is displaced only once from its puncture position into the needle protection position, in which the locking device 2e, 3d blocks the movement of the needle guard 2 in the needle protection position. The locking device 2e, 3d comprises a locking cam 2e, which is formed so as to be elastically deflectable on the needle protection sleeve 2 on an arm, and a locking cam 2e formed on the product container holder 3 or the above-mentioned. Part formed retaining cam 3d (Fig. 9a to 9d).

In the delivery state of the injection device, the locking device is deactivated (FIG. 9 a), wherein the retaining cam 3d is in a first position with respect to the housing 1. The locking cam 2e is arranged on one side of the retaining cam 3d, wherein it bears against a first flank. The flank has a relatively steeply inclined section which, when a force acting in the proximal direction is applied to the needle protection sleeve 2, causes it to be deflected abruptly from the inclined section only when a force threshold value is exceeded. In this way, a piercing can be done by the muscle tension built up in the user's arm. Namely, the user grasps the housing 1 and presses the injection device with the distal end of the needle protection sleeve 2 to the desired puncture site, whereby a force acting in the proximal direction acts on the needle protection sleeve 2.

The locking cam 2e is displaced by the distance traveled by the needle guard 2 from its initial position to the puncturing position, as can be seen from the comparison of FIGS. 9a and 9b. The locking cam 2e, since the retaining cam 3d is in its first position, only so far, i. to be displaced to this path of the needle guard 2, to the proximal end of the retaining cam 3d that the locking cam 2e is not or not completely over the proximal end of the retaining cam 3d moved past. This prevents the locking cam 2e from snapping over the proximal end of the retaining cam 3d. As a result, the locking device 2e, 3d remains disabled. When the needle 9b is removed from the puncture site, the needle guard 11 pushes the needle guard 2 back to its original position. The needle 9b can be re-pierced with the needle guard 2 displaced from the home position to the piercing position, i. the locking cam 2e again assumes the position in FIG. 9b. As long as the locking device 2e, 3d is deactivated, these movements can in principle be repeated as often as desired.

When the needle guard 2 is in its puncture position and the plunger 7 is moved about the delivery stroke HA, in particular the sleeve 6 or 12 to the second partial stroke HA2, the retaining cam 3d from its first position, in particular by the second partial stroke Hm relative shifted to the housing 1 and / or the locking cam 2e in the distal direction, whereby the elastically deflected locking cam 2e snaps past the proximal end of the retaining cam 3d (Figure 9c), whereby the locking cam 2e is arranged on the other side of the retaining cam 3d and the locking device 2e, 3d is activated. When the needle 9b is pulled out of the puncture site, the needle guard 11 pushes the needle guard 2 from the puncture position to the needle guard position. In this case, the locking cam 2e slides along the second flank of the retaining cam 3d, wherein the second flank is shaped so that it elastically deflects the locking cam 2e, and has a locking stop behind which the locking cam 2e engages upon reaching the needle protection position (FIG. 9d). , When trying to move the needle guard 2 from its needle guard position back to the puncture position, the locking cam 2e is pressed against the locking stop, whereby the needle guard 2 is locked against displacement in the proximal direction. Alternatively, elsewhere a latching connection, such as e.g. between the needle guard 2 and housing 1, snap, which prevents the pushing back of the needle guard 2. The injection device is now useless for further uses / manipulations and can be disposed of.

First embodiment

According to the first aspect of the invention, the release of the set dose is prevented when the needle 9b is not pierced or when the needle guard 2 is in its initial position or not in its puncture position. For this purpose, the release sleeve 6 of the first embodiment has an engagement structure 6a, in particular a cam, and the housing 1 or the end cap 5 has a retaining slot 5d, in particular a retaining groove, into which the engagement structure 6a engages. In a first rotational position of the release sleeve 6, which it occupies or assumes in the delivery state of the injection device when the needle guard 2 is in its initial position, the retaining slot 5d holds the engagement structure 6a so that the release sleeve 6 blocks against movement in the distal direction and relative to the housing 1 about the longitudinal axis L is rotatable in a second rotational position. In the second rotational position of the axially fixed engagement of the engagement structure 6a is solved with the retaining slot 5d, whereby the release sleeve 6 is displaceable in the distal direction.

The needle protection sleeve 2 has a guide cam 2c which engages in a guide track 6b formed by the release sleeve 6. The guide track 6b has a gear surface of a gear track section, which extends obliquely with respect to the direction of movement of the needle protection sleeve 2. The guide track 6b has, distally of the gear track section, a first track section running parallel to the longitudinal axis L and optionally a second track section running parallel to the longitudinal axis L, proximally of the gear train section. The guide cam 2c is disposed in the first track section when the needle guard 2 is in its home position. When the needle guard 2 is displaced to the piercing position, it slides out of the first track portion into the gear track portion with the gear surface, translating the longitudinal motion of the guide cam 2c into rotational movement of the release sleeve 6 into its second rotational position while the guide cam 2c slides through the gear train portion , The guide cam 2c is finally moved into the second path section when the release sleeve 6 assumes its second rotational position. If the injection device removed from the puncture site without having started the dose distribution, the needle guard 2 is moved by the needle guard 11 back to its original position, the guide cam 2c slides through the transmission track section back into the first path section, whereby the release sleeve 6 back into their rotated first rotational position and the engagement structure 6a again axially fixed in the retaining slot 5d engages.

The release sleeve 6 has at its proximal end a plurality of circumferentially spaced blocking stops 310. The projection 8b, alternatively another projection, forms a blocking counter-stop 300, which in each of the rotational positions of the dosage setting member 8 is aligned with one of the blocking stops 310 when the release sleeve 6 is in its first rotational position. Attempting to displace the plunger 7, including dose setting element 8, in the distal direction causes the blocking counter-abutment 300 to be pressed against one of the blocking abutments 310. As a result, the movement of the plunger 7 in the distal direction or the implementation of the Ausschütthubs HAblocked.

Between adjacent blocking stops 310, a gap is arranged, which is dimensioned such that the projection 8b can be moved along the longitudinal axis L. Each of the driving stops 310 may be formed by one end of a path or groove associated with the respective driving stop 310, which forms one of the gaps between the blocking stops. Generally speaking, m tracks or grooves may be provided, wherein the n-th groove or track is assigned to the n-th driving stop, in particular upstream or forms with its distal end the n-th driving stop.

When the release sleeve 6 is rotated to its second rotational position, the blocking stop 310 is rotated out of alignment with the blocking counter-stop 300, wherein the blocking stop 310 is aligned in the second rotational position of the release sleeve 6 with one of the tracks or grooves, namely n th path in the n-th rotational position of dose setting 8. The plunger 7 including dose setting 8 can now be moved to the dispensing stroke HAin the distal direction. Due to the displacement of the release sleeve 6 during the second partial stroke HA2, its engagement structure 6a is displaced with respect to the guide slot 5d such that rotation of the release sleeve 6 back to its first rotational position when the injection device is removed from the puncture site no longer affects the axial movement the release sleeve 6 has.

In the delivery state of the device (FIGS. 2 a, 2 b), a retaining clip 4 c formed elastically on the mechanism holder 4 engages in a form-fitting manner a first recess 7 a of the plunger 7. To administer a product dose, the peel cap 10, including the needle cap, is removed from the injection device. By moving the plunger 7 by the priming stroke in the distal direction is primed. The priming stroke is limited by the fact that the priming stop 8c and the priming counterpart stop 4e of the mechanical holder 4 abut (FIG. 3a). When moving the plunger 7 in the distal direction for priming the plunger 7 pushes the retaining snapper 4c out of engagement with the first recess 7a, wherein at the end of the priming stroke of the plunger 7 of the holding snapper 4c snaps into a second recess 7d of the plunger 7. This prevents the plunger 7 from being re-oriented in the proximal direction after priming. can be pulled out of the housing 1. A dose adjustment by turning the dose setting 8 is possible, but a product release is blocked because the blocking counter-abutment 300 at one of the plurality of blocking stops 310 of the release sleeve 6 is present (Fig. 8a), in its first rotational position relative to the housing 1 against movement is blocked along the longitudinal axis L (Fig. 4a, 4b). By turning the dosage setting element 8, the desired product dose is selected.

By moving the needle guard 2 into the puncture position, on the one hand, the needle 9b protrudes from the distal end of the needle guard 2 and, on the other hand, the release sleeve 2 is rotated to its second rotational position by means of the gear 2c, 6b (FIG of the plunger 7 in the distal direction is released (Fig. 5a, 5b, 8b).

Due to the complete execution of the delivery stroke HA, in particular by the entrainment of the release sleeve 2 during the second partial stroke HA2, the locking device 2e, 3d is activated (FIGS. 6a, 6b, 9c). Due to the entrainment of the release sleeve 6 of the product container holder 3 and thus the retaining cam 3d is moved relative to the housing 1 and the product container 9 in the distal direction. In this case, the holding snapper 1c is pressed out of engagement with the first latching recess 3a, wherein the holding snapper 1c in the second position of the holding cam 3d snaps so with the product container holder 3, in particular snaps into a second latching recess 3f that the product container holder 3 against displacement relative to the housing 1 is blocked in the proximal direction. This prevents the product container holder 3 from being displaced in the proximal direction when the needle guard 2 is in its needle protecting position and trying to displace it in the proximal direction. The needle protection sleeve 2 is in fact supported by the locking engagement of its locking cam 2e (FIG. 9d) on the retaining cam 3d and thus on the product container holder 3.

Second embodiment

According to the first aspect of the invention, the release of the set dose is prevented when the needle 9b is not pierced or when the needle guard 2 is in its home position or not in its puncture position. For this purpose, the second embodiment has a release sleeve 6 and a driving sleeve 12. The axially fixed to the product container holder 3 connected driving sleeve 12 forms - as described above - the multiple driving stops 210, 211, 212. The driving sleeve 12 has a transversely to the longitudinal axis L deflectable engaging member 12b, which engages in a recess of the housing 1, that the driving sleeve 12 is at least not displaceable relative to the housing 1 in the distal direction (FIG. 11a). The release sleeve 6, which is axially fixedly connected to the needle protection sleeve 2, has a first retaining surface 6m, which in the initial position of the needle protection sleeve 2 is positioned next to the engagement member 12b so as to block movement of the engagement member 12b out of the recess of the housing 1.

The mechanism holder 4 distally supported on the proximal end of the product container 9 has a first holding snapper 4m and a second holding snapper 4n. In the state of delivery of the device (FIGS. 11 a, 11 b), the second retaining clip 4 n formed elastically on the mechanism holder 4 engages positively in a second recess 7 n of the plunger 7, the first retaining clip 4 m being spaced apart from the priming stroke by a blocking stop 310 of the plunger 7 , By moving the plunger 7 by the priming stroke in the distal direction is primed. When moving the plunger 7 in the distal direction for priming the plunger 7 pushes the second Halteschnapper 4n out of engagement with the second recess 7n, wherein at the end of the priming stroke of the plunger 7 of the second Halteschnapper 4n snaps into the plunger 7 that the Stroke 7 is blocked against movement in the proximal direction (Fig. 12a). This prevents the plunger 7 from being re-oriented in the proximal direction after priming. can be pulled out of the housing 1. When the plunger 7 is displaced in the distal direction for the priming, the blocking stopper 7 abuts against the first holding snapper 4m, so that movement of the plunger 7 in the distal direction is blocked. The first holding snapper 4m is deflectable transversely to the longitudinal axis L, but is prevented by a second holding surface 6n of the release sleeve 6 therefrom. The second holding surface 6n is arranged in the initial position of the needle guard 2 next to the first holding snapper 4m, that it is prevented from moving away from the plunger 7 transversely to the longitudinal axis L. This prevents the first retaining snapper 4m from being able to snap over the blocking stopper 310, thereby blocking movement of the plunger 7 in the distal direction.

Thereafter, the adjustment of the dose may be made in the manner described herein in detail, with the dispensing being disabled during the dose setting (Figures 13a, 13b).

A displacement of the needle guard 2 from its initial position to its piercing position causes a displacement of the release sleeve 6 in the proximal direction, the support surface 6m in a position in which it does not block the movement of the engaging member 12b from the recess with the housing 1, ie releases and the support surface 6n in a position in which it does not block the movement of the first retaining snapper 4m transversely to the longitudinal axis L away from the plunger 7, i. releases.

The plunger 7 including the dose setting element 8 is now displaceable around the delivery stroke HA in the distal direction. By the displacement of the plunger 7 in the distal direction of the blocking stopper 310 pushes the first holding snapper 4m outwards, whereby the blocking stop 310 on the first holding snapper 4m in the distal direction is moved past (Fig. 14b). During the first partial stroke HA1 of the delivery stroke HA, the plunger 7 is moved in the distal direction relative to the entrainment sleeve 12. During the second partial stroke HA2, the driving sleeve 12 is moved by the counter-counterpart stop 200 about the second partial stroke HA2, whereby the engaging member 12b is pressed out of engagement with the housing 1 transversely to the longitudinal axis L and the product container holder 3 and thus the retaining cam 3d (FIG. 9c) Partial stroke HA2 are moved in the distal direction, whereby the locking means 2e, 3d is activated (Fig. 15a, 15b).

The removal of the injection device from the puncture allows the needle guard 11 to move the needle guard 2 in the distal direction in the needle protection position, whereby the locking cam 2e snaps behind the locking stop of the retaining cam 3d.

LIST OF REFERENCE NUMBERS

[0071] <Tb> 1 <September> Housing <Tb> 1b <September> window <Tb> 1c <September> holding snapper <Tb> 1 i <September> Einstechgegenanschlag <Tb> <September> <Tb> 2 <September> needle guard <Tb> 2c <September> Keying <Tb> 2d <September> Einstechanschlag <Tb> 2e <September> locking cam <Tb> <September> <Tb> 3 <September> product container holder / syringe holder <tb> 3a <SEP> first recess <Tb> 3d <September> cam lock <tb> 3f <SEP> second recess <Tb> <September> <Tb> 4 <September> mechanism holder <Tb> 4c <September> holding snapper <Tb> 4e <September> priming counter-abutment <Tb> 4f <September> Switching snapper <tb> 4m <SEP> first stop snap <tb> 4n <SEP> second stop snap <Tb> <September> <Tb> 5 <September> endcap <Tb> 5d <September> holding backdrop <Tb> <September> <Tb> 6 <September> release sleeve <Tb> 6 <September> engagement structure <Tb> 6b <September> guideway <tb> 6m <SEP> first holding surface <tb> 6n <SEP> second holding surface <Tb> <September> <Tb> 7 <September> ram <tb> 7a <SEP> first recess <tb> 7d <SEP> second recess <Tb> 7e <September> ratchet <tb> 7n <SEP> second recess <Tb> <September> <Tb> 8 <September> dose setting / dose dial sleeve <Tb> 8 <September> <Tb> 8b <September> Abragung <Tb> 8c <September> priming abutment <Tb> 8d <September> recesses <Tb> 8 n <September> Abragung <Tb> <September> <Tb> 9 <September> product container <Tb> 9b <September> Needle <Tb> 9c <September> Piston <Tb> <September> <Tb> 10 <September> pull cap <Tb> <September> <Tb> 11 <September> needle guard spring <Tb> <September> <Tb> 12 <September> driver sleeve <Tb> 12b <September> engagement member <Tb> <September> <Tb> 100 <September> dose selection stop <Tb> <September> <tb> 110 <SEP> first dosing stop <tb> 111 <SEP> second dosing stop <tb> 112 <SEP> third dosing stop <Tb> <September> <Tb> 200 <September> Take counterstop <tb> 210 <SEP> first take-up stop <tb> 211 <SEP> second take-up stop <tb> 212 <SEP> third take-up stop <Tb> <September> <Tb> 300 <September> blocking counter-stop <Tb> 310 <September> blocking stop <Tb> <September> <Tb> HA <September> delivery stroke <tb> HA1 <SEP> first partial lift <tb> HA2 <SEP> second partial stroke <Tb> <September> <Tb> L <September> longitudinal axis

Claims (15)

1. Injection device for administering a liquid product, in particular medicament, the injection device comprising: A housing (1) and a product container (9) accommodated in the housing (1) in which a piston (9c) is slidably received and to which a needle (9b) is attached, - A plunger (7) which is arranged in the housing (1) and in particular by muscle power of the user of the injection device along a longitudinal axis (L) in the distal direction is displaceable, wherein the displacement of the plunger (7) causes in the distal direction in that the piston (9c) is entrained by the plunger (7) and the product is displaced out of the product container (9) via the needle (9b), - A needle protection sleeve (2) projecting from the distal end of the housing (1) and projecting from a starting position, in which a distal end of the needle protection sleeve (2) projects distally over the needle tip, into a puncturing position in which the needle (9b) protrudes protrudes the distal end of the needle protection sleeve (2), is displaceable, marked by A blocking device (6, 6a, 5d, 300, 310, 4m, 310, 12b, 6) which can be switched from a blocking state into a release state, wherein the blocking device (6, 6a, 5d, 300, 310, 4m, 310 12b, 6) in its blocking state prevents the plunger (7) from being moved in the distal direction and, in its release state, allows the plunger (7) to be moved by muscle force about a delivery stroke (HA) in the distal direction, - By means of the displacement of the needle guard (2) from its initial position into its puncturing position the blocking device (6, 6a, 5d, 300, 310; 4m, 310, 12b, 6) is switched from the blocking state in the release state or switched. 2. Injection device according to claim 1, characterized in that the blocking device (6, 6a, 5d, 300, 310; 4m, 310, 12b, 6) has a release sleeve (6) which relative to the housing (1) consists of a first Rotary position in which the release sleeve (6) is axially fixed to the housing (1), in a second rotational position in which the release sleeve (6) relative to the housing (1) along the longitudinal axis (L), in particular in the distal direction , is displaceable, is rotatable, wherein the release sleeve (6) forms at least one blocking stop (310), wherein the plunger (7) or a part axially connected thereto, in particular a Doseinstellelement (8), a blocking counter-stop (300), in particular a driving counter-stop (200), wherein the blocking counter-abutment (300) with the at least one blocking stop (310) is aligned with the longitudinal axis (L) when the release sleeve (6) is in its first rotational position, the displacement of the Na delschutzhülse (2) from its initial position in the puncturing causes the release sleeve (6) is rotated from its first rotational position to the second rotational position, wherein in the second rotational position of the release sleeve (6) of the at least one blocking stop (310) from the escape or angularly offset from the blocking counter-abutment (300) such that the blocking counter-abutment (300) is movable past the blocking abutment (310) in the distal direction. 3. Injection device according to the preceding claim, characterized in that the needle protection sleeve (2) and the release sleeve (6) via a transmission (2 c, 6 b) are coupled, which causes the displacement of the needle guard (2) from its initial position in the Einstechposition the release sleeve (6) turns from its first rotational position to the second rotational position. 4. Injection device according to claim 1, characterized in that the blocking device (6, 6a, 5d, 300, 310, 4m, 310, 12b, 6) has a release sleeve (6) and a holding snapper (4m), which positively engages the plunger (4). 7), whereby the plunger (7) is blocked against movement in the distal direction, wherein the release sleeve (6) is positioned next to the retaining clip (4m) so as to prevent the retaining clipper (4m) from moving out of position releasing engagement, wherein the displacement of the needle guard (2) from its initial position to the puncturing position causes the release sleeve (6) from its position in which it prevents the retaining snap (4m) to release from the positive engagement, in a position, in particular along the longitudinal axis (L) in the proximal direction, is displaced, in which the holding snapper (6) with a movement transverse to the longitudinal axis (L) from the engagement with the plunger (7) is movable. 5. Injection device, in particular according to one of the preceding claims, for the administration of a liquid product, in particular medicament, the injection device comprising: a housing (1) and a product container (9) accommodated in the housing (1) in which a piston (9c) is slidably received and to which a needle (9b) is attached, <tb> - <SEP> a plunger (7) which is arranged in the housing (1) and in particular by muscle power of the user of the injection device along a longitudinal axis (L) in the distal direction about a dispensing stroke (HA) is displaceable, the displacement of the plunger (7) in the distal direction causes the piston (9c) to be taken away by the plunger (7) and the product to be displaced out of the product container (9) via the needle (9b), <tb> - <SEP> a needle protection sleeve (2) protruding from the distal end of the housing (1), <tb> <SEP> which is relative to the housing (1) from a starting position in which the distal end of the needle guard (2) protrudes distally over the needle tip, into a puncture position in which the needle (9b) protrudes a distal end of the needle protection sleeve (2) protrudes, is movable and <tb> <SEP> <SEP> is movable relative to the housing (1) from the puncture position in the distal direction to a needle guard position in which the distal end of the needle guard (2) projects distally over the needle tip, characterized by - A locking device (2e, 3d), which is switchable by means of the displacement of the plunger (7) in the distal direction from a deactivated state to an activated state, wherein in the deactivated state of the locking device (2e, 3d), the needle protection sleeve (2) between its initial position and its piercing position is repeatedly displaced back and forth, and in the activated state of the locking device (2e, 3d) the needle guard (2) from its puncture position once in the needle protection position is displaceable, in which a movement of the needle guard (2) in the puncture position is blocked. 6. Injection device according to claim 5, characterized in that the locking device (2e, 3d) comprises a retaining cam (3d) and a locking cam (2e), wherein - The locking cam (2 e) arranged elastically deflectable on an arm (2 f) and so coupled to the needle guard (2), in particular on the needle guard (2) is formed, that the locking cam (2 e) the movements of the needle guard (2) along the Longitudinal axis (L) participates, - The retaining cam (3d) has a proximal end and at least during a part of the Ausschütthubs (HA) of the plunger (7) from a first position in the distal direction is displaceable in a second position, - wherein the locking cam (2e), when the retaining cam (3d) is in its first position, by displacement of the needle guard (2) in its puncture position only so far towards the proximal end of the retaining cam (3d) is displaceable that the locking cam ( 2e) is not or not completely moved past the proximal end of the retaining cam (3d), whereby the locking device (2e, 3d) in particular remains deactivated, - wherein the retaining cam (3d), when the needle guard (2) is in its puncture position, is displaceable so far in the distal direction that the locking cam (2e) transversely to the direction of displacement of the retaining cam (3d) at the proximal end of the retaining cam (3d) snaps past, whereby the locking device (2e, 3d) is particularly activated. 7. Injection device according to claim 6, characterized in that the needle protection sleeve (2) by means of a needle protection spring (11) when the locking cam (2 e) at the proximal end of the retaining cam (3d) is snapped past, in the needle protection position is movable, wherein the locking cam (2e) in the needle protection position in front of a locking or locking stop, the example of the part forming the retaining cam (3d) or formed by the retaining cam (3d) snaps, which prevents or blocks a movement of the locking cam (2e) and thus the needle guard (2) in the proximal direction. 8. Injection device according to claim 6 or 7, characterized in that the retaining cam (3d) has a first flank and a second flank, wherein the locking cam (2e) bears against the first flank and by the first flank and by means of the displacement of the locking cam ( 2e) is deflected elastically to the proximal end of the retaining cam (3d) transversely to the direction of displacement of the needle protection sleeve (2), wherein: - When the retaining cam (3d) is in its first position and the needle guard (2) is moved from its puncture position in the distal direction, the retaining cam (3d) slides along the first edge, or - When the retaining cam (3d) is in its second position and the needle guard (2) is moved from its puncture position in the distal direction, the retaining cam (3d) slides along the second flank. 9. Injection device according to one of claims 6 to 8, characterized in that the retaining cam (3d) on a product container holder (3) in which the product container (9) is laterally enclosed, is formed, wherein the product container holder (3) at least during a Part of the Ausschütthubs (HA) of the plunger (7) in the distal direction is displaced or moved. 10. Injection device according to one of claims 6 to 9, characterized in that the housing (1) has a holding snapper (1c), wherein the holding snapper (1c) in the first position of the holding cam (3d) so snaps with the housing (1) in that a part forming the retaining cam (3d) is movable in the distal direction and immovable in the proximal direction, the retaining snapper (1c) being movable by moving the retaining cam (3d) from the first position to the second position the snapping with the part is releasable, wherein the holding snapper (1c) snaps with the part at another location when the retaining cam (3d) is in its second position or reaches its second position. 11. Injection device according to one of claims 5 to 10, characterized by at least one driving stop (210, 211, 212) which is formed on a driving sleeve (12) or a release sleeve (6) located at the proximal end of the product container holder (3 ), wherein the plunger (7) or an axially fixedly connected to the plunger (7) element, a Mitnahmegegenanschlag (200), wherein the Mitgegengegenanschlag (200) during a first Teilhubs (HA1) of the Ausschütthubs (HA) to the driving stop ( 210; 211; 212) and abuts against the driving stop (210; 211; 212) during a second part (HA2) of the delivery stroke (HA) and the driving stop (210; 211; 212) and thus the driving sleeve (12). or shifts the release sleeve (6), and the product container holder (3) and the retaining cam (3d) in the distal direction. 12. Injection device according to one of the preceding claims, characterized by a dose setting element (8) which is rotatable relative to a dose selection stop (100) and / or the plunger (7) for adjusting a dose of the product to be dispensed from the product container (9) and at least two different ones, in particular can assume rotational positions predetermined by latching positions relative to the dose-selection stop (100) and / or the plunger (7), the dose-setting element having a plurality of metering stops (110, 111), wherein, in a first rotational position of the at least two rotational positions, the dose selection stop (100) and a first metering stop (110) of the plurality of metering stops (110; 111) are arranged in alignment along the longitudinal axis (L), wherein in a second rotational position of the at least two rotational positions of the dose selection stop (100) about the longitudinal axis (L) angularly offset from the first Dosieranschlag (110) is arranged and / or the dose selection stop and a second metering of the plurality of dosing stops in an alignment along the longitudinal axis (L) are arranged, <Tb> - <September> where, <tb> <SEP> • <SEP> when the dose setting member (8) is in its first rotational position and the plunger (7) is displaced in the distal direction, the first metering stopper (110) abuts on the dose selection stopper (100), and or <tb> <SEP> • <SEP> when the dose setting member (8) is in its second rotational position and the plunger (7) is displaced in the distal direction, the first metering stop (110) on the dose selection stop (100) along the longitudinal axis (FIG. L) is moved past or is moved past and / or the second dosing stop (111) to the dose selection stop (100) abuts. 13. Injection device according to one of claims 5 to 12, characterized by a plurality of driving stops (210, 211) which are formed on a holding sleeve (12) or a release sleeve (6) which is supported on the proximal end of the product container holder (3), wherein the dose setting element (8) has a driving counterstop (200), <tb> - <SEP> wherein in the first rotational position of the at least two rotational positions of the driving counter-stop (200) and a first driving stop (210) of the plurality of driving stops (210; 211) are arranged in alignment along the longitudinal axis (L), <tb> - <SEP> wherein in a second rotational position of the at least two rotational positions of the driving counter-abutment (200) and a second driving stop (211) of the plurality of driving stops (210, 211) are arranged in alignment along the longitudinal axis (L), <Tb> - <September> where, <tb> <SEP> • <SEP> when the dose setting member (8) is in its first rotational position and the plunger (7) is displaced in the distal direction, the driving counter stop (200) first abuts against the first driving stop (210) and this entrains, whereby the retaining cam (3d) is moved in the distal direction to its second position, and / or <tb> <SEP> • <SEP> when the dose setting element (8) is in its second rotational position and the plunger (7) is displaced in the distal direction, the driving counter stop (200) on the first driving stop (210) along the longitudinal axis ( L) is moved past or is moved past and / or the driving counter-stop (200) on the second driving stop (211) abuts, whereby the retaining cam (3d) is moved in the distal direction to its second position. 14. auto-injector according to claim 12 or 13, characterized in that the first metering stop (110) and the second metering stop (111) with respect to each other along the longitudinal axis (L) and spaced from the longitudinal axis (L) are arranged angularly offset and / or the first driving stop (210) and the second driving stop (211) are spaced relative to each other along the longitudinal axis (L) and angularly offset about the longitudinal axis (L). 15. Injection device according to one of claims 1 to 14, characterized in that in the puncture position of the needle protection sleeve (2) formed by the needle protection sleeve (2) Einstechanschlag (2d) on a Einstechgegenanschlag (1i) of the housing (1) or a housing-fixed element , which blocks a movement of the needle guard (2) in the proximal direction, is applied.