CH709878A2 - Drive and metering with a limiting element for preventing the measurement of the dose. - Google Patents

Abstract

A dose setting device for an injection device for adjusting a dose to be dispensed from a product container comprising a housing having a longitudinal axis with distal and proximal ends, the product container being attached or attachable to the distal end, a dose setting element for adjusting a dose to be dispensed from the product container is rotatable relative to the housing, and is operatively connected to the housing such that upon increasing the set dose, the dose setting member is rotated in a first rotational direction and extends along the longitudinal axis in the proximal direction of the housing. Furthermore, the dose setting device comprises an actuating element, which is received or receivable at the proximal end of the dose setting element and actuated for the release of the set dose, preferably pressed, and is thus axially displaced from the non-actuated to the actuated position by an actuating stroke, wherein Actuated by the actuator for delivering the set dose, the dose setting element is rotated or rotated in a second direction of rotation opposite to the first direction of rotation, and moves distally along the longitudinal axis towards the housing, wherein the actuating element does not rotate. The dose setting device is characterized in that the actuating element and the dose setting element are designed such that the actuation of the actuating element does not impair or only slightly affects the rotation of the dose setting element in the second rotational direction when the adjusted dose is released.

Description

The invention relates to a drive and Dosiervorlichtung for an injection device, which prevents a mechanism for preventing the setting of a dose which exceeds the amount of the product in a product container. Furthermore, the invention relates to a dose setting device for an injection device with a dose setting and actuating element, which prevents or reduces an accidental impairment of the distribution upon actuation of the actuating element. The drive and metering device serves to dispense a liquid product, in particular a medicament. Preferably, the medicament may be insulin or, generally, a medicament for the treatment of diabetes.

Injection devices, which are also referred to as injection pens, are known from the prior art. With such injection devices, individual, to be administered product doses can be adjusted and then distribute. This process can be repeated several times. Since the amount of drug is limited in the product container, namely often 300 International Units (IU), it may happen that a dose is set, which is greater than the ausschüttbare from the product container amount, in particular nominal filling, which also as in the Product container contained quantity can be designated. This causes e.g. 35 IL), whereby with the subsequent payout only 20 IU can be distributed. The difference of 15 IU is missing in the therapy. This can be completely overlooked by the user of the device, so that it can lead to dangerous incorrect dosages.

In the prior art, therefore, mechanisms are proposed which prevent that a dose can be set which is greater than the amount of product contained in the product container. WO 01/19434 A1 proposes e.g. in the Fig. 3, such a mechanism having a drive sleeve which surrounds a piston rod and on its outer side has a thread which is in engagement with an internal thread of a stop nut. The stop nut has a recess which is in a rotationally fixed and axially displaceable engagement with a sleeve surrounding the stop nut. If the outer sleeve is rotated relative to the drive sleeve, as is done in the dose setting, the stop nut is rotated and thereby screwed along the thread of the drive nut along to a stop position. When dispensing the dose, the stop nut is stationary with respect to the drive sleeve and the outer sleeve, so that a counter is formed, which counts the set and distributed doses. In an attempt to set a dose exceeding the amount of product in the product container, the stop nut abuts against a stop of the drive sleeve and blocks further dose increase, thus preventing the setting of a dose exceeding the amount contained in the product container.

An alternative device with the same effect is shown for example in WO 2007/017 052. There is u.a. a stop nut is described which is in threaded engagement with an external thread of a piston rod. The piston rod is rotatable relative to the housing for delivery of the adjusted dose and in threaded engagement with the housing such that rotation of the piston rod causes it to be screwed in the dispensing direction. When setting a dose that would exceed the amount of product contained in the product container, the stop nut abuts a stopper formed at the proximal end of the piston rod, thereby blocking the mechanism and preventing the setting of a dose exceeding the amount of product contained in the product container , In WO 2007/017 052, a dose setting knob is rotated during the dose setting and the release is subsequently triggered by means of a release button attached to the side of the injection device.

In WO 2005/018 721 an injection device is shown with a dose setting element that is rotated relative to the housing at the dose setting and this rotation is transmitted to a dose scale. Upon release of the adjusted dose, the dose setting element is decoupled from the dose scale and dispensing mechanics so that during dispensing, the dose setting can rotate relative to the dose scale and / or dispensing mechanics. Thus, the user does not affect the turning back of the dose scale or Ausschüttmechanik when operating the dose setting. However, this device needs an additional coupling between the dose setting element and the dispensing mechanism.

WO 9 938 554 shows a dose setting device with a dose setting element and an actuating element which is encompassed by the dose setting element at the proximal end of the injection device. The actuator protrudes beyond the proximal end of the dose setting member, and when the adjusted dose is dispensed, the reverse rotation of the dose setting member upon actuation by the user may be impaired. For example, the thumb of the user partially touches the dose setting member upon actuation of the actuator. This is hereinafter referred to as the brake drum effect.

In EP 0 608 343 an injection device is described wherein for setting a dose a dose setting is rotated with respect to a housing, and thereby removes the dose setting from the proximal end of the housing. For dispensing, an actuator located at the proximal end of the dose setting member is actuated, and the dose setting member rotates back into the housing with the actuator not rotating. The actuator is designed plate-shaped and is stored rotationally free relative to the dose setting. The outer diameter of the plate is smaller than or equal to the outer diameter of the dose setting, so that a mutual contact of the plate and dose Einein element can not be prevented and thus the brake drum effect can not occur.

It is an object of the invention to provide a drive and metering device or a dose setting device for an injection device, which offers an alternative to the above-mentioned mechanisms or eliminates their disadvantages.

The object is achieved with the dose setting device with the features of claim 1. Advantageous developments emerge from the dependent claims, the description and the figures.

The drive and metering device with dose setting device according to the invention has a housing, which, e.g. can be multi-part or one-piece. The housing may e.g. be elongated. e.g. For example, the housing may be sleeve-shaped or one or more sleeves, e.g. may be arranged concentrically. The housing may have an outer sleeve that can be grasped by the user of the device. The housing may e.g. an inner sleeve, which is often also referred to as a mechanism holder, have, which is rotationally and preferably also axially fixed to the outer sleeve, in particular latched or glued or welded. The housing may e.g. a pointing device, e.g. have a window in which the currently set dose can be read. The window may e.g. a transparent material, in particular a lens, or have a breakthrough through the housing.

At the distal end of the housing, e.g. sleeve-shaped product container holder, which may also be referred to as a product container receptacle, be releasably or permanently attached or be. In the product container holder, a product container, or a carpule, is received or receivable.

The device further comprises a piston rod having a distal end, a proximal end and a thread, in particular an external thread and is movable for a product discharge with respect to the housing in a dispensing direction. The thread is disposed between the distal and proximal ends. At the distal end of the piston rod, e.g. a plate-shaped flange may be arranged, which press against the attached to the output and metering device or attachable product container and this can move it. The piston rod is preferably displaceable relative to the housing in and in particular against the dispensing direction, and rotationally fixed. The piston rod can be secured against rotation by the housing or a guide member connected at least in a rotationally fixed manner to the housing. The guide member may be rotationally fixed with respect to the housing, wherein the piston rod may also be rotationally mounted on the guide member. Preferably, the piston rod is axial relative to the guide member, i. along the longitudinal axis of the device, displaceable. The piston rod may e.g. a non-circular cross-section, in particular one or more, e.g. two, along the longitudinal axis of the piston rod extending grooves or flats, in which the guide member engages, so that the piston rod is axially displaceable and rotationally fixed. The guide member may e.g. be axially fixed or displaceable with respect to the housing. The guide member may be a part of the housing or a separate part, in particular when the guide member along the longitudinal axis of the device is displaceable relative to the housing. In particular, when the guide member is rotationally and axially fixed with respect to the housing, it may be considered part of the housing.

The drive and metering or dose setting further comprises a rotary member which is operatively, in particular rotationally fixed, connected to a stop stop, and engages in the thread of the piston rod. Rotation of the rotary member relative to the piston rod causes the piston rod to be moved along the longitudinal axis of the device relative to the housing and with its distal end forward in the dispensing direction. The rotary member may be axially fixed or axially movable with respect to the housing. By rotation of the rotary member relative to the housing, the piston rod is screwed to the rotary member in the distal direction, i. between the rotary member and the piston rod takes a screwing, and longitudinally guided on the housing or the guide member, so that the piston rod axially displaces in the discharge direction (by a Ausschütthub) and does not rotate, i. is rotationally fixed with respect to the housing.

Further, a dose setting is provided, which is rotatable relative to the housing and / or the piston rod in a first rotational direction to increase a dose to be dispensed from the product container. The dose setting element may be axially fixed, in particular during the dose setting and dispensing with respect to the housing. Preferably, however, the dose setting member is screwable with respect to the housing so that the dose member can be screwed out of the housing by its rotational movement in the first direction of rotation, and by its rotational movement in the opposite direction of rotation, i. in the second direction of rotation, in the housing is screwed back. Preferably, the dose setting member is disposed at the proximal end of the housing and may be screwed out of the proximal end of the housing and screwed into the proximal end of the housing. Preferably, the dose setting can be screwed into the housing to reduce the dose to be distributed and / or for product distribution or rotated at least in the second direction of rotation. By rotation of the dose setting element in the second direction of rotation, a dose reduction or dose correction can be performed. The dose setting element is preferably graspable by the user of the device and rotatable relative to the housing. The dose setting element may also be referred to as a dosing button.

The drive and metering or dose setting further comprises a limiting element which has a thread which engages in a further thread of the piston rod or the thread, in which engages the rotary member. The dose setting member is coupled to the restriction member such that rotation of the dose adjustment member relative to the piston rod and / or to the housing in the first rotational direction causes rotation of the restriction member relative to the piston rod, preferably in the same rotational direction as the dose setting member. By the rotation of the dose setting element and / or the delimiting element, in particular in the first direction of rotation, the limiting element can be screwed to the distal end of the piston rod. The restricting member has a counter stop which is moved toward the stop stop or to a stop position by the rotation of the dose setting member in the first rotational direction. The distance along a helical curve corresponding to the thread in which the limiting element engages, measured distance between the stop stop and the counter-stop is proportional to the (distributable) amount, in particular either nominal or discharge amount, of the product in the product container. This distance is reduced by rotating the dose setting element in the first direction of rotation. When the counter-abutment abuts the stop-stop, the restriction member blocks the setting of a dose, e.g. which exceeds the amount of product in the product container or, in other words, the rotation of the dose setting element in the first direction of rotation. This can prevent the setting of a dose which reduces the amount of product in the product container, i. exceeds the nominal filling, even if in principle a higher dose would be adjustable with the drive and metering device or in the pointing device a value of the dose scale appears, which is less than the maximum value of the dose scale. Alternatively, this can prevent the setting of a dose, which would cause that remains in the product container less than the remaining amount of the nominal filling quantity, or that their distribution would also cause the distribution of at least a subset of the residual amount; In particular, even if a higher dose could in principle be set with the drive and metering device or a value of the dose scale appears in the pointing device which is less than the maximum value of the dose scale. Particular reference will be made to the further aspect described below. The adjusted dose or the distributable dose contained in the product container can be read via the pointing device on a dose display drum. As a result, the user of the device is reliably displayed, which dose he can administer safely with the device.

Characterized in that the limiting element abuts the particular non-rotatably connected to the rotary member stop stop, a very stable mechanism is achieved because the parts lock member, piston rod and limiting element with respect to each other when the counter-stop abuts the stop stop, i. the limiting element is in its stop position.

Particularly preferably, the rotary member forms the stop stop. The rotary member may be one or more parts. If the rotary member is multi-part, it is preferred that the parts forming the rotary member are firmly connected to each other and / or behave like a single part. The advantage of a multi-part rotary member is that one part is made of a first plastic and the other part of a second plastic, which is different from the first plastic, i. has other properties, may be formed. e.g. For example, the part that is threadedly engaged with the piston rod may have optimized friction characteristics, i. form a friction pair with a low coefficient of friction with the piston rod. The other part, e.g. forms the stop stop can be optimized in terms of its strength, i. e.g. be formed of a fiber-reinforced plastic. The latter part can e.g. have one or more coupling structures, such as e.g. Gearing. In particular, in coupling structures, it is advantageous to pay attention to increased strength.

In preferred embodiments of the invention, the dose setting or Dosierknopf to reduce one or the set dose in the second, the first direction of rotation opposite direction of rotation can be rotated. Rotation of the dose setting member relative to the piston rod in the second rotational direction may cause rotation of the restriction member relative to the piston rod, preferably also in the second rotational direction. By this rotation, the limiting element can be screwed to the proximal end of the piston rod. In this case, the limiting element is preferably also moved along the longitudinal axis of the housing. In particular, rotation of the dose setting member and / or the restriction member relative to the piston rod during dose setting causes the counter stop to be moved away from the stop stop. That is, the distance between the counter-stop and the stop-stop increases.

The drive and metering device or dose setting device advantageously comprises an actuating element which is actuated, preferably pressed, for the distribution of the set dose by the user of the device. The actuating element is preferably arranged at the proximal end of the drive and metering device. In particular, the actuating element can be moved during the actuation relative to the dose setting element along the longitudinal axis and / or in the distal direction. The actuator may be received by the dose setting element. For example, the actuating element may form the proximal end of the drive and metering device. The actuating element can be configured in particular as an actuating button. The actuator is conveniently arranged so that the user of the device, the actuator with the thumb of the hand, which surrounds the housing of the drive and metering device actuate, in particular can press. The actuator may be urged from an unactuated position relative to the housing and / or the dose setting member in the distal direction to an actuated position. Preferably, a spring is provided, which is tensioned upon actuation of the actuating element. When the actuator is released, it can be displaced from the actuated position to the unactuated position, in particular by the preloaded spring.

In embodiments in which the dosage setting element for the dose increase is screwed out of the proximal end of the housing, it is preferred that the pressing of the actuating element initially causes a movement of the actuating element relative to the dose setting element in the distal direction (actuating stroke of the actuating element) wherein further depression of the actuator causes the dose setting element to be screwed back into the housing (drive stroke of the dose setting element or the actuating element).

In a preferred embodiment of the invention, a so-called brake drum effect, which affects the rotation of the dose setting element upon actuation of the actuating element in the distribution, prevents or at least reduces. The user preferably presses the actuator with his thumb for dispensing, and may, as described in the prior art, touch both the actuator and the dose setting. Upon release, the actuator does not rotate while the dose setting member rotates and moves axially toward the housing. The actuator follows the axial movement of the dose setting element. The design of the actuating element in connection with the dose setting is such that a brake drum effect is prevented or at least reduced. This can be achieved for example by an extension of the actuating element relative to the dose setting element, and / or an enlargement of the outside diameter of the actuating element with respect to the dose setting element. As an alternative, it is also possible to design the actuating element at the proximal end with a cap which partially overlaps or laterally covers the dose setting element.

The extension of the actuating element is designed so that the distance between the proximal end of the actuating element and the proximal end of the dose setting is at least twice as large as the axial distance between the non-actuated and actuated position of the actuating element. This axial distance can be referred to as operating stroke. The enlargement of the outer diameter at the proximal end of the actuating element is such that the outer diameter at the proximal end of the actuating element is at least equal to the outer diameter of the dose setting element.

A cap at the proximal end of the actuator comprises a circular lid and a distally extending rim. The actuator is axially fixedly connected to the center of the lid, and rotatably mounted relative to the dose setting and / or a dosing sleeve. The distally extending edge at least partially overlaps a portion of the dose setting element and the height from the edge is at least twice as large as the actuation stroke. The Doseinstellelement is preferably cylindrical with a uniform outer diameter, but may also have a smaller outer diameter at the proximal end, preferably where the edge of the cap overlaps the dose setting, in particular, the outer diameter can continuously taper or form a step.

Preferably, the pressing of the actuating element by the user to the drive stroke causes the rotary member relative to the housing and the piston rod, in particular in the second rotational direction, is rotated, whereby the piston rod moves relative to the housing in the dispensing direction. At the same time the limiting element is screwed towards the proximal end of the piston rod, wherein the distance between the stop stop and the counter stop ideally remains constant. By screwing the Doseinstellelements back into the housing, the rotary member is rotated relative to the housing and the piston rod, in particular in the second direction of rotation, resulting in the said effects. The limiting element stands by this movement, i. during the dispensing relative to the housing axially fixed and rotates in the second direction of rotation. This ensures that the distance between the stop stop and the counter-stop remains constant, but the limiting element screwed in relation to the piston rod in the proximal direction, since the piston rod performs no rotary motion during product distribution, but a pure axial movement.

In particular, it is preferred that between the housing and the rotary member, a unidirectional coupling, in particular a ratchet, is arranged, which causes the rotation of the rotary member in a rotational direction, which causes the movement of the piston rod in the dispensing direction, preferably in the second direction of rotation , eg with the application of a low torque which elastically deforms a yielding or elastic means (spring or pawl) of the unidirectional coupling, and does not permit in the opposite direction of rotation, in particular in the first direction of rotation. Advantageously, this can be achieved in that attempting to rotate the dose setting in the first direction of rotation when the counter-stop of the actuating element abuts against the stop of the rotary member, i. the restriction member is in its stop position, the rotation of the dose setting member in the first rotational direction is prevented. Advantageously, the torque applied to the dose setting member in the first rotational direction is directed into the rotating member via the restricting member and into the housing from the rotating member via the unidirectional coupling, thereby blocking rotation of the dose setting member in the first rotational direction when the restricting member is in its stop position located.

As an alternative to the unidirectional coupling can be provided between the housing and the rotary member, a bidirectional coupling acting in the engaged state, the rotation of the rotary member relative to the housing in the first rotational direction and in the second rotational direction blocks or prevents, in particular the actuating element is unactuated or in its unactuated position, and in the disengaged state, in particular when the actuating element is actuated or in its actuated position, allows the rotation of the rotary member relative to the housing, in particular in both directions of rotation or at least in the second direction of rotation. The bidirectional coupling can be achieved by actuating, i. Moving the actuator from its unactuated position to the actuated position, be disengaged. In this way, it can also be achieved that in an attempt to rotate the dose setting element in the first direction of rotation when the counter stop of the actuating element abuts against the stop of the rotary element, i. the restriction member is in its stop position, the rotation of the dose setting member in the first rotational direction is prevented. Advantageously, the torque applied to the dose setting member in the first rotational direction is directed into the rotating member via the restricting member and into the housing from the rotary member via the bidirectional coupling, thereby blocking the rotation of the dose setting member in the first rotational direction when the restricting member is in its stop position located.

In particular, in embodiments where a spent, i. deflated product container against a new, i. filled product container can be replaced, it is advantageous that the unidirectional coupling between an activated switching state and an inactivated switching state is switched back and forth. In its activated switching state allows the unidirectional coupling rotation of the rotary member in the direction of rotation, which causes the movement of the piston rod in the dispensing direction, in particular in the second direction of rotation, and in the opposite direction, in particular the first direction of rotation, not. In its inactivated switching state, the unidirectional coupling allows the rotation of the rotary member in the opposite direction of rotation, in particular the first direction of rotation. The unidirectional clutch preferably assumes its inactivated switching state when the product container holder is detached from the housing or attached to the housing, but no product container is inserted into the product container holder. The unidirectional clutch may be in its activated switching state when the product container holder without product container or only with product container is attached to the housing. This results in two different embodiments, namely an embodiment in which the product container holder activates a mechanism that switches the unidirectional coupling to its activated switching state, or an embodiment in which the product container activates this mechanism.

In particular, between the product container or the product container holder and the unidirectional coupling, a switching element may be arranged, which is displaceable by attaching the product container holder, with or without product container, relative to the housing, in particular in the proximal direction, and the unidirectional coupling in their activated switching state switches. The switching element can be displaced or displaced by releasing the product container holder or the product container, in particular in the distal direction, and switching the unidirectional coupling into its inactivated switching state. Preferably, a spring may be provided which is stretched in the proximal direction during displacement of the switching member and which displaces the switching member in the distal direction when removing the product container holder or the product container.

The switching element may e.g. relative to the housing rotationally fixed and slidably disposed along the longitudinal axis of the device. e.g. The product container holder can be attached to the housing with a rotational movement. The product container holder may have a gear surface which acts as an activation element, which slides relative to the housing or the switching member on the switching member during the rotational movement of the product container holder and thereby causes a movement of the switching member along the longitudinal axis of the housing or the device. The product container holder may e.g. screwed to the housing with a thread. Alternatively, the product container holder can be fastened to the housing by means of a bayonet closure. The advantage of a bayonet catch is that it usually allows attachment of the product container holder to the housing by rotation of the product container holder less than one revolution relative to the housing, such as e.g. by 35 °, 45 ° or 90 °, preferably less than or equal to 90 °. The bayonet closure may be such that first a pure plugging movement and then a pure rotary movement of the product container holder are carried out relative to the housing for the attachment. Alternatively, the bayonet catch may be configured to secure the product container holder in attachment with a simultaneous combined rotational-axial movement relative to the housing. It is particularly preferred in all embodiments that the bayonet closure is designed so that the product container holder at the end of the fastening movement a pure rotational movement, i. executes without movement of the product container holder along the longitudinal axis of the housing.

In embodiments in which the spent product container can be replaced with a new one, it is preferred that the piston rod be reset, i. in the housing of the drive and metering device, in particular in the proximal direction, can be pushed back. Upon reset, the piston rod is moved relative to the housing in the proximal direction. This can be done by pressing against the distal end of the piston rod when the product container or product container holder is disengaged, in particular when the unidirectional coupling is inactivated, e.g. by a user's finger or by the piston of the new product container. For this purpose, it is preferred that the thread pitch of the intermeshing threads of the rotary member and the piston rod is at least so great that no self-locking occurs when the piston rod is reset in the inactivated unidirectional coupling against the discharge direction. When resetting or displacing the piston rod in the proximal direction, the rotary member performs a rotation in the direction of rotation, which is opposite to the direction of rotation for the product distribution. In particular, when reset, the rotary member performs rotation in the first direction of rotation relative to the housing and / or the piston rod. The piston rod is in particular by means of the guide member, rotatably relative to the housing when the piston rod is reset.

Preferably, when the piston rod is reset with respect to the piston rod, the limiting element is secured against rotation and axially fixed so that the limiting element is displaced together with the piston rod relative to the housing in the proximal direction.

During the resetting of the piston rod, the dose setting element does not perform any rotational movement and / or axial movement relative to the housing.

In preferred embodiments, in which the set dose is to be particularly easy to read, the drive and metering device may comprise a dose display sleeve which is at least rotationally fixed, preferably also axially fixed coupled to the dose setting, in particular indirectly or directly coupled. In particularly preferred embodiments, the dose indicating sleeve may be integrally connected or snapped, glued or welded to the dose setting element, the actuating element or trigger button being preferably at least partially received and / or overlapped by the dose setting element. In particular, the dose setting member and the dose indicating sleeve may behave as a common part. The dose indicator sleeve may have a helically arranged dose scale over its preferably outer circumference. The dose scale preferably comprises a plurality of individual dose values or at least symbols representing a particular dose, the values or symbols being arranged along a helical line to give the helical dose scale. The dose scale may e.g. Have values from 0 to 60 or 80 or even 100 IU, e.g. in steps of 1, 2 or 5 As already mentioned, the housing may have a pointing device, in particular a window, in which the value or that symbol of the dose scale which corresponds to the currently or actually set or to be dispensed dose can be read. The dose indicating drum, by rotation of the dose setting member, performs a screwing motion relative to the housing so that the values of the helical dose scale move along or through the pointing device on the pointing device.

The dose indicator sleeve may e.g. have a thread which preferably has the same pitch as the helically arranged dose scale, the thread being e.g. may be in threaded engagement with the housing. The housing may e.g. an internal thread and the dose display drum have an external thread. Alternatively, the dose indicator drum may have an internal thread and the housing may have an external thread for threaded engagement. The pitch of the thread or the threaded engagement is preferably such that no self-locking occurs when the product dispensing actuator is actuated or pushed about the drive stroke into the housing so that the dose setting member screws into the housing together with the dose indicating drum when Actuator (about the drive stroke) is pressed in the distal direction.

In particularly preferred embodiments, the dose display drum can be screwed between a zero dose position and a maximum dose position, wherein a zero dose stop in the zero dose position of the dose display drum causes rotation of the dose indicating drum in the direction of rotation, particularly in the second direction of rotation, which causes a reduction in the dose prevented and allowed in the first direction of rotation, and a maximum dose stop in the maximum dose position of the dose display drum prevents the rotation of the dose indicating drum in the direction of rotation, in particular the first direction of rotation causing the dose to increase, and in the second direction of rotation causing the dose to decrease , allows. It is preferred that in the pointing device the maximum value of the dose scale is readable when the dose display drum is in its maximum dose position and the zero dose dose is readable when the dose display drum is in its zero dose position. The dose set in the maximum dose position is the maximum dose that can be distributed by the drive and metering device, even if the product container contains more product than the maximum dose. The maximum dose stop and / or the zero dose stop preferably act in the circumferential direction and can in particular be designed as rotational stops. The same applies mutatis mutandis to a maximum dose counter-stroke and / or the zero-dose counter-stroke.

In a first variant, the maximum dose stop or / and the zero dose stop may e.g. on the housing or a housing-fixed element, which may be considered in particular as belonging to the housing, such as e.g. an insert forming the window of the pointing device may be formed from transparent or opaque material, in particular plastic. Preferably, the dose indicator drum may form the maximum dose counter-stroke that strikes the maximum dose stop in the maximum dose position. The dose indicator drum or dose setting element may form the zero dose counter-stroke which strikes in the zero-dose position at the zero-dose stop.

In a second variant, the maximum dose stop or / and the zero dose stop may e.g. be arranged on an intermediate sleeve, in particular dosing sleeve, which can be arranged between the dose setting and the limiting element and is rotationally connected to the dose setting. Preferably, the intermediate sleeve, in particular one end of a thread or thread of the intermediate sleeve form the maximum dose stop. Alternatively or additionally, the intermediate sleeve, in particular an end of a thread of the intermediate sleeve, in particular the end of the thread or the thread, which is opposite to the end forming the maximum dose stop, form the zero dose stop. Preferably, the maximum dose stop is located distal to the zero dose stop, or vice versa. The maximum dose counter-stroke and / or the zero dose counter-stroke may e.g. are formed by a coupling member, in particular a coupling sleeve, which is in a threaded engagement with the intermediate sleeve, in particular dosing sleeve, and rotatably and axially slidably connected to the dose display drum, in particular in a rotationally fixed and axially displaceable engagement with the dose display drum. The coupling member may have an internal thread, in particular at least one internal thread segment, which engages in an external thread, in particular in the thread of the intermediate sleeve, which forms at least one of maximum dose stop and zero dose stop, wherein it is preferred that one end of the thread segment, the zero dose counter-stop and the other end of the same or another thread segment makes the maximum dose counter-stroke.

The first variant and the second variant are alternatively combinable. For example, the zero dose stop or / and the zero dose counter stop according to the first variant and the maximum dose stop or / and the maximum dose counter stop according to the second variant can be formed. Alternatively, the maximum dose stop or / and the maximum dose counter-stop according to the first variant and the zero-dose stop or / and the zero-dose counter-stop according to the second variant can be formed.

In the dose setting, the dose setting member is preferably rotated by the user relative to the housing, with the dose indicator and / or dose display drum moving in the proximal direction and the distance between the dose setting member and / or dose indicating drum and the proximal end of the housing increasing. The actuator or trigger button moves proximally along with the dose setting element at dose setting. When setting the maximum dose, the axial distance between the actuator and the proximal end of the housing is maximum. For the distribution, the injection device is preferably encompassed by the hand of a user, and actuates the actuating element with the thumb. The higher the axial distance between the housing and the actuating element, the greater the risk that when dispensing a set dose, the user simultaneously touches both the actuating element and the dose setting element and thus impairs or even prevents a reverse rotation of the dose setting element. The design of the dose setting element and the actuating element in the previously described embodiments at least prevent or reduce this brake drum effect.

The counter-abutment of the restriction member abuts the stopper stop and the restriction member prevents the rotation of the dose-indicating drum in the direction of rotation which causes an increase in the dose if the dose-indicating drum is not in its maximum dose position and / or if the amount of product in the product container less than the dose in the maximum dose position of the dose indicating drum.

In other words, the maximum dose can be adjusted and distributed on the drive and metering device as often as this maximum dose is actually contained in the amount of the product in the product container. If the amount of product in the product container is less than the maximum dose, stop stop and counter stop abut each other, thus preventing an increase in the dose.

In preferred embodiments, the limiting element is at least during the dose setting and the distribution of the set dose rotatably coupled to the dose display drum and / or the dose setting. The coupling can be permanent, in particular in all operating states. e.g. For example, the limiting element may be indirectly, e.g. be coupled via an intermediate sleeve with the dose display drum and / or the dose setting. Alternatively, the restriction member may be coupled directly to or engage with the dose setting member or the dose indicating drum. Preferably, the dose indicating drum and / or dose setting member are movable with respect to the restriction member along the longitudinal axis of the drive and metering device.

In preferred embodiments, in particular kinematically, between the dose setting element and the limiting element at least one intermediate sleeve, such as. a drive sleeve and / or dosing sleeve, or a first and e.g. second coupling sleeve, be arranged, in which the limiting element engages against rotation and axially displaceable. The at least one intermediate sleeve is preferably rotationally and optionally axially displaceably coupled to the dose setting element. This causes the rotation of the dose setting member to be transmitted to the restriction member which is rotated in the same rotational direction as the dose setting member.

The restriction member is coupled to the dose setting member such that during the dose setting, i. during rotation in the first direction of rotation and / or in rotation in the second direction of rotation, and the administration of the set dose is screwed along the piston rod. In particular, when the dose is increased, the restricting member is screwed towards the distal end of the piston rod and during dose reduction and during dose distribution towards the proximal end of the piston rod. The inventive arrangement is further causes the limiting element in the zero dose position immediately after a release of a set dose with respect to the piston rod occupies the same position as in the zero dose position immediately before setting the dose for this distribution. In other words, regardless of the degree of filling of the product container or the delivery stroke of the piston rod with respect to the piston rod, the limiting element always assumes the same position in the zero dose position of the dose indicator sleeve. By such kinematics, the limiting element can be integrated to save space in the drive and metering device.

Particularly preferably, the drive and metering device on a Ausschüttkupplung which is closed by means of actuation, in particular pressing, of the actuator to the operating stroke by the user of the device and opened by letting go of the actuator or can be. In particular, the spring, which is tensioned upon actuation of the actuator and when closing the Ausschüttkupplung open the Ausschüttkupplung and reset the actuator to its original position.

The rotary member is rotationally coupled to the dose indicating drum and / or the dose sub-element when the dispensing coupling is closed and in particular the actuator is actuated. The dose indicating drum and / or dose setting member are rotatable relative to the rotation member when the discharge coupling is opened, d, h. the actuator is inactivated or released, i. when the actuator is in its unactuated position.

For the dose setting, the actuator is unconfirmed, being actuated for the product distribution. That is, at the time of product dispensing, the dispensing coupling is closed, being open during dose setting. The discharge coupling may e.g. have a first coupling structure and a second coupling structure, which engage positively with one another in the closed discharge coupling and are disengaged when the discharge coupling is open. Preferably, the coupling structures can be brought into and out of engagement with each other along the longitudinal axis of the drive and metering device. If the drive and metering device has at least one intermediate sleeve, a coupling structure can be permanently secured against rotation with the intermediate sleeve, such as e.g. on a drive sleeve, the other coupling structure being e.g. may be formed on the rotary member. The coupling structure, which is brought into engagement with the coupling structure of the rotary member, is preferably permanently secured against rotation with respect to the limiting element. This causes the coupling structure to participate in the rotational movement of the restriction member during the dose increase, the dose reduction and the dose distribution.

Another aspect concerns the limitation of the distributable amount from a product container. This aspect can be appreciated not only in the drive and metering devices described herein, but also in the e.g. found in the prior art mechanisms for preventing the setting of a dose application, as described for example in the cited patent literature. The Applicant reserves the right to generally pursue this aspect with a separate application or with claims at least in this respect.

The injection device further comprises an elongate and preferably sleeve-shaped housing and a Doseinstellelement which is rotatable for increasing the dose to be distributed relative to the housing in a first rotational direction, and preferably for a reduction of the dose auszuschüttenden relative to the housing in one of the first Rotational direction opposite, second direction of rotation is rotatable on. For the design of the housing, the dose setting and the dose display drum reference is made to the embodiments described herein, regardless of the specific design and integration of the limiting element. The same applies to the actuator.

A limiting member coupled to the dose setting member, preferably non-rotatably, guides in the first direction of rotation during rotation of the dose setting member, i. when increasing the dose to be dispensed, move toward the stop stop. As a result, a distance, in particular extending along a helical curve, which is in particular directly proportional to the discharge quantity, is reduced between the stop stop and the delimiting element.

The limiting element coupled to the dose setting element guides in the second direction of rotation during rotation of the dose setting element, i. in reducing the dose to be dispensed, move away from the stop stop. As a result, the distance which, in particular, extends along the helical curve, which distance is in particular directly proportional to the discharge quantity, is increased between the stop stop and the delimiting element.

Preferably, the limiting element engages in a thread on which it can be screwed along during the rotation of the dose setting element. The thread prefers the helical curve.

The limiting element does not move during the distribution of the set dose with respect to the stop stop, i. E. the limiting element is stationary with respect to the stop stop, e.g. in the meantime it is able to move in relation to the housing.

The injection device may preferably have a discharge coupling, which can be switched by pressing, in particular pressing, an actuating element, in particular an actuating button at the proximal end of the injection device. The dump clutch couples the stop stopper and the restriction member so that the restriction member and the stopper stopper are movable relative to each other by rotation of the dose setting member when the actuator is inoperative, i. is in its unactuated position, and that the limiting element and the stop stop are immovable relative to each other, in particular rotationally fixed, when the actuating element is actuated, i. in its actuated position.

The invention has been described with reference to several preferred embodiments and developments. In the following, particularly preferred embodiments of a drive and metering device will be described with reference to figures. The features disclosed therein form the subject of the invention in each case individually and in any feature combination, in particular also with one or more of the aforementioned features, advantageously further. Show it: <Tb> FIG. 1 <SEP> an exploded view of the individual parts of a drive and metering device according to a first embodiment, <Tb> FIG. 2a, 2b show the drive and dosing device of the first embodiment in an initial state with a completely filled product container, FIG. 2b being a sectional view rotated by 90 ° with respect to FIG. 2a about the longitudinal axis, FIG. <Tb> FIG. 3 <SEP> the device of FIG. 2 in a maximum dose position, wherein an actuator is unactuated, <Tb> FIG. 4 <SEP> the view from FIG. 3, wherein the actuating element is actuated, <Tb> FIG. 5 <SEP> the device according to the first embodiment, after a discharge or in a zero-dose position after the dose set in FIGS. 3 and 4 has been distributed, <Tb> FIG. 6 <SEP> the device according to the first embodiment, wherein a dose increase is blocked by means of a limiting element, <Tb> FIG. 7 <SEP> the device according to the first embodiment, after a discharge or in a zero-dose position after the dose set in FIG. 6 has been distributed, <Tb> FIG. 8 <SEP> the device according to the first embodiment, wherein the product container and a product container holder are removed from the drive and metering device, <Tb> FIG. 9 <SEP> the drive and metering device according to the first embodiment, wherein a piston rod has been reset and a new product container and a product container holder are attached to the drive and metering device, <Tb> FIG. 10a, 10b <SEP> the device according to the first embodiment, wherein a new product container is inserted, and the actuator is actuated in the zero-dose position, <Tb> FIG. 11a, 11b <dose adjustment device according to the first embodiment, wherein the actuating element is not actuated (FIG. 11a) or in the actuated position (FIG. 11b), FIG. <Tb> FIG. 12a, 12b <dose> Dosage setting device according to a second embodiment wherein the actuating element has been extended compared to the first embodiment. 12a shows the actuating element in the non-actuated position, and FIG. 12b in the actuated position, FIG. <Tb> FIG. 13a, 13b <dose adjustment device according to a third embodiment wherein the diameter at the proximal end of the actuating element is at least equal to the outer diameter of the dose setting element, <Tb> FIG. 14a, 14b <SEP> dose setting device according to a fourth embodiment, wherein the dose setting element is covered by a cap of the actuating element, <Tb> FIG. 15a, 15b <SEP> Injection device with a dose setting device according to the first embodiment, wherein the actuating element is pressed by the thumb and in the actuated position, Fig. 15a shows an overview, Fig. 15b shows a detail, <Tb> FIG. 16a, 16b <SEP> Injection device with a dose setting device according to the second embodiment, wherein the actuating element is pressed by the thumb and in the actuated position, Fig. 16a shows an overview, Fig. 16b shows a detail, <Tb> FIG. 17a, 17b <SEP> Injection device with a dose setting device according to the third embodiment, wherein the actuator is pressed by the thumb and in the actuated position, Fig. 17a shows an overview, Fig. 17b shows a detail, <Tb> FIG. 18a, 18b <<SEP> Injection device with a dose setting device according to the fourth embodiment, wherein the actuator is pressed by the thumb and in the actuated position, Fig. 18a shows an overview, Fig. 18b shows a detail.

The first embodiment of a drive and metering device shown in FIGS. 1 to 10 has a housing 4, 18 which has an outer housing sleeve 18 and an inner housing sleeve 4 which is arranged inside and in particular concentrically with the outer housing sleeve 18 is referred to as a mechanism holder 4, has. The mechanism holder 4 is fixed to the outer housing sleeve 18, i. rotationally and axially connected. The housing 4, 18, namely the mechanism holder 4, has a thread 4a, in which engages a thread formed on the inner periphery of a dose display drum 9, so that the dose display drum 9 on the housing 4, 18 and its longitudinal axis L is screwed along. The dose indicator drum is fixed, i. rotatably and axially fixed to a dose setting 10, namely locked in this example. The dose setting element 10 is graspable by the user of the device and rotatable with respect to the housing 4, 18. By rotating the dose setting member 10 in a first direction of rotation, a product dose to be dispensed is increased and rotated by turning it to the opposite, i.e., the same position. second direction of rotation reduced. By rotating the dose setting member 10 in the first direction of rotation, the dose indicating drum 9 is moved out of the proximal, i.e. screwed rear end of the housing 4, 18 out and screwed by turning in the second direction of rotation in the housing 4, 18.

The housing 4, 18, namely the outer housing sleeve 18 has a pointing device 18 a, which is a breakthrough through the housing 18 in the example shown. In the pointing device 18a, the user of the device can read the set product dose by looking at a dose scale through the pointing device 18a. The dose-indicating drum 9 has on its outer circumference a dose scale 9b which extends helically over its outer circumference and has a multiplicity of numerical values arranged next to one another, the numerical values 0 to 60 being indicated in two steps in the example shown. The numerical values represent a dose in international units (IU). Should e.g. a dose of 30 IU are set, the dosage setting element 10 is rotated with respect to the housing 4, 18 until the number 30 in the pointing device 18a is read. At the proximal end of the drive and metering device, an actuator 21 is arranged in the form of an actuating button, and in particular forms the proximal end of the drive and metering device. The actuating element 21 is received by the dose setting element 10, in particular accommodated such that the actuating element 21 can perform an actuating stroke relative to the dose setting element 10. For this purpose, the actuating element 21 has, for example, an annular groove into which an inwardly directed projection 10b of the dose setting element engages. For example, in Figs. 2a, 2b and 3, the actuator 21 is shown in its unactuated position. 4 and 10a, 10b, the actuating element 21 is shown in its actuated position, wherein it has performed an actuating stroke compared to FIG. Actuator 21, due to its positioning at the proximal end of the device, can be pushed in a simple manner by the thumb of the hand of the user grasping housing 4, 18. be operated.

In order to release the adjusted product dose, the actuating element 21 is pressed even further in the distal direction, so that the dose setting element 10 together with the dose indicating drum 9 are screwed back into the housing 4, 18 (compare FIGS. 4 and 5). The actuating element 21 and the dose setting element 10 perform a drive stroke relative to the housing 4, 18.

At the distal end of the mechanism holder 4 and the housing 4, 18, a sleeve-shaped product container holder 11 is mounted, in which a product container 11a is received in the shape of a carpule. The carpule 11a has at its distal end a needle pierceable septum and a plunger which is suitable for product dispensing in the dispensing direction, i. slidable towards the septum, around the liquid product located between the septum and the piston, e.g. Insulin to displace from the product container 11a. On the piston, a piston rod 19 is supported. The piston rod 19 has a preferably multi-threaded external thread 19a, in which an internal thread 13a of the rotary member 13, 15 engages. The rotary member 13, 15 is rotatable and axially fixed relative to the housing 4,18. The rotary member 13,15 is in the example shown in two parts and has a threaded nut 13 and a coupling sleeve 15 which are rotatably and axially fixed snapped with each other. Between the threaded nut 13 and the coupling sleeve 15, an annular groove is formed, in which a part of the housing 4,18, namely a part of the mechanism holder 4 engages, so that the rotary member 13,15 relative to the housing 4 is rotatable but not axially movable.

A guide member 2, which is rotatably connected to the housing 4, 18 and with respect to the housing 4,18 along the longitudinal axis L is not or at least limited (eg in the range of one or more millimeters, such as smaller than 5 mm) is axially movable, the piston rod 19 rotatably, so that the piston rod 19 is not rotatable relative to the housing 4.18. However, the piston rod 19 is movable relative to the guide member 2 along the longitudinal axis L. The piston rod 19 has at least one guide and / or longitudinal groove 19d, which is superimposed on the external thread 19a and extends parallel to the longitudinal axis L. In the guide groove 19 d, the guide member 2 engages, so that the piston rod 19 is secured against rotation relative to the guide member 2 and axially along the longitudinal axis L is displaceable.

The drive and metering device comprises the rotary member 13, 15, which at the dose setting, i. the dose increase or / and -reducing rotationally fixed with respect to the piston rod 19 and / or the housing 4,18 and is rotated for the product distribution relative to the piston rod 19 and / or the housing 4,18 about the axis L, in particular the second direction of rotation of the dose setting element 10. The rotation member 13, 15 entrains the rotational movement of the dosage setting element 10 for the product distribution. The rotary member 13, 15 engages with an internal thread 13a in the external thread 19a of the piston rod 19. The rotary member 13,15 is axially fixed and rotatably connected to the housing 4,18, in particular with the mechanism holder 4. The rotary member 13,15 has two parts, namely a threaded nut 13 and a coupling sleeve 15 which are rotatably locked together and axially fixed and behave like a single part. The threaded nut 13 is made of a plastic, e.g. Teflon formed, which forms a friction pairing with the material of the piston rod 19 with a low coefficient of friction. The coupling sleeve 15 is formed of a plastic having a higher strength than the plastic of the threaded nut 13, such as e.g. made of fiber-reinforced plastic. Between the threaded nut 13 and the coupling sleeve 15 is an over the circumference of the rotary member 13, 15 extending annular groove disposed in which a part of the housing 4, 18 or a housing-fixed element, in this example, the mechanism holder 4 engages. For example, the threaded nut 13 and the coupling sleeve 15 limit the annular groove. As a result, an assembly of the rotary member 13,15 is facilitated. Preferably, the rotary member 13,15 may be arranged axially fixed in relation to the housing 4,18 in all operating conditions of the drive and metering device.

A Ausschüttkupplung 81, 82 is closed by pressing the actuator 21 in the distal direction by the user of the device and opened by releasing the actuator 21. The Ausschüttkupplung 81, 82 rotatably couples the rotary member 13, 15 with the dose setting 10 when the Ausschüttkupplung 81, 82 is closed. When the dispensing coupling 81, 82 is opened, the dose setting element 10 is rotationally decoupled from the rotary member 13, 15, i. in particular, that the dose setting element 10 is rotatable relative to the rotary member 13,15.

The ejection coupling 81, 82 has a first coupling structure 81, which may also be referred to as a first Ausschüttkupplungsstruktur, and a second coupling structure 82, which may also be referred to as a second Ausschüttkupplungsstruktur on, which are brought into a rotational engagement with each other, when the clutch 81, 82 is closed. The clutch 81, 82 further includes a spring 5 which urges the first clutch structure 81 and the second clutch structure 82 out of engagement, in particular by the spring energy stored in the spring 5. The actuation of the activation element 21 closes the clutch 81, 82 ie the first coupling structure 81 is brought into a rotationally fixed engagement with the second coupling structure 82, wherein the spring 5 is tensioned. The spring 5 is also used in particular for resetting the actuating element 21 in its unactuated position.

The first coupling structure 81 is in the example shown a circumferentially extending internal toothing, wherein the second coupling structure 82 is a circumferentially extending external toothing, wherein the first and second coupling structure 81, 82 with a movement along the longitudinal axis L can be brought into engagement. The second coupling structure 82 is in particular rotatably coupled to the rotary member 13,15. Preferably, the second coupling structure 82 of the rotary member 13,15, in particular the coupling sleeve 15 is formed.

The first coupling structure 81 may e.g. be a drive sleeve 8, which may be arranged geometrically and / or kinematically between the rotary member 13, 15 and the actuator 21. By pressing the actuating element 21, the drive sleeve 8 is displaced along the longitudinal axis L and relative to the housing 4, 18 and / or the piston rod 19 in the distal direction and by releasing the actuating element 21 by means of the spring energy stored in the spring 5 in the proximal direction.

The drive sleeve 8 is preferably permanently, in particular during the dose setting and dose distribution rotatably connected to the dose setting 10. In particular, it is preferred that the first coupling structure 81 is permanently connected in a rotationally fixed manner to the dose setting element 10.

Between the drive sleeve 8 and the actuating element 21, a metering sleeve 7 is arranged, which engages in the drive sleeve 8 in a rotationally fixed and axially displaceable manner. The dosing sleeve 7 has on its inner periphery one or more guide slots 7c which extend parallel to the longitudinal axis L and into which one or more guide ribs 8c, which are formed on the outer circumference of the drive sleeve 8, engage the non-rotatable but axially displaceable connection between the dosing sleeve 7 and the drive sleeve 8 to form.

The dosing sleeve 7 has at its outer periphery a thread 7b, which is distally bounded by a maximum dose stop 7e and proximal of a zero dose stop 7d. A coupling member 6 has at least one internal thread segment 6b, which engages in the thread 7b. Although it is an internal thread segment 6b this is visible in Fig. 1 on the outer circumference of the coupling member 6, since for manufacturing reasons from the outside recesses are introduced to avoid material accumulation during injection molding. The at least one female thread segment 6b forms, with a circumferentially facing end, the maximum dose stop which strikes the maximum dose stop 7e in the maximum dose position in an attempt to rotate the dose setting element 10 in the first rotational direction, and the zero dose counter stop with the opposite circumferential end, which abuts the zero dose stop 7d in the zero dose position in an attempt to rotate the dose setting element 10 in the second rotational direction. The thread 7b is multi-speed, in this example four-speed. In particular, the thread 7b may have the same pitch as the thread 4a.

Alternatively, the mechanism holder 4 or the housing 4, 18 may have the zero dose stop 4c, which may be e.g. may be formed by the distal end of the thread 4a. The zero dose counter-stroke can be detected by the dose-indicating drum 9, e.g. be formed on the inner circumference. For example, the zero dose counter stop may be formed by one end of the internal thread or internal thread segment of the dose indicating drum 9 engaged with the thread 4a.

The dosing sleeve 7 is preferably permanently non-rotatably and axially displaceably connected to the dose setting element 10. For this purpose, the dosing sleeve 7 has one or more ribs 7a which extend parallel to the longitudinal axis L and engage in one or more recesses 10a of the dose setting element 10.

Between the mechanism holder 4 and the dosing sleeve 7, the coupling member 6, which is designed as a sleeve and thus can be referred to as a coupling sleeve 6, arranged. The coupling sleeve 6 is in a rotationally secured and axially displaceable engagement with the mechanism holder 4. For this purpose, the coupling sleeve 6 on its outer periphery one or more ribs 6a, which engages in a parallel to the longitudinal axis L extending groove of the mechanism holder 4. The coupling sleeve 6 has an internal thread, which engages in the thread 7b of the dosing sleeve 7.

The actuating element 21 is freely rotatably attached to the dosing sleeve 7 at the proximal end of the dosing sleeve 7.

Between the housing 4, 18, a unidirectional coupling 71, 72, 73, 74 is arranged, which is generally described below by the reference numeral 70. During dose setting and / or dispensing, the diverting clutch 70 does not permit rotation of the rotary member 13, 15 in the first rotational direction relative to the housing 4, 18 and / or the piston rod 19, and in the second rotational direction. The unidirectional clutch 70 may be formed as a ratchet. The unidirectional clutch 70 prevents the rotational member 13, 15 is rotated in the first direction of rotation due to any friction occurring between the dose setting 10 and the rotary member 13, 15 or due to elasticities of the piston of the product container 11 a trying to the Push the piston rod 19a in the proximal direction back.

If the drive and metering device should be designed as a disposable device, which is disposed of after complete emptying of the product container 11a, the unidirectional coupling 70 can act permanently and not be solved. However, if the drive and metering device is intended for reusable use, i. that the product container 11a is to be exchanged for another product container 11a, it is preferable that the unidirectional coupling 70 is detachable when replacing the product container 11a, whereby the rotary member 13, 15 can rotate in the first rotational direction relative to the housing 4, 18 , so that the piston rod 19 can be reset to its starting position.

The unidirectional clutch 70 has a first coupling structure 71 and a second coupling structure 72, wherein the first and second coupling structure 71,72 engage each other and are rotatable relative to each other only in one direction of rotation. The first coupling structure 71 may e.g. be connected to the housing 4, 18 or at least secured against rotation with the housing 4, 18, such. are formed on a switching element 12. The second coupling structure 72 may be e.g. of the rotary member 13, 15, in particular of the coupling sleeve 15 or at least of a part rotationally fixed at least temporarily to the rotary member 13, 15, e.g. be connected to a coupling ring 14 or formed thereon. The coupling ring 14 is preferably rotationally fixed and axially displaceable with respect to the rotary member, at least during dose setting and dispensing. In particular, the first and second coupling structures 71, 72 are formed by a spring, in particular the spring 5, which is e.g. supported on the coupling ring 14, held in engagement. Preferably, the first coupling structure 71 and the second coupling structure 72 are each configured as circumferentially distributed sawtooth-shaped teeth. The first coupling structure 71 preferably points in the proximal direction, with the second coupling structure 72 preferably pointing in the distal direction. The teeth of the first coupling structure 71 and the teeth of the second coupling structure 72 preferably face each other. The saw teeth of the coupling structures 71, 72 have a steep flank and a flat flank, wherein the flat flank of a coupling structure on the flat flank of the other coupling structure can slide, whereby the second coupling structure 72 is rotatable relative to the first coupling structure 71 in the second direction of rotation , In an attempt to rotate the second coupling structure 72 relative to the first coupling structure 71 in the first rotational direction, the steep flanks of the coupling structures 71, 72 are pressed against each other, thereby blocking the rotation of the second coupling structure in the first direction of rotation.

To adjust the dose, the dose setting element 10 is rotated in the first direction of rotation relative to the housing 4, 18, whereby the dosage setting element 10 is unscrewed from the proximal end of the housing 4, 18 together with the dose display drum 9 (Figure 3). The set dose can be read on the pointing device 18a on the dose scale 9b. The Ausschüttkupplung 81, 82 is open during the dose setting. In Fig. 3, the device is shown in a state in which the dispensed product dose is set.

For discharging the product dose set in Fig. 3, the actuating member 21 is pressed relative to the dose setting member 10 by an actuating stroke in the distal direction (see Fig. 3 and 4), whereby the dosing sleeve 7 also relative to the actuating stroke of the actuating element 21 relative is moved to the housing 4, 18. Due to the threaded engagement between the dosing member 7 and the coupling sleeve 6, the coupling sleeve 6 is displaced relative to the housing 4, 18 in the distal direction, namely by the actuating stroke of the actuating element 21. The coupling member 6 is supported on the drive sleeve 8, whereby the drive sleeve 8 is also displaced in the distal direction, in particular by the actuating stroke of the actuating element 21. As a result, the formed on the drive sleeve 8 first coupling structure 81 in a rotationally fixed engagement with the second coupling structure 82nd the rotary member 13, 15 brought, whereby the discharge coupling 81, 82 is closed. FIG. 4 shows the device when the actuating element 21 is actuated.

If the actuating element 21 is pressed further in the distal direction, the dose setting element 10 is screwed back into the housing 4, 18 by a drive stroke (compare FIGS. 4 and 5). Here, the dose values of the dose scale in the pointing device 18a count back. When screwing back the dose setting 10, the rotational movement of the dose setting 10 on the metering sleeve 7 on the drive sleeve 8 and the drive sleeve 8 via the closed Ausschüttkupplung 81, 82 transmitted to the rotary member 13, 15, whereby the rotary member 13, 15 a rotational movement relative to the Piston rod 19 and / or to the housing 4, 18 in the second direction of rotation, namely in the same direction of rotation as the dose setting 10 performs. By this rotational movement, the piston rod 19 is displaced in the distal direction, wherein the piston rod 19 by the guide member 2 rotatably with respect to the housing 4, 18 is held. The flange disposed at the distal end of the piston rod 19 presses against the piston and displaces the piston of the product container 11a in the discharge direction, so that the product contained in the product container 11a is displaced out of the product container 11a according to the set product dose. The piston rod 19 carries out a driven stroke. Preferably, the drive stroke of the dose setting element 10 is proportional to and greater than the output stroke of the piston rod 19, whereby a translation is formed and decreases the force to be exerted on the actuator 21 to displace the piston.

This process can be repeated several times, wherein in each case an individual dose is adjustable.

In Fig. 6, the device is shown in a state in which the distributable amount contained in the product container 11a is smaller than the maximum adjustable dose with the device. In order to prevent the device from being able to adjust a dose which is greater than the amount of product which can be distributed in the product container 11a, the device has a limiting element 20, which in the example shown is sleeve-shaped and has an internal thread 20b which is in the thread 19a of the piston rod 19 engages. The limiting element 20 is further secured against rotation and axially displaceably connected to the drive sleeve 8, in particular in such an engagement with the drive sleeve 8. The drive sleeve 8 may e.g. for this purpose have at least one longitudinal groove on its circumference, in which a projection 20c on the outer periphery of the limiting element 20 engages.

The limiting element 20 further has, in particular at its distal end, a counter-abutment 20a in the form of a surface whose surface normal points in the circumferential direction. The rotary member 13, 15, in particular the coupling sleeve 15, has a stop stop in the form of a surface whose surface normal points in the circumferential direction. The distance between the stop stop 15a and the counterstop 20a along a helical curve, in particular with the pitch of the thread 19a, is proportional to the dose or quantity that can be set and / or distributed from the product container.

The limiting element 20 is preferably permanently connected in a rotationally fixed manner to the dosage setting element 10, so that it participates in the rotations in the metering and dispensing movements of the dose setting element 10. In Figs. 2a and 2b, the restriction member 20 is shown with respect to the piston rod 19 in a home position or zero dose position at which the dose is zero. When the dose setting restriction member 20 is rotated in a first direction of rotation for a dose increase relative to the piston rod 19, the restriction member 20 non-rotatably connected to the dose setting member 10 also rotates relative to the piston rod 19, thereby limiting the restriction member 20 relative to the piston rod 19 and the housing 4, 18 in the distal direction is screwed (Fig. 3). When the dose setting member 10 is rotated in the second rotational direction relative to the housing 4, 18 for dose correction or reduction, the restriction member 20 is screwed relative to the piston journal 19 and relative to the housing 4, 18 in the proximal direction.

When the dose setting member 10 for the dose distribution, i. with actuated actuator 21, rotated in the second direction of rotation (Fig. 4), the limiting element 20 is screwed relative to the piston rod 19 to the proximal end of the piston rod 19, wherein the limiting element 20 with respect to the housing 4, 18 and / or on the rotary member 13, 15 maintains its position along the longitudinal axis L. During the dose distribution, the limiting element 20 executes only a rotational movement and no axial movement relative to the housing 4,18. Preferably, the limiting element 20 during the dose distribution is rotationally fixed with respect to the rotary member 13,15. This means that the distance between the stop stop 15a and the counter-stop 20a does not change during the dose distribution. At the end of dispensing, that is, when zero is readable in the pointing device, the restriction member 20 assumes the same position with respect to the piston rod 19 as before the setting of the dispensed dose (see Figures 2a, 2b with FIG. 5).

When the amount contained in the product container 11a is less than the maximum adjustable dose, the counter stopper 20a of the restriction member 20 abuts on the stopper stopper 15a when the dose setting member 10 is rotated in the first rotational direction for increasing the dose. In an attempt to further rotate the dose setting member 10 in the first rotational direction, the dose setting member 10 is locked against rotation in the first rotational direction due to the restriction member 20 abutting on the rotational member 13, 15. Adjusting a dose containing the dose contained in the product container 11a , exceeds the distributable product amount is thereby prevented.

In an alternative, not shown, the distance between counter-stop 20a and stop-stop 15b is reduced as compared to the illustrated embodiment, i. the limiting element is located farther left in the drawings, preventing rotation of the dose setting element 10 in the first direction of rotation earlier. In the product container 11a remains after the distribution of the last dose, a residual amount, which is the difference between the nominal filling quantity of the product container 11a and the distributed amount or Ausschüttmenge. In the alternative, the setting of a dose which would cause the product container 11a to remain less than the remaining quantity of the nominal filling quantity is prevented.

For dispensing the dose set in Fig. 6, the actuator 21 is operated as described above and screwed the dose setting 10 back to the drive in the housing. At the end of the payout (Figure 7), the restriction member 20 again assumes the same position relative to the piston rod 19 as in the zero dose positions of the previous payouts (Figures 2a, 2b, 5).

In embodiments in which a deflated product container 11a (Figure 8) can be replaced with a new product container 11a (Figure 9), the sleeve-shaped product container holder 11 receiving the product container 11a can be released from the drive and metering device and removed. From the removed product container holder 11, the product container 11a is removed. In the product container holder 11, a new product container 11 a is inserted over the proximal end of the product container holder 11. The product container holder 11 is then attached to the drive and metering device by means of a bayonet closure or a plug-in rotary closure.

The product container holder 11 has on its outer circumference on a cam 11b and a particular circumferential annular collar 11d on the circumference. The housing 4, 18, in particular the mechanism holder 4, has a bayonet slot 4b, which has a section extending approximately parallel to the longitudinal axis L and a section extending in the circumferential direction, which adjoins, in particular, the section extending in the axial direction. In the attached state (see, e.g., Fig. 7), the cam 11b of the product container holder 11 is located in the circumferentially extending portion of the bayonet slot 4b. The collar 11d abuts against the distal end of the housing 4, 18, in particular the mechanism holder 4. To release the product container holder 11, it is rotated in a direction of rotation relative to the housing 4, 18, so that the cam 11b moves in the section of the bayonet slot 4b extending along the longitudinal axis L. When the cam 11b has arrived there, the product container holder 11 with a movement along the longitudinal axis L can be pulled out of the drive and metering device and removed. For attaching the product container holder 11 to the drive and metering device, this process is carried out vice versa. The product container holder 11 is inserted in the opposite direction in the distal end of the drive and metering device, wherein the cam 11 b is inserted into the extending along the longitudinal axis L portion of the bayonet slot 4 b. By rotating the product container holder 11 relative to the housing 4, 18, the cam is moved in the circumferentially extending portion of the bayonet slot 4b, thereby fixing the product container holder 11 to the housing. In particular, the collar 11d can thereby be pressed against the distal end of the mechanism holder 4.

The receivable in the product container holder 11 product container 11a, which are also referred to as a carpule, are usually made of plastic or glass. The length of the product container 11a is subject to relatively high tolerances, e.g. in the range of several tenths mm. The device shown in FIGS. 1 to 10b has a device which ensures that the product container 11a is always firmly held in the product container holder 11 despite high manufacturing tolerances. To this device belongs the guide member 2, which is displaceable by means of the proximal end of the product container 11a along the longitudinal axis L or relative to the housing 4, 18. On the guide member 2 acts a spring 3, which can also be referred to as tolerance compensation spring. The spring 3 is supported with its distal end on the guide member 2 and with its proximal end on the housing 4, 18, in particular on the mechanism holder 4 from. When attaching the product container holder 11 to the drive and metering device, the proximal end acts against the guide member 2, whereby the guide member 2 is displaced in the proximal direction relative to the housing 4, 18 and the spring 3 is tensioned, in particular the proximal end of the product container 11a is located on the Guide member 2 on. The spring 3 pushes the product container 11a into an axially fixed seat with the product container holder 11. Due to the resilient arrangement of the guide member 2, length tolerances of the product container 11a can be compensated. Between the spring 3 and the proximal end of the product container 11a, the guide member 2 is arranged.

When releasing the product container holder 11 from the drive and metering device, the guide member 2 is displaced along the longitudinal axis L and relative to the housing 4,18 in the distal direction due to the prestressed spring third

As can be seen from Figs. 8 and 9, the piston rod 19 must be reset for securing a new product container 11a in its original position.

The unidirectional clutch 70 is for this purpose from an active switching state in which it blocks the rotation of the rotary member 13, 15 in the first direction of rotation, in an inactive switching state in which it allows the rotation of the rotary member 13,15 in the first direction of rotation , switchable.

The coupling 70 has a third coupling structure 73 on the coupling ring 14 and a fourth coupling structure 74 on the rotary member 13, 15, and in particular on the coupling sleeve 15. When the product container holder 11 is attached to the drive and metering device, the third coupling structure 73 and the fourth coupling structure 74 are in a rotationally secured engagement, so that the rotation member 13,15 rotatably, i. is rotatably coupled in both directions with the coupling ring 14. The product container holder 11 is coupled to the third coupling structure 73 such that the third coupling structure 73 is moved out of engagement with the fourth coupling structure 74 when the product container holder 11 is released by the drive and metering device, in particular with a movement along the longitudinal axis L and relative to the housing 4,18 in the distal direction. The clutch 70 is then in its inactive switching state. The product container holder 11 is coupled to the third coupling structure 73 so that when attaching the product container holder 11 to the drive and metering device, the third coupling structure 73 is moved into engagement with the fourth coupling structure 74. The fourth coupling structure 74 in this case performs a movement along the longitudinal axis L and relative to the housing 4, 18 in the proximal direction. In particular, the third coupling structure 73, in particular the coupling ring 14, on which the third coupling structure is formed, are displaced against the force of the spring 5 in the proximal direction, whereby the spring 5 is tensioned. In particular, the spring 5 can move the third coupling structure 73, in particular the coupling ring 14, in the distal direction when the product container holder 11 is released from the housing 4, 18. For this purpose, the spring 5 can be supported on the coupling ring 14, in particular with its distal end.

The third coupling structure 73 is preferably an internal toothing, wherein the fourth coupling structure 74 is preferably an external toothing.

The third coupling structure 73, in particular the coupling ring 14, is coupled to the product container holder 11 via the switching element 12, which is rotationally fixed relative to the housing 4, 18 and displaceable along the longitudinal axis L. In the example shown, the switching member 12 is coupled to the product container holder 11 such that rotation of the product container holder 11 relative to the housing 4, 18 causes axial movement of the switching member 12 along the longitudinal axis L. The switching member 12 is moved in the distal direction when the product container holder 11 is rotated in a rotational direction which causes the detachment of the product container holder 11 from the housing 4, 18. The switching member 12 is moved in the proximal direction when the product container holder 11 is rotated in a rotational direction, which causes attachment of the product container holder 11 to the housing 4, 18. In particular, the product container holder 11 can slide on the switching element 12 during a rotational movement relative to the housing 4, 18 and the switching element 12. The product container holder 11 has at its proximal end e.g. an activation element 11c, which comprises a bevelled gear surface, which slides on the switching member 12 when the product container holder 11 is rotated relative to the switching member 12, whereby the axial movement of the switching member 12 is effected. Preferably, the switching member 12 has a recess 12c, which is adapted to the shape of the activation element 11c, wherein the activation element 11c is plugged into the recess 12c during the insertion of the projection 11b into the axial section of the bayonet slot 4b. During the following rotation of the product container holder 11 relative to the switching member 12, the activation element 11c is rotated out of the recess 12c, wherein the switching member 12 is moved along the longitudinal axis L. When rotating the product container holder 11 in the opposite direction of rotation for the release of the product container holder 11 from the drive and metering device, the activation element 11c is rotated into the recess 12c, wherein the switching member 12 in the distal direction due to the force acting in the distal direction of the biased spring 5 is moved.

As already mentioned, the clutch 70 is in an inactive switching state when the product container holder 11 is released from the drive and metering device (FIG. 8). The piston rod 19 can then be reset or pushed back into the drive and metering device, in particular by means of the user's muscular strength. Here, the piston rod 19 is rotationally fixed with respect to the housing 4,18, wherein the piston rod 19 is pushed back with an axial movement along the longitudinal axis L in the housing 4, 18. As a result, the limiting element 20 is taken, wherein the limiting element 20 is rotationally and axially fixed with respect to the piston rod 19. Further, upon resetting of the piston rod 19, the rotary member 13, 15 is rotated in its first rotational direction, since - as stated - the clutch 70 is in its inactive switching state.

After the piston rod 19 has been reset (Figure 9), the product container holder 11 can be attached to the drive and metering device as described.

The drive and metering device of FIGS. 1 to 10b also has a mechanism which emits an acoustic and / or tactile signal during dose setting, in particular during the dose increase and the dose reduction, which are also referred to as "clicks" can, and / or discrete angular steps for the dose setting 10, by which the dose setting 10 is rotatable relative to the housing 4, 18. The mechanism comprises, in particular, a ratchet sleeve 16, a ratchet ring 17 and the drive sleeve 8. Attached to an outwardly projecting annular collar of the drive sleeve 8 is a first signal coupling structure 91 pointing in the distal direction, which in this example is sawtooth-shaped toothing. The ratcheting ring 17 has a second signal coupling structure 92 facing in the proximal direction and in engagement with the first signal coupling structure 91. The ratchet ring 17 further includes a third signal coupling structure 93 that faces distally and engages a fourth signal coupling structure 94 that is proximal and disposed on the ratchet sleeve 16. The signal coupling structures 91 to 94 are each about the circumference of the respective component extending sawtooth-shaped teeth. The individual saw teeth of the toothing are spaced apart from one another with an angular spacing which predetermines the discrete angular steps for the dose setting element 10. For example, with the drive and metering device, cans in increments of 1 I.U. are to be adjusted, the angular pitch of the saw teeth is such that a discrete angular step of the dose setting element 10 of the rotation of the dose setting element 10 for 1 I.U. equivalent. Accordingly, an acoustic or tactile signal can be output during the rotation of the dose setting element for each discrete angular step. For the sake of completeness, it should be noted that the angle division is also greater than or less than 1 I.U. for angular steps. may be, such as 0.5 or 2 or 5 I.U. The ratchet sleeve 16 engages against rotation and slidably along the longitudinal axis L in the housing 4,18, in particular in the mechanism holder 4 when the actuator 21 is unconfirmed and is displaced from this engagement along the longitudinal axis L when the actuator 21 is actuated, so the ratchet sleeve 16 is rotatable relative to the housing 4, 18. The ratchet sleeve 16 has an outer toothing 16a, which engages in an internal toothing 4d on the inner periphery of the mechanism holder 4, whereby the ratchet sleeve 16 is secured against rotation relative to the housing 4, 18. When the actuator 21 is actuated, the external gear 16a is displaced along the longitudinal axis L out of engagement with the internal gear 4d, so that the ratchet sleeve 16 is rotatable relative to the housing 4, 18. In other words, the ratchet sleeve 16 is rotationally fixed relative to the housing 4, 18 during dose setting, and rotatable relative to the housing 4, 18 during product dispensing.

Said mechanism also serves, in the embodiment shown, to provide the drive member 8 with a certain rotational resistance against rotation in the second direction of rotation in order to move during the operating stroke of the actuating element 21, i. when the actuator is not yet in its actuated position to prevent premature rotation of the drive member 8. The rotational resistance is preferably (minimally) greater than that caused by the displacement of the actuating element 21, in particular due to the threaded engagement between dosing sleeve 7 and coupling member 6, on the drive member 8 torque. If, during actuation, the intermediate position of the actuating element 21, which is described in more detail below in particular, has been exceeded, the rotational resistance described is eliminated.

Optionally, since the dispensing clutch 81, 82 is already closed, the unidirectional clutch 70 can provide the drive member 8 with some rotational resistance against rotation in the second direction of rotation in order to move during the operating stroke of the operating member 21, i. if the actuator 21 is not yet in its actuated position to prevent premature rotation of the drive member 8 in the second direction of rotation. When the actuator 21 is in its actuated position and pushed further by the user in the distal direction, the rotational resistance of the unidirectional clutch 70 is overcome, whereby the drive member 8 and the rotary member 13,15 are rotated in the second direction of rotation.

At the dose increase, i. the rotation of dose setting element 10 in the first direction of rotation and in the dose reduction, i. upon rotation of the dose setting element 10 in the second direction of rotation, the drive sleeve 8 is rotated in each case relative to the ratchet sleeve 16. The ratchet ring 17 arranged between the first signal coupling structure 91 and the fourth signal coupling structure 94 causes the ratcheting ring 17 to rotate relative to a ratchet sleeve 16 and drive sleeve 8 when increasing the dose and not to rotate with ratchet sleeve 16 and drive sleeve 8 relative to the other. When reducing the dose, the ratchet ring 17 rotates relative to the one of ratchet sleeve 16 and drive sleeve 8 not with and to the other of ratchet sleeve 16 and drive sleeve 8 with. In the example shown, as the dose is increased, the ratchet ring 17 is rotated relative to the ratchet sleeve 16, with the ratchet ring 17 co-rotating the drive sleeve 8. In the dose reduction, the ratchet sleeve 8 is rotated relative to the ratchet ring 17, wherein the ratchet ring 17 is not rotated relative to the ratchet sleeve 16. Since signal coupling structures 91 to 94 always slide off each other during the dose increase and decrease, the so-called clicks are generated. The spring 5 is supported at its proximal end on the ratchet sleeve 16 and holds the ratchet sleeve 16, the ratchet ring 17 and the drive sleeve 8 in a ratchet engagement. Further, the spring 5 - as described - the actuator 21 is returned to its original position. By pressing the actuating element 21, the ratchet sleeve 16 and the external teeth 16a are displaced in a distal direction from the rotationally fixed engagement with the housing 4, 18 or the internal toothing 4d by displacing the drive sleeve 8 and the ratchet ring 17, whereby the click-generating mechanism deactivates during product dispensing is. During the displacement of the actuator 21, i. when the actuator 21 between the actuated position and the unactuated position, i. is shifted to an intermediate position, it is preferred that the Ausschüttkupplung 81, 82 is closed and the clutch 16a, 4d are closed. This ensures that during the operating stroke of the actuating element 21, the clutch 16a, 4d is only opened when the Ausschüttkupplung 81, 82 is already closed. This ensures that there is no inadvertent adjustment of the set dose during the actuation stroke.

In the second to fourth embodiments of the invention shown in Figs. 12 to 18, the dose setting apparatus has various variants for the configuration of the dose setting member (10) and the operating member (21). FIG. 11 shows, by way of example, the dose setting device according to the first embodiment. In the second embodiment, the length of the operating member (21) has been lengthened so that the risk of simultaneous contact of both the operating member and the dose setting member (10) upon discharge is reduced. In the first embodiment, the axial distance between the end of the actuator (21) and the end of the dose setting member (10) is twice the axial distance between the non-actuated and actuated position of the actuator (21) (Figure 11). In the second embodiment, with extended actuator (21), the axial distance between the proximal end of the dose setting member (10) and the end of the actuator (21) is about three times the distance between the non-actuated and actuated position of the actuator (21) (FIG. Fig. 12).

The third embodiment of the actuating element (21) and dose setting element (10) is shown in FIG. The actuating element (21) has a mushroom-shaped proximal end, wherein the outer diameter at the proximal end of the actuating element (21) is at least the same size as the outer diameter of the dose setting element (10). In the third embodiment, the actuator (21) additionally has beveled surfaces (21b) at the proximal end, thereby further reducing the risk of simultaneous contact with the dose setting member (10) and actuator (21) because of the shape of the bevelled surfaces of the anatomy of the thumb is adjusted during operation.

The fourth embodiment (Figure 14) shows at the proximal end of the actuating element (21) a cap (21c) which is fastened or fastened, wherein the cap (21c) is axially and rotationally fixedly connected to the actuating element (21). Preferably, the cap (21c) and the actuator (21) are molded from one piece. The cap (21c) has a circular lid (21d) at the proximal end with a pin (21f) on the distal side pointing in the distal direction, the pin being axially fixed to the dosing sleeve (7). Thus, the actuating element (21) is mounted without rotation relative to the dosing sleeve (7), which in turn is axially and rotationally fixed connected to the dose setting (10). The cap (21c) further has a cylindrical edge (21 e) which is connected to the lid (21d) on the proximal side. The edge (21e) overlaps or surrounds a taper (10c) of the dose setting element so that the outer diameter of the cap (21c) at the distal end of the cylindrical rim (21e) is at least equal to the outer diameter of the dose setting element (10). The design of the cap (21c) thus reduces the possibility of both the actuating element (21) and the dose setting element (10) being touched simultaneously upon actuation of the actuating element (21).

FIGS. 15 to 18 show by way of example the variants for the actuating element (21) on the basis of an injection direction which is held by one hand, wherein after setting a dose the actuating element is pressed by the thumb. In the angular region between the end member and the base member of the thumb, the risk of touching the dose setting element is most pronounced (FIG. 15b). Extension of the actuator (Figure 16b) reduces the possibility of simultaneous contact of both the actuator (21) and the dose setting member (10). The risk of a possible and undesired brake drum effect is also reduced by selecting a mushroom-shaped variant (FIG. 17b) or the variant with overlapping cap (FIG. 18b) for the actuating element (21).

LIST OF REFERENCE NUMBERS

[0106] <Tb> 1 <September> cap <Tb> 2 <September> guide member <Tb> 2 <September> engaging portion <Tb> 3 <September> Spring <Tb> 4 <September> mechanism holder <Tb> 4 <September> Thread <Tb> 4b <September> bayonet slot <tb> 4c <SEP> zero dose stop (alternative) <Tb> 4d <September> internal gear <Tb> 5 <September> Spring <Tb> 6 <September> coupling member / coupling sleeve <Tb> 6 <September> rib <tb> 6b <SEP> female thread / female thread segment <Tb> 7 <September> dosing <Tb> 7 <September> rib <Tb> 7b <September> Thread <Tb> 7c <September> guide slot <Tb> 7d <September> zero dose stop <Tb> 7e <September> maximum dose stop <Tb> 8 <September> drive sleeve <Tb> 8c <September> guide ribs <Tb> 9 <September> dose indicator barrel <Tb> 9b <September> dose scale <Tb> 10 <September> dose setting <Tb> 10 <September> engagement member <Tb> 10b <September> Abragung <tb> 10c <SEP> Stage, rejuvenation <Tb> 11 <September> product container holder / absorption <Tb> 11 <September> product container / carpule <Tb> 11b <September> Bajonettabragung <Tb> 11c <September> activation element <Tb> 11d <September> collar <Tb> 12 <September> switching element <Tb> 12c <September> recess <Tb> 13 <September> nut <Tb> 13 <September> internal thread <Tb> 14 <September> coupling ring <Tb> 15 <September> coupling sleeve <Tb> 15 <September> Stop stop <Tb> 16 <September> ratchet sleeve <Tb> 16 <September> External Teeth <Tb> 17 <September> ratchet ring <tb> 18 <SEP> Housing / outer housing sleeve <Tb> 18 <September> pointer / window <Tb> 19 <September> piston rod <Tb> 19 <September> external thread <tb> 19b <SEP> Flange / distal end <tb> 19c <SEP> proximal end <Tb> 19d <September> longitudinal groove / guide <Tb> 20 <September> limiting element <Tb> 20 <September> counterstop <Tb> 20b <September> internal thread <Tb> 20c <September> Abragung <Tb> 21 <September> actuator / actuating button <tb> 21b <SEP> Beveled surface <Tb> 21c <September> cap <tb> 21 d <SEP> Lid <tb> 21 e <SEP> Crossing edge <tb> 21 f <SEP> pen <tb> 31 <SEP> first coupling sleeve <tb> 32 <SEP> second coupling sleeve <Tb> 32 <September> Abragung <Tb> 33 <September> coupling sleeve <tb> 71 <SEP> first (payload) coupling structure / sawtooth toothing <tb> 72 <SEP> second (payload) coupling structure / sawtooth toothing <tb> 73 <SEP> third (payout) coupling structure / internal toothing <tb> 74 <SEP> fourth (payout) coupling structure / external toothing <tb> 75 <SEP> Coupling Ring / Annular Element <tb> 81 <SEP> first discharge clutch structure / internal toothing <tb> 82 <SEP> second discharge clutch structure / external teeth <tb> 91 <SEP> first signal coupling structure / sawtooth toothing <tb> 92 <SEP> second signal coupling structure / sawtooth toothing <tb> 93 <SEP> third signal coupling structure / sawtooth toothing <tb> 94 <SEP> 4th signal coupling structure / sawtooth toothing

Claims (7)

A dose setting device for an injection device for adjusting a dose to be dispensed from a product container comprising: a) a housing (4, 18) having a longitudinal axis, with a distal and proximal end, wherein the product container is fastened or attachable to the distal end, b) a dose setting element (10) which is rotatable relative to the housing (4, 18) for setting a dose to be dispensed from the product container (11a), and operably connected to the housing such that as the adjusted dose is increased, the dose setting member is rotated in a first direction of rotation and extends proximally from the housing (4, 18) along the longitudinal axis, c) an actuator (21) which is received or receivable at the proximal end of the dose setting member (10) and is actuated, preferably pressed, for dispensing the adjusted dose and thus axially displaced from the unactuated to the actuated position by one actuation stroke . wherein, upon actuation of the actuated member (21) to release the adjusted dose, the dose setting member (10) is rotated or rotated in a second rotational direction counter to the first rotational direction and moves distally along the longitudinal axis toward the housing (4, 18), the actuator (21) does not rotate, characterized, in that the actuation element (21) and the dose setting element (10) are designed such that the actuation of the actuation element does not impair or only slightly affects the rotation of the dose setting element (10) in the second direction of rotation when the adjusted dose is released. 2. dose setting device according to claim 1, characterized in that the actuating element (21) is coaxial with the dose setting element (10), wherein the outer diameter of the actuating element (21) is smaller than the inner diameter of the dose setting element (10) and the proximal end of the actuating element ( 21) projects beyond the proximal end of the dose setting element (10). 3. dose setting device according to claim 2, characterized in that in the non-actuated position of the actuating element (21) the axial distance between the proximal end of the actuating element (21) and the proximal end of the dose setting (10) is at least twice as high as the axial Distance between the non-actuated and actuated position of the actuator (21). 4. dose setting device according to claim 2, characterized in that the outer diameter at the proximal end of the actuating element (21) is at least equal to the outer diameter of the dose setting element (10). 5. Dosage adjustment device according to claim 2, characterized in that the proximal end of the actuating element (21) comprises a cap (21c) which engages over or overlaps at least a part of the proximal end of the dose setting element (10). 6. dose setting device according to claim 2, characterized in that the dose setting (10) comprises a dosing sleeve (7) and / or dose display drum (9), wherein the actuating element (10) axially fixed and rotatably mounted freely in the dosing sleeve (7) or the dose indicator drum (9). 7. Doseinstellvorrichtung according to claim 6, characterized in that the dose setting element (10) via a threaded connection with the housing (4,18) is connected.