CH658250A5 - Nuovi antibiotici macrolidici semisintetici, procedimenti microbiologici per la loro preparazione nuovi intermedi per la loro preparazione e composizioni farmaceutiche che li contengono. - Google Patents
Nuovi antibiotici macrolidici semisintetici, procedimenti microbiologici per la loro preparazione nuovi intermedi per la loro preparazione e composizioni farmaceutiche che li contengono. Download PDFInfo
- Publication number
- CH658250A5 CH658250A5 CH98/82A CH9882A CH658250A5 CH 658250 A5 CH658250 A5 CH 658250A5 CH 98/82 A CH98/82 A CH 98/82A CH 9882 A CH9882 A CH 9882A CH 658250 A5 CH658250 A5 CH 658250A5
- Authority
- CH
- Switzerland
- Prior art keywords
- formula
- fluoroerythromycin
- salts
- esters
- preparation
- Prior art date
Links
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- 230000002906 microbiologic effect Effects 0.000 title description 5
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- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000196833 Kocuria rhizophila DC2201 Species 0.000 description 1
- 102100027116 Low-density lipoprotein receptor-related protein 10 Human genes 0.000 description 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
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- 235000020224 almond Nutrition 0.000 description 1
- 229940072049 amyl acetate Drugs 0.000 description 1
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
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- YHASWHZGWUONAO-UHFFFAOYSA-N butanoyl butanoate Chemical compound CCCC(=O)OC(=O)CCC YHASWHZGWUONAO-UHFFFAOYSA-N 0.000 description 1
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- 238000011097 chromatography purification Methods 0.000 description 1
- AJSDVNKVGFVAQU-BIIVOSGPSA-N cladinose Chemical compound O=CC[C@@](C)(OC)[C@@H](O)[C@H](C)O AJSDVNKVGFVAQU-BIIVOSGPSA-N 0.000 description 1
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- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 1
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- 239000000314 lubricant Substances 0.000 description 1
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- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- WLCYBNZFNFSYSO-UHFFFAOYSA-N methyl 4-hydroxybenzoate propane-1,2,3-triol propyl 4-hydroxybenzoate Chemical compound OCC(O)CO.COC(=O)C1=CC=C(O)C=C1.CCCOC(=O)C1=CC=C(O)C=C1 WLCYBNZFNFSYSO-UHFFFAOYSA-N 0.000 description 1
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- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/888—Streptomyces antibioticus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8119082A IT1190651B (it) | 1981-01-09 | 1981-01-09 | Antibiotici macrolidici semisintetici,procedimento microbiologico per la loro preparazione e relatico microorganismo,intermedio per la loro preparazione e composizioni farmaceutiche che li contengono |
| IT25346/81A IT1139875B (it) | 1981-11-27 | 1981-11-27 | Antibiotici macrolidici semisintetici,procedimento microbiologico per la loro preparazione,intermedio per la loro preparazione e composizioni farmaceutiche che li contengono |
| IT25344/81A IT1139874B (it) | 1981-11-27 | 1981-11-27 | Preparazione di antibiotici macrolidici semisintetici,procedimento microbiologico e intermedio per la loro preparazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH658250A5 true CH658250A5 (it) | 1986-10-31 |
Family
ID=27272929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH98/82A CH658250A5 (it) | 1981-01-09 | 1982-01-08 | Nuovi antibiotici macrolidici semisintetici, procedimenti microbiologici per la loro preparazione nuovi intermedi per la loro preparazione e composizioni farmaceutiche che li contengono. |
Country Status (7)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1195299B (it) * | 1981-11-27 | 1988-10-12 | Pierrel Spa | Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici |
| IT1163796B (it) * | 1983-07-18 | 1987-04-08 | Pierrel Spa | Procedimento per la preparazione di (8s)-8-fluoroeritromicina |
| GB8333624D0 (en) * | 1983-12-16 | 1984-01-25 | Lepetit Spa | Antibiotics l 17054 and l 17392 |
| IT1196041B (it) * | 1984-03-08 | 1988-11-10 | Pierrel Spa | Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti |
| JPS6187625A (ja) * | 1984-10-05 | 1986-05-06 | Satoshi Omura | 消化管収縮運動促進剤 |
| CA2292359C (en) | 1999-01-28 | 2004-09-28 | Pfizer Products Inc. | Novel azalides and methods of making same |
| WO2001079520A1 (en) * | 2000-04-13 | 2001-10-25 | Biotica Technology Limited | Hybrid glycosylated products and their production and use |
| KR100903485B1 (ko) | 2007-09-17 | 2009-06-18 | (주) 제노텍 | 케토라이드류 항생물질의 전구체인 5-ｏ-데소사미닐에리스로노라이드 ａ의 조합생합성방법 및 재조합 균주개발 |
| CN105418706B (zh) * | 2015-10-27 | 2019-05-17 | 华南理工大学 | 一种大环内酯类抗菌化合物及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1341022A (en) * | 1970-04-13 | 1973-12-19 | Lilly Industries Ltd | Erythromycylamine compounds |
| US3697547A (en) * | 1970-12-18 | 1972-10-10 | Abbott Lab | Erythronolide b derivatives |
| US3816397A (en) * | 1972-06-15 | 1974-06-11 | Abbott Lab | 11,12-epoxyerythromycins |
| US3855200A (en) * | 1973-04-23 | 1974-12-17 | Polska Akademia Nauk Instytut | Process for preparing 8-hydroxyerthromycin a and intermediates therefor |
| US3992264A (en) * | 1974-02-04 | 1976-11-16 | Hoffmann-La Roche Inc. | Antibiotic 1745A/X and methods for the production thereof |
| JPS53144589A (en) * | 1977-05-21 | 1978-12-15 | Taisho Pharmaceut Co Ltd | Erythromycin a derivatives |
| US4440857A (en) * | 1980-07-29 | 1984-04-03 | Eli Lilly And Company | Process for preparing mycarosyltylactone |
| IT1169013B (it) * | 1981-01-09 | 1987-05-20 | Pierrel Spa | Composti macrolidici ad attivita' antibiotica, procedimento e microorganismo per la loro preparazione e relative composizioni farmaceutiche |
-
1982
- 1982-01-08 EP EP82200019A patent/EP0056291B1/en not_active Expired
- 1982-01-08 CA CA000393832A patent/CA1169375A/en not_active Expired
- 1982-01-08 US US06/338,105 patent/US4439426A/en not_active Expired - Lifetime
- 1982-01-08 FR FR8200187A patent/FR2502155A1/fr active Granted
- 1982-01-08 FI FI820057A patent/FI72346C/fi not_active IP Right Cessation
- 1982-01-08 DE DE8282200019T patent/DE3268339D1/de not_active Expired
- 1982-01-08 CH CH98/82A patent/CH658250A5/it not_active IP Right Cessation
-
1984
- 1984-01-16 US US06/570,833 patent/US4540662A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1169375A (en) | 1984-06-19 |
| EP0056291A2 (en) | 1982-07-21 |
| US4439426A (en) | 1984-03-27 |
| DE3268339D1 (en) | 1986-02-20 |
| EP0056291B1 (en) | 1986-01-08 |
| EP0056291A3 (en) | 1982-10-27 |
| US4540662A (en) | 1985-09-10 |
| FR2502155B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-10-19 |
| FI820057L (fi) | 1982-07-10 |
| FI72346C (fi) | 1987-05-11 |
| FI72346B (fi) | 1987-01-30 |
| FR2502155A1 (fr) | 1982-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NV | New agent |
Representative=s name: PATENTANWAELTE SCHAAD, BALASS, MENZL & PARTNER AG |
|
| PFA | Name/firm changed |
Owner name: PHARMACIA S.P.A. TRANSFER- PHARMACIA & UPJOHN S.P. |
|
| PUE | Assignment |
Owner name: PIERREL S.P.A. TRANSFER- PHARMACIA S.P.A. |
|
| PL | Patent ceased |