CH613444A5 - Process for the preparation of trans- DELTA <2>-prostaglandins - Google Patents
Process for the preparation of trans- DELTA <2>-prostaglandinsInfo
- Publication number
- CH613444A5 CH613444A5 CH659678A CH659678A CH613444A5 CH 613444 A5 CH613444 A5 CH 613444A5 CH 659678 A CH659678 A CH 659678A CH 659678 A CH659678 A CH 659678A CH 613444 A5 CH613444 A5 CH 613444A5
- Authority
- CH
- Switzerland
- Prior art keywords
- prostaglandins
- trans
- alkyl
- delta
- preparation
- Prior art date
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000020335 dealkylation Effects 0.000 abstract 1
- 238000006900 dealkylation reaction Methods 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14373873A JPS5432774B2 (xx) | 1973-12-25 | 1973-12-25 | |
| JP372674A JPS5418242B2 (xx) | 1973-12-29 | 1973-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH613444A5 true CH613444A5 (en) | 1979-09-28 |
Family
ID=26337362
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1728874A CH609043A5 (en) | 1973-12-25 | 1974-12-24 | Process for the preparation of trans- DELTA <2>-prostaglandins |
| CH659678A CH613444A5 (en) | 1973-12-25 | 1974-12-24 | Process for the preparation of trans- DELTA <2>-prostaglandins |
| CH659778A CH613684A5 (en) | 1973-12-25 | 1974-12-24 | Process for the preparation of trans- DELTA <2>-prostaglandins |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1728874A CH609043A5 (en) | 1973-12-25 | 1974-12-24 | Process for the preparation of trans- DELTA <2>-prostaglandins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH659778A CH613684A5 (en) | 1973-12-25 | 1974-12-24 | Process for the preparation of trans- DELTA <2>-prostaglandins |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4024174A (xx) |
| AU (1) | AU7678474A (xx) |
| CA (1) | CA1066699A (xx) |
| CH (3) | CH609043A5 (xx) |
| DE (1) | DE2460285A1 (xx) |
| FI (1) | FI373274A (xx) |
| FR (1) | FR2255056B1 (xx) |
| GB (1) | GB1483240A (xx) |
| LU (1) | LU71563A1 (xx) |
| NL (1) | NL189350C (xx) |
| SE (1) | SE423541B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1525282A (en) * | 1975-08-08 | 1978-09-20 | Ono Pharmaceutical Co | 16-chloroprostaglandin analogues |
| GB1588196A (en) * | 1977-06-14 | 1981-04-15 | Ono Pharmaceutical Co | Prostaglandin analogues |
| DE2830079A1 (de) * | 1978-07-08 | 1980-01-17 | Hoechst Ag | Neue prostaglandinderivate der delta 2,4-11-desoxy-pge-reihe |
| DE2834249A1 (de) * | 1978-08-04 | 1980-02-28 | Hoechst Ag | Neue prostaglandinderivate in der delta 2-11-desoxy-pgf tief 2 bzw. pge tief 2 -reihe |
| JPS6033429B2 (ja) * | 1980-04-28 | 1985-08-02 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| US4360688A (en) * | 1981-05-21 | 1982-11-23 | American Cyanamid Company | Precursors and synthesis of d1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates |
| US5166369A (en) * | 1981-05-21 | 1992-11-24 | American Cyanamid Company | Precursors and synthesis of D1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates |
| DE3347128A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| SE9403158D0 (sv) * | 1994-09-21 | 1994-09-21 | Pharmacia Ab | New use of prostaglandins |
| US5616793A (en) * | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792803A (fr) * | 1971-12-17 | 1973-03-30 | Erba Carlo Spa | Derives d'acide 8,12-diisoprostanoique optiquement actifs, leurpreparation et compositions en contenant |
| CH599147A5 (en) * | 1973-07-09 | 1978-05-12 | Sandoz Ag | Long-acting synthetic prostaglandins |
-
1974
- 1974-12-19 DE DE19742460285 patent/DE2460285A1/de not_active Withdrawn
- 1974-12-19 US US05/534,509 patent/US4024174A/en not_active Expired - Lifetime
- 1974-12-20 FI FI3732/74A patent/FI373274A/fi unknown
- 1974-12-23 NL NLAANVRAGE7416804,A patent/NL189350C/xx not_active IP Right Cessation
- 1974-12-23 SE SE7416251A patent/SE423541B/xx unknown
- 1974-12-23 CA CA216,687A patent/CA1066699A/en not_active Expired
- 1974-12-23 GB GB55472/74A patent/GB1483240A/en not_active Expired
- 1974-12-23 AU AU76784/74A patent/AU7678474A/en not_active Expired
- 1974-12-23 FR FR7442457A patent/FR2255056B1/fr not_active Expired
- 1974-12-24 CH CH1728874A patent/CH609043A5/xx not_active IP Right Cessation
- 1974-12-24 CH CH659678A patent/CH613444A5/xx not_active IP Right Cessation
- 1974-12-24 LU LU71563A patent/LU71563A1/xx unknown
- 1974-12-24 CH CH659778A patent/CH613684A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL189350C (nl) | 1993-03-16 |
| CH609043A5 (en) | 1979-02-15 |
| GB1483240A (en) | 1977-08-17 |
| FR2255056A1 (xx) | 1975-07-18 |
| CH613684A5 (en) | 1979-10-15 |
| AU7678474A (en) | 1976-06-24 |
| DE2460285A1 (de) | 1975-07-03 |
| US4024174A (en) | 1977-05-17 |
| NL7416804A (nl) | 1975-06-27 |
| CA1066699A (en) | 1979-11-20 |
| SE7416251L (xx) | 1975-06-26 |
| FI373274A (xx) | 1975-06-26 |
| NL189350B (nl) | 1992-10-16 |
| FR2255056B1 (xx) | 1978-09-01 |
| SE423541B (sv) | 1982-05-10 |
| LU71563A1 (xx) | 1975-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |