CH611621A5 - Process for producing compounds derived from 9-hydroxyellipticine - Google Patents

Process for producing compounds derived from 9-hydroxyellipticine

Info

Publication number
CH611621A5
CH611621A5 CH516576A CH516576A CH611621A5 CH 611621 A5 CH611621 A5 CH 611621A5 CH 516576 A CH516576 A CH 516576A CH 516576 A CH516576 A CH 516576A CH 611621 A5 CH611621 A5 CH 611621A5
Authority
CH
Switzerland
Prior art keywords
hydroxyellipticine
compounds derived
producing compounds
derivatives
compounds
Prior art date
Application number
CH516576A
Inventor
Jean Bernard Le Pecq
Claude Paoletti
Nguyen Dat-Xuong
Original Assignee
Anvar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anvar filed Critical Anvar
Publication of CH611621A5 publication Critical patent/CH611621A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The compounds of formula I in which R is an alkyl group and X is a halogen atom are prepared by quaternisation of the nitrogen atom in position 2 of 9-hydroxyellipticine by means of a compound RX. By ion exchange, the derivatives in which X is an acetoxy group are obtained. The compounds of formula I and their derivatives have an antitumour activity, in particular against murine leukaemia L 1210 and murine leukaemia P 388. <IMAGE>
CH516576A 1975-04-25 1976-04-23 Process for producing compounds derived from 9-hydroxyellipticine CH611621A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7513145A FR2308365A2 (en) 1975-04-25 1975-04-25 DERIVATIVES OF HYDROXY-9 ELLIPTICIN AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
CH611621A5 true CH611621A5 (en) 1979-06-15

Family

ID=9154526

Family Applications (2)

Application Number Title Priority Date Filing Date
CH516576A CH611621A5 (en) 1975-04-25 1976-04-23 Process for producing compounds derived from 9-hydroxyellipticine
CH810078A CH616937A5 (en) 1975-04-25 1978-07-27 Process for producing 9-hydroxyellepticine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH810078A CH616937A5 (en) 1975-04-25 1978-07-27 Process for producing 9-hydroxyellepticine derivatives

Country Status (4)

Country Link
CH (2) CH611621A5 (en)
DE (1) DE2618223A1 (en)
FR (1) FR2308365A2 (en)
GB (1) GB1508388A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310667A (en) * 1976-04-22 1982-01-12 Agence Nationale De Valorisation De La Recherche (Anvar) 2-N Quaternary ammonium salt derivatives of 9-hydroxy ellipticine
FR2485015A1 (en) * 1980-06-18 1981-12-24 Anvar OLIVACIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
FR2527209A1 (en) * 1982-05-24 1983-11-25 Sanofi Sa PROCESS FOR THE PREPARATION OF ELLIPTICIN DERIVATIVES, NOVEL COMPOUNDS THUS OBTAINED, AND THEIR ANTI-TUMOR ACTIVITY
FR2582649A1 (en) * 1985-05-29 1986-12-05 Centre Nat Rech Scient METHYL BIS 7H PYRIDOCARBAZOLES METHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
AU666416B2 (en) * 1993-01-29 1996-02-08 Tanabe Seiyaku Co., Ltd. Ellipticine derivative and process for preparing the same

Also Published As

Publication number Publication date
GB1508388A (en) 1978-04-26
FR2308365B2 (en) 1978-08-25
CH616937A5 (en) 1980-04-30
DE2618223C2 (en) 1989-08-17
FR2308365A2 (en) 1976-11-19
DE2618223A1 (en) 1976-11-11

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Legal Events

Date Code Title Description
PL Patent ceased