CH596237A5 - 9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones - Google Patents

9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones

Info

Publication number
CH596237A5
CH596237A5 CH1376473A CH1376473A CH596237A5 CH 596237 A5 CH596237 A5 CH 596237A5 CH 1376473 A CH1376473 A CH 1376473A CH 1376473 A CH1376473 A CH 1376473A CH 596237 A5 CH596237 A5 CH 596237A5
Authority
CH
Switzerland
Prior art keywords
dihalo
pregn
diones
homo
beta
Prior art date
Application number
CH1376473A
Inventor
Leo Dr Alig
Andor Dr Fuerst
Marcel Dr Mueller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1376473A priority Critical patent/CH596237A5/en
Priority to CH167679A priority patent/CH616950A5/en
Priority to DK531173AA priority patent/DK142289B/en
Priority to NO3800/73A priority patent/NO140672C/en
Priority to SE7313269A priority patent/SE418402B/en
Priority to ZA00745316A priority patent/ZA745316B/en
Priority to IL45516A priority patent/IL45516A/en
Priority to AU72633/74A priority patent/AU480546B2/en
Priority to US05/501,558 priority patent/US3939193A/en
Priority to YU2430/74A priority patent/YU36745B/en
Priority to CA209,719A priority patent/CA1031323A/en
Priority to PH16322A priority patent/PH11410A/en
Priority to FI2767/74A priority patent/FI54604C/en
Priority to IE1963/74A priority patent/IE40178B1/en
Priority to NL7412590A priority patent/NL7412590A/en
Priority to FR7432164A priority patent/FR2244474B1/fr
Priority to JP49108925A priority patent/JPS595600B2/en
Priority to LU70979A priority patent/LU70979A1/xx
Priority to EG423/74A priority patent/EG11212A/en
Priority to DD181284A priority patent/DD115354A5/xx
Priority to ES430370A priority patent/ES430370A1/en
Priority to CS7600005074A priority patent/CS179948B2/en
Priority to PL1974174320A priority patent/PL95291B1/en
Priority to CS7400006584A priority patent/CS179927B2/en
Priority to DE2445817A priority patent/DE2445817C2/en
Priority to CS7600005075A priority patent/CS179949B2/en
Priority to PL1974182346A priority patent/PL95272B1/en
Priority to HU74HO00001726A priority patent/HU172657B/en
Priority to BE148858A priority patent/BE820304A/en
Priority to PL1974182344A priority patent/PL95271B1/en
Priority to GB4170774A priority patent/GB1445945A/en
Priority to AT771974A priority patent/AT335087B/en
Priority to CS7600005076A priority patent/CS179950B2/en
Priority to PL1974172345D priority patent/PL95273B1/en
Priority to PL1974182348A priority patent/PL95270B1/pl
Priority to SU752145928A priority patent/SU683630A3/en
Priority to SU752145939A priority patent/SU612638A3/en
Priority to SU752145940A priority patent/SU635875A3/en
Priority to SU752145930A priority patent/SU634676A3/en
Priority to SU752145938A priority patent/SU867316A3/en
Priority to SU7502145936A priority patent/SU564814A3/en
Priority to AR259890A priority patent/AR211000A1/en
Priority to US05/629,439 priority patent/US4026923A/en
Priority to AT561476A priority patent/AT346507B/en
Priority to AT561376A priority patent/AT348165B/en
Priority to ES455107A priority patent/ES455107A1/en
Priority to ES455105A priority patent/ES455105A1/en
Priority to ES455104A priority patent/ES455104A1/en
Priority to ES455101A priority patent/ES455101A1/en
Priority to ES455106A priority patent/ES455106A1/en
Priority to ES455103A priority patent/ES455103A1/en
Priority to ES455100A priority patent/ES455100A1/en
Priority to ES455102A priority patent/ES455102A1/en
Publication of CH596237A5 publication Critical patent/CH596237A5/en
Priority to YU2967/80A priority patent/YU36980B/en
Priority to YU2966/80A priority patent/YU36979B/en
Priority to JP57147865A priority patent/JPS5928560B2/en
Priority to JP57147864A priority patent/JPS596880B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cpds. of formula (I) are new (where R6 is H, F, Cl, Br or CH3; R" is OH, F or Cl; R9 is H, F, Cl or Br, when R" is OH, or R9 is Cl or Br when R" is F or Cl; R21 is halo or R when R" is OH, or R21 is R when R" is F or Cl; R is sulphate of phosphate or the residue of a di- or tricarboxylic acid in the form of a water-sol. salt; R17a is H or acyloxy; the dashed line is an optional 1,2-bond). (I) are e.g. prepd. by hydroxylation of (I; where R21 is halogen) in the 11-posn. using a microorganism or enzyme. (I) have endocrinal (esp. anti-inflammatory) activity with high selectivity. 9,11-dihalo cpds. have esp. strong topical and weak systemic activity Dose is 0.01-1% in topical prepns. or 0.1-10 mg per application unit systemically.
CH1376473A 1973-03-28 1973-09-26 9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones CH596237A5 (en)

Priority Applications (57)

Application Number Priority Date Filing Date Title
CH1376473A CH596237A5 (en) 1973-09-26 1973-09-26 9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones
CH167679A CH616950A5 (en) 1973-03-28 1973-09-26 Process for the preparation of D-homosteroids.
DK531173AA DK142289B (en) 1973-03-28 1973-09-28 Analogous procedure for the preparation of D-homopregn-4-ene-3,20-dione.
NO3800/73A NO140672C (en) 1973-03-28 1973-09-28 ANALOGICAL PROCEDURES FOR THE MANUFACTURE OF NEW ANTI-INFLAMMATORY EFFECTIVE STEROIDS
SE7313269A SE418402B (en) 1973-03-28 1973-09-28 FURTHER DEVELOPMENT OF PROCEDURES ACCORDING TO PATENT 404 530 FOR THE PREPARATION OF D-HOMOSTEROIDS
ZA00745316A ZA745316B (en) 1973-03-28 1974-08-19 Novel steroids
IL45516A IL45516A (en) 1973-03-28 1974-08-22 3,20-dioxo-17aalpha-hydroxy-d-homopregn-4-enes their manufacture and pharmaceutical compositions containing them
AU72633/74A AU480546B2 (en) 1973-09-26 1974-08-23 Novel steroids
US05/501,558 US3939193A (en) 1973-03-28 1974-08-29 D-Homosteroids
YU2430/74A YU36745B (en) 1973-03-28 1974-09-09 Process for obtaining new d-homosteroids
CA209,719A CA1031323A (en) 1973-03-28 1974-09-20 D-homo-steroids
PH16322A PH11410A (en) 1973-03-28 1974-09-23 Novel steroids
FI2767/74A FI54604C (en) 1973-03-28 1974-09-23 FOERFARANDE FOER FRAMSTAELLNING AV ENDOKRINT VERKSAMMA NYA D-HOMOSTEROIDER
IE1963/74A IE40178B1 (en) 1973-03-28 1974-09-23 Steroids of the d-homopregnange series
NL7412590A NL7412590A (en) 1973-03-28 1974-09-24 PROCEDURE FOR PREPARING NEW OSTEROIDS.
FR7432164A FR2244474B1 (en) 1973-03-28 1974-09-24
JP49108925A JPS595600B2 (en) 1973-03-28 1974-09-24 D - homosteroid
LU70979A LU70979A1 (en) 1973-03-28 1974-09-24
EG423/74A EG11212A (en) 1973-03-28 1974-09-24 Method for preparation of new d homo steroids
DD181284A DD115354A5 (en) 1973-03-28 1974-09-24
ES430370A ES430370A1 (en) 1973-03-28 1974-09-25 D-Homosteroids
CS7600005074A CS179948B2 (en) 1973-03-28 1974-09-25 Method for production of novel d-homopregn-4-ene3,20-diones
PL1974174320A PL95291B1 (en) 1973-03-28 1974-09-25 METHOD OF MAKING NEW D-HOMOSTEROIDS
CS7400006584A CS179927B2 (en) 1973-03-28 1974-09-25 Method for production of novel d-homopregn-4ene-3,20-diones
DE2445817A DE2445817C2 (en) 1973-03-28 1974-09-25 D-homosteroids and preparations containing them
CS7600005075A CS179949B2 (en) 1973-03-28 1974-09-25 Method for production of novel d-homopregn-4-ene 3,20-diones
PL1974182346A PL95272B1 (en) 1973-03-28 1974-09-25 METHOD OF MAKING NEW D-HOMOSTEROIDS
HU74HO00001726A HU172657B (en) 1973-03-28 1974-09-25 Process for producing new d-homeo-steroides
BE148858A BE820304A (en) 1973-03-28 1974-09-25 NEW STEROIDS
PL1974182344A PL95271B1 (en) 1973-03-28 1974-09-25 METHOD OF MAKING NEW D-HOMOSTEROIDS
GB4170774A GB1445945A (en) 1973-03-28 1974-09-25 Steroids of the d-homo-pregnane series
AT771974A AT335087B (en) 1973-03-28 1974-09-25 METHOD OF PRODUCING NEW D-HOMOSTEROIDS
CS7600005076A CS179950B2 (en) 1973-03-28 1974-09-25 Method for production of novel d-homopregn-4-ene 3,20-diones
PL1974172345D PL95273B1 (en) 1973-03-28 1974-09-25 METHOD OF MAKING NEW D-HOMOSTEROIDS
PL1974182348A PL95270B1 (en) 1973-03-28 1974-09-25
SU752145928A SU683630A3 (en) 1973-03-28 1975-06-20 Method for the preparation of d-gomosteroids
SU752145939A SU612638A3 (en) 1973-03-28 1975-06-20 Method of obtaining d-homosteroids
SU752145940A SU635875A3 (en) 1973-03-28 1975-06-20 Method of obtaining d-homosteroids
SU752145930A SU634676A3 (en) 1973-03-28 1975-06-20 Method of obtaining d-homosteroids
SU752145938A SU867316A3 (en) 1973-03-28 1975-06-20 Method of preparing d-homosteriods
SU7502145936A SU564814A3 (en) 1973-03-28 1975-06-20 Method for obtaining d-homosteroids
AR259890A AR211000A1 (en) 1973-03-28 1975-08-04 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF D-HOMO-PREGN -4-EN -3, 20 DIONAS THAT HAVE USEFUL ENDOCRINE ACTIVITY, ESPECIALLY ANTI-INFLAMMATORY.
US05/629,439 US4026923A (en) 1973-03-28 1975-11-06 D-Homosteroids
AT561476A AT346507B (en) 1973-03-28 1976-07-29 METHOD FOR PRODUCING NEW D-HOMOSTEROIDS
AT561376A AT348165B (en) 1973-03-28 1976-07-29 METHOD FOR PRODUCING NEW D-HOMOSTEROIDS
ES455107A ES455107A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455105A ES455105A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455104A ES455104A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455101A ES455101A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455106A ES455106A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455103A ES455103A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455100A ES455100A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
ES455102A ES455102A1 (en) 1973-03-28 1977-01-17 D-Homosteroids
YU2967/80A YU36980B (en) 1973-03-28 1980-11-21 Process for obtaining new d-homosteroids
YU2966/80A YU36979B (en) 1973-03-28 1980-11-21 Process for obtaining new d-homosteroids
JP57147865A JPS5928560B2 (en) 1973-03-28 1982-08-27 Method for producing D-homosteroid
JP57147864A JPS596880B2 (en) 1973-03-28 1982-08-27 Method for producing D-homosteroid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1376473A CH596237A5 (en) 1973-09-26 1973-09-26 9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones

Publications (1)

Publication Number Publication Date
CH596237A5 true CH596237A5 (en) 1978-03-15

Family

ID=4395106

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1376473A CH596237A5 (en) 1973-03-28 1973-09-26 9-Alpha-11-beta-dihalo-D-homo-pregn-4-en-3,20-diones

Country Status (1)

Country Link
CH (1) CH596237A5 (en)

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