CH567478A5 - 1-(2-(2-phenylpropionyl) tetrahydroisoquinolinyl-7-sulphonyl)-3- - cyclohexylamino-ureas prepn - useful as hypoglycaemics - Google Patents
1-(2-(2-phenylpropionyl) tetrahydroisoquinolinyl-7-sulphonyl)-3- - cyclohexylamino-ureas prepn - useful as hypoglycaemicsInfo
- Publication number
- CH567478A5 CH567478A5 CH1787771A CH1787771A CH567478A5 CH 567478 A5 CH567478 A5 CH 567478A5 CH 1787771 A CH1787771 A CH 1787771A CH 1787771 A CH1787771 A CH 1787771A CH 567478 A5 CH567478 A5 CH 567478A5
- Authority
- CH
- Switzerland
- Prior art keywords
- substd
- opt
- reacting
- cyclohexylamino
- aralkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Abstract
Cpds. of formula (I): (where Q is a gp. of formula: R1-chMe-CO-N and R1 is phenyl opt. substd. by Cl, Br, Me or CF3), are prepd. by (a) reacting Q-SO2NH2 or its alkali metal salt with X-CO-R (where R = cyclohexylamino and X is halogen, amino or OH or SH substd. by opt. substd. alkyl, aralkyl or aryl); (b) reacting Q-SO2NHCOY with cyclohexylamine (where Y is as X or is mono- or di-substd. amino); (c) oxidising Q-SO2N=C(SR2)-R (where R2 = H or opt. substd. alkyl, aralkyl or aryl); (d) reacting Q-SO2-NCO with cyclohexylamine; (e) dealkylating Q-SO2N=C(OR3)-R (where R3 = opt. substd. alkyl, aralkyl or aryl); (f) reaction of Q-SO2Hal (where Hal = Cl or Br) with cyclohexylparabanic acid followed b acid or base hydrolysis; or (g) reacting 1-(1,2,3,4-tetrahydro-7-isoquinolinylsulphonyl)-3-cyclohexyl-urea with R1CH(Me)COZ (where Z is OH, alkoxy, acyloxy, amino or a reactive gp.; e.g. halogen, opt. formed in situ).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702060720 DE2060720A1 (en) | 1969-07-01 | 1970-12-10 | 1-(2-(2-phenylpropionyl) tetrahydroisoquinolinyl-7-sulphonyl)-3- - cyclohexylamino-ureas prepn - useful as hypoglycaemics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH567478A5 true CH567478A5 (en) | 1975-10-15 |
Family
ID=5790525
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1787771A CH567478A5 (en) | 1970-12-10 | 1971-12-08 | 1-(2-(2-phenylpropionyl) tetrahydroisoquinolinyl-7-sulphonyl)-3- - cyclohexylamino-ureas prepn - useful as hypoglycaemics |
| CH1459874A CH568292A5 (en) | 1970-12-10 | 1971-12-08 | |
| CH1460074A CH567479A5 (en) | 1970-12-10 | 1971-12-08 | |
| CH1460374A CH568293A5 (en) | 1970-12-10 | 1971-12-08 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1459874A CH568292A5 (en) | 1970-12-10 | 1971-12-08 | |
| CH1460074A CH567479A5 (en) | 1970-12-10 | 1971-12-08 | |
| CH1460374A CH568293A5 (en) | 1970-12-10 | 1971-12-08 |
Country Status (9)
| Country | Link |
|---|---|
| AT (7) | AT317917B (en) |
| BG (6) | BG20573A3 (en) |
| CA (1) | CA960675A (en) |
| CH (4) | CH567478A5 (en) |
| DD (1) | DD96068A5 (en) |
| ES (7) | ES397789A1 (en) |
| HU (1) | HU163804B (en) |
| RO (1) | RO61566A (en) |
| SE (1) | SE378244B (en) |
-
1970
- 1970-12-29 SE SE1767770A patent/SE378244B/xx unknown
-
1971
- 1971-12-08 CH CH1787771A patent/CH567478A5/en unknown
- 1971-12-08 RO RO6899471A patent/RO61566A/ro unknown
- 1971-12-08 CH CH1459874A patent/CH568292A5/xx not_active IP Right Cessation
- 1971-12-08 HU HUTO000864 patent/HU163804B/hu unknown
- 1971-12-08 CH CH1460074A patent/CH567479A5/xx not_active IP Right Cessation
- 1971-12-08 CH CH1460374A patent/CH568293A5/xx not_active IP Right Cessation
- 1971-12-09 BG BG2293571A patent/BG20573A3/xx unknown
- 1971-12-09 CA CA129,728A patent/CA960675A/en not_active Expired
- 1971-12-09 BG BG2293171A patent/BG20786A3/xx unknown
- 1971-12-09 AT AT00268/73A patent/AT317917B/en not_active IP Right Cessation
- 1971-12-09 AT AT00266/73A patent/AT317915B/en not_active IP Right Cessation
- 1971-12-09 ES ES397789A patent/ES397789A1/en not_active Expired
- 1971-12-09 AT AT00267/73A patent/AT317916B/en not_active IP Right Cessation
- 1971-12-09 BG BG2293371A patent/BG20572A3/xx unknown
- 1971-12-09 AT AT00264/73A patent/AT317913B/en not_active IP Right Cessation
- 1971-12-09 AT AT00265/73A patent/AT317914B/en not_active IP Right Cessation
- 1971-12-09 AT AT00263/73A patent/AT317912B/en not_active IP Right Cessation
- 1971-12-09 BG BG2293671A patent/BG19137A3/xx unknown
- 1971-12-09 DD DD15946471A patent/DD96068A5/xx unknown
- 1971-12-09 AT AT1060671A patent/AT313914B/en not_active IP Right Cessation
- 1971-12-09 BG BG2293471A patent/BG20343A3/xx not_active Expired
- 1971-12-09 BG BG2293271A patent/BG20571A3/xx unknown
-
1972
- 1972-01-18 ES ES72398953A patent/ES398953A1/en not_active Expired
- 1972-01-18 ES ES398957A patent/ES398957A1/en not_active Expired
- 1972-01-18 ES ES398956A patent/ES398956A1/en not_active Expired
- 1972-01-18 ES ES398954A patent/ES398954A1/en not_active Expired
- 1972-01-18 ES ES398955A patent/ES398955A1/en not_active Expired
- 1972-01-18 ES ES398958A patent/ES398958A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA960675A (en) | 1975-01-07 |
| AT317914B (en) | 1974-09-25 |
| ES398954A1 (en) | 1974-10-01 |
| BG20786A3 (en) | 1975-12-20 |
| ES398953A1 (en) | 1974-10-01 |
| RO61566A (en) | 1977-01-15 |
| BG20571A3 (en) | 1975-12-05 |
| BG19137A3 (en) | 1975-04-30 |
| CH567479A5 (en) | 1975-10-15 |
| ES398958A1 (en) | 1974-10-16 |
| AT313914B (en) | 1974-03-11 |
| CH568293A5 (en) | 1975-10-31 |
| HU163804B (en) | 1973-10-27 |
| ES398956A1 (en) | 1974-10-16 |
| BG20572A3 (en) | 1975-12-05 |
| SE378244B (en) | 1975-08-25 |
| ES398955A1 (en) | 1974-10-16 |
| DD96068A5 (en) | 1973-03-05 |
| BG20343A3 (en) | 1975-11-05 |
| AT317917B (en) | 1974-09-25 |
| AT317912B (en) | 1974-09-25 |
| CH568292A5 (en) | 1975-10-31 |
| AT317913B (en) | 1974-09-25 |
| ES397789A1 (en) | 1974-06-01 |
| ES398957A1 (en) | 1974-10-16 |
| AT317916B (en) | 1974-09-25 |
| AT317915B (en) | 1974-09-25 |
| BG20573A3 (en) | 1975-12-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1377250A (en) | 4,4-divinyldiphenyl compounds | |
| SE7502286L (en) | ||
| ES439833A1 (en) | Process for the manufacture of bis-azomethine metal complex colorants | |
| CH567478A5 (en) | 1-(2-(2-phenylpropionyl) tetrahydroisoquinolinyl-7-sulphonyl)-3- - cyclohexylamino-ureas prepn - useful as hypoglycaemics | |
| GB1086838A (en) | Salicylic acid derivatives | |
| FR2028991A1 (en) | Anilides having herbicidal activity | |
| GB1428990A (en) | Arylmercaptonaphtholactams | |
| GB866843A (en) | Sulphonamidopyrimidines | |
| GB1342350A (en) | Naphthalimide derivatives | |
| GB1351031A (en) | Manufacture of tetramisole and analogues thereof and of intermediates therefor | |
| FR2145691A1 (en) | 4-hydroxy-1-benzothiopyran-3-carboxamide-s-dioxides - - as antiinflammatories | |
| GB1118798A (en) | Substituted benzylamines | |
| GB1074084A (en) | Dibenzocycloheptene compounds | |
| FR2205337A1 (en) | Para-phenyl thio phenoxy alkylcarboxylic acid derivs - as hypolipidaemic agents | |
| GB1059813A (en) | Novel processes for the preparation of intermediates useful in the preparation of colchicine compounds, and the intermediates thus prepared | |
| GB1109308A (en) | Heterocyclic alkanoic acid amides | |
| GB1470461A (en) | Process fot the manufacture of cyano-substituted bis-styryl compounds | |
| GB1382459A (en) | Bisbenzoxazolyl-naphthalenes and their use as optical brighteners | |
| GB1504957A (en) | Distilbenyl-oxdiazoles their preparation and use as brightening agents | |
| GB1464832A (en) | Process for the preparation of a-oxothiodimethylamides | |
| GB1050740A (en) | ||
| ES378757A1 (en) | Procedure for the preparation of new derivatives of isoquinolein. (Machine-translation by Google Translate, not legally binding) | |
| GB728368A (en) | Improvements in or relating to the production of 3-pyrazolidones | |
| GB1435276A (en) | Oxazolidines and conversion to propanolamines | |
| GB1510367A (en) | Isoindoles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PLZ | Patent of addition ceased |