CH519498A - 1 acyl 3 indolyl carboxylic acid derivs - activity - Google Patents

1 acyl 3 indolyl carboxylic acid derivs - activity

Info

Publication number
CH519498A
CH519498A CH670970A CH670970A CH519498A CH 519498 A CH519498 A CH 519498A CH 670970 A CH670970 A CH 670970A CH 670970 A CH670970 A CH 670970A CH 519498 A CH519498 A CH 519498A
Authority
CH
Switzerland
Prior art keywords
halogen
alkyl
activity
acyl
carboxylic acid
Prior art date
Application number
CH670970A
Other languages
German (de)
Inventor
Yamamoto Hisao
Nakao Masaru
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP4272366A external-priority patent/JPS4938260B1/ja
Priority claimed from JP4272166A external-priority patent/JPS4913781B1/ja
Priority claimed from JP322367A external-priority patent/JPS5138699B1/ja
Priority claimed from JP353067A external-priority patent/JPS5138700B1/ja
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of CH519498A publication Critical patent/CH519498A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B19/00—Liquid-phase epitaxial-layer growth
    • C30B19/02—Liquid-phase epitaxial-layer growth using molten solvents, e.g. flux
    • C30B19/04—Liquid-phase epitaxial-layer growth using molten solvents, e.g. flux the solvent being a component of the crystal composition
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B19/00—Liquid-phase epitaxial-layer growth
    • C30B19/06—Reaction chambers; Boats for supporting the melt; Substrate holders
    • C30B19/061—Tipping system, e.g. by rotation
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/10—Inorganic compounds or compositions
    • C30B29/40—AIIIBV compounds wherein A is B, Al, Ga, In or Tl and B is N, P, As, Sb or Bi
    • C30B29/42—Gallium arsenide

Abstract

Cpds. (I) R' = H, aryl opt. subst. by (1-4C)alkyl, (1-4C) alkoxy, (1-4C)alkyl S-, NO2, CN or halogen, or a heterocyclic residue with 5 or 6 ring atoms, opt. subst. by Me, Et, or halogen. R2 and R3 = H or (1-3 C) alkyl R4 = H, CO2H or (2-4C) CO2alkyl R5 = (1-4C) alkoxy, PhCH2O, tetrahydropyranyloxy, NH2 or OH R6 = (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylS-, NO2, (2-4C)alkenyl, (2-4C)alkenyloxy, halogen, or H. A = a (1-5C) satd. or unsatd. hydrocarbon residue opt. subst. by halogen, or Ph. m = 0 or 1 p = 0 or 1 n = 0-3. Antiinflammatories, analgesics, and antipyretics, of high activity and very low toxicity.
CH670970A 1966-01-12 1967-05-10 1 acyl 3 indolyl carboxylic acid derivs - activity CH519498A (en)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
JP199966 1966-01-12
JP2730066 1966-04-28
JP2730166 1966-04-28
JP2812566 1966-05-02
JP2840066 1966-05-04
JP4059166 1966-06-21
JP4203966 1966-06-27
JP4272366A JPS4938260B1 (en) 1966-06-30 1966-06-30
JP4272166A JPS4913781B1 (en) 1966-06-30 1966-06-30
JP4472366 1966-07-08
JP4472466 1966-07-08
JP5069166 1966-08-01
JP5467566 1966-08-19
JP5467466 1966-08-19
JP135267 1967-01-06
JP149967 1967-01-07
JP322367A JPS5138699B1 (en) 1967-01-16 1967-01-16
JP353267 1967-01-17
JP353067A JPS5138700B1 (en) 1967-01-17 1967-01-17

Publications (1)

Publication Number Publication Date
CH519498A true CH519498A (en) 1972-02-29

Family

ID=27586245

Family Applications (1)

Application Number Title Priority Date Filing Date
CH670970A CH519498A (en) 1966-01-12 1967-05-10 1 acyl 3 indolyl carboxylic acid derivs - activity

Country Status (1)

Country Link
CH (1) CH519498A (en)

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