CH471134A - Verfahren zur Herstellung von Pyrazinoylbenzamidinen - Google Patents

Verfahren zur Herstellung von Pyrazinoylbenzamidinen

Info

Publication number
CH471134A
CH471134A CH1462064A CH1462064A CH471134A CH 471134 A CH471134 A CH 471134A CH 1462064 A CH1462064 A CH 1462064A CH 1462064 A CH1462064 A CH 1462064A CH 471134 A CH471134 A CH 471134A
Authority
CH
Switzerland
Prior art keywords
pyrazinoylbenzamidines
preparation
Prior art date
Application number
CH1462064A
Other languages
English (en)
Inventor
Jethro Jr Cragoe Edward
Beeh Bicking John
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH471134A publication Critical patent/CH471134A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH1462064A 1963-11-15 1964-11-12 Verfahren zur Herstellung von Pyrazinoylbenzamidinen CH471134A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US323886A US3274191A (en) 1963-11-15 1963-11-15 N-(3-aminopyrazinoyl) benzamidines and process for preparing

Publications (1)

Publication Number Publication Date
CH471134A true CH471134A (de) 1969-04-15

Family

ID=23261144

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1462064A CH471134A (de) 1963-11-15 1964-11-12 Verfahren zur Herstellung von Pyrazinoylbenzamidinen

Country Status (11)

Country Link
US (1) US3274191A (de)
BE (1) BE655397A (de)
BR (1) BR6464322D0 (de)
CH (1) CH471134A (de)
DE (2) DE1470101A1 (de)
DK (1) DK112736B (de)
FR (1) FR4193M (de)
GB (1) GB1070589A (de)
IL (1) IL22360A (de)
NL (1) NL6413272A (de)
SE (1) SE301152B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6501301A (de) * 1964-04-03 1965-10-04
US3859287A (en) * 1971-05-05 1975-01-07 Walter Wesley Parish Thiopteridines and process for producing same
US4029657A (en) * 1976-06-14 1977-06-14 The Dow Chemical Company 6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
US4208413A (en) * 1977-03-04 1980-06-17 Merck & Co., Inc. N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
US4920123A (en) * 1988-10-21 1990-04-24 Beyer Jr Karl H Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida
PT2931713T (pt) 2012-12-17 2017-02-22 Parion Sciences Inc Derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por insuficiente hidratação das mucosas
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Also Published As

Publication number Publication date
DK112736B (da) 1969-01-13
IL22360A (en) 1968-07-25
DE1470101A1 (de) 1969-05-29
NL6413272A (de) 1965-05-17
SE301152B (de) 1968-05-27
DE1620058A1 (de) 1970-07-23
GB1070589A (en) 1967-06-01
FR4193M (de) 1966-05-31
BE655397A (de) 1965-05-06
US3274191A (en) 1966-09-20
BR6464322D0 (pt) 1973-07-26

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Legal Events

Date Code Title Description
PL Patent ceased