CH434134A - Process for the preparation of solid digestive compositions suitable for the preparation of beverages - Google Patents
Process for the preparation of solid digestive compositions suitable for the preparation of beveragesInfo
- Publication number
- CH434134A CH434134A CH747265A CH747265A CH434134A CH 434134 A CH434134 A CH 434134A CH 747265 A CH747265 A CH 747265A CH 747265 A CH747265 A CH 747265A CH 434134 A CH434134 A CH 434134A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- protease
- enzymes
- lipase
- compositions suitable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000007787 solid Substances 0.000 title claims description 5
- 230000001079 digestive effect Effects 0.000 title claims description 4
- 235000013361 beverage Nutrition 0.000 title description 2
- 102000004190 Enzymes Human genes 0.000 claims description 14
- 108090000790 Enzymes Proteins 0.000 claims description 14
- 229940088598 enzyme Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 108091005804 Peptidases Proteins 0.000 claims description 10
- 239000004365 Protease Substances 0.000 claims description 10
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 102000004882 Lipase Human genes 0.000 claims description 9
- 108090001060 Lipase Proteins 0.000 claims description 9
- 239000004367 Lipase Substances 0.000 claims description 9
- 235000019421 lipase Nutrition 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000470 constituent Substances 0.000 claims description 6
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 229920000856 Amylose Polymers 0.000 claims description 2
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- VOIFKEWOFUNPBN-QIUUJYRFSA-N beta-D-glucuronamide Chemical compound NC(=O)[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O VOIFKEWOFUNPBN-QIUUJYRFSA-N 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 229950004542 glucuronamide Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Natural products O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- -1 turn it into one Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Procédé pour la préparation de compositions solides digestives appropriées à la préparation-de boissons - - La présente invention concerne une nouvelle caté gorie de compositions solides digestives, destinées à per mettre, par dissolution dans Peau ordinaire,
la prépara- tion instantanée d'eaux minérales douées de propriétés enzymatiques facilitant la digestion.
On connaît depuis peu de temps des compositions solides, présentées sous forme de comprimés qui, par introduction dans de Peau ordinaire, donnent lieu à la fois à la dissolution dans l'eau de certains constituants détoxifiiants, et à une effervescence par dégagement d'an- hydride carbonique,
qui; exerce une action favorable sur la digestion.
L'invention vise des compositions du même genre, mais dont les constituants actifs comprennent, à la place des constituants détoxifiants, des enzymes améliorant les différents catabolismes, à savoir une lipase pour le cata bolisme des lipides, une protéase pour celui des protéines,
une cellulase pour celui de 1a cellulose et une @amylase pour celui des hydrates de carbone.
Ces compositions peuvent comprendre en outre un composé provoquant l'effervescence et jouant en même temps <B>l</B>e rôle de cata- lyseur ou d'activateur pour ces enzymes, à savoir essen- tiellement le carbonate de potassium et un composé donnant une réaction acide en solution,
par exemple l'acide citrique.
Les proportions relatives de ces différents enzymes seront très variables, tirais dans la pratique, on a trouvé exceptionnellement satisfaisante une composition dans laquelle les enzymes sont présents dans les quantités suivantes, exprimées pour un comprimé effervescent:
Protéase . . . 10.000 unités Amylose . . . 5.000 unités Cellulase . . . 2.000 unités Lipase . . . 1.000 unités Il convient de noter qu'il n'est normalement pas pos sible d'introduire dans la même composition de la protéase et de la lipase,
car cette dernière absorbe et détruit la protéase. Pour éviter cet inconvénient, salon une autre caractéirstique de l'invention,
la lipase ou la protéase est enrobée d'un produit protecteur empêchant le phénomène indésirable de se produire pendant un temps suffisant après la préparation de P(ceau minérale que constituera la solution aqueuse des compositions selon rinvention. Un tel <RTI
ID="0001.0127"> produit protecteur peut être par exemple de da cellulose recouvrant les cristaux.
Les compositions obtenues par le procédé selon l'in- vention se présentent donc de préférence sous forme de comprimés (à double noyau) dont la portion interne est constituée par de la lipase enrobée par une pellicule de produit protecteur, et la potion externe est consti tuée par un mélange des autres enzymes,
de carbonate de potassium et d'un composé à réaction acide suscep- tible de réagir avec ce dernier en solution dans l'eau pour provoquer l'effervescence. Comme composé à réac tion acide; on peut utiliser par exemple racide citrique, qui a l'avantage de contribuer à l'aromatisation du produit.
Bien entendu les aurores composants de l'excipient pourront être très variés, connue il ressort des exemples ci-après.
De tels comprimés, introduits dans un verre d'eau ordinaire, transforment celle-ci en un,
verre d'eau miné- rale gazeuse contenant en solution les enzymes précités à l'exception de (la hipase dont la dissolution est retardée pendant Duntemps suffisant pour éviter son action néfaste sur la protéase.
Le carbonate de potassium est choisi de :préférence aux autres carbonates, en raison de l'influence favorable de Pion potassium sur la cinétique des réactions enzyma tiques:
Bien que le principe de l'obtention de belles eaux minérales effervescentes par dissolution de comprimés solides de l'eau ordinaire soit connu, une :
telle eau gazeuse enzymatique n'a jamais été proposée, -et en par ticulier une eau comportant dans sa composition tous les enzymes nécessaires à la bonne digestion et les ions métalliques favorables aux réactions physiologiques im pliquées par.l'administrafiion de ces enzymes.
Bien. que ce ne sont pas essentiel, à est préférable que les enzymes utilisés et-plus spécialement la lipase soient d'origine- fongique, en,
raison de la remarquable activité et stabilité des enzymes decette owigine. _ _ - Exemple- de composition Extrait 6nzynïaiiquetotal . . . 250 mg - - Gluouronamidë -_. -. :
. . . . 400 mg Vitamine C . . . . . . . . 500 mg Monofumarate de sodium . . .<B>1950</B> mg Bicarbonaté .de potassium .. . . 950 mg _ .
Excipient, y compris Polyéthylène- - glycol 6000 . . . . q. s. p. - 4500 mg
Process for the preparation of solid digestive compositions suitable for the preparation of beverages - - The present invention relates to a new category of solid digestive compositions, intended to allow, by dissolution in ordinary water,
the instantaneous preparation of mineral waters endowed with enzymatic properties facilitating digestion.
Solid compositions, presented in the form of tablets, which, on introduction into ordinary water, give rise both to the dissolution in water of certain detoxifying constituents in water, and to an effervescence by release of an - carbon dioxide,
who; exerts a favorable action on digestion.
The invention relates to compositions of the same type, but the active constituents of which comprise, instead of the detoxifying constituents, enzymes which improve the different catabolisms, namely a lipase for the catabolism of lipids, a protease for that of proteins,
a cellulase for that of cellulose and an amylase for that of carbohydrates.
These compositions may further comprise a compound which induces effervescence and at the same time acts as a catalyst or activator for these enzymes, namely essentially potassium carbonate and a. compound giving an acid reaction in solution,
for example citric acid.
The relative proportions of these various enzymes will be very variable, drawn in practice, we have found exceptionally satisfactory a composition in which the enzymes are present in the following amounts, expressed for an effervescent tablet:
Protease. . . 10,000 Amylose units. . . 5,000 Cellulase units. . . 2,000 Lipase units. . . 1,000 units It should be noted that it is not normally possible to introduce protease and lipase in the same composition,
because the latter absorbs and destroys protease. To avoid this drawback, according to another characteristic of the invention,
the lipase or protease is coated with a protective product preventing the undesirable phenomenon from occurring for a sufficient time after the preparation of P (mineral water which will constitute the aqueous solution of the compositions according to the invention. Such a <RTI
ID = "0001.0127"> protective product can be for example da cellulose covering the crystals.
The compositions obtained by the process according to the invention are therefore preferably in the form of tablets (with a double core), the internal portion of which consists of lipase coated with a film of protective product, and the external potion is formed. killed by a mixture of other enzymes,
potassium carbonate and an acid reacting compound capable of reacting with the latter in solution in water to induce effervescence. As a compound with an acid reaction; citric racide, for example, can be used, which has the advantage of contributing to the flavoring of the product.
Of course, the component aurorae of the excipient may be very varied, as it emerges from the examples below.
Such tablets, introduced into a glass of ordinary water, turn it into one,
glass of carbonated mineral water containing in solution the aforementioned enzymes with the exception of hipase, the dissolution of which is delayed for a sufficient time to avoid its harmful action on the protease.
The potassium carbonate is chosen from: preference to other carbonates, because of the favorable influence of the potassium ion on the kinetics of the enzymatic reactions:
Although the principle of obtaining beautiful effervescent mineral waters by dissolving solid tablets of ordinary water is known, a:
such enzymatic carbonated water has never been proposed, -and in particular a water comprising in its composition all the enzymes necessary for good digestion and the metal ions favorable to the physiological reactions implicated by the administration of these enzymes.
Well. that these are not essential, it is preferable that the enzymes used and-more especially the lipase are of fungal origin, in,
due to the remarkable activity and stability of the enzymes of this owigin. _ _ - Example- of composition Extract 6nzynïaiiquetal. . . 250 mg - - Gluouronamidë -_. -. :
. . . . 400 mg Vitamin C. . . . . . . . 500 mg Sodium monofumarate. . . <B> 1950 </B> mg Potassium bicarbonate ... . 950 mg _.
Excipient, including Polyethylene- - glycol 6000. . . . q. s. p. - 4500 mg
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8093A FR3536M (en) | 1964-06-16 | 1964-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH434134A true CH434134A (en) | 1967-04-15 |
Family
ID=9694045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH747265A CH434134A (en) | 1964-06-16 | 1965-05-28 | Process for the preparation of solid digestive compositions suitable for the preparation of beverages |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE663658A (en) |
| CH (1) | CH434134A (en) |
| ES (1) | ES313078A1 (en) |
| FR (1) | FR3536M (en) |
| GB (1) | GB1107824A (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723327A (en) * | 1972-06-05 | 1973-03-27 | Lever Brothers Ltd | Granular proteolytic enzyme composition |
| US4265847A (en) * | 1978-03-30 | 1981-05-05 | Kirby Pharmaceuticals Ltd | Tabletting process |
| AR220239A1 (en) * | 1979-12-04 | 1980-10-15 | Scherz Sara | EDIBLE COMPOSITION |
| JPS5826822A (en) * | 1981-08-10 | 1983-02-17 | Kaken Pharmaceut Co Ltd | Preventing and pemedy for liver and kidney diseases |
| US5817350A (en) * | 1993-03-11 | 1998-10-06 | Triarco Industries | Carbohydrase enzyme food supplement composition |
| US5436003A (en) * | 1994-02-10 | 1995-07-25 | Triarco Industries, Inc. | Method of alleviating gastrointestinal distress with a composition containing beta-fructofuransidase, cellulase and hemi-cellulase |
| US6099844A (en) * | 1994-08-22 | 2000-08-08 | Triarco Industries, Inc. | Increasing yield of extractable substances from botanicals with an enzyme composition |
| BR9808551C1 (en) * | 1997-04-14 | 2002-03-05 | Procter & Gamble | Sparkling component |
| WO2003014304A2 (en) * | 2001-08-09 | 2003-02-20 | Doctor's Signature Sales And Marketing International Corp. [(Dba)] Life Force International | Protonic formulation |
| US6558666B1 (en) | 2002-04-03 | 2003-05-06 | Triarco Industries, Inc. | Chromium-containing carbohydrase enzyme food supplement composition |
| WO2010025126A1 (en) * | 2008-08-26 | 2010-03-04 | Cystic Fibrosis Foundation Therapeutics, Inc. | Rapidly disintegrating tablets comprising lipase, amylase, and protease |
-
1964
- 1964-06-16 FR FR8093A patent/FR3536M/fr not_active Expired
-
1965
- 1965-05-10 BE BE663658D patent/BE663658A/xx unknown
- 1965-05-18 ES ES0313078A patent/ES313078A1/en not_active Expired
- 1965-05-28 CH CH747265A patent/CH434134A/en unknown
- 1965-06-16 GB GB25552/65A patent/GB1107824A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES313078A1 (en) | 1965-10-01 |
| GB1107824A (en) | 1968-03-27 |
| BE663658A (en) | 1965-09-01 |
| FR3536M (en) | 1965-09-13 |
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