CH434134A - Process for the preparation of solid digestive compositions suitable for the preparation of beverages - Google Patents

Process for the preparation of solid digestive compositions suitable for the preparation of beverages

Info

Publication number
CH434134A
CH434134A CH747265A CH747265A CH434134A CH 434134 A CH434134 A CH 434134A CH 747265 A CH747265 A CH 747265A CH 747265 A CH747265 A CH 747265A CH 434134 A CH434134 A CH 434134A
Authority
CH
Switzerland
Prior art keywords
preparation
protease
enzymes
lipase
compositions suitable
Prior art date
Application number
CH747265A
Other languages
French (fr)
Inventor
Yves Mauvernay Roland
Original Assignee
Yves Mauvernay Roland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yves Mauvernay Roland filed Critical Yves Mauvernay Roland
Publication of CH434134A publication Critical patent/CH434134A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38Other non-alcoholic beverages
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/40Effervescence-generating compositions
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007Effervescent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Description

       

  Procédé     pour    la     préparation    de     compositions        solides        digestives    appropriées  à la     préparation-de        boissons    - -    La     présente        invention        concerne        une    nouvelle caté  gorie de     compositions        solides        digestives,    destinées à per  mettre, par     dissolution    dans Peau     ordinaire,

      la     prépara-          tion        instantanée    d'eaux minérales douées de     propriétés     enzymatiques     facilitant    la digestion.  



  On connaît     depuis    peu de temps des     compositions     solides, présentées sous     forme    de     comprimés    qui,     par          introduction        dans    de     Peau        ordinaire,    donnent     lieu    à la  fois à la dissolution dans l'eau de     certains        constituants          détoxifiiants,    et à une     effervescence    par dégagement     d'an-          hydride        carbonique,

          qui;        exerce        une        action    favorable sur  la     digestion.     



       L'invention    vise des compositions du même genre,  mais dont les constituants actifs     comprennent,    à la     place     des constituants     détoxifiants,    des enzymes     améliorant    les       différents    catabolismes, à     savoir    une     lipase    pour le cata  bolisme des lipides, une     protéase    pour celui des     protéines,

       une     cellulase        pour        celui    de 1a     cellulose    et une     @amylase     pour     celui    des hydrates de carbone.

   Ces compositions       peuvent    comprendre en outre     un    composé provoquant       l'effervescence    et jouant en     même        temps   <B>l</B>e rôle de     cata-          lyseur    ou     d'activateur    pour     ces    enzymes, à     savoir        essen-          tiellement    le     carbonate    de     potassium    et un composé  donnant     une    réaction acide en     solution,

      par     exemple     l'acide citrique.  



  Les     proportions    relatives de ces     différents    enzymes  seront très     variables,        tirais    dans la pratique, on a trouvé       exceptionnellement        satisfaisante        une        composition    dans  laquelle les enzymes sont présents dans les quantités       suivantes,        exprimées        pour    un     comprimé    effervescent:

         Protéase    . . . 10.000     unités     Amylose . . . 5.000 unités       Cellulase    . . . 2.000     unités     Lipase . . . 1.000     unités          Il        convient    de     noter        qu'il    n'est     normalement    pas pos  sible d'introduire dans la même     composition    de la         protéase        et    de la     lipase,

      car     cette    dernière absorbe et       détruit    la     protéase.    Pour éviter     cet        inconvénient,    salon  une autre     caractéirstique    de     l'invention,

      la     lipase    ou     la          protéase    est enrobée     d'un    produit protecteur     empêchant     le phénomène     indésirable    de se     produire        pendant    un       temps        suffisant    après la     préparation    de     P(ceau    minérale    que     constituera    la     solution    aqueuse des     compositions     selon     rinvention.    Un     tel     <RTI  

   ID="0001.0127">   produit        protecteur    peut     être        par          exemple    de da     cellulose    recouvrant les     cristaux.     



  Les     compositions        obtenues    par le     procédé    selon     l'in-          vention    se présentent donc de préférence sous forme de       comprimés    (à double noyau) dont la     portion        interne     est     constituée    par de la     lipase        enrobée    par     une        pellicule     de     produit    protecteur, et la potion externe est consti  tuée par un     mélange    des autres enzymes,

   de carbonate  de     potassium    et d'un composé à réaction     acide        suscep-          tible    de réagir     avec    ce     dernier    en     solution    dans l'eau  pour provoquer     l'effervescence.        Comme    composé à réac  tion     acide;    on peut     utiliser        par    exemple     racide        citrique,     qui a     l'avantage    de contribuer à     l'aromatisation    du  produit.  



       Bien    entendu     les        aurores        composants    de     l'excipient     pourront     être        très    variés,     connue        il        ressort    des exemples  ci-après.  



  De     tels        comprimés,        introduits    dans     un        verre    d'eau       ordinaire,        transforment        celle-ci    en     un,

      verre     d'eau        miné-          rale    gazeuse contenant en solution les enzymes précités  à     l'exception    de     (la        hipase    dont la     dissolution    est retardée  pendant     Duntemps        suffisant    pour     éviter    son     action    néfaste  sur la     protéase.     



       Le    carbonate de     potassium    est     choisi    de     :préférence     aux autres     carbonates,        en    raison de     l'influence    favorable  de     Pion        potassium        sur    la     cinétique    des réactions enzyma  tiques:

    Bien que le     principe    de l'obtention de     belles    eaux       minérales        effervescentes        par        dissolution    de     comprimés          solides    de l'eau     ordinaire        soit        connu,        une    :

  telle eau           gazeuse        enzymatique    n'a     jamais        été    proposée,     -et    en par  ticulier une eau comportant dans sa composition tous  les     enzymes        nécessaires    à la bonne     digestion    et les ions       métalliques        favorables    aux     réactions        physiologiques    im  pliquées     par.l'administrafiion    de     ces        enzymes.     



       Bien.        que        ce        ne        sont    pas     essentiel,    à est     préférable    que  les     enzymes        utilisés    et-plus spécialement la lipase soient       d'origine-        fongique,        en,

      raison de la     remarquable    activité  et stabilité des     enzymes        decette        owigine.        _          _    -     Exemple-    de     composition          Extrait        6nzynïaiiquetotal    . . . 250 mg -     -          Gluouronamidë        -_.        -.    :

   . . . . 400 mg       Vitamine    C . . . . . . . . 500 mg       Monofumarate    de sodium . . .<B>1950</B> mg       Bicarbonaté        .de        potassium        ..    . .     950        mg        _    .  



       Excipient,    y     compris        Polyéthylène-    -   glycol 6000 . . . . q. s. p. - 4500 mg



  Process for the preparation of solid digestive compositions suitable for the preparation of beverages - - The present invention relates to a new category of solid digestive compositions, intended to allow, by dissolution in ordinary water,

      the instantaneous preparation of mineral waters endowed with enzymatic properties facilitating digestion.



  Solid compositions, presented in the form of tablets, which, on introduction into ordinary water, give rise both to the dissolution in water of certain detoxifying constituents in water, and to an effervescence by release of an - carbon dioxide,

          who; exerts a favorable action on digestion.



       The invention relates to compositions of the same type, but the active constituents of which comprise, instead of the detoxifying constituents, enzymes which improve the different catabolisms, namely a lipase for the catabolism of lipids, a protease for that of proteins,

       a cellulase for that of cellulose and an amylase for that of carbohydrates.

   These compositions may further comprise a compound which induces effervescence and at the same time acts as a catalyst or activator for these enzymes, namely essentially potassium carbonate and a. compound giving an acid reaction in solution,

      for example citric acid.



  The relative proportions of these various enzymes will be very variable, drawn in practice, we have found exceptionally satisfactory a composition in which the enzymes are present in the following amounts, expressed for an effervescent tablet:

         Protease. . . 10,000 Amylose units. . . 5,000 Cellulase units. . . 2,000 Lipase units. . . 1,000 units It should be noted that it is not normally possible to introduce protease and lipase in the same composition,

      because the latter absorbs and destroys protease. To avoid this drawback, according to another characteristic of the invention,

      the lipase or protease is coated with a protective product preventing the undesirable phenomenon from occurring for a sufficient time after the preparation of P (mineral water which will constitute the aqueous solution of the compositions according to the invention. Such a <RTI

   ID = "0001.0127"> protective product can be for example da cellulose covering the crystals.



  The compositions obtained by the process according to the invention are therefore preferably in the form of tablets (with a double core), the internal portion of which consists of lipase coated with a film of protective product, and the external potion is formed. killed by a mixture of other enzymes,

   potassium carbonate and an acid reacting compound capable of reacting with the latter in solution in water to induce effervescence. As a compound with an acid reaction; citric racide, for example, can be used, which has the advantage of contributing to the flavoring of the product.



       Of course, the component aurorae of the excipient may be very varied, as it emerges from the examples below.



  Such tablets, introduced into a glass of ordinary water, turn it into one,

      glass of carbonated mineral water containing in solution the aforementioned enzymes with the exception of hipase, the dissolution of which is delayed for a sufficient time to avoid its harmful action on the protease.



       The potassium carbonate is chosen from: preference to other carbonates, because of the favorable influence of the potassium ion on the kinetics of the enzymatic reactions:

    Although the principle of obtaining beautiful effervescent mineral waters by dissolving solid tablets of ordinary water is known, a:

  such enzymatic carbonated water has never been proposed, -and in particular a water comprising in its composition all the enzymes necessary for good digestion and the metal ions favorable to the physiological reactions implicated by the administration of these enzymes.



       Well. that these are not essential, it is preferable that the enzymes used and-more especially the lipase are of fungal origin, in,

      due to the remarkable activity and stability of the enzymes of this owigin. _ _ - Example- of composition Extract 6nzynïaiiquetal. . . 250 mg - - Gluouronamidë -_. -. :

   . . . . 400 mg Vitamin C. . . . . . . . 500 mg Sodium monofumarate. . . <B> 1950 </B> mg Potassium bicarbonate ... . 950 mg _.



       Excipient, including Polyethylene- - glycol 6000. . . . q. s. p. - 4500 mg


    

Claims (1)

REVENDICATION _ Procédé pour la préparation de compositions solides digestives appropriées à la préparation-de bosons, CLAIM _ Process for the preparation of solid digestive compositions suitable for the preparation of bosons, carac- térisé en ce que l'on comprime ensemble à l'état pulvé- rulent au moins un enzyme et les constituants détermi nant un dégagement gazeux par. dissolution dans l'eau. __._ _SOUS-REVENDICATIONS _ 1. characterized in that at least one enzyme and the constituents determining gas evolution are compressed together in the pulverulent state. dissolving in water. __._ _SUBCLAIMS _ 1. Procédé selon la revendication, caractérisé en ce que les enzymes sont la protéase, l'amylose, la cellulase et/ou la lipase. _ 2. Procédé selon la revendication dans lequel: on utilise un mélange des enzymes mentionnés ci-dessus, caractérisé en ce qu'on ajoute au mélange des enzymes du glucuronamide et du monofumarate de sodium. 3. Process according to claim, characterized in that the enzymes are protease, amylose, cellulase and / or lipase. _ 2. Method according to claim in which: a mixture of the enzymes mentioned above is used, characterized in that the mixture of enzymes is added glucuronamide and sodium monofumarate. 3. Procédé selon la revendication dans lequel on uti@Lise simultanément la lipase et la protéase, caractérisé en ce qu'on enrobe la lipase ou la protéase d'un produit protecteur pour empêcher la destruction de da protéase. 4. A method according to claim in which the lipase and the protease are used simultaneously, characterized in that the lipase or the protease is coated with a protective product to prevent destruction of the protease. 4. Procédé selon la revendication et la sous-reven- dication 3, caractérisé en ce que le produit protecteur est polyéthylèneglyeol 6000. Process according to claim and subclaim 3, characterized in that the protective product is polyethylene glycol 6000. 5. Procédé selon la revendication caractérisé en ce qu'on emploie comme constituants déterminant un déga gement gazeux le carbonate de potassium et l'acide citrique 6. 5. Method according to claim characterized in that potassium carbonate and citric acid 6 are used as constituents determining a gaseous release. Procédé selon la revendication caractérisé en ce qu'on emploie comme constituants déterminant un déga gement gazeux le carbonate de potassium et l'acide _ asco_rbique." - _ Process according to claim, characterized in that potassium carbonate and _ asco_rbic acid are used as constituents determining a gas evolution. "- _
CH747265A 1964-06-16 1965-05-28 Process for the preparation of solid digestive compositions suitable for the preparation of beverages CH434134A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8093A FR3536M (en) 1964-06-16 1964-06-16

Publications (1)

Publication Number Publication Date
CH434134A true CH434134A (en) 1967-04-15

Family

ID=9694045

Family Applications (1)

Application Number Title Priority Date Filing Date
CH747265A CH434134A (en) 1964-06-16 1965-05-28 Process for the preparation of solid digestive compositions suitable for the preparation of beverages

Country Status (5)

Country Link
BE (1) BE663658A (en)
CH (1) CH434134A (en)
ES (1) ES313078A1 (en)
FR (1) FR3536M (en)
GB (1) GB1107824A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723327A (en) * 1972-06-05 1973-03-27 Lever Brothers Ltd Granular proteolytic enzyme composition
US4265847A (en) * 1978-03-30 1981-05-05 Kirby Pharmaceuticals Ltd Tabletting process
AR220239A1 (en) * 1979-12-04 1980-10-15 Scherz Sara EDIBLE COMPOSITION
JPS5826822A (en) * 1981-08-10 1983-02-17 Kaken Pharmaceut Co Ltd Preventing and pemedy for liver and kidney diseases
US5817350A (en) * 1993-03-11 1998-10-06 Triarco Industries Carbohydrase enzyme food supplement composition
US5436003A (en) * 1994-02-10 1995-07-25 Triarco Industries, Inc. Method of alleviating gastrointestinal distress with a composition containing beta-fructofuransidase, cellulase and hemi-cellulase
US6099844A (en) * 1994-08-22 2000-08-08 Triarco Industries, Inc. Increasing yield of extractable substances from botanicals with an enzyme composition
CA2287000A1 (en) * 1997-04-14 1998-10-22 Alan Thomas Brooker Foaming component
WO2003014304A2 (en) * 2001-08-09 2003-02-20 Doctor's Signature Sales And Marketing International Corp. [(Dba)] Life Force International Protonic formulation
US6558666B1 (en) 2002-04-03 2003-05-06 Triarco Industries, Inc. Chromium-containing carbohydrase enzyme food supplement composition
EP2328609A1 (en) * 2008-08-26 2011-06-08 Cystic Fibrosis Foundation Therapeutics, Inc. Rapidly disintegrating tablets comprising lipase, amylase, and protease

Also Published As

Publication number Publication date
FR3536M (en) 1965-09-13
ES313078A1 (en) 1965-10-01
GB1107824A (en) 1968-03-27
BE663658A (en) 1965-09-01

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