CH269424A - Process for the preparation of a basic ester. - Google Patents
Process for the preparation of a basic ester.Info
- Publication number
- CH269424A CH269424A CH269424DA CH269424A CH 269424 A CH269424 A CH 269424A CH 269424D A CH269424D A CH 269424DA CH 269424 A CH269424 A CH 269424A
- Authority
- CH
- Switzerland
- Prior art keywords
- ester
- propyl
- acetic acid
- methyl
- preparation
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines basischen Esters. Gegenstand vorliegenden Patentes ist. ein Verfahren zur Herstellung eines basischen Esters. Das Verfahren ist dadurch gekenn zeichnet, dass man einen reaktionsfähigen Ester von Methyl-di-n-propyl-essigsäure-(y- oxy-propyl)-est.er, wie z. B. einen Halogenwas- serstoff- oder Arylsulfonsäureester, mit Di- äthylamin umsetzt.
Die erhaltene neue Ver bindung, der I)iäthylaminopropylester der b1ethyl-di-n-propy l-essigsäture, ist eine Base vom Siedepunkt 147-1500 unter 11 mm Druck. Sie lässt sich mit anorganischen oder organischen Säuren in Salze überführen. Sie soll therapeutische Verwendung finden.
<I>Beispiel:</I> 23,5 Teile des aus Metliyl-di-n-propyl-essig- säurechlorid und Propylenchlorhydrin erhal tenen ;Niethyl-di-ri-propyl-essigsäure-(y-ehlor- propyl)-esters werden in der "lärme mit 14,6 Teilen Diäthylamin umgesetzt. Das Gemisch wird in verdünnter Salzsäure gelöst und durch Ausschütteln mit Äther von geringen Mengen von Neutralteilen befreit. Aus der sauren, wässrigen Lösung wird hierauf durch Zusatz von konzentriertem Ammoniak der basische Ester abgeschieden.
Er wird in Äther aufge nommen, die ätherische Lösung mit Wasser gewaschen und getrocknet. Der nach dem Ab destillieren des Äthers als Rückstand erhal tene Diäthylaminopropylester der Methy 1-di- n-propy 1-essigsäure siedet bei 147-150o unter 11 mm Druck.
Process for the preparation of a basic ester. Subject of the present patent is. a process for producing a basic ester. The method is characterized in that a reactive ester of methyl-di-n-propyl-acetic acid (y-oxy-propyl) -est.er, such as. B. a hydrogen halide or aryl sulfonic acid ester with diethylamine.
The new connection obtained, the I) ethylaminopropyl ester of b1ethyl-di-n-propy l-acetic acid, is a base with a boiling point of 147-1500 under 11 mm pressure. It can be converted into salts with inorganic or organic acids. It should find therapeutic use.
<I> Example: </I> 23.5 parts of the methyl-di-n-propyl-acetic acid chloride and propylene chlorohydrin obtained; niethyl-di-ri-propyl-acetic acid (y-chloropropyl) ester The mixture is dissolved in dilute hydrochloric acid and freed from small amounts of neutral components by shaking with ether. The basic ester is then separated from the acidic, aqueous solution by adding concentrated ammonia.
It is taken up in ether, the ethereal solution washed with water and dried. The diethylaminopropyl ester of methyl 1-di-n-propy 1-acetic acid obtained as a residue after distilling off the ether boils at 147-150 ° under 11 mm pressure.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH269424T | 1943-08-04 | ||
CH245220T | 1943-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH269424A true CH269424A (en) | 1950-06-30 |
Family
ID=25729044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH269424D CH269424A (en) | 1943-08-04 | 1943-08-04 | Process for the preparation of a basic ester. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH269424A (en) |
-
1943
- 1943-08-04 CH CH269424D patent/CH269424A/en unknown
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