CH266275A - Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. - Google Patents
Process for the preparation of a new pyrimidyl mercaptocarboxylic acid.Info
- Publication number
- CH266275A CH266275A CH266275DA CH266275A CH 266275 A CH266275 A CH 266275A CH 266275D A CH266275D A CH 266275DA CH 266275 A CH266275 A CH 266275A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- pyrimidyl
- new
- preparation
- mercaptocarboxylic acid
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung einer neuen Pyrimidylmereaptocarbonsäure. Das vorliegende Patent betrifft ein Ver fahren zur Herstellung einer neuen Pyrimi- dylmercaptocarbonsäure, welches dadurch ge kennzeichnet ist, dass man auf 2-Mereapto-4- oxy-6-äthyl-pyrimidin eine Monohalogenessig- säure, wie Monoehloressigsäure, einwirken lässt.
Die so erhaltene 4-Oxy-6-äthyl-pyrimidyl- (2)-mereaptoessigsäure schmilzt. bei 1700. Sie soll als Heilmittel oder als Zwischenprodukt Verwendung finden.
Bei der Umsetzung arbeitet man z\,veck- mässig in Gegenwart eines Verdünnungsmit tels, wie Wasser, oder eines organischen Lö sungsmittels, beispielsweise Methyl- oder Äthylalkohol oder Aceton, wobei vorteilhafter weise ein säurebindendes Mittel zugesetzt wird.
Von der erhaltenen neuen Säure lassen sich Salze gewinnen, wobei sowohl anorga nische wie organische Basen als salzbildende Mittel zur Anwendung gelangen können. Von besonderem Interesse sind die Natrium- und Ammoniumsalze wegen ihrer leichten Löslich keit, ferner auch die Calciumsalze. Zur Salz bildung können auch physiologisch aktive or ganische Basen verwendet werden, beispiels weise das für seine antithyreotisehe Wirkung bekannte 2-Amino-thiazol. <I>Beispiel:
</I> Zu einer Lösung von 12 Gewichtsteilen 2- Mercapto-4-oxy-6-äthyl-pyrimidin in 46 Vo- lumteilen 3,3n-Natronlauge werden 30 Volum- teile einer 2,6 molaren wässerigen Natrium- ehloracetatLösung gegeben. Hierauf wird eine halbe Stunde lang auf 80 bis<B>900</B> erwärmt, abgekühlt und mit Salzsäure 1:1 schwach kongosauer gestellt.
Die 4-Oxy-6-äthyl-py-rimi- dyl-(2)-mereaptoessigsäure der Formel
EMI0001.0035
fällt dabei als farblose Substanz aus. g Aus 50 % igem Äthylalkohol umkristallisiert. schmilzt sie bei 1700.
Process for the preparation of a new pyrimidylmereaptocarboxylic acid. The present patent relates to a process for the production of a new pyrimidylmercaptocarboxylic acid, which is characterized in that a monohaloacetic acid, such as monoehloroacetic acid, is allowed to act on 2-mereapto-4-oxy-6-ethyl-pyrimidine.
The 4-oxy-6-ethyl-pyrimidyl- (2) -mereaptoacetic acid thus obtained melts. at 1700. It is said to be used as a remedy or as an intermediate product.
The reaction is usually carried out in the presence of a diluent, such as water, or an organic solvent, for example methyl or ethyl alcohol or acetone, an acid-binding agent being advantageously added.
Salts can be obtained from the new acid obtained, and both inorganic and organic bases can be used as salt-forming agents. The sodium and ammonium salts are of particular interest because of their easy solubility, as are the calcium salts. Physiologically active organic bases can also be used for salt formation, for example 2-amino-thiazole, which is known for its antithyroidism. <I> example:
30 parts by volume of a 2.6 molar aqueous sodium chloride solution are added to a solution of 12 parts by weight of 2-mercapto-4-oxy-6-ethyl-pyrimidine in 46 parts by volume of 3.3N sodium hydroxide solution. The mixture is then heated to 80 to 900 for half an hour, cooled and made slightly acidic to Congo with hydrochloric acid 1: 1.
The 4-oxy-6-ethyl-py-rimidyl- (2) -mereaptoacetic acid of the formula
EMI0001.0035
precipitates as a colorless substance. g Recrystallized from 50% ethyl alcohol. it melts at 1700.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH266275T | 1946-12-09 | ||
| CH262798T | 1946-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH266275A true CH266275A (en) | 1950-01-15 |
Family
ID=25730593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH266275D CH266275A (en) | 1946-12-09 | 1946-12-09 | Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH266275A (en) |
-
1946
- 1946-12-09 CH CH266275D patent/CH266275A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH266275A (en) | Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. | |
| DE934890C (en) | Process for the preparation of basic benzhydryl ethers | |
| DE558647C (en) | Process for the production of basic ethers of aromatic ketones | |
| DE907293C (en) | Process for the preparation of polysulfuric acid esters and salts thereof | |
| CH262799A (en) | Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. | |
| AT165072B (en) | Process for the preparation of new pyridinium compounds | |
| DE630910C (en) | Process for the preparation of C, C-disubstituted barbituric acids | |
| AT152824B (en) | Process for the preparation of quaternary ammonium compounds. | |
| DE644839C (en) | Process for the preparation of pyridine-o-dicarboxylic acid amides | |
| DE1004194B (en) | Process for the production of uniform, skin-friendly tertiary N- (ª ‰, ª † -dioxypropyl) amines | |
| DE830646C (en) | Process for the preparation of an N, N-dimethyl-N '- (2-pyridyl) -N' - (halo-2-thienylmethyl) -aethylene diamine | |
| DE928530C (en) | Process for the preparation of p-aminosalicylates from antihistamine bases | |
| DE862601C (en) | Process for the production of new diphenyl- (A2,3-2-methyl-propenyl) -acetic acid dialkylamino-alkyl esters and their salts | |
| DE915812C (en) | Process for the production of xanthanes or thioxanthanes | |
| DE726739C (en) | Process for the production of clumps of 4-aminobenzenesulfonamides | |
| DE764384C (en) | Process for the production of diphenylsulfone pellets | |
| AT158301B (en) | Process for the production of vitamin B1. | |
| DE2523208C3 (en) | Thienylacetic acid esters, a process for their preparation and pharmaceuticals | |
| CH265095A (en) | Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. | |
| CH263037A (en) | Process for the preparation of a new derivative of 2-oxy-5-aminobenzoic acid. | |
| CH172511A (en) | Method for preparing a mercaptopyrimidine metal complex compound. | |
| DE1067028B (en) | ||
| CH262798A (en) | Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. | |
| CH265096A (en) | Process for the preparation of a new pyrimidyl mercaptocarboxylic acid. | |
| DE2053735A1 (en) | Quaternary pyridinium salts |