CH262958A - Process for the preparation of the new a-B-di- (4-methyl-thiazolyl- (2)) - ethylene. - Google Patents

Process for the preparation of the new a-B-di- (4-methyl-thiazolyl- (2)) - ethylene.

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Publication number
CH262958A
CH262958A CH262958DA CH262958A CH 262958 A CH262958 A CH 262958A CH 262958D A CH262958D A CH 262958DA CH 262958 A CH262958 A CH 262958A
Authority
CH
Switzerland
Prior art keywords
methyl
thiazolyl
ethylene
dehydrating agents
new
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Ciba
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of CH262958A publication Critical patent/CH262958A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung des neuen     a,ss-Di-[4-methyl-thiazolyl-(2)]-äthylens.       Es wurde gefunden, dass man zum neuen       a,ss-Di[4-methyl-thiazolyl-(2)]-äthylen    ge  langt, wenn man     a,l-Di-[4-met.hyl-thia.zolyl-          (2)    ]     -äthan    bei erhöhter Temperatur mit de  hydrierenden Mitteln behandelt.  



       Als    dehydrierende Mittel kommen bei  spielsweise milde Oxydationsmittel in Be  tracht. Beispiele dafür sind: Verbindungen       des    zweiwertigen Quecksilbers, wie     Mereuri-          acetat    oder Quecksilberoxyd, Kaliumperman  ganat oder Braunstein, Kupferoxyd oder Kup  fersulfat, Wasserstoffsuperoxyd,     Selendioxyd,     Platinoxyd, schliesslich oxydierend wirkende  organische Verbindungen, wie     Nitroverbin-          dungen,    z. B. Nitrobenzol. Weiterhin eignen  sich auch     Ferrisalze,    wie     Ferrichlorid.     



  Eine weitere Gruppe von dehydrierenden  Mitteln bilden die Elemente Selen und  Schwefel.  



  Schliesslich können als dehydrierende Mit  tel auch     Dehydrierungskatalysatoren,    z. B.  feinverteiltes Nickel, Kupfer, Platin oder  Palladium, sei es für sich oder auf Träger  aufgebracht, herangezogen werden.  



  Die geeignetsten     Dehy        drierungsmittel    sind  jedoch milde Oxydationsmittel, wie insbeson  dere     Mereurisalze.     



  Die Behandlung     mti    den dehydrierenden  Mitteln erfolgt bei erhöhter Temperatur, z. B.  bei 80 bis 150 , vorzugsweise in Gegenwart  von Lösungsmitteln für das     a,ss-Di-[4-methyl-          thiazolyl-    (2) ]     -äthan,    z. B. unter Zusatz von       Eisessig    oder verdünnten Mineralsäuren. So    kann man zum Beispiel das in Eisessig lös  liche     Mercuriacetat    auf die Lösung des     a,ss-          Di-[4-methyl-thia.zolyl-(2)    ]     -äthans    in Eisessig  zur Einwirkung bringen, z.

   B. bei 100 bis  1500.     Ferrichlorid    kann zum Beispiel bei 80  bis 1000 C zur Einwirkung gebracht werden,  vorteilhaft in Gegenwart von verdünnter  Salzsäure.  



  Das gemäss vorliegendem Verfahren erhal  tene     a,ss-Di-[4-methyl-thiazolyl-(2)        ]-äthylen     bildet ein     gelbstichiges    Pulver, dessen     alko-          bolische    Lösung im ultravioletten Licht inten  siv blau fluoresziert. Es kann als optisches  Bleichmittel verwendet werden.    <I>Beispiel:</I>    1,6 Teile     a,,ss-Di-[4-methyl-thiazolyl-(2)]-          äthan    werden mit 1,8 Teilen     konz.    Salzsäure,  25 Teilen Wasser und 13 Teilen     Ferrichlorid     auf dem siedenden Wasserbad während 6 Stun  den erhitzt. In dieser Zeit scheiden sich ge  ringe Mengen fester Anteile ab. Nun setzt.

    man etwa 80 Teile Wasser hinzu, zerdrückt  die festen Anteile     und    fügt     Sodalösung    bis  zur alkalischen Reaktion hinzu. Hierauf wird  die Lösung mit Äther extrahiert und das Lö  sungsmittel     abdestilliert.    Nach kurzer Zeit  kristallisiert der ölig anfallende Rückstand,  welcher aus nicht völlig reinem     a,,l-Di-[4-me-          thyl-thiazolyl-    (2) ]     -äthylen    besteht.

   Durch Ab  pressen auf Ton und     Umkristallisieren    aus       Petrolät.her    kann das reine     Äthy        lenderivat    als       gelbstichiges    Pulver gewonnen werden.      Eine     alkoholische        Lösung    des Reaktions  produktes     fluoresziert    im ultravioletten Licht       intensiv    blau.



  Process for the preparation of the new a, ss-di- [4-methyl-thiazolyl- (2)] - ethylene. It has been found that the new a, ss-di [4-methyl-thiazolyl- (2)] -ethylene is obtained if a, l-di- [4-met.hyl-thia.zolyl- (2 )] ethane treated at elevated temperature with de hydrogenating agents.



       As dehydrating agents, mild oxidizing agents can be used, for example. Examples are: Compounds of divalent mercury, such as Mereuri- acetate or mercury oxide, Kaliumperman ganat or manganese dioxide, copper oxide or copper sulfate, hydrogen peroxide, selenium dioxide, platinum oxide, and finally oxidizing organic compounds such as nitro compounds, z. B. nitrobenzene. Ferric salts such as ferric chloride are also suitable.



  Another group of dehydrating agents are the elements selenium and sulfur.



  Finally, dehydrogenation catalysts such. B. finely divided nickel, copper, platinum or palladium, whether by itself or applied to a carrier, can be used.



  However, the most suitable dehydrating agents are mild oxidizing agents, such as mereuri salts in particular.



  The treatment with the dehydrating agents is carried out at an elevated temperature, e.g. B. at 80 to 150, preferably in the presence of solvents for the a, ss-di- [4-methyl-thiazolyl- (2)] -ethane, z. B. with the addition of glacial acetic acid or dilute mineral acids. For example, you can bring the solution of a, ss- di- [4-methyl-thia.zolyl- (2)] -ethans in glacial acetic acid to the action of the mercuric acetate solution in glacial acetic acid, z.

   B. at 100 to 1500. Ferric chloride can be brought into action, for example, at 80 to 1000 C, advantageously in the presence of dilute hydrochloric acid.



  The α, β-di- [4-methyl-thiazolyl- (2)] -ethylene obtained in accordance with the present process forms a yellow-tinged powder, the alcoholic solution of which fluoresces intensely blue in ultraviolet light. It can be used as an optical bleach. <I> Example: </I> 1.6 parts of a ,, ss-di- [4-methyl-thiazolyl- (2)] - ethane are concentrated with 1.8 parts. Hydrochloric acid, 25 parts of water and 13 parts of ferric chloride are heated on a boiling water bath for 6 hours. During this time, small amounts of solid fractions separate out. Well sets.

    about 80 parts of water are added, the solid fractions are crushed and soda solution is added until the reaction is alkaline. The solution is then extracted with ether and the solvent is distilled off. After a short time, the oily residue obtained, which consists of not completely pure α ,, l-di- [4-methyl-thiazolyl- (2)] -ethylene, crystallizes.

   By pressing on clay and recrystallizing from petroleum ether, the pure ethylene derivative can be obtained as a yellowish powder. An alcoholic solution of the reaction product fluoresces intensely blue in ultraviolet light.

 

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des neuen a,ss- Di-[4-methyl-thiazolyl-(2)]-äthylens, dadurch gekennzeichnet, dass man a,ss-Di-[4-methyl- thiazolyl (2) ] -äthan bei erhöhter Temperatur mit dehydrierenden Mitteln behandelt. PATENT CLAIM: Process for the preparation of the new a, ss-di- [4-methyl-thiazolyl- (2)] -ethylene, characterized in that a, ss-di- [4-methyl-thiazolyl (2)] -ethane treated with dehydrating agents at elevated temperature. Das gemäss vorliegendem Verfahren erhal tene a,ss-Di-[4-methyl-thiazolyl-(2) [-äthylen bildet ein gelbstichiges Pulver, dessen alko holische Lösung im ultravioletten Licht in tensiv blau fluoresziert. Es kann als optisches Bleichmittel verwendet werden. LTNTERAN SPRtCHE 1. The a, ss-di- [4-methyl-thiazolyl- (2) [-ethylene obtained according to the present process forms a yellowish powder, the alcoholic solution of which fluoresces intensely blue in ultraviolet light. It can be used as an optical bleach. LTNTERAN LANGUAGE 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man die dehydrie renden Mittel in Gegenwart eines Lösungs mittels für das a,ss-Di-[4-methyl-thiazolyl- (2) ]-äthans einwirken lässt. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man als dehydrie rende Mittel milde Oxydationsmittel ver wendet. 3. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man als dehydrie rende Mittel Ferrisalze benützt. 4. Process according to claim, characterized in that the dehydrating agents are allowed to act in the presence of a solvent for the α, β-di- [4-methyl-thiazolyl- (2)] -ethane. 2. The method according to claim, characterized in that mild oxidizing agents are used as dehydrating agents. 3. The method according to claim, characterized in that ferric salts are used as dehydrating agents. 4th Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man Ferrichlorid bei 80 bis 1001) C in Gegenwart von verdünn ter Mineralsäure einwirken lässt. Process according to patent claim, characterized in that ferric chloride is allowed to act at 80 to 1001) C in the presence of dilute mineral acid.
CH262958D 1944-12-21 1945-12-18 Process for the preparation of the new a-B-di- (4-methyl-thiazolyl- (2)) - ethylene. CH262958A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH251643T 1944-12-21
CH262958T 1945-12-18

Publications (1)

Publication Number Publication Date
CH262958A true CH262958A (en) 1949-07-31

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CH262958D CH262958A (en) 1944-12-21 1945-12-18 Process for the preparation of the new a-B-di- (4-methyl-thiazolyl- (2)) - ethylene.

Country Status (1)

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CH (1) CH262958A (en)

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