CH240069A - Process for the preparation of a salt from antipyrine salicylate. - Google Patents

Process for the preparation of a salt from antipyrine salicylate.

Info

Publication number
CH240069A
CH240069A CH240069DA CH240069A CH 240069 A CH240069 A CH 240069A CH 240069D A CH240069D A CH 240069DA CH 240069 A CH240069 A CH 240069A
Authority
CH
Switzerland
Prior art keywords
salt
antipyrine
antipyrine salicylate
preparation
salicylate
Prior art date
Application number
Other languages
German (de)
Inventor
Rosenthaler Leopold Dr Prof
Original Assignee
Rosenthaler Leopold Dr Prof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosenthaler Leopold Dr Prof filed Critical Rosenthaler Leopold Dr Prof
Publication of CH240069A publication Critical patent/CH240069A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines Salzes aus     Antipyrinsalieylat.       Obgleich bekannt ist, dass das sogenannte       Antipyrinsalicylat        (Antipyrinumsalicylicum)     saure     Eigenschaften    besitzt, so sind doch  Salze dieses Stoffes bisher nicht dargestellt  worden.     Gegenstand    des vorliegenden Paten  tes ist ein Verfahren zur Herstellung eines  Salzes aus     Antipyrinsalicylat,    welches da  durch gekennzeichnet ist, dass man auf     Anti-          pyrinsalicylat        Kalziumcarbonat    einwirken  lässt.  



  <I>Beispiel:</I>  Man erhitzt 65,2g     Antipyrinsalicylat    mit  1 Liter Wasser und etwa 10 g     Kalziumcarbo-          nat    unter     Aufrechterhaltung    schwach saurer  Reaktion, bis alles     Antipyrinsalicylat    in Lö  sung gegangen ist, und filtriert heiss. Beim  Erkalten erhält man die Kristalle des     anti-          pyrinsalicylsauren    Kalziums. Aus der nach       Abfiltrieren    des Niederschlags erhaltenen  Flüssigkeit erhält man durch Einengen wei  tere Mengen der     genannten    Verbindung.

   Das  so dargestellte     antipyrinsalicylsaure    Kalzium  bildet farblose kristallinische Schollen, löslich  in etwa 20 Teilen Wasser (25 ), leichter lös  lich in siedendem Wasser, auch in     Weingeist     löslich. Die Zusammensetzung der Verbin-         dung    entspricht der Formel     Ca(Cl$H1704N_)z.     Die     wässrige    Lösung der Verbindung gibt mit  Säuren (Salzsäure, Essigsäure) Niederschläge,  die sich im     TJberschuss    der     ,Säuren    lösen;

   ein  später sich bildender Niederschlag ist     Salicyl-          säure;    mit     Ferrichlorid    gibt die Lösung einen       dunkelbraunen    Niederschlag. Die mit Salz  säure versetzte Lösung gibt mit Natrium  nitrat Grünfärbung     (Antipyrin).    Die     ammo-          niakalische    Lösung gibt     mit        Ammonoxalat     eine Fällung von     Kalziumogalat.  



  Process for the preparation of a salt from antipyrin salylate. Although it is known that the so-called antipyrine salicylate (Antipyrinumsalicylicum) has acidic properties, salts of this substance have not yet been shown. The subject matter of the present patent is a process for the production of a salt from antipyrine salicylate, which is characterized in that the antipyrine salicylate is allowed to act on calcium carbonate.



  <I> Example: </I> 65.2 g of antipyrine salicylate are heated with 1 liter of water and about 10 g of calcium carbonate while maintaining the weakly acidic reaction until all of the antipyrine salicylate has dissolved, and the mixture is filtered hot. When it cools down, the crystals of antipyrine salicylic acid calcium are obtained. From the liquid obtained after filtering off the precipitate, further amounts of the compound mentioned are obtained by concentration.

   The antipyrinsalicylic acid calcium thus represented forms colorless crystalline clods, soluble in about 20 parts of water (25), more easily soluble in boiling water, also soluble in alcohol. The composition of the compound corresponds to the formula Ca (Cl $ H1704N_) z. The aqueous solution of the compound and acids (hydrochloric acid, acetic acid) give precipitates which dissolve in excess of the acids;

   a precipitate that forms later is salicylic acid; with ferric chloride, the solution gives a dark brown precipitate. The solution mixed with hydrochloric acid gives a green color (antipyrine) with sodium nitrate. The ammoniacal solution and ammonoxalate precipitate calcium ogalate.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Salzes aus Antipyrinsalicylat, dadurch gekennzeich net, dass man auf Antipyrinsalicylat Kal- ziumcarbonat einwirken lässt. Die so erhal tene Verbindung soll therapeutische Verwen dung finden. Sie besitzt die Zusammenset zung Ca(C"H"04N2),; sie löst sich in etwa 20 Teilen Wasser und ist auch in Weingeist löslich. PATENT CLAIM: Process for the production of a salt from antipyrine salicylate, characterized in that calcium carbonate is allowed to act on the antipyrine salicylate. The compound thus obtained is intended to find therapeutic use. It has the composition Ca (C "H" 04N2); it dissolves in about 20 parts of water and is also soluble in alcohol.
CH240069D 1944-01-26 1944-01-26 Process for the preparation of a salt from antipyrine salicylate. CH240069A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH240069T 1944-01-26

Publications (1)

Publication Number Publication Date
CH240069A true CH240069A (en) 1945-11-30

Family

ID=4461603

Family Applications (1)

Application Number Title Priority Date Filing Date
CH240069D CH240069A (en) 1944-01-26 1944-01-26 Process for the preparation of a salt from antipyrine salicylate.

Country Status (1)

Country Link
CH (1) CH240069A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2472565A1 (en) * 1979-11-09 1981-07-03 Toho Pharma Co Ltd N - ((ISOPROPYL-4-METHYL-2-PHENYL-1-PYRAZOLONE-5-YL-3) METHYL) ACETOXY-2-BENZAMIDE, PROCESS FOR PREPARING THE SAME, AND MEDICAMENTS CONTAINING THE SAME

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2472565A1 (en) * 1979-11-09 1981-07-03 Toho Pharma Co Ltd N - ((ISOPROPYL-4-METHYL-2-PHENYL-1-PYRAZOLONE-5-YL-3) METHYL) ACETOXY-2-BENZAMIDE, PROCESS FOR PREPARING THE SAME, AND MEDICAMENTS CONTAINING THE SAME

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