CH234540A - Process for the production of a mixture containing oxyprogesterone propionate which is always qualitatively the same. - Google Patents

Process for the production of a mixture containing oxyprogesterone propionate which is always qualitatively the same.

Info

Publication number
CH234540A
CH234540A CH234540DA CH234540A CH 234540 A CH234540 A CH 234540A CH 234540D A CH234540D A CH 234540DA CH 234540 A CH234540 A CH 234540A
Authority
CH
Switzerland
Prior art keywords
sep
propionate
same
production
mixture containing
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH234540A publication Critical patent/CH234540A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines     qualitativ    stets gleich zusammengesetzten,       Oayprogesteronpropionate    enthaltenden Gemisches.    Gegenstand des vorliegenden Zusatzpaten  tes ist ein Verfahren zur Herstellung eines  qualitativ stets gleich zusammengesetzten,     Oxy        -          progesteronpropionate    enthaltenden Gemisches,  welches dadurch     gekennzeichnet    ist, dass man       Bleitetrapropionat    auf Progesteron einwirken  lässt.  



  Das neue Gemisch ist ein zähes Öl, wel  ches schwer zur     Kristallisation    zu bringen ist  und     ammoniakalische    Silbersalzlösung und       Fehlingsche    Lösung reduziert. Es soll als  Heilmittel verwendet werden.  



  Das Gemisch zeigt eine besonders hohe  Wirksamkeit, wenn bei seiner Herstellung  1,5     Mol    des     Bleitetrapropionats    auf 1     Mol     Progesteron angewendet wurde.  



  Da das     Bleitetrapropionat    an mehreren  Stellen des Progesterons angreifen kann, ent  steht bei der Umsetzung ein Gemisch, das  jedoch     qualitativ    stets aus den gleichen Ver  bindungen besteht.         Beispiel:       3,14 g Progesteron werden mit 7,5 g     Blei-          tetrapropionat    in 100 cm'     Propionsäure    7--8       Stunden    bei 75-85   C unter Rühren erwärmt.  



  Danach     wird    die     Reaktionslösung    in Wasser  <B>9</B>     eLyossen,    die kolloide Lösung     ausgeäthert,     die Ätherlösung mit Soda neutral gewaschen  und     schliesslich    über Natriumsulfat getrocknet.  Nach     Abfiltrieren    von Natriumsulfat wird die  Ätherlösung     eingedampft.    Es bleibt ein Rück  stand von 3,46 g.     Er    zeigt stets die gleiche  qualitative     Zusammensetzung.  



  Process for the production of a mixture containing oayprogesterone propionate which is always qualitatively the same. The subject of the present additional patent is a process for the production of a mixture containing oxy-progesterone propionate, which is always qualitatively the same and which is characterized in that lead tetrapropionate is allowed to act on progesterone.



  The new mixture is a viscous oil which is difficult to crystallize and reduces ammoniacal silver salt solution and Fehling's solution. It is said to be used as a remedy.



  The mixture shows a particularly high effectiveness when 1.5 mol of the lead tetrapropionate was applied to 1 mol of progesterone in its preparation.



  Since lead tetrapropionate can attack several parts of the progesterone, a mixture is created during the implementation, which, however, always consists of the same compounds qualitatively. Example: 3.14 g of progesterone are heated with 7.5 g of lead tetrapropionate in 100 cm of propionic acid for 7-8 hours at 75-85 ° C. while stirring.



  The reaction solution is then dissolved in water 9 eLyossen, the colloidal solution is extracted with ether, the ether solution is washed neutral with soda and finally dried over sodium sulfate. After filtering off the sodium sulfate, the ethereal solution is evaporated. There remains a residue of 3.46 g. It always shows the same qualitative composition.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines qualitativ stets gleich zusammengesetzten, Oxyprogeste- ronpropionate enthaltenden Gemisches, da durch gekennzeichnet, dass man Bleitetrapro- pionat auf Progesteron einwirken lässt. Das neue Gemisch ist ein zähes Öl, welches schwer zur 1,Cristallisation zu bringen ist und ammoniakalische Silbersalzlösung und h'eh- lingsche Lösung reduziert. PATENT CLAIM: Process for the production of a mixture containing oxyprogesterone propionate, which is always qualitatively the same, as it is characterized in that lead tetrapropionate is allowed to act on progesterone. The new mixture is a viscous oil which is difficult to crystallize and which reduces ammoniacal silver salt solution and h'ehling's solution. Es soll als 11ei1- inittel verwendet werden. EMI0002.0010 UNTERANSPRUCH: <tb> Verfahren <SEP> nach <SEP> Patentanspruch, <SEP> dadurch <tb> gekennzeichnet, <SEP> da1.; <SEP> inan <SEP> 1,5 <SEP> liol <SEP> des <SEP> Blei tetrapropionats <SEP> auf <SEP> 1 <SEP> llol <SEP> Progesteron <SEP> bei <tb> einer <SEP> Temperatur <SEP> von <SEP> 75 <SEP> - <SEP> $.5 <SEP> " <SEP> C <SEP> einwirken <tb> läht. It is intended to be used as a medium. EMI0002.0010 SUBClaim: <tb> Method <SEP> according to <SEP> patent claim, <SEP> thereby <tb> marked, <SEP> da1 .; <SEP> inan <SEP> 1.5 <SEP> liol <SEP> of the <SEP> lead tetrapropionate <SEP> on <SEP> 1 <SEP> llol <SEP> progesterone <SEP> <tb> a <SEP> temperature <SEP> of <SEP> 75 <SEP> - <SEP> $ .5 <SEP> "<SEP> C <SEP> <tb> paralyzes.
CH234540D 1937-07-05 1938-07-05 Process for the production of a mixture containing oxyprogesterone propionate which is always qualitatively the same. CH234540A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE234540X 1937-07-05
CH225258T 1938-07-05

Publications (1)

Publication Number Publication Date
CH234540A true CH234540A (en) 1944-09-30

Family

ID=25726848

Family Applications (1)

Application Number Title Priority Date Filing Date
CH234540D CH234540A (en) 1937-07-05 1938-07-05 Process for the production of a mixture containing oxyprogesterone propionate which is always qualitatively the same.

Country Status (1)

Country Link
CH (1) CH234540A (en)

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