CH231852A - Process for the production of a condensation product. - Google Patents

Process for the production of a condensation product.

Info

Publication number
CH231852A
CH231852A CH231852DA CH231852A CH 231852 A CH231852 A CH 231852A CH 231852D A CH231852D A CH 231852DA CH 231852 A CH231852 A CH 231852A
Authority
CH
Switzerland
Prior art keywords
production
condensation product
product
condensing agent
tetraminopyrimidine
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH231852A publication Critical patent/CH231852A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Description

  

      Verfahren    zur Herstellung eines Kondensationsproduktes.    Gegenstand des vorliegenden Zusatzpaten  tes ist ein Verfahren zur Herstellung eines  Kondensationsproduktes, welches dadurch ge  kennzeichnet ist, dass man     2,4,5,6-Tetramino-          pyrimidin    mit     Glyoxylsäure    unter Erwär-         mung    in Gegenwart eines Kondensationsmit  tels umsetzt und das     2,6-Diamino-8-oxypyri-          midinazin    isoliert. Das neue Produkt     stellt     eine gelbe Substanz dar und soll als Heil  mittel     Verwendung    finden.

    
EMI0001.0010     
    2,4 g     2,4,5,6-Tetraminopyrimidinsulfat    und  8 g     Glyoxylsäure-bisulfitbarium    werden in  30 cm' 80%iger Schwefelsäure 20 Minuten  auf dem Wasserbad erwärmt. Man giesst die  Mischung in 100 cm' Wasser, trennt die Lö  sung vom ausgeschiedenen     Bariumsulfat    und  kühlt das Filtrat, wobei weisse     Nädelchen     (etwa 0,3) auskristallisieren, die das Sulfat  eines     Azins    darstellen.



      Process for the production of a condensation product. The subject of the present additional patent is a process for the production of a condensation product, which is characterized in that 2,4,5,6-tetraminopyrimidine is reacted with glyoxylic acid with warming in the presence of a condensation agent and the 2,6- Diamino-8-oxypyrimidinazine isolated. The new product is a yellow substance and should be used as a medicinal product.

    
EMI0001.0010
    2.4 g of 2,4,5,6-tetraminopyrimidine sulfate and 8 g of glyoxylic acid bisulfite barium are heated on a water bath for 20 minutes in 30 cm 'of 80% strength sulfuric acid. The mixture is poured into 100 cm 'of water, the solution is separated from the barium sulfate which has separated out and the filtrate is cooled, with white needles (about 0.3) crystallizing out, which represent the sulfate of an azine.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Konden sationsproduktes, dadurch gekennzeichnet, dass man 2,4,5,6-Tetraminopyrimidinmit Gly- oxylsäure unter Erwärmung in Gegenwart eines Kondensationsmittels umsetzt und das 2,6-Diamino-8-oxy-pyrimidinazin isoliert. Das Produkt ist eine gelbe Substanz. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man stärkere Schwefel säure als Kondensationsmittel verwendet. Claim: Process for the production of a condensation product, characterized in that 2,4,5,6-tetraminopyrimidine is reacted with glyoxylic acid with heating in the presence of a condensing agent and the 2,6-diamino-8-oxy-pyrimidinazine is isolated. The product is a yellow substance. SUBClaim: Method according to claim, characterized in that stronger sulfuric acid is used as the condensing agent.
CH231852D 1940-08-09 1941-06-17 Process for the production of a condensation product. CH231852A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE231852X 1940-08-09
CH222903T 1941-11-01

Publications (1)

Publication Number Publication Date
CH231852A true CH231852A (en) 1944-04-15

Family

ID=25726664

Family Applications (1)

Application Number Title Priority Date Filing Date
CH231852D CH231852A (en) 1940-08-09 1941-06-17 Process for the production of a condensation product.

Country Status (1)

Country Link
CH (1) CH231852A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2667486A (en) * 1951-05-24 1954-01-26 Research Corp 2,4-diamino pteridine and derivatives
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US10285990B2 (en) 2015-03-04 2019-05-14 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11286257B2 (en) 2019-06-28 2022-03-29 Gilead Sciences, Inc. Processes for preparing toll-like receptor modulator compounds
US11396509B2 (en) 2019-04-17 2022-07-26 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11583531B2 (en) 2019-04-17 2023-02-21 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2667486A (en) * 1951-05-24 1954-01-26 Research Corp 2,4-diamino pteridine and derivatives
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7501513B2 (en) 1998-12-28 2009-03-10 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US10285990B2 (en) 2015-03-04 2019-05-14 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11124487B2 (en) 2016-09-02 2021-09-21 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11827609B2 (en) 2016-09-02 2023-11-28 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11396509B2 (en) 2019-04-17 2022-07-26 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11583531B2 (en) 2019-04-17 2023-02-21 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11286257B2 (en) 2019-06-28 2022-03-29 Gilead Sciences, Inc. Processes for preparing toll-like receptor modulator compounds

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