CH191466A - Process for the preparation of diphenylacetic acid-2-diallylaminoethanol ester. - Google Patents

Process for the preparation of diphenylacetic acid-2-diallylaminoethanol ester.

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Publication number
CH191466A
CH191466A CH191466DA CH191466A CH 191466 A CH191466 A CH 191466A CH 191466D A CH191466D A CH 191466DA CH 191466 A CH191466 A CH 191466A
Authority
CH
Switzerland
Prior art keywords
diallylaminoethanol
ester
diphenylacetic acid
acid
act
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH191466A publication Critical patent/CH191466A/en

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Description

  

  Verfahren zur Herstellung von     Diphenylessigsänre-2-diallylaminoäthanolester.       Es wunde gefunden, da. man zu     Diphe-          nylessigsäure-2-diallylaminoäthanole-ster    ge  langen kann, wenn man auf eine Verbindung,  die das Radikal der     Diphenylessi:gsäure    ent  hält, wie z. B. ihre     Ester    oder     Halogenide     oder ihr     Anhydrid,        2-Diallylaminoäthauol     einwirken lässt.  



  Der so erhaltene     Diphenylessigsäure-2-          diallylaminoäthanolester        bildet    ein     farbloses     01 vom     Kpo,a"145-150     , dessen     Hydrochlo-          rid    in     Wasser    leicht löslich ist.  



  Die neue Verbindung soll     therapeutische          Verwendung    finden.    <I>Beispiel:</I>       2$    Teile     Diphenylessigsäurechlorid    lässt  man mit 14 Teilen     Diallylaminoäthanol          (Kp253-54     , dargestellt aus     Diallylamin     und     Glykolchlorhydrin)        reagieren,        nimmt    das       Reaktionsprodukt    in Äther     und    Natrium  carbonatlösung auf     und    trocknet die äthe  rische Lösung.

   Man erhält so nach     dem        Ab-          destillieren,    des     Lösungsmittels    Diphenyl-         essigsäure    - 2 -     diallylaminoäthanolester,    der  durch Destillation im Vakuum gereinigt wer  den kann.  



  An Stelle von     Diphenylessigsäurechlori-rl     kann auch ein anderes     Halogenid,    wie z. B.       Diphenylessigsäurebromid,        Verwendung    fin  den. Dieselbe Verbindung wird auch gewon  nen, wenn man     äquivalente    Mengen     Diphe-          nyless        #i#gsäurem:ethylesterun:

  d        21-Diallylamino-          äthanol    in der Wärme     umsetzt    und das       Reaktionsprodukt    im Vakuum     fraktioniert          destilliert.    Auch andere     DiphenylesQigsäure-          ester    können als     Ausgangsmaterial    dienen.



  Process for the production of diphenyl acetic acid 2-diallylaminoethanol ester. Found it sore there. you can get to Diphenylessigsäure-2-diallylaminoethanol-ster ge if you look at a compound that contains the radical of Diphenylessi: gäure ent, such as. B. their esters or halides or their anhydride, 2-diallylaminoethauol can act.



  The diphenylacetic acid-2-diallylaminoethanol ester thus obtained forms a colorless oil from Kpo, a "145-150, the hydrochloride of which is readily soluble in water.



  The new compound should find therapeutic use. <I> Example: </I> 2 parts of diphenylacetic acid chloride are allowed to react with 14 parts of diallylaminoethanol (Kp253-54, made up of diallylamine and glycol chlorohydrin), the reaction product is absorbed in ether and sodium carbonate solution and the ethereal solution is dried.

   After the solvent has been distilled off, diphenylacetic acid - 2 - diallylaminoethanol ester, which can be purified by distillation in vacuo, is obtained.



  Instead of Diphenylessigsäurechlori-rl, another halide, such as. B. Diphenylacetic acid bromide, use fin the. The same compound is also obtained when equivalent amounts of diphenyless # i # gic acid: ethyl ester:

  d 21-Diallylamino- ethanol converts in the heat and the reaction product is fractionally distilled in vacuo. Other diphenyl acetic acid esters can also serve as starting material.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von Diphenyl- essigsäure - 2 - @diallylaminoäthanolester, da durch gekennzeichnet, dass man auf eine Ver bindung, die das Radikal der Diphenylessig- säure enthält, 2-Diallylaminoäthanol einwir ken lässt. Der so erhaltene Diphenylessigsäure-2- diallylaminoäthanolester bildet ein farbloses Öl vom Kpo,o1z5145-1.50 , PATENT CLAIM: Process for the production of diphenylacetic acid - 2 - @ diallylaminoethanol ester, characterized in that 2-diallylaminoethanol is allowed to act on a compound which contains the radical of diphenylacetic acid. The diphenylacetic acid-2-diallylaminoethanol ester thus obtained forms a colorless oil from Kpo, o1z5145-1.50, dessen Hydrochlo- rid in Wasser leicht löslich ist. Die neue Verbindung soll therapeutische Verwendung finden. UNTERANSPRüCHE: , 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man auf einen Diphe- nyle3si#gsäureester \2-Diallylaminoäthanol einwirken lässt. 2. whose hydrochloride is easily soluble in water. The new compound should find therapeutic use. SUBClaims:, 1. Process according to patent claim, characterized in that a diphenyl3sigic acid ester 2-diallylaminoethanol is allowed to act. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man auf Diphenyl- essigsäureanhy dri@d 2-Diallylaminoäthanol einwirken lässt. 3. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man auf ein Diphe- nylessigsäurehalogenid 2 - Diallylamino- äthanol einwirken lässt. Process according to patent claim, characterized in that diphenylacetic anhydride is allowed to act on 2-diallylaminoethanol. 3. The method according to claim, characterized in that a diphenyl acetic acid halide 2 - diallylamino ethanol is allowed to act.
CH191466D 1934-07-12 1934-07-12 Process for the preparation of diphenylacetic acid-2-diallylaminoethanol ester. CH191466A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH191466T 1934-07-12
CH187825T 1934-07-12

Publications (1)

Publication Number Publication Date
CH191466A true CH191466A (en) 1937-06-15

Family

ID=25721587

Family Applications (1)

Application Number Title Priority Date Filing Date
CH191466D CH191466A (en) 1934-07-12 1934-07-12 Process for the preparation of diphenylacetic acid-2-diallylaminoethanol ester.

Country Status (1)

Country Link
CH (1) CH191466A (en)

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