CH176254A - Process for the preparation of 2-ethylmercury-mercaptothiazole-5-carboxylic acid sodium. - Google Patents
Process for the preparation of 2-ethylmercury-mercaptothiazole-5-carboxylic acid sodium.Info
- Publication number
- CH176254A CH176254A CH176254DA CH176254A CH 176254 A CH176254 A CH 176254A CH 176254D A CH176254D A CH 176254DA CH 176254 A CH176254 A CH 176254A
- Authority
- CH
- Switzerland
- Prior art keywords
- carboxylic acid
- ethylmercury
- mercaptothiazole
- preparation
- acid sodium
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung von 2-äthylquecksilber-mercaptothiazol-ö-carbonsaurem Natrium. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von 2-äthyl- quecksilber-mercaptothiazol- 5 - carbonsaurem Natrium, das dadurch gekennzeichnet ist, dass man Äthylquecksilberchlorid mit 2-Mercapto- benzothiazol-5-carbonsäure umsetzt und die so erhaltene Säure in das Natriumsalz überführt.
Die entstandene neue Verbindung ist leicht löslich in Wasser und Methylalkohol, schwerer in Äthylalkohol und unlöslich in Äther und Aceton. Sie soll als Arzneimittel und Anti- septicum verwendet werden. Beispiel: In eine wässerig-alkoholische Aufschläm mung von 7,93gr Äthylquecksilberchlorid wird eine stark alkalische Lösung von 14 gr 2- Mercaptobenzothiazol - 5 - carbonsäure einge rührt. Aus der zunächst klaren Flüssigkeit scheidet sich nach kurzer Zeit ein gelber Niederschlag aus.
Der Niederschlag wird ab gesaugt, in Wasser gelöst, filtriert und an- gesäuert. Die ausgeschiedene, gelbe, organi sche, quecksilberhaltige Säure wird abgesaugt, in Methylalkohol verteilt, durch Zusatz von Natronlauge curcuma-alkalisch gemacht, von geringen Verunreinigungen abfiltriert und das Filtrat in Äther eingerührt. Das ausgeschie dene 2-äthylquecksilber-mercaptobenzothiazol- 5-carbonsaure Natrium von der Formel
EMI0001.0024
wird abgesaugt und mit Äther gewaschen. Das gelbe Produkt löst sich leicht in Wasser und Methylalkohol, schwerer in Äthylalkohol und ist unlöslich in Äther und Aceton.
Die als Ausgangsstoff dienende 2-Mercapto- benzothiazol-5-carbonsäure kann erhalten wer den, indem man S-Nitro-4-chlor-l-benzoesäure durch Einwirkung einer wässerigen Lösung von Natriumpolysulfid in 3-Amino-4-meroapto- 1-benzoesäure verwandelt und diese mit Kaliumganthogenat umsetzt (vergl. deutsche Patentschrift 519987, Beispiel 6, wo die Dar stellung der entsprechenden Arsinsäure be schrieben ist).
Die Mercaptosäure ist ein gelbes Pulver, unlöslich in Wasser, leicht löslich in Methylalkohol und verdünnten Alkalien.
Process for the preparation of 2-ethylmercury-mercaptothiazole-ö-carboxylic acid sodium. The present invention relates to a process for the preparation of 2-ethylmercury-mercaptothiazole-5-carboxylic acid sodium, which is characterized in that ethylmercuric chloride is reacted with 2-mercaptobenzothiazole-5-carboxylic acid and the acid thus obtained is converted into the sodium salt convicted.
The resulting new compound is easily soluble in water and methyl alcohol, more difficult in ethyl alcohol and insoluble in ether and acetone. It is said to be used as a medicine and an antiseptic. Example: A strongly alkaline solution of 14 g of 2-mercaptobenzothiazole-5-carboxylic acid is stirred into an aqueous-alcoholic suspension of 7.93 grams of ethyl mercury chloride. A yellow precipitate separates out from the initially clear liquid after a short time.
The precipitate is filtered off with suction, dissolved in water, filtered and acidified. The precipitated, yellow, organic, mercury-containing acid is suctioned off, distributed in methyl alcohol, made turmeric-alkaline by adding sodium hydroxide solution, minor impurities are filtered off and the filtrate is stirred into ether. The excreted 2-ethylmercury-mercaptobenzothiazole-5-carboxylic acid sodium of the formula
EMI0001.0024
is suctioned off and washed with ether. The yellow product dissolves easily in water and methyl alcohol, more difficultly in ethyl alcohol, and is insoluble in ether and acetone.
The 2-mercapto-benzothiazole-5-carboxylic acid used as starting material can be obtained by adding S-nitro-4-chloro-1-benzoic acid by the action of an aqueous solution of sodium polysulfide in 3-amino-4-meroapto-1-benzoic acid transformed and this converts with potassium ganthogenate (see. German Patent 519987, Example 6, where the Dar position of the corresponding arsic acid is written).
Mercapto acid is a yellow powder, insoluble in water, easily soluble in methyl alcohol and dilute alkalis.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE176254X | 1932-04-16 | ||
| CH167320T | 1933-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH176254A true CH176254A (en) | 1935-03-31 |
Family
ID=25718407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH176254D CH176254A (en) | 1932-04-16 | 1933-04-13 | Process for the preparation of 2-ethylmercury-mercaptothiazole-5-carboxylic acid sodium. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH176254A (en) |
-
1933
- 1933-04-13 CH CH176254D patent/CH176254A/en unknown
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