CH160940A - Process for the preparation of a 4-oxypyridine derivative. - Google Patents

Process for the preparation of a 4-oxypyridine derivative.

Info

Publication number
CH160940A
CH160940A CH160940DA CH160940A CH 160940 A CH160940 A CH 160940A CH 160940D A CH160940D A CH 160940DA CH 160940 A CH160940 A CH 160940A
Authority
CH
Switzerland
Prior art keywords
preparation
oxypyridine
derivative
amyl alcohol
oxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ernst Dr Koenigs
Greiner Heinz
Original Assignee
Ernst Dr Koenigs
Greiner Heinz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ernst Dr Koenigs, Greiner Heinz filed Critical Ernst Dr Koenigs
Priority to CH160940D priority Critical patent/CH160940A/en
Publication of CH160940A publication Critical patent/CH160940A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Description

  

      Terfabren    zur Darstellung eines     4-Oxypyridinderivates.       Gegenstand vorliegender Erfindung ist ein  Verfahren zur Darstellung eines     4-Oxypyri-          dinderivates,    dadurch gekennzeichnet, dass  man     4-Pyridyl-pyridiniumdichlorid    der Ein  wirkung einer Verbindung der Formel     C5Hi1          0R,    wobei R einen mit Chlor in Reaktion  tretenden     Substituenten,    wie Wasserstoff oder  Metall, bedeutet,     unterwült.    Die neue Ver  bindung soll als Zwischenprodukt für die  Herstellung von Farbstoffen und pharmazeu  tischen Produkten Verwendung finden.  



       Beispiel   <I>1:</I>  Zu einer Lösung von 30     gr    gereinigtem       4-Pyridyl-pyridiniumdichlorid    in 500     eins          Amylalkohol    lässt man allmählich eine Auf  lösung von 10     gr    Natrium in     Xmylalkohol     unter Erwärmen     zutropfen.    Nach 4 Stunden  wird mit Wasser versetzt, angesäuert, der       Amylalkohol    mit Wasserdampf abgetrieben,  der Rückstand alkalisch gemacht und mit       Wasserdampf    destilliert.

   Das Destillat wird  mit viel     Kaliumkarbonat        versetzt,        ausgeäthert       und die ätherische Lösung vom Äther befreit.  Der Rückstand liefert den     Amyläther    des       r-Oxypyridins    vom Siedepunkt     240-243'.     Sein     Pikrat    schmilzt bei     129-130'.     



  <I>Beispiel 2:</I>  Zu derselben Verbindung gelangt man  auch, wenn man 115     Pyridyl-pyridiniumdi-          chlorid    in 500 cm'     Amylalkohol    24 Stunden  erhitzt und das Reaktionsgemisch wie oben  aufarbeitet.



      Terfabren for the preparation of a 4-oxypyridine derivative. The present invention relates to a process for the preparation of a 4-oxypyridine derivative, characterized in that 4-pyridyl-pyridinium dichloride is added to the action of a compound of the formula C5Hi1 0R, where R is a substituent that reacts with chlorine, such as hydrogen or metal, means undermined. The new connection is intended to be used as an intermediate for the manufacture of dyes and pharmaceutical products.



       Example <I> 1: </I> To a solution of 30 g of purified 4-pyridyl-pyridinium dichloride in 500 units of amyl alcohol, a solution of 10 g of sodium in xmyl alcohol is gradually added dropwise with heating. After 4 hours, water is added, the mixture is acidified, the amyl alcohol is driven off with steam, the residue is made alkaline and distilled with steam.

   The distillate is mixed with a lot of potassium carbonate, etherified and the ethereal solution is freed from the ether. The residue provides the amyl ether of r-oxypyridine with a boiling point of 240-243 '. His picrate melts at 129-130 '.



  <I> Example 2: </I> The same compound is also obtained if 115 pyridylpyridinium dichloride is heated in 500 cm 2 of amyl alcohol for 24 hours and the reaction mixture is worked up as above.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines 4-Oxy- pyridinderivates, dadurch gekennzeichnet, dass man 4-Pyridyl-pyridiniumdicblorid der Ein wirkung einer Verbindung der Formel C5HisOR, wobei R einen mit Chlor in Reaktion treten den Substituenten bedeutet, unterwirft. Der so erhaltene Amyläther des r-Oxy- pyridins hat den Siedepunkt 240-243 . Sein Pikrat schmilzt bei 129-130<B>0</B> C. UNTERANSPRtiCHE: 1. Claim: Process for the preparation of a 4-oxy-pyridine derivative, characterized in that 4-pyridyl-pyridinium dicloride is subjected to the action of a compound of the formula C5HisOR, where R is a substituent which reacts with chlorine. The amyl ether of r-oxy-pyridine thus obtained has a boiling point of 240-243. Its picrate melts at 129-130 <B> 0 </B> C. SUBClaims: 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man Amylalkohol verwendet. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man eine Metallver bindung des Amylalkohols verwendet. Process according to claim, characterized in that amyl alcohol is used. 2. The method according to claim, characterized in that one uses a Metallver bond of amyl alcohol.
CH160940D 1931-04-25 1931-04-25 Process for the preparation of a 4-oxypyridine derivative. CH160940A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH160940D CH160940A (en) 1931-04-25 1931-04-25 Process for the preparation of a 4-oxypyridine derivative.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH160940D CH160940A (en) 1931-04-25 1931-04-25 Process for the preparation of a 4-oxypyridine derivative.
CH155447T 1931-04-25

Publications (1)

Publication Number Publication Date
CH160940A true CH160940A (en) 1933-03-31

Family

ID=25716575

Family Applications (1)

Application Number Title Priority Date Filing Date
CH160940D CH160940A (en) 1931-04-25 1931-04-25 Process for the preparation of a 4-oxypyridine derivative.

Country Status (1)

Country Link
CH (1) CH160940A (en)

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