CH122294A - Process for preparing a new bile acid compound. - Google Patents

Process for preparing a new bile acid compound.

Info

Publication number
CH122294A
CH122294A CH122294DA CH122294A CH 122294 A CH122294 A CH 122294A CH 122294D A CH122294D A CH 122294DA CH 122294 A CH122294 A CH 122294A
Authority
CH
Switzerland
Prior art keywords
bile acid
acid compound
preparing
new
new bile
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH122294A publication Critical patent/CH122294A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Description

  

  Verfahren zur Darstellung einer neuen     Gallensäureverbindung.       Vorliegende Erfindung     betrifft    ein Ver  fahren zur Darstellung einer neuen Gallen  säureverbindung, welches dadurch gekenn  zeichnet ist, dass man     Monobenzoylpiperazin     auf     Dehydrocholsäure    einwirken lässt.  



  Die neue Verbindung kann zum Beispiel  durch Zusammenschmelzen der beiden Kom  ponenten oder durch Eindampfen oder     Ein-          dunsten    der Lösungen der Komponenten er  halten werden.  



  Das     dehydrocholsaure        Benzoylpiperazin     bildet feine, weisse     Nädelchen,    die bei zirka  165   zu sintern beginnen und bei zirka 188    klar geschmolzen sind. Es ist in Alkohol,  Holzgeist, Aceton ziemlich leicht, in Äther  schwer löslich.  



  Die neue Verbindung soll zu therapeuti  schen Zwecken verwendet werden.    <I>Beispiel</I>  Molekulare Mengen     Dehydrocholsäure    und       Monobenzoylpiperazin    werden in heissem Holz  geist gelöst, worauf die Lösung durch Er  kalten zur Kristallisation gebracht wird.



  Process for the preparation of a new bile acid compound. The present invention relates to a method for preparing a new bile acid compound, which is characterized in that monobenzoylpiperazine is allowed to act on dehydrocholic acid.



  The new compound can be obtained, for example, by melting the two components together or by evaporating or evaporating the solutions of the components.



  The dehydrocholic acid benzoylpiperazine forms fine, white needles that begin to sinter at around 165 and are clearly melted at around 188. It is fairly easily soluble in alcohol, wood spirit, and acetone, and sparingly soluble in ether.



  The new compound is intended to be used for therapeutic purposes. <I> Example </I> Molecular amounts of dehydrocholic acid and monobenzoylpiperazine are dissolved in hot wood, whereupon the solution is crystallized by cooling it.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer neuen Gallensäureverbindung, dadurch gekennzeich net, dass man Monobenzoylpiperazin auf De- hydrocholsäure einwirken lässt. Das dehydrocholsaure Benzoylpiperazin bildet feine, weisse Nädelchen, die bei zirka <B>1650</B> zu sintern beginnen und bei zirka<B>188'</B> klar geschmolzen sind. Es ist in Alkohol, Holzgeist, Aceton ziemlich leicht, in Äther. schwer löslich. Die neue Verbindung soll zu therapeu tischen Zwecken verwendet werden. PATENT CLAIM: Process for the preparation of a new bile acid compound, characterized in that monobenzoylpiperazine is allowed to act on dehydrocholic acid. The dehydrocholic acid benzoylpiperazine forms fine, white needles that begin to sinter at around <B> 1650 </B> and are clearly melted at around <B> 188 '</B>. It is quite light in alcohol, wood spirit, acetone, in ether. poorly soluble. The new compound is intended to be used for therapeutic purposes.
CH122294D 1925-09-02 1925-09-02 Process for preparing a new bile acid compound. CH122294A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH119077T 1925-09-02
CH122294T 1925-09-02

Publications (1)

Publication Number Publication Date
CH122294A true CH122294A (en) 1927-09-01

Family

ID=25709156

Family Applications (1)

Application Number Title Priority Date Filing Date
CH122294D CH122294A (en) 1925-09-02 1925-09-02 Process for preparing a new bile acid compound.

Country Status (1)

Country Link
CH (1) CH122294A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541584A (en) * 1947-06-11 1951-02-13 Nat Aluminate Corp N-acylated piperazines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541584A (en) * 1947-06-11 1951-02-13 Nat Aluminate Corp N-acylated piperazines

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