CH109389A - Process for the preparation of a basic bismuth salt of guaiacol carboxylic acid. - Google Patents

Process for the preparation of a basic bismuth salt of guaiacol carboxylic acid.

Info

Publication number
CH109389A
CH109389A CH109389DA CH109389A CH 109389 A CH109389 A CH 109389A CH 109389D A CH109389D A CH 109389DA CH 109389 A CH109389 A CH 109389A
Authority
CH
Switzerland
Prior art keywords
guaiacol
carboxylic acid
preparation
bismuth salt
basic bismuth
Prior art date
Application number
Other languages
German (de)
Inventor
Farbenfabriken Vorm Friedr Co
Original Assignee
Farbenfab Vorm Bayer F & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farbenfab Vorm Bayer F & Co filed Critical Farbenfab Vorm Bayer F & Co
Publication of CH109389A publication Critical patent/CH109389A/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung eines basischen     Wismutsalzes    der     Guajakolkarbonsäure.       Es wurde gefunden, dass sich das in  Wasser unlösliche basische     Wismutsalz    der       Guaiakol-o-Karbonsäure    der Formel  
EMI0001.0005     
    in öliger oder ähnlicher Suspension hervor  ragend zur Behandlung luetischer Erkran  kungen eignet. Die Eigenschaft der     CTuajakol-          karbonsäure,        anästhesierend    zu wirken, kommt  auch bei der Verwendung dieses Salzes zur  Wirkung und ist geeignet, die bei Ein  spritzungen von     Wismutverbindungen    oft auf  tretende Schmerzempfindung zu verhindern.

    Durch diese Eigenschaft ist die neue Ver  bindung schon bekannten ähnlichen     Prödukten     überlegen. Man kann das Produkt durch Be  handeln der Säure mit     Wismuthydroxyd    dar  stellen. Sein     Wismutgehalt    beträgt 53-54      /o.          Beispiel:     200 Gewichtsteile     (Mol.        Gew.    483,5)     ge-          pulvertes        Wismutnitrat    werden in 150-200  Gewichtsteilen 30      /o    Essigsäure gelöst, fil  triert und mit Natronlauge eben alkalisch  gemacht, darauf wiederholt mit Wasser de  kantiert bis zur Neutralität.

   Mit etwas heissem    Wasser     aufgeschlemmt    wird das     Hydroxyd     unter starkem Rühren zugegeben zu einer  siedenden Lösung von 200 Gewichtsteilen       Guajakolkarbonsäure    in 20,000 Gewichtsteilen  Wasser. Unter starkem Umrühren wird sieben  Stunden am     Rückfiusskühler    gekocht. Dann  wird heiss filtriert, der Niederschlag mit heissem  Wasser bis zur Neutralität gewaschen und  im Trockenschrank getrocknet, pulverisiert  und durch ein Seidensieb getrieben.  



  Aus dem Filtrat kristallisiert die über  schüssige     Guajakolkarbonsäure    aus. Die Mut  terlauge wird eingedampft. Die wiederge  wonnene Säure kann bei einer neuen Partie  wieder verwendet werden.



  Process for the preparation of a basic bismuth salt of guaiacol carboxylic acid. It has been found that the water-insoluble basic bismuth salt of guaiacol-o-carboxylic acid of the formula
EMI0001.0005
    In oily or similar suspension, it is ideally suited for the treatment of syphilitic diseases. The anesthetic effect of CTuajakolcarboxylic acid also comes into play when this salt is used and is suitable for preventing the pain sensation that often occurs when bismuth compounds are injected.

    This property makes the new compound superior to similar products that are already known. The product can be presented by treating the acid with bismuth hydroxide. Its bismuth content is 53-54 / o. Example: 200 parts by weight (mol. Wt. 483.5) of powdered bismuth nitrate are dissolved in 150-200 parts by weight of 30 / o acetic acid, filtered and made alkaline with sodium hydroxide solution, then repeatedly decanted with water until neutral.

   Suspended with a little hot water, the hydroxide is added with vigorous stirring to a boiling solution of 200 parts by weight of guaiacolic acid in 20,000 parts by weight of water. It is boiled on the reflux condenser for seven hours, stirring vigorously. It is then filtered hot, the precipitate is washed with hot water until neutral and dried in a drying cabinet, pulverized and driven through a silk sieve.



  The excess guaiacol carboxylic acid crystallizes out of the filtrate. The mother liquor is evaporated. The recovered acid can be used again in a new batch.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung des basischen Wismutsalzes der Guajakol-o-karbonsäure, da durch gekennzeichnet, dass man die genannte Säure mit Wismuthydroxyd behandelt. Das Salz hat die Eigenschaft, anästhesierend zu wirken und eignet sich zur Behandlung hre- tischer Erkrankungen. PATENT CLAIM: Process for the preparation of the basic bismuth salt of guaiacol-o-carboxylic acid, characterized in that the acid mentioned is treated with bismuth hydroxide. The salt has the property of having an anesthetic effect and is suitable for the treatment of heretical diseases.
CH109389D 1923-10-08 1924-03-19 Process for the preparation of a basic bismuth salt of guaiacol carboxylic acid. CH109389A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE109389X 1923-10-08

Publications (1)

Publication Number Publication Date
CH109389A true CH109389A (en) 1925-03-16

Family

ID=5651707

Family Applications (1)

Application Number Title Priority Date Filing Date
CH109389D CH109389A (en) 1923-10-08 1924-03-19 Process for the preparation of a basic bismuth salt of guaiacol carboxylic acid.

Country Status (2)

Country Link
AT (1) AT101337B (en)
CH (1) CH109389A (en)

Also Published As

Publication number Publication date
AT101337B (en) 1925-10-26

Similar Documents

Publication Publication Date Title
CH109389A (en) Process for the preparation of a basic bismuth salt of guaiacol carboxylic acid.
DE696318C (en) n- (2, 4) -acid-1)
DE506349C (en) Process for the preparation of more than doubly halogen-substituted 2-arylquinoline-4-carboxylic acids
DE546144C (en) Process for the preparation of derivatives of 5, 5'-diamino-6, 6'-dioxy-3, 3'-arsenopyridine which are readily soluble in water
AT69476B (en) Process for the production of therapeutically valuable bactericidal preparations.
AT112135B (en) Process for the preparation of basic oxime ethers and their salts.
DE488891C (en) Process for the preparation of N-substituted arsenobenzimidazolones
AT234700B (en) Process for the preparation of the new 2-methyl-3- (2'-methyl-3'-chlorophenyl) -quinazolons- (4)
AT113002B (en) Process for the preparation of monoboric acid choline.
AT123401B (en) Process for the preparation of 3.3'-dichloro-4.4'-dioxy-5.5'-bisacylaminoarsenobenzenes.
AT228187B (en) Process for the production of metal gluconates
AT111573B (en) Process for the preparation of alkyl and aralkyl derivatives of 1-aryl-3,4-trimethylene-5-pyrazolones.
AT133519B (en) Process for the preparation of glycolylaminobenzenic acids.
DE411051C (en) Process for the preparation of derivatives of 2-phenylquinoline-4-carboxylic acid
AT87644B (en) Process for the preparation of compounds of yohimbine containing arsenic.
AT105354B (en) Process for the preparation of basic calcium hypochlorite compounds.
AT119486B (en) Process for the preparation of N-substituted arsenobenzimidazolones.
AT208000B (en) Process for the production of antibacterially active compounds
DE160348C (en)
DE889301C (en) Process for rendering chlorophenoxyacetic acids and chloromethylphenoxyacetic acids odorless or their salts and esters
DE1620538C (en) Vitamin B deep 1 derivative
CH184300A (en) Process for the preparation of a condensation product from the a-naphthylamide of 2,3-oxynaphthoic acid and formaldehyde.
CH132447A (en) Process for the preparation of Arseno-3,4-benz- (4-N-methyl) -imidazolone.
CH304265A (en) Process for the production of a condensation product.
CH194876A (en) Process for the preparation of 2 (3 ', 5'-Diiodo-2'-B-oxethyl-4'-oxypheny) - 6-iodoquinoline-4-carboxylic acid.