CA988511A - PROCESS FOR THE PREPARATION OF 7-(D-(.alpha.-AMINO-.alpha.-PHENYLACETAMIDO))-3-(S-(5-HYDROXYMETHYL-1,3,4-OXADIAZOL-2-YL)-THIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID - Google Patents

PROCESS FOR THE PREPARATION OF 7-(D-(.alpha.-AMINO-.alpha.-PHENYLACETAMIDO))-3-(S-(5-HYDROXYMETHYL-1,3,4-OXADIAZOL-2-YL)-THIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID

Info

Publication number
CA988511A
CA988511A CA141,387A CA141387A CA988511A CA 988511 A CA988511 A CA 988511A CA 141387 A CA141387 A CA 141387A CA 988511 A CA988511 A CA 988511A
Authority
CA
Canada
Prior art keywords
alpha
phenylacetamido
cephem
thiomethyl
oxadiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA141,387A
Other languages
English (en)
Other versions
CA141387S (en
Inventor
Leonard B. Crast (Jr.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Canada Inc
Original Assignee
Bristol Myers Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Canada Ltd filed Critical Bristol Myers Canada Ltd
Application granted granted Critical
Publication of CA988511A publication Critical patent/CA988511A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA141,387A 1971-05-07 1972-05-05 PROCESS FOR THE PREPARATION OF 7-(D-(.alpha.-AMINO-.alpha.-PHENYLACETAMIDO))-3-(S-(5-HYDROXYMETHYL-1,3,4-OXADIAZOL-2-YL)-THIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID Expired CA988511A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14141771A 1971-05-07 1971-05-07

Publications (1)

Publication Number Publication Date
CA988511A true CA988511A (en) 1976-05-04

Family

ID=22495600

Family Applications (1)

Application Number Title Priority Date Filing Date
CA141,387A Expired CA988511A (en) 1971-05-07 1972-05-05 PROCESS FOR THE PREPARATION OF 7-(D-(.alpha.-AMINO-.alpha.-PHENYLACETAMIDO))-3-(S-(5-HYDROXYMETHYL-1,3,4-OXADIAZOL-2-YL)-THIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID

Country Status (10)

Country Link
US (1) US3757014A (ja)
JP (1) JPS5114489B1 (ja)
CA (1) CA988511A (ja)
DE (1) DE2222434C2 (ja)
DK (1) DK138458B (ja)
FR (1) FR2137586B1 (ja)
GB (1) GB1392536A (ja)
HU (1) HU163486B (ja)
NL (1) NL7205644A (ja)
SE (1) SE390171B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987041A (en) * 1970-12-17 1976-10-19 Smithkline Corporation P-hydroxymethylphenylacetamidocephalosporins
US3891634A (en) * 1970-12-17 1975-06-24 Smithkline Corp P-Hydroxymethylphenylacetamidocephalosporins
PH16419A (en) * 1973-01-31 1983-09-29 Bristol Myers Co 7-(d-alpha-amino-alpha-(3'-methyl-4'-hydroxyphenyl)-acetamido)-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid,pharmaceutically acceptable esters and salts thereof
AR207752A1 (es) * 1973-03-30 1976-10-29 Fujisawa Pharmaceutical Co Procedimiento para obtener acidos 7-amino-sustituido-3-tiometilsustituido-3-cefem-4-carboxilicos
US4205166A (en) * 1974-02-20 1980-05-27 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
US4033956A (en) * 1975-07-22 1977-07-05 Richardson-Merrell Inc. 7[α-Amino-ω-(2,3-methylenedioxy-phenyl)acylamido]cephalosporanic acid derivatives
US4020060A (en) * 1975-07-22 1977-04-26 Richardson-Merrell Inc. 7-[α-Amino-ω-(3,4-methylenedioxyphenyl)acylamido]cephalosporanic acid derivatives
US6728315B2 (en) * 2002-07-24 2004-04-27 Apple Computer, Inc. Method and apparatus for variable accuracy inter-picture timing specification for digital video encoding with reduced requirements for division operations
ITMI20022724A1 (it) * 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
CN109535144A (zh) * 2019-01-08 2019-03-29 贵州大学 一类1,3,4-噁二唑硫醚类化合物及其制备方法和应用
CN110590878B (zh) * 2019-09-26 2023-03-31 中国科学院海洋研究所 6-噁/噻二唑壳寡糖衍生物及其制备和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH527215A (de) * 1967-04-15 1972-08-31 Fujisawa Pharmaceutical Co Verfahren zur Herstellung von 3,7-disubstituierten Cephalosporinderivaten
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
HU163486B (ja) 1973-09-27
DK138458C (ja) 1979-02-12
FR2137586B1 (ja) 1976-04-16
GB1392536A (en) 1975-04-30
FR2137586A1 (ja) 1972-12-29
DE2222434C2 (de) 1982-11-04
SE390171B (sv) 1976-12-06
DK138458B (da) 1978-09-11
DE2222434A1 (de) 1972-11-23
JPS5114489B1 (ja) 1976-05-10
NL7205644A (ja) 1972-11-09
US3757014A (en) 1973-09-04

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