CA966123A - Process for the production of triazolobenzodiazepines and intermediates - Google Patents

Process for the production of triazolobenzodiazepines and intermediates

Info

Publication number
CA966123A
CA966123A CA131,732A CA131732A CA966123A CA 966123 A CA966123 A CA 966123A CA 131732 A CA131732 A CA 131732A CA 966123 A CA966123 A CA 966123A
Authority
CA
Canada
Prior art keywords
triazolobenzodiazepines
intermediates
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA131,732A
Other languages
English (en)
Other versions
CA131732S (en
Inventor
Jackson B. Hester (Jr.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to CA167,614A priority Critical patent/CA963467A/en
Priority claimed from US00372313A external-priority patent/US3856792A/en
Priority to CA211,538A priority patent/CA995223A/en
Priority to CA211,539A priority patent/CA995224A/en
Application granted granted Critical
Publication of CA966123A publication Critical patent/CA966123A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
CA131,732A 1971-02-09 1972-01-05 Process for the production of triazolobenzodiazepines and intermediates Expired CA966123A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA167,614A CA963467A (en) 1971-02-09 1973-03-30 Process for the production of triazolobenzodiazepine intermediates
CA211,538A CA995223A (en) 1971-02-09 1974-10-16 Triazolobenzodiazepine intermediates
CA211,539A CA995224A (en) 1971-02-09 1974-10-16 Triazolobenzodiazepine intermediates

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11404971A 1971-02-09 1971-02-09
US24075672A 1972-04-03 1972-04-03
US00372313A US3856792A (en) 1971-02-09 1973-06-21 2-{8 2-(substituted aminomethyl)-4h-1,2,4-triazol-4-yl{9 benzophenones

Publications (1)

Publication Number Publication Date
CA966123A true CA966123A (en) 1975-04-15

Family

ID=27381433

Family Applications (1)

Application Number Title Priority Date Filing Date
CA131,732A Expired CA966123A (en) 1971-02-09 1972-01-05 Process for the production of triazolobenzodiazepines and intermediates

Country Status (14)

Country Link
US (1) US3709898A (de)
JP (1) JPS4966679A (de)
BE (1) BE779144A (de)
BR (1) BR7200590D0 (de)
CA (1) CA966123A (de)
CH (2) CH570404A5 (de)
DE (2) DE2265617C3 (de)
DK (1) DK513578A (de)
FR (1) FR2124559B1 (de)
GB (4) GB1374823A (de)
HK (1) HK2580A (de)
NL (1) NL151709B (de)
SE (1) SE414928B (de)
ZA (1) ZA7251B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE397831B (sv) * 1971-06-05 1977-11-21 Takeda Chemical Industries Ltd Sett att framstella s-triazolo-(4,3-a)(1,4)bensodiazepinderivat
US3904641A (en) * 1971-06-18 1975-09-09 Yoshitomi Pharmaceutical Triazolothienodiazepine compounds
BE790838A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles 1-aminophenyl-6-phenyl-s-triazolo (4,3-a) (1,4)- benzodiazepines, leur procede de preparation et medicament les contenant
US3842090A (en) * 1973-02-14 1974-10-15 Upjohn Co Certain 1-aminomethyl-6-phenyl 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
CA999000A (en) * 1973-02-14 1976-10-26 Jackson B. Hester (Jr.) Process for new benzodiazepines and intermediates
US3879413A (en) * 1973-02-14 1975-04-22 Upjohn Co Process for the production of 6-phenyl-4-H-s-triazolo {8 4,3-a{9 {8 1,4{9 benzodiazepines
US4263310A (en) * 1974-03-02 1981-04-21 Boehringer Ingelheim Gmbh 8-Bromo-6-(o-chloro-phenyl)-4H-S-triazolo-[3,4,-c]-thieno-[2,3-e]-1,4-diazepines and salts thereof
GB1517164A (en) * 1974-08-20 1978-07-12 Roche Products Ltd Substituted-phenyl ketones and a process for the manufacture thereof
US4000151A (en) * 1974-09-11 1976-12-28 The Upjohn Company Triazolyl benzophenone compounds
US4000153A (en) * 1974-09-26 1976-12-28 The Upjohn Company Triazolobenzodiazepine intermediates
NL7512983A (nl) * 1974-11-06 1976-05-10 Parke Davis & Co Werkwijze voor het bereiden van diazepineverbin- dingen, werkwijze voor het bereiden van een far- maceutisch preparaat met toepassing daarvan als- mede een zo gevormd preparaat.
CH601267A5 (de) * 1975-12-12 1978-06-30 Ciba Geigy Ag
US4105851A (en) * 1975-09-08 1978-08-08 Parke, Davis & Company 1,3,8-Trimethylimidazopyrazolodiazepine compounds
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
US4405518A (en) * 1981-07-23 1983-09-20 Hoffmann-La Roche Inc. Pyrrolo[3,4-d] [2] benzazepines
US4409390A (en) * 1981-07-23 1983-10-11 Hoffmann-La Roche Inc. Pyrrolo[3,4-D][2]Benzazepines
US4375473A (en) * 1982-01-04 1983-03-01 The Upjohn Company Method
US4501698A (en) * 1983-03-31 1985-02-26 The Upjohn Company Preparing 1-(hydroxymethyl)-triazolobenzodiazepines and 1-(aminomethyl)-triazolobenzodiazepines
MX354217B (es) 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
CN103180318B (zh) 2010-05-14 2017-05-10 达那-法伯癌症研究所 雄性避孕组合物以及使用方法
BR122014024883A2 (pt) * 2010-05-14 2019-08-20 Dana-Farber Cancer Institute, Inc. Compostos no tratamento de neoplasia
AU2015201727B2 (en) * 2010-05-14 2018-03-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
WO2012151512A2 (en) 2011-05-04 2012-11-08 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (de) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendungen
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
WO2015013635A2 (en) 2013-07-25 2015-01-29 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
RU2016122654A (ru) 2013-11-08 2017-12-14 Дана-Фарбер Кэнсер Инститьют, Инк. Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка
EP3099677A4 (de) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidinbenzolsulfonderivate und verwendungen davon
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
CN106456653A (zh) 2014-02-28 2017-02-22 腾沙治疗公司 高胰岛素血症相关病症的治疗
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide
CA2955077A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
BR112017002369A2 (pt) 2014-08-08 2017-12-05 Dana Farber Cancer Inst Inc derivados de diazepana e usos dos mesmos
EA033325B1 (ru) 2014-10-27 2019-09-30 Тэнша Терапеутикс, Инк. Ингибиторы бромодомена
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
WO2017044792A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazoldiazepines and uses thereof
BR112018004618A2 (pt) 2015-09-11 2018-09-25 Dana-Farber Cancer Institute, Inc. ciano tienotriazoldiazepinas e usos das mesmas
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3413346A (en) * 1966-01-19 1968-11-26 Hoffmann La Roche 2-(2-haloethylamino)-5-halo-benzophenones
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
DE1955349C2 (de) * 1969-11-04 1982-01-28 Takeda Chemical Industries, Ltd., Osaka s-Triazolo [4,3-a] [1,4] benzodiazepine
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives

Also Published As

Publication number Publication date
BR7200590D0 (pt) 1973-07-17
DE2203782A1 (de) 1972-08-24
GB1374822A (en) 1974-11-20
GB1374823A (en) 1974-11-20
NL7201692A (de) 1972-08-11
SE414928B (sv) 1980-08-25
GB1374825A (en) 1974-11-20
NL151709B (nl) 1976-12-15
JPS4966679A (de) 1974-06-27
FR2124559B1 (de) 1975-08-01
BE779144A (fr) 1972-08-09
DE2265617C3 (de) 1982-05-06
DE2265617B2 (de) 1981-07-16
ZA7251B (en) 1972-09-27
CH569736A5 (de) 1975-11-28
DK513578A (da) 1978-11-17
US3709898A (en) 1973-01-09
HK2580A (en) 1980-01-25
FR2124559A1 (de) 1972-09-22
AU3772572A (en) 1973-07-12
GB1374824A (en) 1974-11-20
DE2203782C2 (de) 1982-05-13
CH570404A5 (de) 1975-12-15

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