CA3253017A1 - MODIFIED NUCLEASE, COMPOSITIONS AND THEIR METHODS OF USE - Google Patents
MODIFIED NUCLEASE, COMPOSITIONS AND THEIR METHODS OF USEInfo
- Publication number
- CA3253017A1 CA3253017A1 CA3253017A CA3253017A CA3253017A1 CA 3253017 A1 CA3253017 A1 CA 3253017A1 CA 3253017 A CA3253017 A CA 3253017A CA 3253017 A CA3253017 A CA 3253017A CA 3253017 A1 CA3253017 A1 CA 3253017A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- acid residues
- sequence
- seq
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
- C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
- C12N9/226—Class 2 CAS enzyme complex, e.g. single CAS protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263315159P | 2022-03-01 | 2022-03-01 | |
| US63/315,159 | 2022-03-01 | ||
| US202263380178P | 2022-10-19 | 2022-10-19 | |
| US63/380,178 | 2022-10-19 | ||
| US202263385171P | 2022-11-28 | 2022-11-28 | |
| US63/385,171 | 2022-11-28 | ||
| PCT/US2023/063446 WO2023168242A1 (en) | 2022-03-01 | 2023-03-01 | Engineered nucleases, compositions, and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3253017A1 true CA3253017A1 (en) | 2023-09-07 |
Family
ID=87884328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3253017A Pending CA3253017A1 (en) | 2022-03-01 | 2023-03-01 | MODIFIED NUCLEASE, COMPOSITIONS AND THEIR METHODS OF USE |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12054756B2 (https=) |
| EP (1) | EP4486882A4 (https=) |
| JP (1) | JP2025507822A (https=) |
| KR (1) | KR20240152394A (https=) |
| CN (1) | CN119137268A (https=) |
| AU (1) | AU2023229364A1 (https=) |
| CA (1) | CA3253017A1 (https=) |
| WO (1) | WO2023168242A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3192654A1 (en) | 2020-09-01 | 2022-03-10 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Synthetic miniature crispr-cas (casmini) system for eukaryotic genome engineering |
| CN119137268A (zh) | 2022-03-01 | 2024-12-13 | 埃皮克里斯皮尔生物技术公司 | 工程化核酸酶、组合物及其使用方法 |
| WO2025231397A1 (en) * | 2024-05-03 | 2025-11-06 | Tenaya Therapeutics, Inc. | Modified hek cell lines for improved aav production |
| CN118315068B (zh) * | 2024-05-15 | 2025-08-08 | 西湖实验室(生命科学和生物医学浙江省实验室) | 基于蛋白标志物预测卵巢癌患者化疗敏感性的装置、蛋白标志物分类器的构建方法和应用 |
| WO2025264819A1 (en) * | 2024-06-18 | 2025-12-26 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of znf410 expression |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| EP3080259B1 (en) | 2013-12-12 | 2023-02-01 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| US10648020B2 (en) | 2015-06-18 | 2020-05-12 | The Broad Institute, Inc. | CRISPR enzymes and systems |
| WO2016205749A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| EP4485466A3 (en) | 2016-08-17 | 2025-04-02 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US11970719B2 (en) * | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| AU2018370588B2 (en) | 2017-11-21 | 2022-09-08 | Genkore Co. Ltd. | Composition for Genome Editing Using Crispr/CPF1 System and Use Thereof |
| KR102929494B1 (ko) | 2018-10-29 | 2026-02-20 | 차이나 어그리컬처럴 유니버시티 | 신규 CRISPR/Cas12f 효소 및 시스템 |
| US12258594B2 (en) | 2018-12-05 | 2025-03-25 | The Broad Institute, Inc. | Cas proteins with reduced immunogenicity and methods of screening thereof |
| WO2020123887A2 (en) * | 2018-12-14 | 2020-06-18 | Pioneer Hi-Bred International, Inc. | Novel crispr-cas systems for genome editing |
| MX2021010559A (es) * | 2019-03-07 | 2021-12-15 | Univ California | Polipéptidos efectores de crispr-cas y métodos de uso de estos. |
| WO2020223634A1 (en) | 2019-05-01 | 2020-11-05 | Mammoth Biosciences, Inc. | Programmable nucleases and methods of use |
| EP3772329A1 (fr) * | 2019-08-08 | 2021-02-10 | PKvitality | Systeme de surveillance corporelle comprenant une microaiguille |
| WO2021084533A1 (en) * | 2019-10-28 | 2021-05-06 | Targetgene Biotechnologies Ltd | Pam-reduced and pam-abolished cas derivatives compositions and uses thereof in genetic modulation |
| CN114846146B (zh) | 2019-10-29 | 2024-04-12 | 基恩科雷有限责任公司 | 用于增加CRISPR/Cas12f1系统的效率的工程化引导RNA及其用途 |
| CA3192654A1 (en) * | 2020-09-01 | 2022-03-10 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Synthetic miniature crispr-cas (casmini) system for eukaryotic genome engineering |
| CN116568803A (zh) | 2020-10-08 | 2023-08-08 | 基恩科雷有限责任公司 | 用于增加CRISPR/Cas12f1系统的效率的包含富含U的尾部的经工程化的引导RNA及其用途 |
| CA3198435A1 (en) | 2020-10-08 | 2022-04-14 | Genkore Inc. | Engineered guide rna for optimized crispr/cas12f1 (cas14a1) system and use thereof |
| EP4227411A4 (en) | 2020-10-08 | 2025-07-09 | Genkore Inc | MODIFIED GUIDE RNA TO INCREASE THE EFFICIENCY OF THE CRISPR/CAS12F1 SYSTEM, AND ITS USE |
| EP4267252A4 (en) | 2020-12-23 | 2025-07-23 | Mammoth Biosciences Inc | COMPOSITIONS AND METHODS OF USING PROGRAMMABLE NUCLEASES TO INDUCE CELL DEATH |
| WO2022150372A1 (en) | 2021-01-05 | 2022-07-14 | Horizon Discovery Ltd. | Guide rna designs and complexes for type v cas systems |
| WO2022266324A1 (en) | 2021-06-17 | 2022-12-22 | Epicrispr Biotechnologies, Inc. | Systems and methods for regulating aberrant gene expressions |
| KR20230007218A (ko) * | 2021-07-05 | 2023-01-12 | 주식회사 진코어 | 초소형 염기교정 시스템 및 이의 용도 |
| IL310116A (en) | 2021-07-20 | 2024-03-01 | Epicrispr Biotechnologies Inc | Systems and methods for regulating target genes |
| US20240252684A1 (en) | 2021-07-30 | 2024-08-01 | Tune Therapeutics, Inc. | Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) |
| CN119137268A (zh) | 2022-03-01 | 2024-12-13 | 埃皮克里斯皮尔生物技术公司 | 工程化核酸酶、组合物及其使用方法 |
| WO2023172995A1 (en) | 2022-03-11 | 2023-09-14 | Epicrispr Biotechnologies, Inc. | Systems and methods for genetic modulation to treat ocular diseases |
| WO2023173072A1 (en) | 2022-03-11 | 2023-09-14 | Epicrispr Biotechnologies, Inc. | Systems and methods for genetic modulation to treat liver disease |
| EP4490295A4 (en) | 2022-03-11 | 2026-03-18 | Epicrispr Biotechnologies Inc | GENETIC MODULATION SYSTEMS AND METHODS FOR TREATING EYE DISEASES |
| WO2023173110A1 (en) | 2022-03-11 | 2023-09-14 | Epicrispr Biotechnologies, Inc. | Compositions, systems, and methods for treating familial hypercholesterolemia by targeting pcsk9 |
| CA3253453A1 (en) | 2022-03-24 | 2023-09-28 | Epicrispr Biotechnologies, Inc. | MODIFIED GENE EFFECTORS, COMPOSITIONS AND THEIR METHODS OF USE |
-
2023
- 2023-03-01 CN CN202380038039.XA patent/CN119137268A/zh active Pending
- 2023-03-01 JP JP2024551902A patent/JP2025507822A/ja active Pending
- 2023-03-01 AU AU2023229364A patent/AU2023229364A1/en active Pending
- 2023-03-01 CA CA3253017A patent/CA3253017A1/en active Pending
- 2023-03-01 KR KR1020247032210A patent/KR20240152394A/ko active Pending
- 2023-03-01 EP EP23764064.4A patent/EP4486882A4/en active Pending
- 2023-03-01 WO PCT/US2023/063446 patent/WO2023168242A1/en not_active Ceased
- 2023-07-07 US US18/348,948 patent/US12054756B2/en active Active
-
2024
- 2024-06-26 US US18/755,466 patent/US20250011742A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025507822A (ja) | 2025-03-21 |
| WO2023168242A1 (en) | 2023-09-07 |
| EP4486882A4 (en) | 2025-09-17 |
| US20250011742A1 (en) | 2025-01-09 |
| AU2023229364A1 (en) | 2024-09-19 |
| US12054756B2 (en) | 2024-08-06 |
| EP4486882A1 (en) | 2025-01-08 |
| CN119137268A (zh) | 2024-12-13 |
| US20240035009A1 (en) | 2024-02-01 |
| KR20240152394A (ko) | 2024-10-21 |
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