CA3244866A1 - DI-CYCLOPROPYL-BASED IL-17A MODULATORS AND THEIR USES - Google Patents
DI-CYCLOPROPYL-BASED IL-17A MODULATORS AND THEIR USESInfo
- Publication number
- CA3244866A1 CA3244866A1 CA3244866A CA3244866A CA3244866A1 CA 3244866 A1 CA3244866 A1 CA 3244866A1 CA 3244866 A CA3244866 A CA 3244866A CA 3244866 A CA3244866 A CA 3244866A CA 3244866 A1 CA3244866 A1 CA 3244866A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- compound
- halogen
- substituents independently
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263314257P | 2022-02-25 | 2022-02-25 | |
| US63/314,257 | 2022-02-25 | ||
| PCT/US2023/013710 WO2023164057A1 (en) | 2022-02-25 | 2023-02-23 | Di-cyclopropyl based il-17a modulators and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3244866A1 true CA3244866A1 (en) | 2023-08-31 |
Family
ID=85776163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3244866A Pending CA3244866A1 (en) | 2022-02-25 | 2023-02-23 | DI-CYCLOPROPYL-BASED IL-17A MODULATORS AND THEIR USES |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20250177383A1 (https=) |
| EP (1) | EP4482823A1 (https=) |
| JP (2) | JP7642932B1 (https=) |
| KR (1) | KR20240157703A (https=) |
| CN (1) | CN119072465A (https=) |
| AR (1) | AR128586A1 (https=) |
| AU (1) | AU2023223283A1 (https=) |
| CA (1) | CA3244866A1 (https=) |
| CL (1) | CL2024002479A1 (https=) |
| CO (1) | CO2024011455A2 (https=) |
| DO (1) | DOP2024000163A (https=) |
| IL (1) | IL314827A (https=) |
| JO (1) | JOP20240187A1 (https=) |
| MX (1) | MX2024010218A (https=) |
| PE (1) | PE20251689A1 (https=) |
| TW (1) | TW202345807A (https=) |
| WO (1) | WO2023164057A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024208228A1 (en) * | 2023-04-03 | 2024-10-10 | Nuphase Therapeutics (Hangzhou) Limited., Co. | Novel compounds, compositions comprising the same and uses thereof |
| WO2025201533A1 (en) * | 2024-03-28 | 2025-10-02 | Nuphase Therapeutics (Shanghai) Limited., Co. | Novel acidic compounds, compositions comprising the same and uses thereof |
| WO2025201532A1 (en) * | 2024-03-28 | 2025-10-02 | Nuphase Therapeutics (Shanghai) Limited., Co. | Novel pegylation compounds, compositions comprising the same and uses thereof |
| WO2025209395A1 (en) * | 2024-04-03 | 2025-10-09 | Innocare Pharma Inc. | Il-17 modulators and used thereof |
| WO2026021539A1 (zh) * | 2024-07-24 | 2026-01-29 | 深圳信立泰药业股份有限公司 | 双环il-17a/f抑制剂及其制备方法与应用 |
| WO2026020343A1 (zh) * | 2024-07-24 | 2026-01-29 | 祐森健恒生物医药科技（中山）有限公司 | Il-17a调节剂化合物及其用途 |
| WO2026040422A1 (en) * | 2024-08-19 | 2026-02-26 | Shenzhen Ionova Life Science Co., Ltd. | Novel interleukin-17 inhibtors |
| CN119192167B (zh) * | 2024-11-28 | 2025-03-21 | 英矽智能科技(上海)有限公司 | 一类抑制il-17的化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| BR112021010453A2 (pt) * | 2018-12-19 | 2021-08-24 | Leo Pharma A/S | Composto, e, composição farmacêutica |
| TWI839461B (zh) * | 2019-02-06 | 2024-04-21 | 美商戴斯阿爾法股份有限公司 | Il-17a調節物及其用途 |
| IL291345B2 (en) * | 2019-09-16 | 2024-04-01 | Dice Alpha Inc | Il-17a modulators and uses thereof |
| MX2022015554A (es) * | 2020-06-12 | 2023-01-30 | Leo Pharma As | Moduladores de molecula peque?a de interleucina 17 (il-17). |
| MX2024000504A (es) * | 2021-07-09 | 2024-04-05 | Dice Alpha Inc | Moduladores de il-17a basados en fenilacetamida y usos de los mismos. |
-
2023
- 2023-02-23 US US18/841,320 patent/US20250177383A1/en active Pending
- 2023-02-23 WO PCT/US2023/013710 patent/WO2023164057A1/en not_active Ceased
- 2023-02-23 CA CA3244866A patent/CA3244866A1/en active Pending
- 2023-02-23 AR ARP230100420A patent/AR128586A1/es unknown
- 2023-02-23 MX MX2024010218A patent/MX2024010218A/es unknown
- 2023-02-23 CN CN202380035861.0A patent/CN119072465A/zh active Pending
- 2023-02-23 AU AU2023223283A patent/AU2023223283A1/en active Pending
- 2023-02-23 EP EP23713773.2A patent/EP4482823A1/en active Pending
- 2023-02-23 TW TW112106593A patent/TW202345807A/zh unknown
- 2023-02-23 KR KR1020247031990A patent/KR20240157703A/ko active Pending
- 2023-02-23 JP JP2024550207A patent/JP7642932B1/ja active Active
- 2023-02-23 PE PE2024001841A patent/PE20251689A1/es unknown
- 2023-02-23 IL IL314827A patent/IL314827A/en unknown
-
2024
- 2024-08-19 JO JOJO/P/2024/0187A patent/JOP20240187A1/ar unknown
- 2024-08-19 CL CL2024002479A patent/CL2024002479A1/es unknown
- 2024-08-21 DO DO2024000163A patent/DOP2024000163A/es unknown
- 2024-08-23 CO CONC2024/0011455A patent/CO2024011455A2/es unknown
-
2025
- 2025-02-26 JP JP2025028722A patent/JP2025084837A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025084837A (ja) | 2025-06-03 |
| US20250177383A1 (en) | 2025-06-05 |
| CO2024011455A2 (es) | 2024-11-18 |
| JP7642932B1 (ja) | 2025-03-10 |
| WO2023164057A1 (en) | 2023-08-31 |
| JP2025509111A (ja) | 2025-04-11 |
| DOP2024000163A (es) | 2025-01-31 |
| IL314827A (en) | 2024-10-01 |
| PE20251689A1 (es) | 2025-07-02 |
| CL2024002479A1 (es) | 2025-05-09 |
| CN119072465A (zh) | 2024-12-03 |
| AR128586A1 (es) | 2024-05-22 |
| TW202345807A (zh) | 2023-12-01 |
| AU2023223283A1 (en) | 2024-08-29 |
| EP4482823A1 (en) | 2025-01-01 |
| KR20240157703A (ko) | 2024-11-01 |
| MX2024010218A (es) | 2024-09-02 |
| JOP20240187A1 (ar) | 2024-08-19 |
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