CA3241897A1 - Crosslinking antibodies - Google Patents

Crosslinking antibodies

Info

Publication number
CA3241897A1
CA3241897A1 CA3241897A CA3241897A CA3241897A1 CA 3241897 A1 CA3241897 A1 CA 3241897A1 CA 3241897 A CA3241897 A CA 3241897A CA 3241897 A CA3241897 A CA 3241897A CA 3241897 A1 CA3241897 A1 CA 3241897A1
Authority
CA
Canada
Prior art keywords
antibodies
conjugates
methods
cross
further provided
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3241897A
Other languages
English (en)
French (fr)
Inventor
Sergio Duron
Jason ROLAND
Jerod PTACIN
Analeah HEIDT
Jun Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enlaza Therapeutics Inc
Original Assignee
Enlaza Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enlaza Therapeutics Inc filed Critical Enlaza Therapeutics Inc
Publication of CA3241897A1 publication Critical patent/CA3241897A1/en
Pending legal-status Critical Current

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Classifications

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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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