AU2022419596A1 - Crosslinking antibodies - Google Patents

Crosslinking antibodies Download PDF

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Publication number
AU2022419596A1
AU2022419596A1 AU2022419596A AU2022419596A AU2022419596A1 AU 2022419596 A1 AU2022419596 A1 AU 2022419596A1 AU 2022419596 A AU2022419596 A AU 2022419596A AU 2022419596 A AU2022419596 A AU 2022419596A AU 2022419596 A1 AU2022419596 A1 AU 2022419596A1
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AU
Australia
Prior art keywords
conjugate
uaa
substituted
targeting domain
formula
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Pending
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AU2022419596A
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English (en)
Inventor
Sergio Duron
Analeah HEIDT
Jun Liu
Jerod PTACIN
Jason ROLAND
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Enlaza Therapeutics Inc
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Enlaza Therapeutics Inc
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Publication date
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Publication of AU2022419596A1 publication Critical patent/AU2022419596A1/en
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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