CA3239460A1 - Method of generating functional islets from pluripotent stem cells - Google Patents

Method of generating functional islets from pluripotent stem cells Download PDF

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Publication number
CA3239460A1
CA3239460A1 CA3239460A CA3239460A CA3239460A1 CA 3239460 A1 CA3239460 A1 CA 3239460A1 CA 3239460 A CA3239460 A CA 3239460A CA 3239460 A CA3239460 A CA 3239460A CA 3239460 A1 CA3239460 A1 CA 3239460A1
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Prior art keywords
cells
culture medium
inhibitor
hpsc
islets
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CA3239460A
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English (en)
French (fr)
Inventor
Hongkui Deng
Yuanyuan DU
Zhen Liang
Xiaofeng Wang
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Hangzhou Reprogenix Bioscience Inc
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Individual
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
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    • C12N5/0602—Vertebrate cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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CA3239460A 2021-11-30 2021-11-30 Method of generating functional islets from pluripotent stem cells Pending CA3239460A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2021/134632 WO2023097513A1 (en) 2021-11-30 2021-11-30 Method of generating functional islets from pluripotent stem cells

Publications (1)

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CA3239460A1 true CA3239460A1 (en) 2023-06-08

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CA3239460A Pending CA3239460A1 (en) 2021-11-30 2021-11-30 Method of generating functional islets from pluripotent stem cells

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US (1) US20250002863A1 (https=)
EP (1) EP4440585A4 (https=)
JP (1) JP2024543217A (https=)
KR (1) KR20240146656A (https=)
CN (1) CN118355109A (https=)
AU (1) AU2021476471A1 (https=)
CA (1) CA3239460A1 (https=)
IL (1) IL313150A (https=)
WO (1) WO2023097513A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117511847A (zh) * 2023-11-06 2024-02-06 西安添易秦悦生物科技有限公司 一种自体诱导多能干细胞体外制备胰岛细胞团的方法
CN120158422B (zh) * 2025-05-20 2025-08-19 四川大学华西医院 一种共分化的血管化胰岛类器官及其构建方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201216796D0 (en) * 2012-09-20 2012-11-07 Cambridge Entpr Ltd In vitro pancreatic differentiation
CN120796168A (zh) * 2013-06-11 2025-10-17 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
US11021687B2 (en) * 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
EP3411471B1 (en) * 2016-02-04 2021-01-06 Société des Produits Nestlé S.A. In vitro production of pancreatic beta cells
CN111246864A (zh) * 2017-07-21 2020-06-05 森玛治疗公司 干细胞衍生的胰腺β细胞的重聚
JP7646182B2 (ja) * 2018-05-16 2025-03-17 ワシントン・ユニバーシティ 内胚葉系統の細胞およびベータ細胞を生成するための方法および組成物、ならびにそれらの使用
WO2020033879A1 (en) * 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation

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Publication number Publication date
CN118355109A (zh) 2024-07-16
WO2023097513A1 (en) 2023-06-08
KR20240146656A (ko) 2024-10-08
EP4440585A4 (en) 2025-10-08
EP4440585A1 (en) 2024-10-09
IL313150A (en) 2024-07-01
AU2021476471A1 (en) 2024-06-20
JP2024543217A (ja) 2024-11-19
US20250002863A1 (en) 2025-01-02

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