CA3236433A1 - Tricyclic heterocycles - Google Patents

Tricyclic heterocycles Download PDF

Info

Publication number
CA3236433A1
CA3236433A1 CA3236433A CA3236433A CA3236433A1 CA 3236433 A1 CA3236433 A1 CA 3236433A1 CA 3236433 A CA3236433 A CA 3236433A CA 3236433 A CA3236433 A CA 3236433A CA 3236433 A1 CA3236433 A1 CA 3236433A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
unsubstituted
ring
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3236433A
Other languages
English (en)
French (fr)
Inventor
Timo Heinrich
Sarah SCHLESIGER
Jakub GUNERA
Carl Petersson
Lisa KOETZNER
Emma Carswell
Andrea Unzue Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Cancer Research Technology Ltd
Original Assignee
Merck Patent GmbH
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH, Cancer Research Technology Ltd filed Critical Merck Patent GmbH
Publication of CA3236433A1 publication Critical patent/CA3236433A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3236433A 2021-10-29 2022-10-26 Tricyclic heterocycles Pending CA3236433A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21205456 2021-10-29
EP21205456.3 2021-10-29
PCT/EP2022/079848 WO2023072974A1 (en) 2021-10-29 2022-10-26 Tricyclic heterocycles

Publications (1)

Publication Number Publication Date
CA3236433A1 true CA3236433A1 (en) 2023-05-04

Family

ID=78414452

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3236433A Pending CA3236433A1 (en) 2021-10-29 2022-10-26 Tricyclic heterocycles

Country Status (7)

Country Link
EP (1) EP4423091A1 (https=)
JP (1) JP2024540187A (https=)
CN (1) CN118434743A (https=)
AU (1) AU2022378910A1 (https=)
CA (1) CA3236433A1 (https=)
IL (1) IL312303A (https=)
WO (1) WO2023072974A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119968359A (zh) 2022-09-29 2025-05-09 英矽智能科技知识产权有限公司 Tead抑制剂及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102079255B1 (ko) * 2013-06-18 2020-02-20 삼성디스플레이 주식회사 헤테로고리 화합물 및 이를 포함한 유기 발광 소자
WO2020096416A1 (ko) * 2018-11-09 2020-05-14 한국화학연구원 Yap-tead 결합을 저해하는 화합물 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약제학적 조성물
JP2023524863A (ja) * 2020-05-08 2023-06-13 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式のヘテロ環

Also Published As

Publication number Publication date
AU2022378910A1 (en) 2024-06-13
CN118434743A (zh) 2024-08-02
EP4423091A1 (en) 2024-09-04
JP2024540187A (ja) 2024-10-31
IL312303A (en) 2024-06-01
WO2023072974A1 (en) 2023-05-04

Similar Documents

Publication Publication Date Title
CN102448958B (zh) 嘧啶基和1,3,5-三嗪基苯并咪唑磺酰胺和其在癌症治疗中的用途
AU2019313441B2 (en) TLR7/8 antagonists and uses thereof
CA2979302A1 (en) Substituted quinoxaline derivatives
AU2018312836B2 (en) Novel heterocyclic compounds as CDK8/19 inhibitors
AU2016287335A1 (en) TBK/IKKepsilon inhibitor compounds and uses thereof
CA3185634A1 (en) Tricyclic heterocycles
CA3025220A1 (en) Tricyclic heterocylic derivatives
CA3225045A1 (en) Her2 mutation inhibitors
WO2021224291A1 (en) Tricyclic heterocycles useful as tead binders
ES3053012T3 (en) Condensed pyridine derivatives substitued by amide functions as acss2 inhibitors
CA3236433A1 (en) Tricyclic heterocycles
CA3180798A1 (en) Tricyclic heterocycles useful as tead binders
AU2024317622A1 (en) Substitued bicyclic heterocyclic yap-tead and/or taz-tead inhibitors
CA3237030A1 (en) Heterobifunctional molecules as tead inhibitors
WO2022233442A1 (en) 2,8-dihydropyrazolo[3,4-b]indole derivatives for use in the treatment of cancer
CA3175738A1 (en) Tetrazole derivatives
CA3042988A1 (en) Substituted quinoxaline derivatives as inhibitors of pfkfb
CA3218932A1 (en) 2,8-dihydropyrazolo[3,4-b]indole derivatives for use in the treatment of cancer

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 2ND ANNIV.) - STANDARD

Year of fee payment: 2

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240904

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240904

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240904

P22 Classification modified

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P22-P110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CLASSIFICATION MODIFIED

Effective date: 20240918

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD

Year of fee payment: 3

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250925

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250925