CA3236019A1 - Proteines comprenant le domaine extracellulaire de p75ntr - Google Patents
Proteines comprenant le domaine extracellulaire de p75ntr Download PDFInfo
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- CA3236019A1 CA3236019A1 CA3236019A CA3236019A CA3236019A1 CA 3236019 A1 CA3236019 A1 CA 3236019A1 CA 3236019 A CA3236019 A CA 3236019A CA 3236019 A CA3236019 A CA 3236019A CA 3236019 A1 CA3236019 A1 CA 3236019A1
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- p75ntr
- companion animal
- protein
- pain
- fusion protein
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- 230000008313 sensitization Effects 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 239000004017 serum-free culture medium Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000010473 stable expression Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 101150025395 trkA gene Proteins 0.000 description 1
- 101150113435 trkA1 gene Proteins 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
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- 239000013603 viral vector Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des thérapies efficaces contre la douleur chez des animaux de compagnie. En particulier, l'invention concerne une protéine p75NTR d'animal de compagnie isolée ou une protéine de fusion contenant celle-ci ou des parties de celle-ci. L'invention concerne également des acides nucléiques codant les protéines ainsi que des méthodes d'utilisation de ceux-ci.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17/506,876 | 2021-10-21 | ||
| GBGB2115098.2A GB202115098D0 (en) | 2021-10-21 | 2021-10-21 | Therapeutic molecules |
| US17/506,876 US11608371B1 (en) | 2021-10-21 | 2021-10-21 | Therapeutic molecules |
| GB2115098.2 | 2021-10-21 | ||
| PCT/GB2022/052692 WO2023067358A1 (fr) | 2021-10-21 | 2022-10-21 | Protéines comprenant le domaine extracellulaire de p75ntr |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3236019A1 true CA3236019A1 (fr) | 2023-04-27 |
Family
ID=84084427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3236019A Pending CA3236019A1 (fr) | 2021-10-21 | 2022-10-21 | Proteines comprenant le domaine extracellulaire de p75ntr |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU2022369106A1 (fr) |
| CA (1) | CA3236019A1 (fr) |
| CO (1) | CO2024005719A2 (fr) |
| WO (1) | WO2023067358A1 (fr) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525662D0 (en) | 2005-12-16 | 2006-01-25 | Glaxo Group Ltd | Immunoglobulins |
| PT2825208T (pt) | 2012-03-14 | 2017-08-25 | Levicept Ltd | Proteína de ligação de neurotrofinas p75ntr para utilização terapêutica |
| GB201316592D0 (en) * | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
| GB201504691D0 (en) * | 2015-03-19 | 2015-05-06 | Levicept Ltd | Fusion protein |
| JP2021517461A (ja) | 2018-03-12 | 2021-07-26 | ゾエティス・サービシーズ・エルエルシー | 抗ｎｇｆ抗体およびその方法 |
| US11542333B2 (en) | 2019-01-03 | 2023-01-03 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
| AU2020240120A1 (en) * | 2019-03-20 | 2021-09-30 | Elanco Us Inc. | NGF antagonists for medical use |
-
2022
- 2022-10-21 CA CA3236019A patent/CA3236019A1/fr active Pending
- 2022-10-21 WO PCT/GB2022/052692 patent/WO2023067358A1/fr active Application Filing
- 2022-10-21 AU AU2022369106A patent/AU2022369106A1/en active Pending
-
2024
- 2024-04-30 CO CONC2024/0005719A patent/CO2024005719A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022369106A1 (en) | 2024-04-11 |
| WO2023067358A1 (fr) | 2023-04-27 |
| CO2024005719A2 (es) | 2024-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20240419 |
|
| EEER | Examination request |
Effective date: 20240419 |