CA3233342A1 - Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type - Google Patents

Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type Download PDF

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Publication number
CA3233342A1
CA3233342A1 CA3233342A CA3233342A CA3233342A1 CA 3233342 A1 CA3233342 A1 CA 3233342A1 CA 3233342 A CA3233342 A CA 3233342A CA 3233342 A CA3233342 A CA 3233342A CA 3233342 A1 CA3233342 A1 CA 3233342A1
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ehgt
coding sequence
seq
cells
heterologous coding
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CA3233342A
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English (en)
French (fr)
Inventor
Tanya DAIGLE
Edward Sebastian LEIN
Boaz P. LEVI
Bosiljka Tasic
Jonathan Ting
Hongkui Zeng
John K. Mich
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Allen Institute
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Allen Institute
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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CA3233342A 2021-10-05 2022-10-05 Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type Pending CA3233342A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163252520P 2021-10-05 2021-10-05
US63/252,520 2021-10-05
PCT/US2022/077586 WO2023060112A1 (en) 2021-10-05 2022-10-05 Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type

Publications (1)

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CA3233342A1 true CA3233342A1 (en) 2023-04-13

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CA3233342A Pending CA3233342A1 (en) 2021-10-05 2022-10-05 Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type

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US (1) US20250235550A1 (https=)
EP (1) EP4413142A4 (https=)
JP (1) JP2024537165A (https=)
AU (1) AU2022360979A1 (https=)
CA (1) CA3233342A1 (https=)
WO (1) WO2023060112A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024308266A1 (en) * 2023-06-28 2025-12-18 Allen Institute Artificial expression constructs for modulating gene expression in cardiomyocytes
WO2025179180A1 (en) * 2024-02-23 2025-08-28 Allen Institute Artificial expression constructs for modulating gene expression in motor neurons and cerebellar neurons

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
US20220249703A1 (en) * 2019-02-15 2022-08-11 Allen Institute Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations
CA3173609A1 (en) * 2020-03-27 2021-09-30 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells
AU2021261359A1 (en) * 2020-04-21 2022-12-08 Allen Institute Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons
WO2022246276A2 (en) * 2021-05-21 2022-11-24 Allen Institute Artificial expression constructs for modulating gene expression in neurons within the thalamus

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JP2024537165A (ja) 2024-10-10
AU2022360979A1 (en) 2024-05-09
WO2023060112A1 (en) 2023-04-13
US20250235550A1 (en) 2025-07-24
EP4413142A1 (en) 2024-08-14
EP4413142A4 (en) 2025-11-05

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